| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.105174 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0882463 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0808036 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0803463 |
| AHNAK | AHNAK nucleoprotein | 0.0747175 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.066101 |
| ENO1 | enolase 1, (alpha) | 0.0619483 |
| VEGFA | vascular endothelial growth factor A | 0.0611816 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0587793 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.05776 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0569647 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0564874 |
| FAT1 | FAT atypical cadherin 1 | 0.0561329 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0520124 |
| TPM3 | tropomyosin 3 | 0.051042 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.049057 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0485367 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0484129 |
| PRELID2 | PRELI domain containing 2 | 0.0425327 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0420492 |
| ANXA2 | annexin A2 | 0.0414573 |
| B2M | beta-2-microglobulin | 0.0410433 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.039828 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0384624 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0377826 |
| ATXN1 | ataxin 1 | 0.0375601 |
| NDRG1 | N-myc downstream regulated 1 | 0.036863 |
| WWOX | WW domain containing oxidoreductase | 0.0365095 |
| HLA-A | major histocompatibility complex, class I, A | 0.0361456 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.035773 |
| VCL | vinculin | 0.0352582 |
| DSPP | dentin sialophosphoprotein | 0.0351184 |
| FHIT | fragile histidine triad | 0.0349857 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0348849 |
| HELZ | helicase with zinc finger | 0.0347179 |
| MYO1D | myosin ID | 0.0346547 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0343459 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0341568 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0336919 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0335794 |
| OGA | O-GlcNAcase | 0.0329957 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0327717 |
| ZNF292 | zinc finger protein 292 | 0.0327548 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0318613 |
| ADAR | adenosine deaminase, RNA-specific | 0.0316906 |
| RPL37A | ribosomal protein L37a | 0.0313434 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.031133 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0308198 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0303748 |
| RPS8 | ribosomal protein S8 | 0.0300605 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.029909 |
| PTMA | prothymosin, alpha | 0.0292812 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0289703 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0289183 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.028864 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0288323 |
| PCBP2 | poly(rC) binding protein 2 | 0.0287318 |
| KLF6 | Kruppel-like factor 6 | 0.028726 |
| TPM4 | tropomyosin 4 | 0.0287191 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0285792 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0285595 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0284983 |
| YEATS2 | YEATS domain containing 2 | 0.0282578 |
| RRM2 | ribonucleotide reductase M2 | 0.0279255 |
| RNF24 | ring finger protein 24 | 0.0274048 |
| HLA-B | major histocompatibility complex, class I, B | 0.0270914 |
| TJP1 | tight junction protein 1 | 0.026835 |
| DIAPH1 | diaphanous-related formin 1 | 0.0265462 |
| DSG2 | desmoglein 2 | 0.0262438 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0259678 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0256221 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.025255 |
| RPS3 | ribosomal protein S3 | 0.0246015 |
| SNX9 | sorting nexin 9 | 0.0244537 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0244366 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0242633 |
| BRD4 | bromodomain containing 4 | 0.024263 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0239791 |
| HOXB9 | homeobox B9 | 0.0236998 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.023665 |
| ARRDC3 | arrestin domain containing 3 | 0.023517 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0233761 |
| SMAD3 | SMAD family member 3 | 0.0228963 |
| KIF5B | kinesin family member 5B | 0.0227749 |
| BRD2 | bromodomain containing 2 | 0.0227513 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0225595 |
| RUNX1 | runt-related transcription factor 1 | 0.0225542 |
| UBC | ubiquitin C | 0.0224903 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0224305 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0223363 |
| POTEF | POTE ankyrin domain family, member F | 0.0223039 |
| SFTPA2 | surfactant protein A2 | 0.0221633 |
| SET | SET nuclear proto-oncogene | 0.022135 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0220063 |
| RNF213 | ring finger protein 213 | 0.0219367 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0218723 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0218081 |
| MANBA | mannosidase, beta A, lysosomal | 0.0215361 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0213751 |
| RPS6 | ribosomal protein S6 | 0.0212441 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.204456 |
| TMSB10 | thymosin beta 10 | -0.0732169 |
