Benzbromarone Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/2333
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Genes

199 proteins with high or low expression in Benzbromarone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
PIP prolactin-induced protein 4.99
LZTS1 leucine zipper, putative tumor suppressor 1 4.11
MCOLN3 mucolipin 3 3.15
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.08
MSLN mesothelin 1.91
HSP90AA4P heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene 1.56
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 1.33
RGN regucalcin 1.3
CLTCL1 clathrin, heavy chain-like 1 1.24
TACC2 transforming, acidic coiled-coil containing protein 2 1.23
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 1.22
ENO1 enolase 1, (alpha) 1.11
PCLO piccolo presynaptic cytomatrix protein 1.05
ZFYVE1 zinc finger, FYVE domain containing 1 1.01
FBXO41 F-box protein 41 0.97
B2M beta-2-microglobulin 0.92
CETN1 centrin, EF-hand protein, 1 0.78
VIM vimentin 0.78
PALB2 partner and localizer of BRCA2 0.74
CENPJ centromere protein J 0.73
NAIF1 nuclear apoptosis inducing factor 1 0.73
BBS7 Bardet-Biedl syndrome 7 0.72
MCOLN1 mucolipin 1 0.71
COL17A1 collagen, type XVII, alpha 1 0.66
TMEM64 transmembrane protein 64 0.61
PIWIL2 piwi-like RNA-mediated gene silencing 2 0.61
TMSB10 thymosin beta 10 0.59
WWC3 WWC family member 3 0.58
YBX3 Y box binding protein 3 0.54
SPC24 SPC24, NDC80 kinetochore complex component 0.53
IFRD1 interferon-related developmental regulator 1 0.53
BARD1 BRCA1 associated RING domain 1 0.51
RPE ribulose-5-phosphate-3-epimerase 0.5
ZNF286B zinc finger protein 286B 0.5
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 0.5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.49
BPHL biphenyl hydrolase-like (serine hydrolase) 0.49
NUCB2 nucleobindin 2 0.47
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.47
CCDC15 coiled-coil domain containing 15 0.46
KDM5D lysine (K)-specific demethylase 5D 0.46
NDOR1 NADPH dependent diflavin oxidoreductase 1 0.45
CEP295 centrosomal protein 295kDa 0.45
CORO1A coronin, actin binding protein, 1A 0.43
ZNF250 zinc finger protein 250 0.43
NOP16 NOP16 nucleolar protein 0.43
CAMK1 calcium/calmodulin-dependent protein kinase I 0.42
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.42
STAB1 stabilin 1 0.42
KLHL23 kelch-like family member 23 0.4
TRIP10 thyroid hormone receptor interactor 10 0.4
PRR3 proline rich 3 0.4
HAUS7 HAUS augmin-like complex, subunit 7 0.39
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.39
MCFD2 multiple coagulation factor deficiency 2 0.39
WDR7 WD repeat domain 7 0.38
TESC tescalcin 0.38
MRC2 mannose receptor, C type 2 0.38
GJC1 gap junction protein, gamma 1, 45kDa 0.37
ZNF57 zinc finger protein 57 0.37
ZFAND3 zinc finger, AN1-type domain 3 0.37
TBC1D2 TBC1 domain family, member 2 0.36
ZNF672 zinc finger protein 672 0.36
PACRGL PARK2 co-regulated-like 0.36
MYCBP MYC binding protein 0.36
TNS1 tensin 1 0.35
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.35
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae) 0.35
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.35
ITGB8 integrin, beta 8 0.35
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 0.35
FBRSL1 fibrosin-like 1 0.35
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.35
TTPA tocopherol (alpha) transfer protein 0.34
RPLP1 ribosomal protein, large, P1 0.34
CCHCR1 coiled-coil alpha-helical rod protein 1 0.34
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 0.34
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 0.34
NNT nicotinamide nucleotide transhydrogenase 0.33
GPN3 GPN-loop GTPase 3 0.33
HAUS1 HAUS augmin-like complex, subunit 1 0.33
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.33
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.33
F3 coagulation factor III (thromboplastin, tissue factor) 0.32
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.32
GLI2 GLI family zinc finger 2 0.32
SNIP1 Smad nuclear interacting protein 1 0.32
ARMC7 armadillo repeat containing 7 0.32
PPP1R3D protein phosphatase 1, regulatory subunit 3D 0.32
CRPPA CDP-L-ribitol pyrophosphorylase A 0.31
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.31
NADK NAD kinase 0.31
TNNC2 troponin C type 2 (fast) 0.31
DOHH deoxyhypusine hydroxylase/monooxygenase 0.31
DTWD2 DTW domain containing 2 0.31
MEX3C mex-3 RNA binding family member C 0.31
TIMP2 TIMP metallopeptidase inhibitor 2 0.31
PLAAT3 phospholipase A and acyltransferase 3 0.31
HSPA8 heat shock 70kDa protein 8 0.3

