Bentamapimod_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Bentamapimod perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Bentamapimod_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.240527
EXT1 exostosin glycosyltransferase 1 0.118873
ZSWIM6 zinc finger, SWIM-type containing 6 0.107217
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0888289
ALCAM activated leukocyte cell adhesion molecule 0.0817141
RACK1 receptor for activated C kinase 1 0.078793
SAMD4A sterile alpha motif domain containing 4A 0.0772171
RPL23 ribosomal protein L23 0.067962
EIF1 eukaryotic translation initiation factor 1 0.0653357
POTEF POTE ankyrin domain family, member F 0.0634109
RPS3 ribosomal protein S3 0.061087
DTNA dystrobrevin, alpha 0.0593754
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0591239
FTL ferritin, light polypeptide 0.0573102
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0569275
EFNA5 ephrin-A5 0.0515698
RPS12 ribosomal protein S12 0.0511358
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0507151
RPL9 ribosomal protein L9 0.0489162
RPS8 ribosomal protein S8 0.0474033
RPL37A ribosomal protein L37a 0.0473235
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0456153
RPS17 ribosomal protein S17 0.0453552
RPL12 ribosomal protein L12 0.0445793
RPLP1 ribosomal protein, large, P1 0.0426732
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0411085
MAP1B microtubule-associated protein 1B 0.0402192
RPL37 ribosomal protein L37 0.040082
SQSTM1 sequestosome 1 0.0394624
MACC1 metastasis associated in colon cancer 1 0.039411
PGBD5 piggyBac transposable element derived 5 0.0392278
FBXO32 F-box protein 32 0.0391361
MYO1E myosin IE 0.0386183
GOLGB1 golgin B1 0.0380389
RPLP0 ribosomal protein, large, P0 0.0377453
TJP1 tight junction protein 1 0.0375136
RPL30 ribosomal protein L30 0.0373501
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0367764
APLP2 amyloid beta (A4) precursor-like protein 2 0.0366635
FNIP1 folliculin interacting protein 1 0.0366444
PABPC1 poly(A) binding protein, cytoplasmic 1 0.035982
ATXN1 ataxin 1 0.0347514
LOC102724023 ES1 protein homolog, mitochondrial 0.0345333
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0342932
DSPP dentin sialophosphoprotein 0.0337865
CSNK1A1 casein kinase 1, alpha 1 0.0334407
CD44 CD44 molecule (Indian blood group) 0.0331314
PALLD palladin, cytoskeletal associated protein 0.0329372
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0327422
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0325695
INTS6 integrator complex subunit 6 0.0323763
RPS6 ribosomal protein S6 0.0319722
ETV6 ets variant 6 0.0316151
RPS19 ribosomal protein S19 0.0315267
RAD51B RAD51 paralog B 0.0314638
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0312296
ANKRD17 ankyrin repeat domain 17 0.0311602
RPLP2 ribosomal protein, large, P2 0.0311532
LDHA lactate dehydrogenase A 0.0306025
ZBTB20 zinc finger and BTB domain containing 20 0.0301481
SGMS2 sphingomyelin synthase 2 0.0297817
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0295824
SVIL supervillin 0.0293007
ENO1 enolase 1, (alpha) 0.0292109
RPL7 ribosomal protein L7 0.0291385
VGLL3 vestigial-like family member 3 0.0290039
OCLN occludin 0.0289051
RPL5 ribosomal protein L5 0.0289048
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0285971
PRRC2C proline-rich coiled-coil 2C 0.0283882
EGR1 early growth response 1 0.0282947
SCFD1 sec1 family domain containing 1 0.0279337
RPS29 ribosomal protein S29 0.0278594
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0277836
EEF1G eukaryotic translation elongation factor 1 gamma 0.0274207
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0273834
AKAP13 A kinase (PRKA) anchor protein 13 0.0273039
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0272522
ANKRD12 ankyrin repeat domain 12 0.0269806
ERBIN erbb2 interacting protein 0.0266011
FHIT fragile histidine triad 0.0264236
RPL27 ribosomal protein L27 0.0263503
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0263243
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0261323
ARHGAP5 Rho GTPase activating protein 5 0.0259777
WWTR1 WW domain containing transcription regulator 1 0.0259577
BRD2 bromodomain containing 2 0.0258509
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0258185
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0258089
KIAA1217 KIAA1217 0.0257004
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0256464
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0255619
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0254784
RPS14 ribosomal protein S14 0.025429
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0251615
NAV2 neuron navigator 2 0.024957
HDAC9 histone deacetylase 9 0.0249168
RAB7A RAB7A, member RAS oncogene family 0.0243851
EGFR epidermal growth factor receptor 0.0243742
MYOF myoferlin 0.0243208

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.173705
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.13206
