Benztropine (mesylate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Benztropine (mesylate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.173819
PDE4D phosphodiesterase 4D, cAMP-specific 0.140339
VEGFA vascular endothelial growth factor A 0.104275
PABPC1 poly(A) binding protein, cytoplasmic 1 0.102125
TMSB4X thymosin beta 4, X-linked 0.073545
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0710282
TSHZ2 teashirt zinc finger homeobox 2 0.0694133
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0646095
EEF2 eukaryotic translation elongation factor 2 0.0620767
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.060069
COL1A2 collagen, type I, alpha 2 0.0597446
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0583103
PRKG1 protein kinase, cGMP-dependent, type I 0.0519842
FTH1 ferritin, heavy polypeptide 1 0.0507313
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0504349
ENO1 enolase 1, (alpha) 0.0485026
FER fer (fps/fes related) tyrosine kinase 0.0451903
EGFR epidermal growth factor receptor 0.0445272
GSE1 Gse1 coiled-coil protein 0.0440422
AHNAK AHNAK nucleoprotein 0.0418852
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0415802
CANX calnexin 0.0407073
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0403878
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0397688
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0396249
RPS3 ribosomal protein S3 0.0392422
CALR calreticulin 0.039032
CADM2 cell adhesion molecule 2 0.0382134
RAD51B RAD51 paralog B 0.036603
APLP2 amyloid beta (A4) precursor-like protein 2 0.0364057
LINGO2 leucine rich repeat and Ig domain containing 2 0.0361283
PRELID2 PRELI domain containing 2 0.0361095
RPS8 ribosomal protein S8 0.0351603
MGP matrix Gla protein 0.0343039
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0336004
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0334353
DDIT4 DNA-damage-inducible transcript 4 0.032435
ZFP36L1 ZFP36 ring finger protein-like 1 0.0322588
PTMA prothymosin, alpha 0.0319398
P4HB prolyl 4-hydroxylase, beta polypeptide 0.031896
MACF1 microtubule-actin crosslinking factor 1 0.0317682
THSD4 thrombospondin, type I, domain containing 4 0.0313969
PDIA4 protein disulfide isomerase family A, member 4 0.030346
BCAS3 breast carcinoma amplified sequence 3 0.0299776
WWOX WW domain containing oxidoreductase 0.0294089
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0292163
RACK1 receptor for activated C kinase 1 0.0291358
PDE10A phosphodiesterase 10A 0.0288695
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0287317
ARHGAP21 Rho GTPase activating protein 21 0.0282677
LARP1 La ribonucleoprotein domain family, member 1 0.0281852
NBEA neurobeachin 0.0281147
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0266565
RPL3 ribosomal protein L3 0.0264932
SET SET nuclear proto-oncogene 0.0260839
PHF21A PHD finger protein 21A 0.0260625
BRD2 bromodomain containing 2 0.0260586
RPS2 ribosomal protein S2 0.0252327
RUNX1 runt-related transcription factor 1 0.0250026
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0247471
NDRG1 N-myc downstream regulated 1 0.0246093
MAML2 mastermind-like 2 (Drosophila) 0.0244789
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0241224
BPTF bromodomain PHD finger transcription factor 0.0240116
MAP1B microtubule-associated protein 1B 0.0236395
DLG1 discs, large homolog 1 (Drosophila) 0.0234795
ZRANB3 zinc finger, RAN-binding domain containing 3 0.0234696
TET1 tet methylcytosine dioxygenase 1 0.0234487
ZFHX3 zinc finger homeobox 3 0.0234415
SYAP1 synapse associated protein 1 0.0232043
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0230327
HOXC6 homeobox C6 0.0229982
RHOA ras homolog family member A 0.0229904
FN1 fibronectin 1 0.0229832
GPM6B glycoprotein M6B 0.0229416
MAP4 microtubule-associated protein 4 0.0228104
CKAP5 cytoskeleton associated protein 5 0.022696
RPL37A ribosomal protein L37a 0.0226029
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0225705
TTC3 tetratricopeptide repeat domain 3 0.0224192
EXOC4 exocyst complex component 4 0.0222643
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0221411
PHF14 PHD finger protein 14 0.0221245
B2M beta-2-microglobulin 0.0220032
RBM6 RNA binding motif protein 6 0.0218982
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0218297
AKAP12 A kinase (PRKA) anchor protein 12 0.021559
FGFR1 fibroblast growth factor receptor 1 0.0213816
TOP2A topoisomerase (DNA) II alpha 170kDa 0.021234
GTF2IRD1 GTF2I repeat domain containing 1 0.0211258
DENND1A DENN/MADD domain containing 1A 0.021121
USP37 ubiquitin specific peptidase 37 0.0210466
RPL7A ribosomal protein L7a 0.0210312
MBNL1 muscleblind-like splicing regulator 1 0.0208333
PTBP2 polypyrimidine tract binding protein 2 0.0205984
PDIA3 protein disulfide isomerase family A, member 3 0.020491
FGFR2 fibroblast growth factor receptor 2 0.0204163
DST dystonin 0.0200876
S100A9 S100 calcium binding protein A9 0.0198941
GPC6 glypican 6 0.0197925

decreased expression

Symbol Name Standardized Value
