| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RAD51B | RAD51 paralog B | 0.136571 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.107441 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 0.0998957 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0736555 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0688083 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0683052 |
| TENM3 | teneurin transmembrane protein 3 | 0.0618835 |
| TOX | thymocyte selection-associated high mobility group box | 0.0604969 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0563578 |
| COL5A2 | collagen, type V, alpha 2 | 0.0557273 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0555185 |
| CADM2 | cell adhesion molecule 2 | 0.05525 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0520272 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0519136 |
| JMJD1C | jumonji domain containing 1C | 0.0502492 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0496607 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0474705 |
| ZNF608 | zinc finger protein 608 | 0.0462253 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0431743 |
| DST | dystonin | 0.0411947 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0406219 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0396834 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0396546 |
| NUP58 | nucleoporin 58 | 0.0395511 |
| HHIP | hedgehog interacting protein | 0.0386892 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0384417 |
| ZNF292 | zinc finger protein 292 | 0.0374431 |
| AUTS2 | autism susceptibility candidate 2 | 0.0372324 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0365364 |
| GRID2 | glutamate receptor, ionotropic, delta 2 | 0.0356965 |
| EFNA5 | ephrin-A5 | 0.0343043 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0341676 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0339518 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0337678 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0337197 |
| HELZ | helicase with zinc finger | 0.0335393 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0332158 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0328106 |
| NPAS3 | neuronal PAS domain protein 3 | 0.0326449 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0321623 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0314384 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0292232 |
| CDH18 | cadherin 18, type 2 | 0.0291733 |
| ADAR | adenosine deaminase, RNA-specific | 0.0290343 |
| NFIA | nuclear factor I/A | 0.0279517 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0278583 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0276517 |
| FOXO3 | forkhead box O3 | 0.0268528 |
| QKI | QKI, KH domain containing, RNA binding | 0.0267854 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0262528 |
| PTK2 | protein tyrosine kinase 2 | 0.0262217 |
| B2M | beta-2-microglobulin | 0.0261684 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0260789 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0255162 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0254297 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0254066 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0251036 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.025049 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0249178 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0249097 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0245881 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0238191 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.0237298 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0237161 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0237 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0235837 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0235134 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0228103 |
| NCOR1 | nuclear receptor corepressor 1 | 0.022799 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0227221 |
| USP34 | ubiquitin specific peptidase 34 | 0.022688 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.022516 |
| PHIP | pleckstrin homology domain interacting protein | 0.0225029 |
| KIAA1958 | KIAA1958 | 0.0224873 |
| TPD52 | tumor protein D52 | 0.0224449 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0223516 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0222862 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0222822 |
| EXOC6B | exocyst complex component 6B | 0.0219138 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0218491 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0218211 |
| PARD3 | par-3 family cell polarity regulator | 0.0217427 |
| VEGFC | vascular endothelial growth factor C | 0.0216109 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.021444 |
| SRPK2 | SRSF protein kinase 2 | 0.0214167 |
| GPHN | gephyrin | 0.0213469 |
| OGA | O-GlcNAcase | 0.021237 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0212011 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0210806 |
| SETD5 | SET domain containing 5 | 0.0210073 |
| H1-0 | H1.0 linker histone | 0.0208517 |
| ARFGEF3 | ARFGEF family member 3 | 0.0208214 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0203877 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.020372 |
| FBXO11 | F-box protein 11 | 0.0203563 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0202296 |
| FAT1 | FAT atypical cadherin 1 | 0.0202136 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0202083 |
| TET2 | tet methylcytosine dioxygenase 2 | 0.0201815 |
| CDC73 | cell division cycle 73 | 0.0199717 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0822005 |