TSC22D2 TSC22 domain family, member 2 -0.120592
NDRG1 N-myc downstream regulated 1 -0.117099
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114131
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.106775
FN1 fibronectin 1 -0.103566
NPEPPS aminopeptidase puromycin sensitive -0.0966414
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0778246
PTMA prothymosin, alpha -0.0775431
ASPH aspartate beta-hydroxylase -0.0749845
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0706597
RNF145 ring finger protein 145 -0.0672479
FNDC3B fibronectin type III domain containing 3B -0.0665773
PGK1 phosphoglycerate kinase 1 -0.0637281
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0636917
TFG TRK-fused gene -0.060107
MARCHF6 membrane associated ring-CH-type finger 6 -0.0585
KMT2E lysine (K)-specific methyltransferase 2E -0.0579865
NAMPT nicotinamide phosphoribosyltransferase -0.0568897
TOP1 topoisomerase (DNA) I -0.0565071
CD2AP CD2-associated protein -0.0559408
ADAM9 ADAM metallopeptidase domain 9 -0.0552768
CCNL1 cyclin L1 -0.053613
RBM39 RNA binding motif protein 39 -0.0510717
TMEM123 transmembrane protein 123 -0.0509215
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0503543
UBC ubiquitin C -0.0501255
USP3 ubiquitin specific peptidase 3 -0.0498499
FAM3C family with sequence similarity 3, member C -0.0494861
FAM162A family with sequence similarity 162, member A -0.0487161
RAD21 RAD21 homolog (S. pombe) -0.0486983
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0465771
KDM3A lysine (K)-specific demethylase 3A -0.0448465
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0441514
ITCH itchy E3 ubiquitin protein ligase -0.0433432
TM4SF1 transmembrane 4 L six family member 1 -0.0432357
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0431865
MXD1 MAX dimerization protein 1 -0.0431315
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0429955
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0421048
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0413555
FAM13A family with sequence similarity 13, member A -0.0410987
GRB10 growth factor receptor-bound protein 10 -0.0408489
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0404773
CDK17 cyclin-dependent kinase 17 -0.0394247
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0385727
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0375676
ZFAND3 zinc finger, AN1-type domain 3 -0.037279
KDM5B lysine (K)-specific demethylase 5B -0.0365931
STRN3 striatin, calmodulin binding protein 3 -0.0361027
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.036071
NUP58 nucleoporin 58 -0.0354428
LMO7 LIM domain 7 -0.0346049
QKI QKI, KH domain containing, RNA binding -0.0344934
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0342714
G0S2 G0/G1 switch 2 -0.0336798
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0333435
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0332635
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0331255
GARS1 glycyl-tRNA synthetase 1 -0.0328326
RAB1A RAB1A, member RAS oncogene family -0.0327358
PRRC1 proline-rich coiled-coil 1 -0.0324698
WAC WW domain containing adaptor with coiled-coil -0.0322157
ARHGAP29 Rho GTPase activating protein 29 -0.0320403
RTN4 reticulon 4 -0.0319666
HMGA1 high mobility group AT-hook 1 -0.0313932
SLMAP sarcolemma associated protein -0.0306251
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0299379
SPAG9 sperm associated antigen 9 -0.0298952
ACTG1 actin gamma 1 -0.0297378
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0294155
KCTD9 potassium channel tetramerization domain containing 9 -0.0288572
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0287332
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0286149
PARD3 par-3 family cell polarity regulator -0.0278654
S100A10 S100 calcium binding protein A10 -0.0275377
CDC73 cell division cycle 73 -0.0273198
SSBP2 single-stranded DNA binding protein 2 -0.0272139
TMEM263 transmembrane protein 263 -0.0272057
PDIA3 protein disulfide isomerase family A, member 3 -0.0271188
TRA2A transformer 2 alpha homolog (Drosophila) -0.0265494
WTAP Wilms tumor 1 associated protein -0.0264775
CANX calnexin -0.0260826
ZNF207 zinc finger protein 207 -0.0258626
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0257805
COPA coatomer protein complex, subunit alpha -0.0257461
RIOK3 RIO kinase 3 -0.0254093
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0253826
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0249373
NDFIP1 Nedd4 family interacting protein 1 -0.0248469
OGA O-GlcNAcase -0.024739
RHEB Ras homolog enriched in brain -0.0246984
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0246766
UGCG UDP-glucose ceramide glucosyltransferase -0.0245605
DSCAM Down syndrome cell adhesion molecule -0.024215
S100A6 S100 calcium binding protein A6 -0.0241648
SDC4 syndecan 4 -0.0241054
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0240975
WASF2 WAS protein family, member 2 -0.0239507