| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0940642 |
| CCN2 | cellular communication network factor 2 | 0.0739537 |
| NLGN1 | neuroligin 1 | 0.0718662 |
| AREG | amphiregulin | 0.0714232 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0647125 |
| HLA-A | major histocompatibility complex, class I, A | 0.0632955 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0543086 |
| MMP12 | matrix metallopeptidase 12 | 0.0446088 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0400428 |
| PDGFC | platelet derived growth factor C | 0.0382031 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0375716 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0364867 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0342661 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0340846 |
| BCHE | butyrylcholinesterase | 0.0327352 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.031933 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0318651 |
| RPS12 | ribosomal protein S12 | 0.0299868 |
| TPM3 | tropomyosin 3 | 0.0296465 |
| MTAP | methylthioadenosine phosphorylase | 0.027292 |
| RPS8 | ribosomal protein S8 | 0.0261802 |
| DST | dystonin | 0.0261325 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0256285 |
| NEBL | nebulette | 0.0255491 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0255219 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0253296 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0236218 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0234805 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0231104 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0225094 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0222352 |
| TENM3 | teneurin transmembrane protein 3 | 0.0218637 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0213121 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0212437 |
| ANXA1 | annexin A1 | 0.0209978 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0199506 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0199414 |
| EHBP1 | EH domain binding protein 1 | 0.0196213 |
| FAT1 | FAT atypical cadherin 1 | 0.0187645 |
| TMEM41B | transmembrane protein 41B | 0.0186003 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0183909 |
| CMIP | c-Maf inducing protein | 0.0181007 |
| CLDN1 | claudin 1 | 0.0180245 |
| MED13L | mediator complex subunit 13-like | 0.0174121 |
| LARP1 | La ribonucleoprotein domain family, member 1 | 0.0171373 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0169294 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.016897 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0166479 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0164334 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0163304 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0155254 |
| RPL37A | ribosomal protein L37a | 0.015508 |
| SBF2 | SET binding factor 2 | 0.0154026 |
| AHR | aryl hydrocarbon receptor | 0.0153907 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0153757 |
| HDGF | hepatoma-derived growth factor | 0.015209 |
| NRXN3 | neurexin 3 | 0.014983 |
| WDR43 | WD repeat domain 43 | 0.0149659 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0148481 |
| RTN4 | reticulon 4 | 0.0148206 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0147617 |
| YAP1 | Yes-associated protein 1 | 0.0146859 |
| RPS2 | ribosomal protein S2 | 0.014598 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0144686 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0144584 |
| EXOC6B | exocyst complex component 6B | 0.0144518 |
| RASAL2 | RAS protein activator like 2 | 0.0143971 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0141827 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.014014 |
| MYPN | myopalladin | 0.0139463 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0137323 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | 0.0134787 |
| RNF13 | ring finger protein 13 | 0.0134386 |
| MKI67 | marker of proliferation Ki-67 | 0.0133524 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0133524 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0129304 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0128421 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0128293 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.012771 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0127572 |
| RPN1 | ribophorin I | 0.012753 |
| GSE1 | Gse1 coiled-coil protein | 0.0125889 |
| CLDND1 | claudin domain containing 1 | 0.0125525 |
| AHNAK | AHNAK nucleoprotein | 0.0124896 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0120481 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0120467 |
| BRD4 | bromodomain containing 4 | 0.0120358 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.011897 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0118957 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0118289 |
| NPC1 | Niemann-Pick disease, type C1 | 0.011788 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0117602 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0117547 |
| RPL3 | ribosomal protein L3 | 0.0117069 |
| VMP1 | vacuole membrane protein 1 | 0.0116988 |
| ADAR | adenosine deaminase, RNA-specific | 0.0116551 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0115828 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | 0.011543 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0115374 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0115004 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.132478 |
| TMSB10 | thymosin beta 10 | -0.117756 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0967122 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0887737 |
| FTL | ferritin, light polypeptide | -0.0514716 |
| PTMA | prothymosin, alpha | -0.0433335 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0369958 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0343802 |
| RPLP1 | ribosomal protein, large, P1 | -0.0301009 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0299209 |
| TPI1 | triosephosphate isomerase 1 | -0.0281024 |
| CCND1 | cyclin D1 | -0.0269336 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0265185 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0249561 |
| LDHA | lactate dehydrogenase A | -0.0235495 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0224774 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0221408 |
| RPS24 | ribosomal protein S24 | -0.0220156 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0218495 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0206549 |
| TUBB | tubulin, beta class I | -0.0203023 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.020207 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0201038 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0195394 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0187847 |
| FUS | FUS RNA binding protein | -0.018407 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0183823 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0181287 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0181056 |
| PARK7 | parkinson protein 7 | -0.0173656 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0173426 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0171408 |
| PEG10 | paternally expressed 10 | -0.0170259 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0165868 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0162801 |
| MORF4L2 | mortality factor 4 like 2 | -0.0158222 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0156621 |
| RBM39 | RNA binding motif protein 39 | -0.0154538 |
| HDLBP | high density lipoprotein binding protein | -0.0153381 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0151588 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0140012 |
| PGK1 | phosphoglycerate kinase 1 | -0.0139732 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.01396 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0139063 |
| S100A10 | S100 calcium binding protein A10 | -0.0137878 |
| NPR2 | natriuretic peptide receptor 2 | -0.0137847 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0137333 |
| CCDC47 | coiled-coil domain containing 47 | -0.0136881 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0136418 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.013463 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0133207 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0131359 |
| RPL31 | ribosomal protein L31 | -0.0130019 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0129137 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.0126318 |
| TUBA1B | tubulin, alpha 1b | -0.0126055 |
| CANX | calnexin | -0.0125785 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0124794 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0123785 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0117483 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0116251 |
| MATR3 | matrin 3 | -0.0114648 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.0114346 |
| EGR1 | early growth response 1 | -0.0112037 |
| RLF | rearranged L-myc fusion | -0.0111413 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0108324 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0108047 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0107761 |
| TAOK1 | TAO kinase 1 | -0.0104705 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.010456 |
| HMGA1 | high mobility group AT-hook 1 | -0.0103301 |
| RPS5 | ribosomal protein S5 | -0.0103002 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0102784 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.0101782 |
| GCG | glucagon | -0.0101056 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0100519 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0100502 |
| TPM4 | tropomyosin 4 | -0.0100423 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0100275 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.00997815 |
| GLG1 | golgi glycoprotein 1 | -0.00992693 |
| SERINC3 | serine incorporator 3 | -0.00987009 |
| RAB2A | RAB2A, member RAS oncogene family | -0.00983892 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.00971467 |
| PCYOX1 | prenylcysteine oxidase 1 | -0.0096804 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.00952499 |
| ARF4 | ADP-ribosylation factor 4 | -0.00950925 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.00949273 |
| BTG3 | BTG family, member 3 | -0.00940975 |
| RPL4 | ribosomal protein L4 | -0.00925638 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.00924377 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.00923323 |
| TMEM131 | transmembrane protein 131 | -0.00922459 |
| ARF1 | ADP-ribosylation factor 1 | -0.00919522 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.00916068 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.00912081 |
| LMO7 | LIM domain 7 | -0.00912079 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.00900414 |
| SOD1 | superoxide dismutase 1, soluble | -0.0089002 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.00883388 |
