| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0845384 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0768131 |
| CD44 | CD44 molecule (Indian blood group) | 0.0658405 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0634052 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.063105 |
| ASPH | aspartate beta-hydroxylase | 0.0604552 |
| VEGFA | vascular endothelial growth factor A | 0.0597234 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0597182 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0591004 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0493166 |
| TXNRD1 | thioredoxin reductase 1 | 0.0452049 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0438408 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0432132 |
| B2M | beta-2-microglobulin | 0.0414672 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0411477 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0406547 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0386915 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0359892 |
| PTMA | prothymosin, alpha | 0.0351882 |
| NDRG1 | N-myc downstream regulated 1 | 0.0348527 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0334733 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0330219 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0328557 |
| KYNU | kynureninase | 0.0328557 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0320948 |
| ARRDC3 | arrestin domain containing 3 | 0.0318885 |
| TUSC3 | tumor suppressor candidate 3 | 0.0315259 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0314923 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0314659 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0314177 |
| MSN | moesin | 0.0310899 |
| CA12 | carbonic anhydrase XII | 0.0305005 |
| NRP2 | neuropilin 2 | 0.0302624 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0295676 |
| G0S2 | G0/G1 switch 2 | 0.0290929 |
| MT2A | metallothionein 2A | 0.0290732 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0286944 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0286467 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0282866 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0281248 |
| CANX | calnexin | 0.0280674 |
| ENO1 | enolase 1, (alpha) | 0.0256754 |
| MAP1B | microtubule-associated protein 1B | 0.0254691 |
| SP3 | Sp3 transcription factor | 0.0253533 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0250829 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0248496 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0247825 |
| B4GALT1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.0242829 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0239667 |
| FTL | ferritin, light polypeptide | 0.0232862 |
| TPM3 | tropomyosin 3 | 0.0232818 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0231149 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0224309 |
| LOXL2 | lysyl oxidase-like 2 | 0.0222612 |
| HDGF | hepatoma-derived growth factor | 0.0217996 |
| AHNAK | AHNAK nucleoprotein | 0.0211613 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0209341 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0209336 |
| SAA2-SAA4 | SAA2-SAA4 readthrough | 0.0205905 |
| MX1 | MX dynamin-like GTPase 1 | 0.0203544 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0199744 |
| TPM4 | tropomyosin 4 | 0.0196733 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0195833 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0194572 |
| IRS2 | insulin receptor substrate 2 | 0.0191484 |
| APP | amyloid beta (A4) precursor protein | 0.0190825 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0190814 |
| TPM1 | tropomyosin 1 (alpha) | 0.0190108 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0187101 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0186824 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0185697 |
| TGM2 | transglutaminase 2 | 0.0183579 |
| VCAN | versican | 0.0181644 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0178857 |
| MTDH | metadherin | 0.0176484 |
| RPS4X | ribosomal protein S4, X-linked | 0.0176077 |
| CALR | calreticulin | 0.017605 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.017602 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0175033 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.017403 |
| MPZL1 | myelin protein zero-like 1 | 0.0172789 |
| SAA2 | serum amyloid A2 | 0.0171764 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0170595 |
| ADAR | adenosine deaminase, RNA-specific | 0.0169788 |
| RPS8 | ribosomal protein S8 | 0.0169364 |
| DSTN | destrin (actin depolymerizing factor) | 0.0168371 |
| NRP1 | neuropilin 1 | 0.0166975 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0166417 |
| PFN1 | profilin 1 | 0.0166291 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0164948 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0163108 |
| LYPLA1 | lysophospholipase I | 0.0162568 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0161729 |
| SETD5 | SET domain containing 5 | 0.0161621 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0161545 |
| WASL | Wiskott-Aldrich syndrome-like | 0.016138 |
| SLFN5 | schlafen family member 5 | 0.0161008 |
| CD70 | CD70 molecule | 0.015981 |
| RNF213 | ring finger protein 213 | 0.0159694 |
| GGNBP2 | gametogenetin binding protein 2 | 0.0159156 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0666896 |
| GPC6 | glypican 6 | -0.0481302 |
