| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.126288 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0860119 |
| TC2N | tandem C2 domains, nuclear | 0.0578743 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0566368 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0476279 |
| AHNAK | AHNAK nucleoprotein | 0.043766 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0426908 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0383981 |
| VEGFA | vascular endothelial growth factor A | 0.038263 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0373771 |
| VMP1 | vacuole membrane protein 1 | 0.0346202 |
| GRB7 | growth factor receptor-bound protein 7 | 0.032808 |
| TMEM45B | transmembrane protein 45B | 0.0322141 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | 0.0309292 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0301232 |
| DSPP | dentin sialophosphoprotein | 0.0298048 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0292719 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0289436 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0288577 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0283605 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0276129 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0264558 |
| TMEM165 | transmembrane protein 165 | 0.0259822 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0258404 |
| TPM3 | tropomyosin 3 | 0.0257546 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0256431 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0255076 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0247449 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0247298 |
| ANXA2 | annexin A2 | 0.0244273 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0241677 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0232011 |
| EGFR | epidermal growth factor receptor | 0.022907 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0228181 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0225616 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0221873 |
| ABHD17C | abhydrolase domain containing 17C | 0.0217373 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | 0.0215981 |
| TSC22D2 | TSC22 domain family, member 2 | 0.02141 |
| GSE1 | Gse1 coiled-coil protein | 0.021404 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.021403 |
| TOM1L1 | target of myb1 (chicken)-like 1 | 0.0213854 |
| ZNF217 | zinc finger protein 217 | 0.0211537 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0209301 |
| TPD52 | tumor protein D52 | 0.0208021 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | 0.0206203 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0203549 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0200487 |
| NDRG1 | N-myc downstream regulated 1 | 0.0197255 |
| EZR | ezrin | 0.0193263 |
| DOCK5 | dedicator of cytokinesis 5 | 0.019119 |
| ATXN1 | ataxin 1 | 0.0191123 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0191071 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0188083 |
| TXNRD1 | thioredoxin reductase 1 | 0.018803 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0187158 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0183874 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0181099 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0180666 |
| SMYD3 | SET and MYND domain containing 3 | 0.0178847 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0176537 |
| FBXO32 | F-box protein 32 | 0.017464 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0173966 |
| SET | SET nuclear proto-oncogene | 0.0172483 |
| PTEN | phosphatase and tensin homolog | 0.0171793 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | 0.0170876 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0170789 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0169391 |
| FOXO3 | forkhead box O3 | 0.0169164 |
| TMC5 | transmembrane channel-like 5 | 0.01687 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0168287 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.01667 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0165966 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0164533 |
| MYO1B | myosin IB | 0.0161833 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0159662 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0157997 |
| SMAD3 | SMAD family member 3 | 0.0157263 |
| CD9 | CD9 molecule | 0.0155319 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.0155107 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0154765 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0154297 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0153744 |
| MYOF | myoferlin | 0.0153714 |
| SHROOM3 | shroom family member 3 | 0.0153655 |
| CD47 | CD47 molecule | 0.0153449 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0152713 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0152275 |
| RTN4 | reticulon 4 | 0.0152015 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0151562 |
| ECE1 | endothelin converting enzyme 1 | 0.0149355 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0148204 |
| CANX | calnexin | 0.0147639 |
| CCNL1 | cyclin L1 | 0.0145878 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0144321 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0144184 |
| KIAA1217 | KIAA1217 | 0.0143871 |
| PLEC | plectin | 0.014373 |
| NUP58 | nucleoporin 58 | 0.0143391 |