QKI QKI, KH domain containing, RNA binding -0.0525495
ZEB1 zinc finger E-box binding homeobox 1 -0.0474601
ZFAND3 zinc finger, AN1-type domain 3 -0.0457621
RPS24 ribosomal protein S24 -0.0394647
NIPBL Nipped-B homolog (Drosophila) -0.0378567
RAB7A RAB7A, member RAS oncogene family -0.0361474
RNF130 ring finger protein 130 -0.0356973
TBCA tubulin folding cofactor A -0.0341037
SSBP2 single-stranded DNA binding protein 2 -0.0340222
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0337424
RHEB Ras homolog enriched in brain -0.0329084
TRA2A transformer 2 alpha homolog (Drosophila) -0.032224
MATR3 matrin 3 -0.0310204
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0309633
TULP4 tubby like protein 4 -0.0300682
JMJD1C jumonji domain containing 1C -0.0299149
CENPE centromere protein E, 312kDa -0.0297233
RBM39 RNA binding motif protein 39 -0.0294998
ERBIN erbb2 interacting protein -0.0294181
MED13L mediator complex subunit 13-like -0.0292168
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.0291112
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -0.0285122
TOP1 topoisomerase (DNA) I -0.0284562
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.027543
NPR2 natriuretic peptide receptor 2 -0.0272826
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0263615
TENT4A terminal nucleotidyltransferase 4A -0.0258784
TRIO trio Rho guanine nucleotide exchange factor -0.0257284
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0253175
RAD21 RAD21 homolog (S. pombe) -0.0252714
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0249933
CTBP2 C-terminal binding protein 2 -0.024802
PTK2 protein tyrosine kinase 2 -0.0247988
FBXW11 F-box and WD repeat domain containing 11 -0.0243158
RPL32 ribosomal protein L32 -0.0240931
RLF rearranged L-myc fusion -0.0236006
DNM1L dynamin 1-like -0.0232873
TPST1 tyrosylprotein sulfotransferase 1 -0.023227
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0228733
ELOVL5 ELOVL fatty acid elongase 5 -0.0228421
RBM25 RNA binding motif protein 25 -0.021644
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0214595
PHF3 PHD finger protein 3 -0.0212552
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0211663
SETD2 SET domain containing 2 -0.0209325
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.020925
HBP1 HMG-box transcription factor 1 -0.0207621
TMSB10 thymosin beta 10 -0.0206584
NAMPT nicotinamide phosphoribosyltransferase -0.0204059
MAPK8 mitogen-activated protein kinase 8 -0.0204021
CBFB core-binding factor, beta subunit -0.0201942
GOLGA4 golgin A4 -0.0194972
RFX7 regulatory factor X, 7 -0.0194962
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.019376
PRC1 protein regulator of cytokinesis 1 -0.0193453
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0192562
EP300 E1A binding protein p300 -0.0189043
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.018875
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0187748
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0187364
KIAA0232 KIAA0232 -0.0186888
AFF4 AF4/FMR2 family, member 4 -0.0185029
OXSR1 oxidative stress responsive 1 -0.0184979
TBC1D12 TBC1 domain family, member 12 -0.018388
NF1 neurofibromin 1 -0.018246
CD70 CD70 molecule -0.0179549
GNAS GNAS complex locus -0.0178446
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains -0.0178342
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0177345
TFG TRK-fused gene -0.0176133
SCD5 stearoyl-CoA desaturase 5 -0.0173095
SAR1A secretion associated, Ras related GTPase 1A -0.0172789
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.01725
HDLBP high density lipoprotein binding protein -0.017163
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0171518
MON2 MON2 homolog (S. cerevisiae) -0.0171227
MEMO1 mediator of cell motility 1 -0.0171207
CRY1 cryptochrome circadian clock 1 -0.0171009
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 -0.0170425
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0170287
RNF145 ring finger protein 145 -0.0170102
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.016978
TUBB tubulin, beta class I -0.0165118
ZNF407 zinc finger protein 407 -0.0164998
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0163806
GCLC glutamate-cysteine ligase, catalytic subunit -0.0160397
SEC62 SEC62 homolog (S. cerevisiae) -0.0159404
CEP290 centrosomal protein 290kDa -0.0157034
MTAP methylthioadenosine phosphorylase -0.0156078
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.015604
LCORL ligand dependent nuclear receptor corepressor-like -0.0156037
YAP1 Yes-associated protein 1 -0.0155551
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0155418
COTL1 coactosin-like F-actin binding protein 1 -0.0154831
USP9X ubiquitin specific peptidase 9, X-linked -0.0152689
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.015213
CARD16 caspase recruitment domain family, member 16 -0.0151528
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0151471
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0151067
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0150646