Benztropine (mesylate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benztropine (mesylate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.0716466
FTH1 ferritin, heavy polypeptide 1 0.063124
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0545509
ZNF292 zinc finger protein 292 0.054436
MYH9 myosin, heavy chain 9, non-muscle 0.049017
EEF2 eukaryotic translation elongation factor 2 0.0451444
MT2A metallothionein 2A 0.0444883
ACTG1 actin gamma 1 0.0434152
GOLGA4 golgin A4 0.0415016
FTL ferritin, light polypeptide 0.0410275
UGCG UDP-glucose ceramide glucosyltransferase 0.0391982
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0388685
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0386404
ENO1 enolase 1, (alpha) 0.0381549
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0372373
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0358056
TMSB4X thymosin beta 4, X-linked 0.033864
HELZ helicase with zinc finger 0.0332757
MATR3 matrin 3 0.0324597
KMT2E lysine (K)-specific methyltransferase 2E 0.0318317
RPS8 ribosomal protein S8 0.0313149
RPS6 ribosomal protein S6 0.0295391
BHLHE40 basic helix-loop-helix family, member e40 0.0294084
DDIT4 DNA-damage-inducible transcript 4 0.0293616
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0291271
PDIA3 protein disulfide isomerase family A, member 3 0.0289772
RNF145 ring finger protein 145 0.0289676
TXNRD1 thioredoxin reductase 1 0.0284432
SEPTIN7 septin 7 0.0283211
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0280111
APP amyloid beta (A4) precursor protein 0.0278286
SNX9 sorting nexin 9 0.0273822
YBX1 Y box binding protein 1 0.0268141
CALR calreticulin 0.0267028
RLF rearranged L-myc fusion 0.0263918
IGFBP3 insulin-like growth factor binding protein 3 0.0259478
PTMA prothymosin, alpha 0.0259217
NCKAP1 NCK-associated protein 1 0.025703
SET SET nuclear proto-oncogene 0.0255424
OGA O-GlcNAcase 0.0254646
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0251332
KDM3A lysine (K)-specific demethylase 3A 0.0250287
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0248092
RPS19 ribosomal protein S19 0.0245907
UPP1 uridine phosphorylase 1 0.0245442
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.02394
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0238524
FOSL1 FOS-like antigen 1 0.0236835
EIF4A2 eukaryotic translation initiation factor 4A2 0.0236362
FXR1 fragile X mental retardation, autosomal homolog 1 0.0234725
KIF5B kinesin family member 5B 0.0231635
TPM3 tropomyosin 3 0.0229219
SRRM2 serine/arginine repetitive matrix 2 0.0227987
PKM pyruvate kinase, muscle 0.0222895
RPL19 ribosomal protein L19 0.0219127
CCNL1 cyclin L1 0.0218743
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.021871
USP3 ubiquitin specific peptidase 3 0.0218369
WAC WW domain containing adaptor with coiled-coil 0.021704
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.021203
NAMPT nicotinamide phosphoribosyltransferase 0.0209939
PDS5B PDS5 cohesin associated factor B 0.0209846
PCBP2 poly(rC) binding protein 2 0.0209365
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0208794
RPS3 ribosomal protein S3 0.0207466
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0207282
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0206304
RPL28 ribosomal protein L28 0.0206163
MKI67 marker of proliferation Ki-67 0.0205897
VEZT vezatin, adherens junctions transmembrane protein 0.020531
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0203201
TPD52 tumor protein D52 0.0202485
YTHDC1 YTH domain containing 1 0.0202379
RAD23B RAD23 homolog B (S. cerevisiae) 0.0201737
SPOPL speckle-type POZ protein-like 0.0200315
ANKRD28 ankyrin repeat domain 28 0.0200003
FLNA filamin A, alpha 0.0199515
PGK1 phosphoglycerate kinase 1 0.019945
APLP2 amyloid beta (A4) precursor-like protein 2 0.0198576
NAP1L1 nucleosome assembly protein 1-like 1 0.0198504
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0195978
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0195225
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0194613
VEGFA vascular endothelial growth factor A 0.0193793
SETD5 SET domain containing 5 0.0193472
XPO1 exportin 1 0.0192073
PDIA6 protein disulfide isomerase family A, member 6 0.0192027
RACK1 receptor for activated C kinase 1 0.0191068
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0189755
PHIP pleckstrin homology domain interacting protein 0.0189336
AXL AXL receptor tyrosine kinase 0.018885
CANX calnexin 0.0188473
ANLN anillin, actin binding protein 0.0188116
CSDE1 cold shock domain containing E1, RNA-binding 0.0185615
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0183066
MIS18BP1 MIS18 binding protein 1 0.018266
LMAN1 lectin, mannose-binding, 1 0.0181064
RPS12 ribosomal protein S12 0.0180392
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0179111
POTEF POTE ankyrin domain family, member F 0.0178464

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.0823376
PRELID2 PRELI domain containing 2 -0.0565928
TMSB10 thymosin beta 10 -0.0519621
