| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.268729 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.150043 |
| CD44 | CD44 molecule (Indian blood group) | 0.135324 |
| FN1 | fibronectin 1 | 0.110686 |
| ENO1 | enolase 1, (alpha) | 0.100678 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.094183 |
| AHNAK | AHNAK nucleoprotein | 0.0936092 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0851925 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0806838 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.070352 |
| CANX | calnexin | 0.0631144 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0628574 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0623077 |
| TXNIP | thioredoxin interacting protein | 0.0598896 |
| TENM2 | teneurin transmembrane protein 2 | 0.0568303 |
| UBC | ubiquitin C | 0.0565603 |
| THBS1 | thrombospondin 1 | 0.0535726 |
| EGR1 | early growth response 1 | 0.0504379 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0500412 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0490468 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0463129 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.045468 |
| VEGFA | vascular endothelial growth factor A | 0.0453339 |
| CALR | calreticulin | 0.0451069 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0440521 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0437286 |
| OGA | O-GlcNAcase | 0.0435972 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0405974 |
| FAM13A | family with sequence similarity 13, member A | 0.039896 |
| JUN | jun proto-oncogene | 0.0387155 |
| RPS27A | ribosomal protein S27a | 0.038206 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0373136 |
| PTMA | prothymosin, alpha | 0.0369291 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0367641 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.0360892 |
| GLIS3 | GLIS family zinc finger 3 | 0.0360728 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0360594 |
| PDE10A | phosphodiesterase 10A | 0.0349477 |
| PKM | pyruvate kinase, muscle | 0.033513 |
| ARRDC3 | arrestin domain containing 3 | 0.0330028 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0328244 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0325456 |
| CALU | calumenin | 0.0321967 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0314049 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0304126 |
| CD109 | CD109 molecule | 0.0303265 |
| SYAP1 | synapse associated protein 1 | 0.0299766 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0285313 |
| DUSP6 | dual specificity phosphatase 6 | 0.0284239 |
| COL1A1 | collagen, type I, alpha 1 | 0.0282794 |
| B2M | beta-2-microglobulin | 0.0279065 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0277885 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0273323 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0267158 |
| SYNJ2 | synaptojanin 2 | 0.0266542 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.026605 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0265642 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0257915 |
| SMAD3 | SMAD family member 3 | 0.0251837 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.025096 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0242076 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0240689 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0240651 |
| VCL | vinculin | 0.0238381 |
| TXNRD1 | thioredoxin reductase 1 | 0.0232642 |
| IL1B | interleukin 1, beta | 0.0229896 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.0226204 |
| FLNA | filamin A, alpha | 0.0224945 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.0220057 |
| RTN4 | reticulon 4 | 0.0218502 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0218411 |
| GSE1 | Gse1 coiled-coil protein | 0.0211535 |
| IGF2 | insulin-like growth factor 2 | 0.0208389 |
| TGFB2 | transforming growth factor, beta 2 | 0.0207222 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0205353 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0205109 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0204894 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0204711 |
| RPN1 | ribophorin I | 0.0202753 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0202262 |
| SDC4 | syndecan 4 | 0.0202078 |
| PCBP2 | poly(rC) binding protein 2 | 0.0200541 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0200267 |
| KLF6 | Kruppel-like factor 6 | 0.0195231 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0194508 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0192831 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0192786 |
| RNF213 | ring finger protein 213 | 0.019269 |
| LOX | lysyl oxidase | 0.0189805 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0188375 |
| YBX1 | Y box binding protein 1 | 0.0187368 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0187082 |
| PLEC | plectin | 0.0185863 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0185716 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0185682 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.018413 |
| TRPA1 | transient receptor potential cation channel, subfamily A, member 1 | 0.0180895 |
| HLA-A | major histocompatibility complex, class I, A | 0.017825 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0177864 |
| MRC2 | mannose receptor, C type 2 | 0.0177856 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.143923 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.132897 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.101442 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0797468 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0727864 |
| CDH13 | cadherin 13 | -0.0655055 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0624181 |
| DTNA | dystrobrevin, alpha | -0.0599659 |
| VIM | vimentin | -0.0570814 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0528947 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0525327 |
| MYO10 | myosin X | -0.0520524 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0514513 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0470835 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0462529 |
| NAV2 | neuron navigator 2 | -0.0443921 |
| CLMP | CXADR-like membrane protein | -0.0432069 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0420921 |
| NAV1 | neuron navigator 1 | -0.0419285 |
| CENPF | centromere protein F, 350/400kDa | -0.0415654 |
| NDRG1 | N-myc downstream regulated 1 | -0.0415227 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0396359 |
| DIAPH2 | diaphanous-related formin 2 | -0.0393588 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0383108 |
| PTK2 | protein tyrosine kinase 2 | -0.0382104 |
| FRMD4A | FERM domain containing 4A | -0.037711 |
| RRM2 | ribonucleotide reductase M2 | -0.0358098 |
| RPS6 | ribosomal protein S6 | -0.0355717 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0342614 |
| RRBP1 | ribosome binding protein 1 | -0.0337273 |
| HMGA2 | high mobility group AT-hook 2 | -0.0331792 |
| MT2A | metallothionein 2A | -0.0318802 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0317506 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0314497 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0307723 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0307591 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0306656 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0299679 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0298583 |
| GOLGB1 | golgin B1 | -0.0297214 |
| ASPH | aspartate beta-hydroxylase | -0.0290383 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0284583 |
| RPL12 | ribosomal protein L12 | -0.0276478 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0270274 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0266267 |
| RPS2 | ribosomal protein S2 | -0.0262463 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0257237 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0251377 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0249158 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0239888 |
| MORF4L2 | mortality factor 4 like 2 | -0.023554 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0233266 |
| USP34 | ubiquitin specific peptidase 34 | -0.0233061 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0233046 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0232191 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0225964 |
| SEC24D | SEC24 family member D | -0.0224098 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0221974 |
| EGFR | epidermal growth factor receptor | -0.0217523 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | -0.0217156 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | -0.0207812 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0207514 |
| COL5A1 | collagen, type V, alpha 1 | -0.020486 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0204284 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0204139 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0202302 |
| HJURP | Holliday junction recognition protein | -0.0194607 |
| KIAA1549L | KIAA1549-like | -0.0188681 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0188047 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0187392 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0183844 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0183793 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0183724 |
| RAD51B | RAD51 paralog B | -0.0182209 |
| EFNA5 | ephrin-A5 | -0.0177477 |
| GOLT1B | golgi transport 1B | -0.0176502 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.0171826 |
| RPL9 | ribosomal protein L9 | -0.017083 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0170486 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0169719 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0168066 |
| CLTC | clathrin, heavy chain (Hc) | -0.0166959 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0166221 |
| LAMB3 | laminin, beta 3 | -0.0164142 |
| HM13 | histocompatibility (minor) 13 | -0.0163712 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0163309 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0161579 |
| GPATCH2L | G patch domain containing 2-like | -0.0159951 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0159476 |
| RPL38 | ribosomal protein L38 | -0.0159053 |
| MYO9A | myosin IXA | -0.0157083 |
| RASA2 | RAS p21 protein activator 2 | -0.0157025 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0156691 |
| MTSS1 | metastasis suppressor 1 | -0.0156515 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | -0.0156477 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0156298 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0155959 |
| CCDC138 | coiled-coil domain containing 138 | -0.0155161 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0153501 |
| DNM1L | dynamin 1-like | -0.0153105 |
