| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0858756 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0807451 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0796724 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0714034 |
| VEGFA | vascular endothelial growth factor A | 0.0679391 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0615058 |
| STC1 | stanniocalcin 1 | 0.0508497 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0478448 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0449459 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0432324 |
| TXNIP | thioredoxin interacting protein | 0.0430406 |
| KYNU | kynureninase | 0.0394102 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0389267 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.036418 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0357028 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0338398 |
| MT1X | metallothionein 1X | 0.0321857 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0316448 |
| NDRG1 | N-myc downstream regulated 1 | 0.0308905 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0289023 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0281888 |
| ATXN1 | ataxin 1 | 0.0272267 |
| NABP1 | nucleic acid binding protein 1 | 0.0271704 |
| FAM13A | family with sequence similarity 13, member A | 0.0263776 |
| MSN | moesin | 0.026092 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0260514 |
| FLNA | filamin A, alpha | 0.025476 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0242682 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0237147 |
| METTL15 | methyltransferase like 15 | 0.0236594 |
| NOTCH2 | notch 2 | 0.0233126 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0228308 |
| HELZ | helicase with zinc finger | 0.0225626 |
| STK17B | serine/threonine kinase 17b | 0.0223861 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0223085 |
| EGR1 | early growth response 1 | 0.0221112 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.021789 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0214856 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0213582 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0213366 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0212556 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0212503 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0211289 |
| GOLGB1 | golgin B1 | 0.0204354 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.020318 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0197457 |
| PRELID2 | PRELI domain containing 2 | 0.0195022 |
| TM9SF4 | transmembrane 9 superfamily protein member 4 | 0.0188248 |
| UNC5B | unc-5 homolog B (C. elegans) | 0.0187589 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0187056 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0186239 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0184403 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0182895 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0181338 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.018019 |
| STK17A | serine/threonine kinase 17a | 0.0179031 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0178843 |
| ANK2 | ankyrin 2, neuronal | 0.0178079 |
| CALN1 | calneuron 1 | 0.0177123 |
| ATP13A3 | ATPase type 13A3 | 0.0176653 |
| YBX3 | Y box binding protein 3 | 0.0176475 |
| STXBP1 | syntaxin binding protein 1 | 0.0175686 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0174272 |
| CCPG1 | cell cycle progression 1 | 0.0174246 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0171428 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0170415 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0168978 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0167111 |
| TPM3 | tropomyosin 3 | 0.0164419 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0163793 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0157438 |
| LRRC49 | leucine rich repeat containing 49 | 0.0153803 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0152415 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0152019 |
| ARRDC3 | arrestin domain containing 3 | 0.0151782 |
| CD44 | CD44 molecule (Indian blood group) | 0.0147826 |
| FTL | ferritin, light polypeptide | 0.0146472 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0145285 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.0142585 |
| MEF2A | myocyte enhancer factor 2A | 0.0140973 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0138635 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0137498 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0137216 |
| RPL28 | ribosomal protein L28 | 0.0137161 |
| RNF220 | ring finger protein 220 | 0.0137122 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.013711 |
| PCBP3 | poly(rC) binding protein 3 | 0.0136735 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0136295 |
| SMAD3 | SMAD family member 3 | 0.0133773 |
| ACTN1 | actinin, alpha 1 | 0.0133464 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0133335 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.013273 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.013206 |
| SUCO | SUN domain containing ossification factor | 0.0130892 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0130268 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0130212 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0129475 |
| CLU | clusterin | 0.0129065 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0128351 |
