| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.207622 |
| FN1 | fibronectin 1 | 0.174875 |
| VEGFA | vascular endothelial growth factor A | 0.130197 |
| CD44 | CD44 molecule (Indian blood group) | 0.113157 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.095448 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0871958 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0738983 |
| LOXL2 | lysyl oxidase-like 2 | 0.0638151 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0533796 |
| HMGA2 | high mobility group AT-hook 2 | 0.0497382 |
| STC1 | stanniocalcin 1 | 0.0445723 |
| AHNAK | AHNAK nucleoprotein | 0.0442163 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0434336 |
| SMAD3 | SMAD family member 3 | 0.0419669 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0404941 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0391053 |
| ARRDC3 | arrestin domain containing 3 | 0.0390039 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0379947 |
| GLIS3 | GLIS family zinc finger 3 | 0.0368754 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0361292 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0360404 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0357505 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0354588 |
| KIAA1217 | KIAA1217 | 0.0350137 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0330333 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0328388 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0322661 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0320922 |
| MAP1B | microtubule-associated protein 1B | 0.0313059 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0303732 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0283889 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0276375 |
| ATP13A3 | ATPase type 13A3 | 0.0271259 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0261899 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0259179 |
| B2M | beta-2-microglobulin | 0.0255112 |
| NRP1 | neuropilin 1 | 0.0254252 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0252743 |
| INHBA | inhibin, beta A | 0.0252672 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0251667 |
| TPM4 | tropomyosin 4 | 0.0242144 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0231806 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0230542 |
| VCAN | versican | 0.0230077 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0228379 |
| RIGI | RNA sensor RIG-I | 0.0227687 |
| HAS2 | hyaluronan synthase 2 | 0.022656 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0226142 |
| IL6 | interleukin 6 | 0.0222602 |
| SPAG9 | sperm associated antigen 9 | 0.0219876 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0219801 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0219616 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0218244 |
| OSMR | oncostatin M receptor | 0.021675 |
| KLF6 | Kruppel-like factor 6 | 0.0215138 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0214624 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0212592 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0211827 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0210293 |
| ECE1 | endothelin converting enzyme 1 | 0.0208657 |
| ATXN1 | ataxin 1 | 0.0207307 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | 0.0204516 |
| SH3PXD2B | SH3 and PX domains 2B | 0.0203574 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0200069 |
| SYNJ2 | synaptojanin 2 | 0.0195694 |
| SLC22A23 | solute carrier family 22, member 23 | 0.019433 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.01927 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.019094 |
| MKI67 | marker of proliferation Ki-67 | 0.0190388 |
| FAT1 | FAT atypical cadherin 1 | 0.0188356 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0187326 |
| MT2A | metallothionein 2A | 0.0185635 |
| CD99 | CD99 molecule | 0.0184842 |
| MT1X | metallothionein 1X | 0.0183222 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0182324 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0180849 |
| MTSS1 | metastasis suppressor 1 | 0.0177827 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0174502 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0172532 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0170608 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0166212 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0163867 |
| SOCS5 | suppressor of cytokine signaling 5 | 0.0162835 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0162267 |
| MACROD2 | MACRO domain containing 2 | 0.0160616 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0157685 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0157512 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0157009 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0156003 |
| MX2 | MX dynamin-like GTPase 2 | 0.015549 |
| TMSB4X | thymosin beta 4, X-linked | 0.0155031 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0154778 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0149969 |
| LIMA1 | LIM domain and actin binding 1 | 0.0147386 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0146809 |
| TXNRD1 | thioredoxin reductase 1 | 0.0146572 |
| NREP | neuronal regeneration related protein | 0.0146551 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0146036 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0144519 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0144431 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.163865 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.120516 |
| VIM | vimentin | -0.103152 |
| TMSB10 | thymosin beta 10 | -0.084345 |
| CADM1 | cell adhesion molecule 1 | -0.0788414 |
| NDRG1 | N-myc downstream regulated 1 | -0.0664944 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0645798 |
| COL5A1 | collagen, type V, alpha 1 | -0.050878 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0448241 |
| UBC | ubiquitin C | -0.0431058 |
| FBN1 | fibrillin 1 | -0.0417823 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0364337 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0344201 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0317464 |
| CALR | calreticulin | -0.0314273 |
| GOLGB1 | golgin B1 | -0.030927 |
| COL1A2 | collagen, type I, alpha 2 | -0.0306149 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0286096 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0281948 |
| CDH13 | cadherin 13 | -0.0276564 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0270612 |
| FTL | ferritin, light polypeptide | -0.0262833 |
| RRBP1 | ribosome binding protein 1 | -0.0260906 |
| RPL23 | ribosomal protein L23 | -0.0252019 |
| RBM39 | RNA binding motif protein 39 | -0.0249906 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0248248 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0241281 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0234052 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0233124 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0232848 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0230037 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.022302 |
| RPS8 | ribosomal protein S8 | -0.0222648 |
| TBC1D23 | TBC1 domain family, member 23 | -0.022117 |
| RPS27A | ribosomal protein S27a | -0.0221127 |
| GOLGA4 | golgin A4 | -0.0219525 |
| TFG | TRK-fused gene | -0.0218898 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0216377 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0214767 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0212672 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.021138 |
| SEC24D | SEC24 family member D | -0.0210117 |
| LOX | lysyl oxidase | -0.0209503 |
| SDC2 | syndecan 2 | -0.0207281 |
| MATR3 | matrin 3 | -0.0204934 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0204153 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0203133 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0201739 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0200716 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0198525 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0196975 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0196464 |
| MYO10 | myosin X | -0.0193986 |
| RPS20 | ribosomal protein S20 | -0.0193477 |
| LDHA | lactate dehydrogenase A | -0.0190743 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0190646 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0188457 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0186315 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0184859 |
| ARF4 | ADP-ribosylation factor 4 | -0.0183654 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0183373 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0182819 |
| CALU | calumenin | -0.0179715 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0179243 |
| RPLP1 | ribosomal protein, large, P1 | -0.0177775 |
| ACTN1 | actinin, alpha 1 | -0.0176203 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0175928 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0174553 |
| TMF1 | TATA element modulatory factor 1 | -0.0174047 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0173026 |
| CCNY | cyclin Y | -0.0171825 |
| TPM2 | tropomyosin 2 (beta) | -0.0170942 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0170538 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0170022 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0169718 |
| ASPH | aspartate beta-hydroxylase | -0.0168791 |
| TRAM1 | translocation associated membrane protein 1 | -0.016813 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0167906 |
| SEC24A | SEC24 family member A | -0.016715 |
| IER3 | immediate early response 3 | -0.0165947 |
| SAFB2 | scaffold attachment factor B2 | -0.0164393 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0163062 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.01617 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0160493 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0156939 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0156774 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0155377 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.0155376 |
| MTDH | metadherin | -0.0154642 |
| RPL37A | ribosomal protein L37a | -0.0152544 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0150623 |
| FNIP1 | folliculin interacting protein 1 | -0.015062 |
| HBP1 | HMG-box transcription factor 1 | -0.0149703 |
| S100A6 | S100 calcium binding protein A6 | -0.0149374 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0148262 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0147069 |
| RPS19 | ribosomal protein S19 | -0.0146806 |
| RPL18 | ribosomal protein L18 | -0.0146688 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0143882 |
| SUCO | SUN domain containing ossification factor | -0.0142982 |
