Benztropine (mesylate)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Benztropine (mesylate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.109184
AKAP12 A kinase (PRKA) anchor protein 12 0.101247
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0853024
BAIAP2L1 BAI1-associated protein 2-like 1 0.0787384
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0768552
IGFBP3 insulin-like growth factor binding protein 3 0.063399
POTEF POTE ankyrin domain family, member F 0.0524094
LMTK2 lemur tyrosine kinase 2 0.0446516
FLNB filamin B, beta 0.0413013
EPS8 epidermal growth factor receptor pathway substrate 8 0.0350281
PTMA prothymosin, alpha 0.0347916
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0336004
ACTG1 actin gamma 1 0.031622
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.031059
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0296396
S100A6 S100 calcium binding protein A6 0.0285941
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0278959
RICTOR RPTOR independent companion of MTOR, complex 2 0.0278338
MUC17 mucin 17, cell surface associated 0.0277539
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.027051
TSC22D2 TSC22 domain family, member 2 0.0254557
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.025115
ADAM9 ADAM metallopeptidase domain 9 0.0246449
DSG2 desmoglein 2 0.024067
SLMAP sarcolemma associated protein 0.0238316
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0235534
RTN4 reticulon 4 0.0231354
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0225755
RPS8 ribosomal protein S8 0.0224835
B2M beta-2-microglobulin 0.0223679
UBA6 ubiquitin-like modifier activating enzyme 6 0.0222815
VEZT vezatin, adherens junctions transmembrane protein 0.022079
FOSL1 FOS-like antigen 1 0.0215525
FAM107B family with sequence similarity 107, member B 0.021331
UBC ubiquitin C 0.0212054
HMGA1 high mobility group AT-hook 1 0.020767
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0206708
KCMF1 potassium channel modulatory factor 1 0.0202637
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0202165
ITGA6 integrin, alpha 6 0.0200826
ITPRID2 ITPR interacting domain containing 2 0.0199085
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.019608
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0194763
VIM vimentin 0.019451
NCOA3 nuclear receptor coactivator 3 0.0193208
NEK7 NIMA-related kinase 7 0.0191165
EMP1 epithelial membrane protein 1 0.0190752
FNDC3B fibronectin type III domain containing 3B 0.0189957
GLS2 glutaminase 2 (liver, mitochondrial) 0.0189364
KRT8 keratin 8, type II 0.0188909
ZNF292 zinc finger protein 292 0.0186083
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0185512
SQSTM1 sequestosome 1 0.0183796
KRT18 keratin 18, type I 0.0181789
ANXA2 annexin A2 0.0180141
ARHGAP29 Rho GTPase activating protein 29 0.0178198
RIOK3 RIO kinase 3 0.0177757
LOC112694756 uncharaterized LOC112694756 0.0177704
RAB1A RAB1A, member RAS oncogene family 0.0176847
PTPRR protein tyrosine phosphatase, receptor type, R 0.0176719
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0173702
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.017296
PSD3 pleckstrin and Sec7 domain containing 3 0.0172767
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0172522
BHLHE40 basic helix-loop-helix family, member e40 0.0171568
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0171266
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0170092
ESYT2 extended synaptotagmin-like protein 2 0.0169017
JMJD1C jumonji domain containing 1C 0.0168852
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0168107
ARHGAP42 Rho GTPase activating protein 42 0.0167506
PPARG peroxisome proliferator-activated receptor gamma 0.0167167
PRSS3 protease, serine, 3 0.0166981
TPM3 tropomyosin 3 0.0166446
TPT1 tumor protein, translationally-controlled 1 0.015845
AHNAK AHNAK nucleoprotein 0.0157919
TOP1 topoisomerase (DNA) I 0.015762
RPL12 ribosomal protein L12 0.0156817
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0156358
LMO7 LIM domain 7 0.0154065
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0153881
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0153673
ARRDC3 arrestin domain containing 3 0.0153347
TMEM41B transmembrane protein 41B 0.015244
MYOF myoferlin 0.0151575
QKI QKI, KH domain containing, RNA binding 0.0150791
EIF1 eukaryotic translation initiation factor 1 0.0149997
SBF2 SET binding factor 2 0.01496
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.014833
FOXO3 forkhead box O3 0.0148275
SMAD3 SMAD family member 3 0.0145674
RPL37A ribosomal protein L37a 0.0145099
ADAM17 ADAM metallopeptidase domain 17 0.0144858
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0141214
SERTAD2 SERTA domain containing 2 0.0140754
EEF2 eukaryotic translation elongation factor 2 0.0138116
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0137812
TRA2A transformer 2 alpha homolog (Drosophila) 0.0136596
GOLGA4 golgin A4 0.0136097
RPS12 ribosomal protein S12 0.0136051

decreased expression

Symbol Name Standardized Value
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0438604