| FRMD4A | FERM domain containing 4A | -0.0455733 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0446569 |
| VCL | vinculin | -0.0423506 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0420102 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0380821 |
| NAV2 | neuron navigator 2 | -0.0377586 |
| RBM39 | RNA binding motif protein 39 | -0.0366245 |
| RRBP1 | ribosome binding protein 1 | -0.0341467 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0341423 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0315979 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0304414 |
| CADM1 | cell adhesion molecule 1 | -0.0298209 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0292678 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.029248 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0289186 |
| TMSB10 | thymosin beta 10 | -0.0277404 |
| VIM | vimentin | -0.0274487 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0274205 |
| SEC24D | SEC24 family member D | -0.0270187 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0267985 |
| ATP13A3 | ATPase type 13A3 | -0.026602 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0254098 |
| FRMD5 | FERM domain containing 5 | -0.0245897 |
| RND3 | Rho family GTPase 3 | -0.0238485 |
| COG5 | component of oligomeric golgi complex 5 | -0.0235909 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0234303 |
| MORF4L2 | mortality factor 4 like 2 | -0.0231851 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0229462 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0229258 |
| SCFD2 | sec1 family domain containing 2 | -0.0225836 |
| COG6 | component of oligomeric golgi complex 6 | -0.0223918 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0223712 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0221301 |
| SLC35F3 | solute carrier family 35, member F3 | -0.02181 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0214118 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0209627 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.020779 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0206718 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0199306 |
| DIAPH3 | diaphanous-related formin 3 | -0.0197765 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0194075 |
| HLA-B | major histocompatibility complex, class I, B | -0.0192734 |
| CEP95 | centrosomal protein 95kDa | -0.0192643 |
| TP53BP1 | tumor protein p53 binding protein 1 | -0.0192191 |
| FUS | FUS RNA binding protein | -0.0191081 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0190541 |
| NF1 | neurofibromin 1 | -0.0190498 |
| NUP214 | nucleoporin 214kDa | -0.0189695 |
| UBAP2 | ubiquitin associated protein 2 | -0.018799 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0187613 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0187271 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | -0.0184596 |
| ZNF644 | zinc finger protein 644 | -0.0184539 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0181711 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0179806 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0179509 |
| RAB7A | RAB7A, member RAS oncogene family | -0.017747 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0177328 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0176399 |
| UFM1 | ubiquitin-fold modifier 1 | -0.01734 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0172522 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.017179 |
| COPA | coatomer protein complex, subunit alpha | -0.0170782 |
| NUP98 | nucleoporin 98kDa | -0.017024 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0170028 |
| SMC5 | structural maintenance of chromosomes 5 | -0.016946 |
| SDCBP | syndecan binding protein (syntenin) | -0.016918 |
| SPAG9 | sperm associated antigen 9 | -0.016751 |
| VPS53 | vacuolar protein sorting 53 homolog (S. cerevisiae) | -0.0167144 |
| YTHDF3 | YTH N(6)-methyladenosine RNA binding protein 3 | -0.0162947 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0162206 |
| ATF3 | activating transcription factor 3 | -0.0159458 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0157586 |
| HBP1 | HMG-box transcription factor 1 | -0.0157156 |
| NOP58 | NOP58 ribonucleoprotein | -0.0156761 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0154288 |
| TNS3 | tensin 3 | -0.0153986 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0152673 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0152102 |
| SUCO | SUN domain containing ossification factor | -0.0152085 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | -0.0151749 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0150871 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0150248 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.014894 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0148863 |
| TGFA | transforming growth factor, alpha | -0.0148647 |
| GOLGA3 | golgin A3 | -0.014682 |
| ARF1 | ADP-ribosylation factor 1 | -0.0146144 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0146129 |
| CAPRIN1 | cell cycle associated protein 1 | -0.0146029 |
| USP15 | ubiquitin specific peptidase 15 | -0.0145945 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.014594 |
| FBXO32 | F-box protein 32 | -0.0142687 |
| ECT2 | epithelial cell transforming 2 | -0.0142291 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0142232 |
| PMM2 | phosphomannomutase 2 | -0.0141891 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.014157 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0140132 |
