| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. (Chemical Entities of Biological Interest Ontology, CHEBI_29865) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2336 |
| Similar Terms | |
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199 proteins with high or low expression in Benzo[a]pyrene relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 3.08 |
| CCDC15 | coiled-coil domain containing 15 | 0.93 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.55 |
| SOX13 | SRY (sex determining region Y)-box 13 | 0.54 |
| PWWP3B | PWWP domain containing 3B | 0.53 |
| HAS3 | hyaluronan synthase 3 | 0.52 |
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) | 0.52 |
| STC2 | stanniocalcin 2 | 0.51 |
| HES1 | hes family bHLH transcription factor 1 | 0.49 |
| FAM126B | family with sequence similarity 126, member B | 0.49 |
| DNAH6 | dynein, axonemal, heavy chain 6 | 0.49 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.47 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.47 |
| C18ORF32 | chromosome 18 open reading frame 32 | 0.47 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.46 |
| TIPE1 | TNF alpha induced protein 8 like 1 | 0.44 |
| ADCY7 | adenylate cyclase 7 | 0.43 |
| LMTK2 | lemur tyrosine kinase 2 | 0.43 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.42 |
| SLC16A6 | solute carrier family 16, member 6 | 0.41 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.4 |
| CAPN6 | calpain 6 | 0.39 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | 0.38 |
| TULP4 | tubby like protein 4 | 0.36 |
| SLC4A3 | solute carrier family 4 (anion exchanger), member 3 | 0.36 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.36 |
| RIOX1 | ribosomal oxygenase 1 | 0.36 |
| MPDZ | multiple PDZ domain protein | 0.35 |
| KIAA0232 | KIAA0232 | 0.35 |
| GDF15 | growth differentiation factor 15 | 0.34 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | 0.34 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 0.34 |
| EFNB2 | ephrin-B2 | 0.34 |
| TFPT | TCF3 (E2A) fusion partner (in childhood Leukemia) | 0.34 |
| CARD8 | caspase recruitment domain family, member 8 | 0.34 |
| RXRG | retinoid X receptor, gamma | 0.34 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | 0.34 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.34 |
| PARP16 | poly (ADP-ribose) polymerase family, member 16 | 0.33 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | 0.33 |
| PARPBP | PARP1 binding protein | 0.33 |
| CIR1 | corepressor interacting with RBPJ, 1 | 0.33 |
| VIM | vimentin | 0.33 |
| CEP152 | centrosomal protein 152kDa | 0.33 |
| BPTF | bromodomain PHD finger transcription factor | 0.33 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | 0.32 |
| TMEM106C | transmembrane protein 106C | 0.32 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.32 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.32 |
| TMEM104 | transmembrane protein 104 | 0.31 |
| CCN3 | cellular communication network factor 3 | 0.31 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | 0.31 |
| COA5 | cytochrome c oxidase assembly factor 5 | 0.31 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.31 |
| KLHDC8B | kelch domain containing 8B | 0.31 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | 0.3 |
| DGCR2 | DiGeorge syndrome critical region gene 2 | 0.3 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.3 |
| AARS | alanyl-tRNA synthetase | 0.3 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.29 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.29 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 0.29 |
| COL6A3 | collagen, type VI, alpha 3 | 0.29 |
| PLA2G12A | phospholipase A2, group XIIA | 0.29 |
| MCOLN3 | mucolipin 3 | 0.29 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.28 |
| RBM4B | RNA binding motif protein 4B | 0.28 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | 0.28 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | 0.28 |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | 0.28 |
| RNF13 | ring finger protein 13 | 0.28 |
| CALU | calumenin | 0.28 |
| DPH7 | diphthamide biosynthesis 7 | 0.28 |
| MEGF8 | multiple EGF-like-domains 8 | 0.27 |
| RNF130 | ring finger protein 130 | 0.27 |
| TET2 | tet methylcytosine dioxygenase 2 | 0.27 |
| GAB1 | GRB2-associated binding protein 1 | 0.27 |
| LRP4 | low density lipoprotein receptor-related protein 4 | 0.27 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | 0.27 |
| SMAD3 | SMAD family member 3 | 0.26 |
| TTYH3 | tweety family member 3 | 0.26 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | 0.26 |
| PLPP6 | phospholipid phosphatase 6 | 0.26 |
| ZNF275 | zinc finger protein 275 | 0.26 |
| MFSD14B | major facilitator superfamily domain containing 14B | 0.26 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | 0.26 |
| KITLG | KIT ligand | 0.26 |
| ZNF354A | zinc finger protein 354A | 0.26 |
| RGL2 | ral guanine nucleotide dissociation stimulator-like 2 | 0.26 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.26 |
| TATDN2 | TatD DNase domain containing 2 | 0.25 |
| ZNF483 | zinc finger protein 483 | 0.25 |
| TMEM184B | transmembrane protein 184B | 0.25 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.25 |
| ADCK1 | aarF domain containing kinase 1 | 0.25 |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | 0.25 |
| BHLHA15 | basic helix-loop-helix family, member a15 | 0.24 |