F3 coagulation factor III (thromboplastin, tissue factor) -0.0263274
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0226101
EXT1 exostosin glycosyltransferase 1 -0.0219964
TMSB10 thymosin beta 10 -0.0188125
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0185343
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0172398
SACK1A scaffolding CK1 anchoring protein A -0.0170927
PMM2 phosphomannomutase 2 -0.0156808
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0154798
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0152511
ABTB3 ankyrin repeat and BTB domain containing 3 -0.015221
THSD4 thrombospondin, type I, domain containing 4 -0.0151356
INTS6 integrator complex subunit 6 -0.0145833
HDAC9 histone deacetylase 9 -0.0142605
HMGA2 high mobility group AT-hook 2 -0.01339
SP100 SP100 nuclear antigen -0.0133098
SLC35F3 solute carrier family 35, member F3 -0.0133009
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0128232
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0126454
PDE4D phosphodiesterase 4D, cAMP-specific -0.0126443
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0125582
PPARD peroxisome proliferator-activated receptor delta -0.012243
CLMP CXADR-like membrane protein -0.0121405
LAMC2 laminin, gamma 2 -0.0120644
ZHX2 zinc fingers and homeoboxes 2 -0.0113655
TXNRD1 thioredoxin reductase 1 -0.0113393
TGFA transforming growth factor, alpha -0.0107852
BMP6 bone morphogenetic protein 6 -0.0107221
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.010671
MCL1 myeloid cell leukemia 1 -0.0105666
GOLGB1 golgin B1 -0.0104704
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0102843
EGR1 early growth response 1 -0.0102677
RRBP1 ribosome binding protein 1 -0.00970744
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.00955035
SAMD9 sterile alpha motif domain containing 9 -0.00950275
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.00927476
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.00926303
HDLBP high density lipoprotein binding protein -0.00897118
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.00896536
HOMER1 homer scaffolding protein 1 -0.00877353
EFNA5 ephrin-A5 -0.008769
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0087045
AK1 adenylate kinase 1 -0.00864356
TXNIP thioredoxin interacting protein -0.00849291
MAML2 mastermind-like 2 (Drosophila) -0.00840457
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.00838404
BMAL2 basic helix-loop-helix ARNT like 2 -0.00795894
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 -0.00790862
EFNB2 ephrin-B2 -0.00786026
TM4SF1 transmembrane 4 L six family member 1 -0.00782587
GOLGA3 golgin A3 -0.00777119
ZBTB20 zinc finger and BTB domain containing 20 -0.00776977
LAMA4 laminin, alpha 4 -0.00776622
IFI16 interferon, gamma-inducible protein 16 -0.00774634
SKAP2 src kinase associated phosphoprotein 2 -0.0076753
FUS FUS RNA binding protein -0.00750824
ANTXR2 anthrax toxin receptor 2 -0.00744599
LPP LIM domain containing preferred translocation partner in lipoma -0.0074111
NABP1 nucleic acid binding protein 1 -0.00739447
OSMR oncostatin M receptor -0.0073348
BLZF1 basic leucine zipper nuclear factor 1 -0.00730386
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.00730313
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00719895
FER fer (fps/fes related) tyrosine kinase -0.00713789
CCDC91 coiled-coil domain containing 91 -0.0071368
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.00713659
BABAM2 BRISC and BRCA1 A complex member 2 -0.00707468
NFE2L2 nuclear factor, erythroid 2-like 2 -0.00701985
FOXN2 forkhead box N2 -0.00699644
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.00698141
AHRR aryl-hydrocarbon receptor repressor -0.00694884
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.00691858
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.00683609
NUP98 nucleoporin 98kDa -0.00679443
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0067553
SETX senataxin -0.00668455
RAD51B RAD51 paralog B -0.00663687
ALCAM activated leukocyte cell adhesion molecule -0.00657399
UBAP2 ubiquitin associated protein 2 -0.0064963
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.00646483
ACTN4 actinin, alpha 4 -0.00644116
ZMYND8 zinc finger, MYND-type containing 8 -0.0063893
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.00627929
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.00621508
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.00612952
TLN1 talin 1 -0.0061125
SEPTIN10 septin 10 -0.00608642
EXOC4 exocyst complex component 4 -0.00600462
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.00597673
VCP valosin containing protein -0.00583981
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C -0.00583951
KPNA7 karyopherin alpha 7 (importin alpha 8) -0.00580479
MORF4L2 mortality factor 4 like 2 -0.00576087
AADAC arylacetamide deacetylase -0.00573461
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0057028
ZNF800 zinc finger protein 800 -0.00566879
ERI2 ERI1 exoribonuclease family member 2 -0.00564848
CPNE1 copine I -0.0056171