| ARF4 | ADP-ribosylation factor 4 | -0.06678 |
| HDLBP | high density lipoprotein binding protein | -0.0608978 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0556546 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0446805 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0427135 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0424021 |
| LDHA | lactate dehydrogenase A | -0.041459 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0384372 |
| MORF4L2 | mortality factor 4 like 2 | -0.0372636 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0329525 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0317081 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0317066 |
| FTL | ferritin, light polypeptide | -0.0311772 |
| SCFD2 | sec1 family domain containing 2 | -0.0293128 |
| GOLGA3 | golgin A3 | -0.0286133 |
| COG5 | component of oligomeric golgi complex 5 | -0.0280568 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0276576 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0275069 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0268687 |
| CDK13 | cyclin-dependent kinase 13 | -0.0253012 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0251959 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0242586 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0241945 |
| EHBP1 | EH domain binding protein 1 | -0.0240482 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0232887 |
| MYOF | myoferlin | -0.0231034 |
| SRPRA | SRP receptor subunit alpha | -0.0228435 |
| RPLP1 | ribosomal protein, large, P1 | -0.0228415 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0224808 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0224741 |
| GNAS | GNAS complex locus | -0.0224259 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0222654 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0222225 |
| ATM | ATM serine/threonine kinase | -0.0220724 |
| MKI67 | marker of proliferation Ki-67 | -0.0220644 |
| RPS24 | ribosomal protein S24 | -0.0218256 |
| LMO7 | LIM domain 7 | -0.0217895 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0215838 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0214569 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0212675 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0212602 |
| LARP1B | La ribonucleoprotein domain family, member 1B | -0.0211336 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0210063 |
| PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | -0.0206345 |
| ARF1 | ADP-ribosylation factor 1 | -0.0205182 |
| SQSTM1 | sequestosome 1 | -0.0204966 |
| DYM | dymeclin | -0.0204863 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0204116 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0203353 |
| TMEM123 | transmembrane protein 123 | -0.0203077 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0203012 |
| RPL4 | ribosomal protein L4 | -0.0202589 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.020243 |
| RAB10 | RAB10, member RAS oncogene family | -0.020242 |
| POLR3D | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa | -0.0200119 |
| MORC4 | MORC family CW-type zinc finger 4 | -0.0198309 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0196829 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0196812 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0195855 |
| C11ORF54 | chromosome 11 open reading frame 54 | -0.019508 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0192979 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0191073 |
| RNF43 | ring finger protein 43 | -0.0189925 |
| GOLT1B | golgi transport 1B | -0.0188224 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0187999 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0187989 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0187971 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0186342 |
| SERINC5 | serine incorporator 5 | -0.0184489 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0183451 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0183032 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0181535 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0181027 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.0180258 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0178762 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0177605 |
| HMGB2 | high mobility group box 2 | -0.0177302 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0175932 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.0175599 |
| TESK2 | testis-specific kinase 2 | -0.017277 |
| TFRC | transferrin receptor | -0.0172541 |
| MSI2 | musashi RNA-binding protein 2 | -0.0172142 |
| RPL34 | ribosomal protein L34 | -0.0171685 |
| PRC1 | protein regulator of cytokinesis 1 | -0.0170798 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0169726 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0169699 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0169595 |
| NME7 | NME/NM23 family member 7 | -0.0169247 |
| FOXO3 | forkhead box O3 | -0.0169237 |
| SEC24A | SEC24 family member A | -0.0168072 |
| CERT1 | ceramide transporter 1 | -0.0166396 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0166046 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0165885 |
| CFAP96 | cilia and flagella associated protein 96 | -0.0165248 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.016493 |
| RPL14 | ribosomal protein L14 | -0.0162433 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0161303 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0159833 |