low expression

Symbol Name Standardized Value
SRD5A3 steroid 5 alpha-reductase 3 -5.55
MRPS18C mitochondrial ribosomal protein S18C -2.19
CORO2B coronin, actin binding protein, 2B -2.03
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -1.18
TMEM14C transmembrane protein 14C -1.16
STEAP2 STEAP family member 2, metalloreductase -1.13
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -1.13
TMEM231 transmembrane protein 231 -1.08
PEX16 peroxisomal biogenesis factor 16 -1.05
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -1.01
NCOR1 nuclear receptor corepressor 1 -0.97
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 -0.97
HIST3H2A histone cluster 3, H2a -0.91
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -0.88
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -0.88
TECR trans-2,3-enoyl-CoA reductase -0.88
OTULINL OTU deubiquitinase with linear linkage specificity like -0.84
CSNK1G3 casein kinase 1, gamma 3 -0.81
HMCN1 hemicentin 1 -0.79
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -0.79
USP12 ubiquitin specific peptidase 12 -0.77
TMEM11 transmembrane protein 11 -0.77
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing -0.76
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.76
ELP6 elongator acetyltransferase complex subunit 6 -0.73
TEC tec protein tyrosine kinase -0.71
GGPS1 geranylgeranyl diphosphate synthase 1 -0.7
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.68
HACD2 3-hydroxyacyl-CoA dehydratase 2 -0.67
GALNS galactosamine (N-acetyl)-6-sulfatase -0.67
WASF3 WAS protein family, member 3 -0.66
SGSH N-sulfoglucosamine sulfohydrolase -0.64
BBS9 Bardet-Biedl syndrome 9 -0.63
HBA1 hemoglobin, alpha 1 -0.63
CEP72 centrosomal protein 72kDa -0.63
SYT17 synaptotagmin XVII -0.62
SGMS2 sphingomyelin synthase 2 -0.62
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -0.62
MSI1 musashi RNA-binding protein 1 -0.61
HRAS Harvey rat sarcoma viral oncogene homolog -0.6
SGSM3 small G protein signaling modulator 3 -0.59
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -0.57
TTC7A tetratricopeptide repeat domain 7A -0.56
TBC1D32 TBC1 domain family, member 32 -0.55
LRRC41 leucine rich repeat containing 41 -0.54
ZNF354A zinc finger protein 354A -0.54
BTBD3 BTB (POZ) domain containing 3 -0.54
GOLPH3 golgi phosphoprotein 3 (coat-protein) -0.53
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.53
ALG6 ALG6, alpha-1,3-glucosyltransferase -0.52
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -0.52
MRE11 MRE11 homolog, double strand break repair nuclease -0.51
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.51
SNX13 sorting nexin 13 -0.51
RPL10L ribosomal protein L10-like -0.5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.5
TRIM9 tripartite motif containing 9 -0.5
RTN2 reticulon 2 -0.49
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -0.49
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.49
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -0.48
ZBED5 zinc finger, BED-type containing 5 -0.48
RAB2A RAB2A, member RAS oncogene family -0.47
MAST1 microtubule associated serine/threonine kinase 1 -0.47
PRKACA protein kinase, cAMP-dependent, catalytic, alpha -0.47
TMEM184C transmembrane protein 184C -0.46
EXTL2 exostosin-like glycosyltransferase 2 -0.46
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.46
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) -0.46
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.46
AGFG2 ArfGAP with FG repeats 2 -0.46
ZBED6 zinc finger, BED-type containing 6 -0.45
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -0.45
ZC3H4 zinc finger CCCH-type containing 4 -0.44
TIA1 TIA1 cytotoxic granule-associated RNA binding protein -0.44
TXNDC17 thioredoxin domain containing 17 -0.44
CTU1 cytosolic thiouridylase subunit 1 -0.44
MZT2B mitotic spindle organizing protein 2B -0.44
PROCR protein C receptor, endothelial -0.44
SPPL2A signal peptide peptidase like 2A -0.44
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -0.43
FGGY FGGY carbohydrate kinase domain containing -0.43
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -0.42
PROM1 prominin 1 -0.42
CUEDC1 CUE domain containing 1 -0.42
ZNF92 zinc finger protein 92 -0.41
MPZL2 myelin protein zero-like 2 -0.41
FGB fibrinogen beta chain -0.41
ZNF658 zinc finger protein 658 -0.4
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -0.4
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.4
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) -0.4
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.4
C7 complement component 7 -0.4
CBWD1 COBW domain containing 1 -0.39
DPYSL3 dihydropyrimidinase-like 3 -0.39
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.39
GMPPB GDP-mannose pyrophosphorylase B -0.39
AUP1 ancient ubiquitous protein 1 -0.39
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 -0.39