| WWC1 | WW and C2 domain containing 1 | 0.014317 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL23 | ribosomal protein L23 | -0.251528 |
| RPL19 | ribosomal protein L19 | -0.167182 |
| PTMA | prothymosin, alpha | -0.0680925 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0569835 |
| RPL35A | ribosomal protein L35a | -0.054016 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0530873 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0521803 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0497998 |
| TMSB10 | thymosin beta 10 | -0.0494347 |
| RPL12 | ribosomal protein L12 | -0.0469215 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0467277 |
| CDK12 | cyclin-dependent kinase 12 | -0.0445648 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0441861 |
| SP100 | SP100 nuclear antigen | -0.0420096 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0373834 |
| RAB7A | RAB7A, member RAS oncogene family | -0.036934 |
| RPL34 | ribosomal protein L34 | -0.0364205 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0350174 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0338578 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0321758 |
| RPS24 | ribosomal protein S24 | -0.0317004 |
| PTK2 | protein tyrosine kinase 2 | -0.0313461 |
| RPL9 | ribosomal protein L9 | -0.029501 |
| ACTG1 | actin gamma 1 | -0.0293518 |
| VCP | valosin containing protein | -0.0269258 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0268935 |
| RPL26 | ribosomal protein L26 | -0.0267867 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0261917 |
| PFDN4 | prefoldin subunit 4 | -0.0254627 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0254361 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0252102 |
| RPS19 | ribosomal protein S19 | -0.0245546 |
| DTNA | dystrobrevin, alpha | -0.0239878 |
| VCL | vinculin | -0.0239336 |
| B2M | beta-2-microglobulin | -0.0237475 |
| RPLP1 | ribosomal protein, large, P1 | -0.0233555 |
| PRRC2C | proline-rich coiled-coil 2C | -0.023237 |
| CEP250 | centrosomal protein 250kDa | -0.0232074 |
| LMNA | lamin A/C | -0.0225116 |
| RAD51B | RAD51 paralog B | -0.0224447 |
| EFNA5 | ephrin-A5 | -0.0222405 |
| HLA-B | major histocompatibility complex, class I, B | -0.0222243 |
| TMSB4X | thymosin beta 4, X-linked | -0.0221148 |
| RPL27A | ribosomal protein L27a | -0.0218901 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0211388 |
| INTS6 | integrator complex subunit 6 | -0.0210833 |
| RRBP1 | ribosome binding protein 1 | -0.0208414 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0207389 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.020629 |
| CLTC | clathrin, heavy chain (Hc) | -0.0206256 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0206129 |
| PLSCR1 | phospholipid scramblase 1 | -0.0205018 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0203383 |
| PATJ | PATJ crumbs cell polarity complex component | -0.020289 |
| RPL31 | ribosomal protein L31 | -0.0200963 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0199783 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0198889 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0198874 |
| RPL37 | ribosomal protein L37 | -0.0198744 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.0198483 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0197778 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0194678 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0194088 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0193472 |
| AEBP2 | AE binding protein 2 | -0.0193172 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0190784 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0183746 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.018031 |
| HLA-C | major histocompatibility complex, class I, C | -0.0179204 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0178468 |
| RPL37A | ribosomal protein L37a | -0.0177897 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.017646 |
| RPL30 | ribosomal protein L30 | -0.0175724 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.0173816 |
| RPS12 | ribosomal protein S12 | -0.0173242 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0171126 |
| RNF213 | ring finger protein 213 | -0.0170919 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -0.0170861 |
| RPS29 | ribosomal protein S29 | -0.0169683 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0167086 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0166423 |
| RPS8 | ribosomal protein S8 | -0.0166334 |
| MMP24OS | MMP24 opposite strand | -0.0166235 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0165526 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0164789 |
| SMAD2 | SMAD family member 2 | -0.0163756 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0162903 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0162262 |
| RPS15 | ribosomal protein S15 | -0.0158906 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0158105 |
| TUBB | tubulin, beta class I | -0.0156932 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0156874 |
| RPL35 | ribosomal protein L35 | -0.0156226 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0155042 |
| MYO1D | myosin ID | -0.0154338 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0153873 |
| TMEM123 | transmembrane protein 123 | -0.0151123 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0150658 |
| GOLGB1 | golgin B1 | -0.0150054 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0148706 |