| NEBL | nebulette | -0.0607677 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0566739 |
| TMSB10 | thymosin beta 10 | -0.0407138 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0349344 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.034793 |
| RPLP1 | ribosomal protein, large, P1 | -0.0309145 |
| CENPF | centromere protein F, 350/400kDa | -0.0309068 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0291163 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0288253 |
| ACTG1 | actin gamma 1 | -0.0274996 |
| RPS24 | ribosomal protein S24 | -0.024841 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0225355 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0223003 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0217382 |
| HMGA1 | high mobility group AT-hook 1 | -0.0205229 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0202467 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0195914 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0186999 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0186894 |
| RPS21 | ribosomal protein S21 | -0.0183281 |
| PTMA | prothymosin, alpha | -0.0175767 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0174916 |
| RPL9 | ribosomal protein L9 | -0.0171802 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.016179 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0159327 |
| MKI67 | marker of proliferation Ki-67 | -0.01501 |
| UBTF | upstream binding transcription factor, RNA polymerase I | -0.0146592 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0145771 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0144294 |
| ATP11A | ATPase, class VI, type 11A | -0.0140273 |
| CAVIN1 | caveolae associated protein 1 | -0.0139869 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0139437 |
| RPL34 | ribosomal protein L34 | -0.0139265 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0135565 |
| RPS28 | ribosomal protein S28 | -0.0132672 |
| MAP4 | microtubule-associated protein 4 | -0.0132281 |
| RPLP2 | ribosomal protein, large, P2 | -0.0129669 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0125381 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.012461 |
| TBCA | tubulin folding cofactor A | -0.0123499 |
| RPS6 | ribosomal protein S6 | -0.012336 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0121572 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.0120746 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0120175 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0119311 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0119158 |
| PRKAR1B | protein kinase, cAMP-dependent, regulatory, type I, beta | -0.0119097 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0117662 |
| TOM1L2 | target of myb1-like 2 (chicken) | -0.0116356 |
| RPS27A | ribosomal protein S27a | -0.011622 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0115955 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0113246 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0112664 |
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 | -0.0112473 |
| RPLP0 | ribosomal protein, large, P0 | -0.0112345 |
| RBM28 | RNA binding motif protein 28 | -0.0110813 |
| FBL | fibrillarin | -0.0109855 |
| APTX | aprataxin | -0.0109415 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.0109296 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | -0.0109244 |
| TPM4 | tropomyosin 4 | -0.0108855 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0108455 |
| CDV3 | CDV3 homolog (mouse) | -0.0104949 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0104365 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.010412 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -0.0104054 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0102897 |
| INA | internexin neuronal intermediate filament protein, alpha | -0.0101888 |
| ZNF33A | zinc finger protein 33A | -0.0101813 |
| BRCA1 | breast cancer 1, early onset | -0.0101665 |
| SRSF9 | serine/arginine-rich splicing factor 9 | -0.0101102 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.010028 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0099896 |
| ZNF770 | zinc finger protein 770 | -0.00992519 |
| ZNF33B | zinc finger protein 33B | -0.00990649 |
| BRI3BP | BRI3 binding protein | -0.00985324 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.00968954 |
| STARD7 | StAR-related lipid transfer (START) domain containing 7 | -0.00968022 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.00952071 |
| THBS1 | thrombospondin 1 | -0.00951748 |
| MRFAP1 | Morf4 family associated protein 1 | -0.00925651 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0091065 |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | -0.00908376 |
| RPS20 | ribosomal protein S20 | -0.00907753 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.00904462 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.00903344 |
| ULK4 | unc-51 like kinase 4 | -0.00899884 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.00882117 |
| ANKRD33B | ankyrin repeat domain 33B | -0.00880108 |
| AEBP2 | AE binding protein 2 | -0.00871036 |
| HMGB1 | high mobility group box 1 | -0.00865099 |
| METTL16 | methyltransferase like 16 | -0.00849674 |
| MTREX | Mtr4 exosome RNA helicase | -0.00844679 |
| BRCA2 | breast cancer 2, early onset | -0.0084317 |
| PABPC4 | poly(A) binding protein, cytoplasmic 4 (inducible form) | -0.00842367 |
| PARK7 | parkinson protein 7 | -0.00841295 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.00839817 |
| KIAA1671 | KIAA1671 | -0.00839766 |
| RPL38 | ribosomal protein L38 | -0.00835397 |
