| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Benztropine (mesylate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.138449 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0905462 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0795994 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0672062 |
| KYNU | kynureninase | 0.0525725 |
| SMAD3 | SMAD family member 3 | 0.0442035 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0435942 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0433949 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0387244 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0374282 |
| MT1X | metallothionein 1X | 0.0318553 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0286927 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0285807 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0279916 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0278549 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0267809 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0263174 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.025887 |
| USP3 | ubiquitin specific peptidase 3 | 0.0256394 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0255465 |
| SPAG9 | sperm associated antigen 9 | 0.0254706 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0250696 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0250584 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.024377 |
| HELZ | helicase with zinc finger | 0.0229424 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.022897 |
| MT2A | metallothionein 2A | 0.0214154 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.021088 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0208031 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0207816 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0206885 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0203205 |
| NUP58 | nucleoporin 58 | 0.0199286 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0197575 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0195384 |
| RASA2 | RAS p21 protein activator 2 | 0.0195242 |
| PDE10A | phosphodiesterase 10A | 0.0195206 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0194627 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0193654 |
| TGM2 | transglutaminase 2 | 0.0192428 |
| RNF145 | ring finger protein 145 | 0.0191465 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0190474 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0189205 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0188421 |
| SBF2 | SET binding factor 2 | 0.0187938 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.018793 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0184049 |
| KCTD9 | potassium channel tetramerization domain containing 9 | 0.0179095 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0177549 |
| ECT2 | epithelial cell transforming 2 | 0.0176093 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0169472 |
| BCL2L1 | BCL2-like 1 | 0.0162841 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0162564 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0162219 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0162042 |
| RPL28 | ribosomal protein L28 | 0.0161593 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.016115 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0160958 |
| ATP13A3 | ATPase type 13A3 | 0.0160758 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0159008 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0156642 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0155888 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0155677 |
| WDR43 | WD repeat domain 43 | 0.0154163 |
| RTN4 | reticulon 4 | 0.0153826 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0153019 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0150909 |
| MYOF | myoferlin | 0.0149967 |
| NAV2 | neuron navigator 2 | 0.0145794 |
| RPL18 | ribosomal protein L18 | 0.0144685 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0143829 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0142286 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0141191 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0140854 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0140531 |
| KIAA1217 | KIAA1217 | 0.0138099 |
| ZNF292 | zinc finger protein 292 | 0.0137698 |
| CA8 | carbonic anhydrase VIII | 0.0135633 |
| NCKAP1 | NCK-associated protein 1 | 0.0134526 |
| RAB8B | RAB8B, member RAS oncogene family | 0.013404 |
| XDH | xanthine dehydrogenase | 0.0133724 |
| KIAA1958 | KIAA1958 | 0.0133532 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0130401 |
| OLA1 | Obg-like ATPase 1 | 0.0129274 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0128369 |
| DMXL2 | Dmx-like 2 | 0.0127265 |
| ANGPTL4 | angiopoietin-like 4 | 0.0126764 |
| TBK1 | TANK-binding kinase 1 | 0.0123124 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0122296 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0122289 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0121808 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0121736 |
| YBX1 | Y box binding protein 1 | 0.0119852 |
| CDC27 | cell division cycle 27 | 0.011945 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0119312 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0118396 |
| CLINT1 | clathrin interactor 1 | 0.0117589 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0117074 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0116861 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0114829 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.159007 |
| VIM | vimentin | -0.122319 |
| EFNA5 | ephrin-A5 | -0.0936391 |
| NDRG1 | N-myc downstream regulated 1 | -0.091129 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.06168 |
| EGFR | epidermal growth factor receptor | -0.0528296 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.047415 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0473539 |
| LDHA | lactate dehydrogenase A | -0.0470508 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0437261 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0431963 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0430788 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0404333 |
| ACTG1 | actin gamma 1 | -0.040249 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0377782 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0318637 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0304388 |
| CA12 | carbonic anhydrase XII | -0.0298795 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0293986 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0293783 |
| AUTS2 | autism susceptibility candidate 2 | -0.0293064 |
| ANXA4 | annexin A4 | -0.0291425 |
| GOLGB1 | golgin B1 | -0.0284007 |
| PRKCA | protein kinase C, alpha | -0.0279654 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0276521 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0274507 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0270885 |
| PKM | pyruvate kinase, muscle | -0.0264955 |
| MYO1E | myosin IE | -0.0263302 |
| HMGA2 | high mobility group AT-hook 2 | -0.0258304 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0253725 |
| TPM4 | tropomyosin 4 | -0.0250165 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0243684 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.024025 |
| DUSP16 | dual specificity phosphatase 16 | -0.0236587 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0232937 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0220044 |
| RPLP1 | ribosomal protein, large, P1 | -0.0212875 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0209446 |
| CCDC88A | coiled-coil domain containing 88A | -0.020421 |
| RRBP1 | ribosome binding protein 1 | -0.0203626 |
| S100A6 | S100 calcium binding protein A6 | -0.0203294 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0192968 |
| SP100 | SP100 nuclear antigen | -0.0191102 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0186996 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0186301 |
| RPS24 | ribosomal protein S24 | -0.0180869 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0180319 |
| ZFHX3 | zinc finger homeobox 3 | -0.0179535 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0178334 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0178181 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0177211 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0175598 |
| LMNA | lamin A/C | -0.0175444 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0174704 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0174251 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0173687 |
| IER3 | immediate early response 3 | -0.0173489 |
| EGR1 | early growth response 1 | -0.0173378 |
| S100A10 | S100 calcium binding protein A10 | -0.0173173 |
| TNS3 | tensin 3 | -0.0171206 |
| CAVIN1 | caveolae associated protein 1 | -0.0171068 |
| EXT1 | exostosin glycosyltransferase 1 | -0.01685 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | -0.016758 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0166841 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0166786 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0166099 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.016548 |
| LMO7 | LIM domain 7 | -0.0162399 |
| LOXL2 | lysyl oxidase-like 2 | -0.0162313 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0161696 |
| NRG1 | neuregulin 1 | -0.0161427 |
| EHBP1 | EH domain binding protein 1 | -0.0161212 |
| FBXO11 | F-box protein 11 | -0.0161162 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0159284 |
| RPS6 | ribosomal protein S6 | -0.015491 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0154093 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0154071 |
| MAP7 | microtubule-associated protein 7 | -0.0152998 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0150912 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0148361 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0148293 |
| VCL | vinculin | -0.01468 |
| FUS | FUS RNA binding protein | -0.0143954 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0142738 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0136536 |
| PTMA | prothymosin, alpha | -0.013611 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.013524 |
| RPL31 | ribosomal protein L31 | -0.0134407 |
| ASPH | aspartate beta-hydroxylase | -0.0133721 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0132262 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.013217 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.013199 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0131942 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0130015 |
| HDLBP | high density lipoprotein binding protein | -0.0129648 |
| SQSTM1 | sequestosome 1 | -0.0128793 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0128772 |
| NHSL1 | NHS-like 1 | -0.012544 |
| RIGI | RNA sensor RIG-I | -0.0125076 |
