Bentamapimod_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bentamapimod perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bentamapimod_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYO1E myosin IE 0.14002
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.120143
PDE4D phosphodiesterase 4D, cAMP-specific 0.117667
SAMD4A sterile alpha motif domain containing 4A 0.11628
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0772046
LMO7 LIM domain 7 0.0727604
BACE2 beta-site APP-cleaving enzyme 2 0.0724491
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0671474
SMYD3 SET and MYND domain containing 3 0.0671375
BZW1 basic leucine zipper and W2 domains 1 0.0667744
EGFR epidermal growth factor receptor 0.0652399
ZSWIM6 zinc finger, SWIM-type containing 6 0.06412
DOCK5 dedicator of cytokinesis 5 0.0625198
SVIL supervillin 0.0618339
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0617042
RAD51B RAD51 paralog B 0.0615834
ATXN1 ataxin 1 0.0611849
ELL2 elongation factor, RNA polymerase II, 2 0.0589132
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.055839
AKAP13 A kinase (PRKA) anchor protein 13 0.0514884
MBNL1 muscleblind-like splicing regulator 1 0.0511432
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0509971
SMOC1 SPARC related modular calcium binding 1 0.0509097
CDCP1 CUB domain containing protein 1 0.0506014
MAML3 mastermind-like 3 (Drosophila) 0.0500999
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.049902
EFNA5 ephrin-A5 0.0490396
TM4SF1 transmembrane 4 L six family member 1 0.0485476
RNF213 ring finger protein 213 0.0483493
EHBP1 EH domain binding protein 1 0.047475
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0465074
ARHGAP5 Rho GTPase activating protein 5 0.0455387
PDLIM5 PDZ and LIM domain 5 0.045351
USP53 ubiquitin specific peptidase 53 0.0452955
IGF2 insulin-like growth factor 2 0.0447547
CSNK1A1 casein kinase 1, alpha 1 0.0445632
INTS6 integrator complex subunit 6 0.0428811
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0428062
MTUS1 microtubule associated tumor suppressor 1 0.042229
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0421646
SMAD3 SMAD family member 3 0.0417704
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0411714
CD44 CD44 molecule (Indian blood group) 0.0411467
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0404504
LIMCH1 LIM and calponin homology domains 1 0.040238
NRG1 neuregulin 1 0.0402284
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0401628
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0400992
LDHA lactate dehydrogenase A 0.0397324
DTNA dystrobrevin, alpha 0.0397264
CEP170 centrosomal protein 170kDa 0.0396693
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0394281
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0394233
N4BP2L2 NEDD4 binding protein 2-like 2 0.0391247
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0391234
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.039096
TMEM165 transmembrane protein 165 0.0389447
CXCL8 chemokine (C-X-C motif) ligand 8 0.0387085
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0386888
RORA RAR-related orphan receptor A 0.0385432
FRY furry homolog (Drosophila) 0.0379632
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0376005
RBM47 RNA binding motif protein 47 0.0373029
ANO6 anoctamin 6 0.0372556
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.036996
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.03698
GMDS GDP-mannose 4,6-dehydratase 0.0369735
GLIS3 GLIS family zinc finger 3 0.0364093
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.035891
RPS8 ribosomal protein S8 0.0354549
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0351929
AEBP2 AE binding protein 2 0.0348159
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0348156
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0343012
NACA nascent polypeptide-associated complex alpha subunit 0.0342329
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0341471
EXT1 exostosin glycosyltransferase 1 0.0341296
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0340911
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0338209
MBD5 methyl-CpG binding domain protein 5 0.0333319
GLS2 glutaminase 2 (liver, mitochondrial) 0.0332507
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0329424
RPS27A ribosomal protein S27a 0.0328119
PDE10A phosphodiesterase 10A 0.0324972
TJP1 tight junction protein 1 0.0322202
NEBL nebulette 0.031898
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0318396
IGF1R insulin-like growth factor 1 receptor 0.0317949
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0316534
TOR1AIP2 torsin A interacting protein 2 0.0315912
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0315348
TBC1D22A TBC1 domain family, member 22A 0.0314517
OSMR oncostatin M receptor 0.0310866
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0310355
BRD2 bromodomain containing 2 0.0310265
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0310255
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 0.0307466
PATJ PATJ crumbs cell polarity complex component 0.0305643
SENP6 SUMO1/sentrin specific peptidase 6 0.0304113
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0303848