| JAK1 | Janus kinase 1 | 0.0127915 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | -0.171505 |
| TMSB10 | thymosin beta 10 | -0.155398 |
| FN1 | fibronectin 1 | -0.14358 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.133497 |
| VIM | vimentin | -0.128133 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.105743 |
| GRB10 | growth factor receptor-bound protein 10 | -0.103542 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0949871 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0887953 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0853376 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0730505 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0730138 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0688726 |
| HLA-B | major histocompatibility complex, class I, B | -0.0645782 |
| PTMA | prothymosin, alpha | -0.0584396 |
| TPM4 | tropomyosin 4 | -0.0577566 |
| LDHA | lactate dehydrogenase A | -0.0554489 |
| PRSS23 | protease, serine, 23 | -0.0504408 |
| DST | dystonin | -0.04917 |
| PGK1 | phosphoglycerate kinase 1 | -0.0485083 |
| ASPH | aspartate beta-hydroxylase | -0.0483419 |
| B2M | beta-2-microglobulin | -0.0462696 |
| LOX | lysyl oxidase | -0.0455571 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0402882 |
| MKI67 | marker of proliferation Ki-67 | -0.0386351 |
| INHBA | inhibin, beta A | -0.0381381 |
| EGFR | epidermal growth factor receptor | -0.0373148 |
| FSTL1 | follistatin-like 1 | -0.0362456 |
| GNAS | GNAS complex locus | -0.0360549 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0356932 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.035649 |
| PTK2 | protein tyrosine kinase 2 | -0.0351743 |
| NLGN1 | neuroligin 1 | -0.0338555 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0332517 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0331078 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0330906 |
| NAV1 | neuron navigator 1 | -0.0327339 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0324832 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0320181 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0316741 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0315377 |
| RPS6 | ribosomal protein S6 | -0.0312569 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0312561 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0303633 |
| CLMP | CXADR-like membrane protein | -0.0300726 |
| COL5A2 | collagen, type V, alpha 2 | -0.0298991 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0292355 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0283295 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0281785 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0280329 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0272412 |
| RIGI | RNA sensor RIG-I | -0.0268226 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0268206 |
| CENPF | centromere protein F, 350/400kDa | -0.0267583 |
| FAM20C | family with sequence similarity 20, member C | -0.026273 |
| DTNA | dystrobrevin, alpha | -0.0257452 |
| TENM3 | teneurin transmembrane protein 3 | -0.0253002 |
| RRBP1 | ribosome binding protein 1 | -0.0252998 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | -0.0249583 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0247603 |
| MMP12 | matrix metallopeptidase 12 | -0.0246941 |
| CCND1 | cyclin D1 | -0.0246806 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0243324 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0241758 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0241286 |
| ZNF804A | zinc finger protein 804A | -0.0240857 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.0240126 |
| TUBB | tubulin, beta class I | -0.0236355 |
| NAV3 | neuron navigator 3 | -0.0235651 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.023527 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0234269 |
| COL5A1 | collagen, type V, alpha 1 | -0.0231858 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0229881 |
| GNG12 | guanine nucleotide binding protein (G protein), gamma 12 | -0.0226882 |
| PXDN | peroxidasin | -0.0225784 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0223962 |
| ANXA2 | annexin A2 | -0.0222525 |
| USP34 | ubiquitin specific peptidase 34 | -0.0221176 |
| GLG1 | golgi glycoprotein 1 | -0.0220371 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0219287 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0218715 |
| S100A6 | S100 calcium binding protein A6 | -0.0218391 |
| RPL27A | ribosomal protein L27a | -0.0217987 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0217436 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0217123 |
| HDLBP | high density lipoprotein binding protein | -0.0216873 |
| OXR1 | oxidation resistance 1 | -0.0216494 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0212819 |
| TUBA1B | tubulin, alpha 1b | -0.0210827 |
| IGF2 | insulin-like growth factor 2 | -0.0208155 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0207556 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0204583 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0204419 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0204418 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0202149 |
| TPI1 | triosephosphate isomerase 1 | -0.0200186 |
| NF1 | neurofibromin 1 | -0.0199299 |
| LMNA | lamin A/C | -0.0196432 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0195834 |
| SEPTIN7 | septin 7 | -0.0195286 |