| COQ7 | coenzyme Q7 homolog, ubiquinone (yeast) | 0.24 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -1.07 |
| RPE | ribulose-5-phosphate-3-epimerase | -0.89 |
| E2F2 | E2F transcription factor 2 | -0.85 |
| AHR | aryl hydrocarbon receptor | -0.8 |
| KLK7 | kallikrein-related peptidase 7 | -0.71 |
| SH3TC2 | SH3 domain and tetratricopeptide repeats 2 | -0.69 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.68 |
| SH3BP2 | SH3-domain binding protein 2 | -0.67 |
| TRAK2 | trafficking protein, kinesin binding 2 | -0.59 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.58 |
| CLGN | calmegin | -0.58 |
| SKIL | SKI-like proto-oncogene | -0.58 |
| ANKRD39 | ankyrin repeat domain 39 | -0.55 |
| KALRN | kalirin, RhoGEF kinase | -0.54 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | -0.53 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | -0.5 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.49 |
| ALKBH7 | alkB, alkylation repair homolog 7 (E. coli) | -0.48 |
| HHEX | hematopoietically expressed homeobox | -0.47 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.47 |
| PTPN21 | protein tyrosine phosphatase, non-receptor type 21 | -0.46 |
| DUSP5 | dual specificity phosphatase 5 | -0.45 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | -0.45 |
| FAM185A | family with sequence similarity 185, member A | -0.44 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | -0.43 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.43 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | -0.43 |
| OPTN | optineurin | -0.43 |
| MAGEA2 | melanoma antigen family A2 | -0.41 |
| XTBD1 | XRN2 binding domain containing 1 | -0.41 |
| ZNF618 | zinc finger protein 618 | -0.4 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.4 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.39 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.39 |
| TMUB2 | transmembrane and ubiquitin-like domain containing 2 | -0.39 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.39 |
| FHOD3 | formin homology 2 domain containing 3 | -0.38 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | -0.38 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | -0.38 |
| MEX3A | mex-3 RNA binding family member A | -0.38 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.37 |
| ZNF286B | zinc finger protein 286B | -0.36 |
| TNNI3 | troponin I type 3 (cardiac) | -0.36 |
| C2ORF76 | chromosome 2 open reading frame 76 | -0.35 |
| HIKESHI | heat shock protein nuclear import factor hikeshi | -0.35 |
| FBXO10 | F-box protein 10 | -0.35 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | -0.35 |
| ZNF354B | zinc finger protein 354B | -0.35 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.35 |
| ZNF584 | zinc finger protein 584 | -0.34 |
| ZBTB6 | zinc finger and BTB domain containing 6 | -0.34 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | -0.34 |
| LMOD1 | leiomodin 1 (smooth muscle) | -0.34 |
| PHF1 | PHD finger protein 1 | -0.34 |
| CES2 | carboxylesterase 2 | -0.34 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | -0.33 |
| MIS12 | MIS12 kinetochore complex component | -0.33 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.33 |
| UBQLN1 | ubiquilin 1 | -0.33 |
| MT1L | metallothionein 1L (gene/pseudogene) | -0.33 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.32 |
| COX5A | cytochrome c oxidase subunit Va | -0.31 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.31 |
| GLTP | glycolipid transfer protein | -0.31 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.31 |
| RBM18 | RNA binding motif protein 18 | -0.31 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.31 |
| HDDC3 | HD domain containing 3 | -0.31 |
| POMP | proteasome maturation protein | -0.3 |
| SMIM12 | small integral membrane protein 12 | -0.3 |
| SPC24 | SPC24, NDC80 kinetochore complex component | -0.3 |
| DPP4 | dipeptidyl-peptidase 4 | -0.3 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | -0.3 |
| DESI1 | desumoylating isopeptidase 1 | -0.3 |
| DDX4 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | -0.3 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | -0.3 |
| TBRG1 | transforming growth factor beta regulator 1 | -0.3 |
| ZNF480 | zinc finger protein 480 | -0.3 |
| S100A6 | S100 calcium binding protein A6 | -0.29 |
| CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 | -0.29 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.29 |
| STK19 | serine/threonine kinase 19 | -0.29 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | -0.29 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.29 |
| TMEM9 | transmembrane protein 9 | -0.29 |
| ATE1 | arginyltransferase 1 | -0.29 |
| EME1 | essential meiotic structure-specific endonuclease 1 | -0.29 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.29 |
| MOCS1 | molybdenum cofactor synthesis 1 | -0.29 |
| MIF | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | -0.28 |
| S100A5 | S100 calcium binding protein A5 | -0.28 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.28 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | -0.28 |
| ECI1 | enoyl-CoA delta isomerase 1 | -0.28 |
| IL17RA | interleukin 17 receptor A | -0.27 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.27 |
| KHK | ketohexokinase (fructokinase) | -0.27 |
| HSPA1L | heat shock 70kDa protein 1-like | -0.27 |
| MYCBP | MYC binding protein | -0.27 |
| CLASP2 | cytoplasmic linker associated protein 2 | -0.27 |