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.114548
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.110141
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0931528
TMSB10 thymosin beta 10 -0.0930508
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0913349
TRA2A transformer 2 alpha homolog (Drosophila) -0.0898018
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.088067
GRB10 growth factor receptor-bound protein 10 -0.088065
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0868948
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0795637
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0761514
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0758178
DICER1 dicer 1, ribonuclease type III -0.0731648
SLC38A1 solute carrier family 38, member 1 -0.0720861
SRPK2 SRSF protein kinase 2 -0.0718704
OGA O-GlcNAcase -0.0689207
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0682011
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0662495
KMT2C lysine (K)-specific methyltransferase 2C -0.0646246
MARCHF6 membrane associated ring-CH-type finger 6 -0.0644655
SPAG9 sperm associated antigen 9 -0.0631486
NPTN neuroplastin -0.0623794
KDM6A lysine (K)-specific demethylase 6A -0.0621393
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0598829
GCLC glutamate-cysteine ligase, catalytic subunit -0.0594158
LAMB3 laminin, beta 3 -0.0561125
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0553874
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0548775
NAMPT nicotinamide phosphoribosyltransferase -0.0528608
KDM3A lysine (K)-specific demethylase 3A -0.0521529
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0520286
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0517288
IFIH1 interferon induced with helicase C domain 1 -0.0514134
TPT1 tumor protein, translationally-controlled 1 -0.0512832
RBM39 RNA binding motif protein 39 -0.0511604
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0507553
PICALM phosphatidylinositol binding clathrin assembly protein -0.0503685
H3-3B H3.3 histone B -0.0499414
KMT2E lysine (K)-specific methyltransferase 2E -0.0497924
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0485603
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0480683
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0475356
RAB8B RAB8B, member RAS oncogene family -0.0466883
TNIP1 TNFAIP3 interacting protein 1 -0.04659
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0460447
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0456777
NEK7 NIMA-related kinase 7 -0.0453552
TXNRD1 thioredoxin reductase 1 -0.0449515
PTMA prothymosin, alpha -0.0444746
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0437396
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0434038
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0431183
EPS8 epidermal growth factor receptor pathway substrate 8 -0.042913
RNF149 ring finger protein 149 -0.042102
PTK2 protein tyrosine kinase 2 -0.042046
ZNFX1 zinc finger, NFX1-type containing 1 -0.041511
MXD1 MAX dimerization protein 1 -0.0410657
DENND4C DENN/MADD domain containing 4C -0.0409631
USP34 ubiquitin specific peptidase 34 -0.0407875
RAP1B RAP1B, member of RAS oncogene family -0.0396895
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.039633
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0383424
SNX9 sorting nexin 9 -0.0382888
RIOK3 RIO kinase 3 -0.0381637
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.038015
ACVR1 activin A receptor, type I -0.0377716
FTH1 ferritin, heavy polypeptide 1 -0.0377115
RB1CC1 RB1-inducible coiled-coil 1 -0.0377107
RPL12 ribosomal protein L12 -0.0375935
EML4 echinoderm microtubule associated protein like 4 -0.0375856
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0374081
RPS19 ribosomal protein S19 -0.0367048
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0366661
KLHL24 kelch-like family member 24 -0.0366642
TMSB4X thymosin beta 4, X-linked -0.0365736
NF1 neurofibromin 1 -0.0364542
ATOSA atos homolog A -0.0364267
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0359803
SAR1A secretion associated, Ras related GTPase 1A -0.0359489
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.035838
RPS13 ribosomal protein S13 -0.0357621
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0356133
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0351127
ADAM17 ADAM metallopeptidase domain 17 -0.0350574
BBX bobby sox homolog (Drosophila) -0.0350319
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0348542
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0348151
NCOA7 nuclear receptor coactivator 7 -0.0346974
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0345191
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0344961
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.034048
STAU1 staufen double-stranded RNA binding protein 1 -0.0338325
CCNI cyclin I -0.0335779
LCORL ligand dependent nuclear receptor corepressor-like -0.0335197
RPS29 ribosomal protein S29 -0.0335092
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0331951
THOC2 THO complex 2 -0.0328471
SDCBP syndecan binding protein (syntenin) -0.032827
NPEPPS aminopeptidase puromycin sensitive -0.032509
S100A6 S100 calcium binding protein A6 -0.0320865