HMGA2 high mobility group AT-hook 2 -0.0516331
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0501401
PSD3 pleckstrin and Sec7 domain containing 3 -0.0473051
EGFR epidermal growth factor receptor -0.0460121
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0434712
ALCAM activated leukocyte cell adhesion molecule -0.0384082
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0360954
FHIT fragile histidine triad -0.0354169
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0336389
INTS6 integrator complex subunit 6 -0.0325256
RAD51B RAD51 paralog B -0.0323703
SVIL supervillin -0.0315273
DLC1 DLC1 Rho GTPase activating protein -0.0312007
OSBPL10 oxysterol binding protein-like 10 -0.0290983
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0276914
CD44 CD44 molecule (Indian blood group) -0.0272797
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0272582
ADAM32 ADAM metallopeptidase domain 32 -0.0270834
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0265279
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0258424
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0254144
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0249258
AEBP2 AE binding protein 2 -0.0247398
SMYD3 SET and MYND domain containing 3 -0.0246911
CCDC138 coiled-coil domain containing 138 -0.024382
LPP LIM domain containing preferred translocation partner in lipoma -0.0237241
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0236112
VCL vinculin -0.0231413
SPATA13 spermatogenesis associated 13 -0.022743
GPR39 G protein-coupled receptor 39 -0.0224957
WWTR1 WW domain containing transcription regulator 1 -0.0224906
BICD1 bicaudal D homolog 1 (Drosophila) -0.0221126
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0217797
ITGA6 integrin, alpha 6 -0.0216543
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.021576
CTBP2 C-terminal binding protein 2 -0.0213936
TBC1D22A TBC1 domain family, member 22A -0.0212218
FLNB filamin B, beta -0.0209743
UBASH3B ubiquitin associated and SH3 domain containing B -0.0208106
CMIP c-Maf inducing protein -0.020708
KRT86 keratin 86, type II -0.0205638
LAMA4 laminin, alpha 4 -0.0205174
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0201947
EHBP1 EH domain binding protein 1 -0.0199645
PTPRK protein tyrosine phosphatase, receptor type, K -0.0198858
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0198169
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0196459
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0196174
DIAPH3 diaphanous-related formin 3 -0.0196081
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0194832
CAPN2 calpain 2, (m/II) large subunit -0.0194638
MAML2 mastermind-like 2 (Drosophila) -0.0194172
FNIP1 folliculin interacting protein 1 -0.0192377
LIMCH1 LIM and calponin homology domains 1 -0.0191862
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0191218
LAMC2 laminin, gamma 2 -0.0190548
PRKCA protein kinase C, alpha -0.0188364
TAS2R14 taste receptor, type 2, member 14 -0.01879
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0185199
SNX14 sorting nexin 14 -0.0184501
PCED1B PC-esterase domain containing 1B -0.0182578
FNDC3B fibronectin type III domain containing 3B -0.0182502
ZBTB20 zinc finger and BTB domain containing 20 -0.0182436
CREB5 cAMP responsive element binding protein 5 -0.0181998
ATXN1 ataxin 1 -0.0180562
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0178385
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0177927
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.017728
MYOF myoferlin -0.0175654
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0174952
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0174716
DENND1A DENN/MADD domain containing 1A -0.0173919
MYO1E myosin IE -0.0173696
THSD4 thrombospondin, type I, domain containing 4 -0.0170769
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.017064
UBAP2 ubiquitin associated protein 2 -0.0169946
VCAN versican -0.0169925
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0169574
NABP1 nucleic acid binding protein 1 -0.0167846
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.016524
EXT1 exostosin glycosyltransferase 1 -0.0165026
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0164992
SH3KBP1 SH3-domain kinase binding protein 1 -0.0164965
SPDYA speedy/RINGO cell cycle regulator family member A -0.0163583
ACTN4 actinin, alpha 4 -0.0163568
ANXA3 annexin A3 -0.0163376
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0162342
ATG7 autophagy related 7 -0.0159384
CDK13 cyclin-dependent kinase 13 -0.0159246
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0157244
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.01557
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 -0.0152835
RFC3 replication factor C (activator 1) 3, 38kDa -0.015237
SCLT1 sodium channel and clathrin linker 1 -0.0152146
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0151819
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.015103
RBPMS RNA binding protein with multiple splicing -0.0150917