| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Benztropine (mesylate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.204048 |
| FN1 | fibronectin 1 | 0.176852 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0728321 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0713992 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0701197 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0687846 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0678172 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0672893 |
| AHNAK | AHNAK nucleoprotein | 0.0668764 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0649694 |
| ENO1 | enolase 1, (alpha) | 0.0641918 |
| ZNF292 | zinc finger protein 292 | 0.0581387 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0570065 |
| MT2A | metallothionein 2A | 0.0557152 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0537058 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0529364 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0524381 |
| FMN1 | formin 1 | 0.0523627 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0487455 |
| A2M | alpha-2-macroglobulin | 0.0475252 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0465197 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0461934 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.043024 |
| VGF | VGF nerve growth factor inducible | 0.0426244 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0421042 |
| ANXA2 | annexin A2 | 0.0420551 |
| MRTFA | myocardin related transcription factor A | 0.0420099 |
| RYBP | RING1 and YY1 binding protein | 0.041566 |
| GPC6 | glypican 6 | 0.0410979 |
| PDE10A | phosphodiesterase 10A | 0.0406229 |
| VGLL4 | vestigial-like family member 4 | 0.0389531 |
| TMEM178B | transmembrane protein 178B | 0.0386287 |
| EMP1 | epithelial membrane protein 1 | 0.0380373 |
| UBC | ubiquitin C | 0.0376092 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0373068 |
| ARRDC3 | arrestin domain containing 3 | 0.0367734 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.036258 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0362368 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0360384 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0356286 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0355469 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0353572 |
| SSH1 | slingshot protein phosphatase 1 | 0.0345342 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.034188 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0333819 |
| CALU | calumenin | 0.0328404 |
| CDC73 | cell division cycle 73 | 0.0326974 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.032653 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0320261 |
| APP | amyloid beta (A4) precursor protein | 0.0314836 |
| RLF | rearranged L-myc fusion | 0.0314185 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0311875 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.0310854 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0308828 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0299716 |
| MFSD12 | major facilitator superfamily domain containing 12 | 0.0298302 |
| TRIM9 | tripartite motif containing 9 | 0.0295608 |
| RHEB | Ras homolog enriched in brain | 0.0289296 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0287313 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0285588 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0284292 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0280905 |
| PGK1 | phosphoglycerate kinase 1 | 0.0280088 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0278987 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0276376 |
| RASA3 | RAS p21 protein activator 3 | 0.0275433 |
| ODR4 | odr-4 GPCR localization factor homolog | 0.0273236 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0273028 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0272501 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0269331 |
| COG5 | component of oligomeric golgi complex 5 | 0.0266507 |
| DSTYK | dual serine/threonine and tyrosine protein kinase | 0.0266384 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0265581 |
| TNPO3 | transportin 3 | 0.0265414 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0263515 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0263346 |
| NUP58 | nucleoporin 58 | 0.0260376 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0259961 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0259136 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0258767 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0258603 |
| ACTN4 | actinin, alpha 4 | 0.0258536 |
| RBM33 | RNA binding motif protein 33 | 0.0258131 |
| SPAG9 | sperm associated antigen 9 | 0.0256987 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0256548 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0255811 |
| GSN | gelsolin | 0.0254319 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0252727 |
| ACTG1 | actin gamma 1 | 0.025126 |
| YBX3 | Y box binding protein 3 | 0.0250797 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0245673 |
| CD109 | CD109 molecule | 0.024525 |
| FAT1 | FAT atypical cadherin 1 | 0.0244702 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0243783 |
| SMAD3 | SMAD family member 3 | 0.0243695 |
| FBXO32 | F-box protein 32 | 0.0241829 |
| BBX | bobby sox homolog (Drosophila) | 0.0240987 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0240124 |
| NDRG1 | N-myc downstream regulated 1 | 0.0235704 |
| LOC112694756 | uncharaterized LOC112694756 | 0.023473 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.0853553 |
| CENPF | centromere protein F, 350/400kDa | -0.0562712 |
| EHBP1 | EH domain binding protein 1 | -0.0546323 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0539183 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0502768 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0490979 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0486704 |
| GHR | growth hormone receptor | -0.0475261 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0471208 |
| CTTNBP2 | cortactin binding protein 2 | -0.0452477 |
| PLIN2 | perilipin 2 | -0.0433216 |
| OXR1 | oxidation resistance 1 | -0.0424513 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0403877 |
| PTK2 | protein tyrosine kinase 2 | -0.0386573 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0380009 |
| GDF15 | growth differentiation factor 15 | -0.0378638 |
| PTCHD4 | patched domain containing 4 | -0.0375581 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0346147 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0345091 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0339115 |
| EGR1 | early growth response 1 | -0.0337204 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0335291 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0305224 |
| TMSB10 | thymosin beta 10 | -0.0301362 |
| TRIM2 | tripartite motif containing 2 | -0.0291432 |
| SCFD2 | sec1 family domain containing 2 | -0.028588 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0282088 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0278814 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0269391 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0260467 |
| HLA-B | major histocompatibility complex, class I, B | -0.0253135 |
| CCDC91 | coiled-coil domain containing 91 | -0.0252317 |
| NBAS | neuroblastoma amplified sequence | -0.0252085 |
| RFX7 | regulatory factor X, 7 | -0.0251401 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0249634 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0240802 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0238726 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.023401 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0233712 |
| SRPK2 | SRSF protein kinase 2 | -0.0231939 |
| PRKD1 | protein kinase D1 | -0.0223559 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0222871 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.021588 |
| SBF2 | SET binding factor 2 | -0.0215844 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0214415 |
| RANBP17 | RAN binding protein 17 | -0.021248 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.021045 |
| VIM | vimentin | -0.0208976 |
| TPI1 | triosephosphate isomerase 1 | -0.0206545 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0206378 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0204949 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0204045 |
| CDK14 | cyclin-dependent kinase 14 | -0.0201438 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0201046 |
| JAZF1 | JAZF zinc finger 1 | -0.0199937 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0197425 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0194072 |
| SETD5 | SET domain containing 5 | -0.0192204 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0191378 |
| S100A6 | S100 calcium binding protein A6 | -0.018485 |
| LRAT | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | -0.0184327 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0183967 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0183721 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -0.0182279 |
| MKI67 | marker of proliferation Ki-67 | -0.0176642 |
| GPATCH8 | G patch domain containing 8 | -0.0173098 |
| TAGLN2 | transgelin 2 | -0.0172068 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | -0.017111 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0170678 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.017018 |
| RNF145 | ring finger protein 145 | -0.016947 |
| ITGB8 | integrin, beta 8 | -0.0166445 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0166342 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0166263 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0164849 |
| OSMR | oncostatin M receptor | -0.0163735 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0162911 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.0162368 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | -0.0161314 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.016121 |
| RBM26 | RNA binding motif protein 26 | -0.016093 |
| ATF6 | activating transcription factor 6 | -0.0158514 |
| BPTF | bromodomain PHD finger transcription factor | -0.0158461 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0157804 |
| NPR2 | natriuretic peptide receptor 2 | -0.015652 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0156483 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0155101 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0154629 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0154517 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0154484 |
| CHD6 | chromodomain helicase DNA binding protein 6 | -0.0152883 |
| VPS50 | VPS50 subunit of EARP/GARPII complex | -0.015222 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0152156 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0151123 |
| MEIS2 | Meis homeobox 2 | -0.0150668 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0149786 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0147636 |
| NAV2 | neuron navigator 2 | -0.0147379 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0146599 |
| PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | -0.0145062 |
