Benztropine (mesylate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benztropine (mesylate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.262259
C3 complement component 3 0.262106
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.19742
APOB apolipoprotein B 0.177362
FN1 fibronectin 1 0.155499
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.113154
IGFBP1 insulin-like growth factor binding protein 1 0.100636
DSPP dentin sialophosphoprotein 0.0833564
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0748708
ERRFI1 ERBB receptor feedback inhibitor 1 0.0744125
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0690355
GPC6 glypican 6 0.0673131
MAML2 mastermind-like 2 (Drosophila) 0.0568362
VEGFA vascular endothelial growth factor A 0.0517375
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0516748
ELL2 elongation factor, RNA polymerase II, 2 0.045099
SAMD4A sterile alpha motif domain containing 4A 0.0418805
LRMDA leucine rich melanocyte differentiation associated 0.0382277
ARHGAP9 Rho GTPase activating protein 9 0.0379388
SOS1 son of sevenless homolog 1 (Drosophila) 0.0330197
NPAS2 neuronal PAS domain protein 2 0.0327977
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0308478
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0292291
IGF1R insulin-like growth factor 1 receptor 0.0260147
ABTB3 ankyrin repeat and BTB domain containing 3 0.0259389
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0254242
EEF2 eukaryotic translation elongation factor 2 0.0245702
MALRD1 MAM and LDL receptor class A domain containing 1 0.0236392
MYH9 myosin, heavy chain 9, non-muscle 0.0235622
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.023235
AHNAK AHNAK nucleoprotein 0.0230271
CCL20 chemokine (C-C motif) ligand 20 0.0229204
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0227974
PLAC8 placenta-specific 8 0.0227495
TRIP12 thyroid hormone receptor interactor 12 0.0224912
SMAD3 SMAD family member 3 0.0219512
ITGA1 integrin, alpha 1 0.0219154
PPARD peroxisome proliferator-activated receptor delta 0.021427
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.021004
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0207084
FLNB filamin B, beta 0.0204865
WWTR1 WW domain containing transcription regulator 1 0.0202915
ZMIZ1 zinc finger, MIZ-type containing 1 0.0200519
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0195104
APLP2 amyloid beta (A4) precursor-like protein 2 0.0194643
NKD1 naked cuticle homolog 1 (Drosophila) 0.0190622
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0182668
ANKRD11 ankyrin repeat domain 11 0.0181886
DNAH17 dynein, axonemal, heavy chain 17 0.0181784
CFB complement factor B 0.0178248
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0177703
DOCK5 dedicator of cytokinesis 5 0.0176723
FTH1 ferritin, heavy polypeptide 1 0.0175215
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0174976
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0174749
TNS1 tensin 1 0.0174412
SPRED2 sprouty-related, EVH1 domain containing 2 0.0171237
KAT6A K(lysine) acetyltransferase 6A 0.0168711
NFE2L1 nuclear factor, erythroid 2-like 1 0.0167188
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0166235
MSI2 musashi RNA-binding protein 2 0.0162921
SMYD3 SET and MYND domain containing 3 0.0162864
MBD5 methyl-CpG binding domain protein 5 0.0162407
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0161663
CNKSR3 CNKSR family member 3 0.0161233
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0160675
DSCAM Down syndrome cell adhesion molecule 0.0160588
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0160485
FBF1 Fas (TNFRSF6) binding factor 1 0.0160256
PDGFB platelet-derived growth factor beta polypeptide 0.0159028
SVIL supervillin 0.0158018
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0154793
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.015435
PTPRG protein tyrosine phosphatase, receptor type, G 0.0152946
IL4R interleukin 4 receptor 0.015198
AAK1 AP2 associated kinase 1 0.0151824
BCAR3 breast cancer anti-estrogen resistance 3 0.0150859
HLF hepatic leukemia factor 0.0150179
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0148626
CCDC146 coiled-coil domain containing 146 0.0148062
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.0147056
MYO1D myosin ID 0.0146623
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0145833
SHB Src homology 2 domain containing adaptor protein B 0.0143152
MCL1 myeloid cell leukemia 1 0.0142792
RPN1 ribophorin I 0.0141661
GLIS3 GLIS family zinc finger 3 0.0141157
TMEM45B transmembrane protein 45B 0.0137415
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0136465
HPCAL1 hippocalcin-like 1 0.0135771
SKI SKI proto-oncogene 0.0135051
ATXN1 ataxin 1 0.0133708
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0131858
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0131165
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0130846
F11R F11 receptor 0.0130623
ITGB5 integrin, beta 5 0.0130343
TBC1D22A TBC1 domain family, member 22A 0.0128902
OSMR oncostatin M receptor 0.0127526
UBASH3B ubiquitin associated and SH3 domain containing B 0.0127387

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.0725952
FTL ferritin, light polypeptide -0.0710983
APOA2 apolipoprotein A-II -0.0685765
RPS6 ribosomal protein S6 -0.0634991
GPC3 glypican 3 -0.0561513
TMSB10 thymosin beta 10 -0.0515204
RPLP1 ribosomal protein, large, P1 -0.0504697
RPS24 ribosomal protein S24 -0.0478459
MT2A metallothionein 2A -0.0445885
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0430807
HMGA1 high mobility group AT-hook 1 -0.0427718
RPL35A ribosomal protein L35a -0.0423785
RPS19 ribosomal protein S19 -0.0420889
GNAS GNAS complex locus -0.0407944
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0395275
RPL23 ribosomal protein L23 -0.0391787
RPL11 ribosomal protein L11 -0.0385306
RPL34 ribosomal protein L34 -0.0376645
RPS8 ribosomal protein S8 -0.0364058
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0335508
RPL12 ribosomal protein L12 -0.0330608
RPLP0 ribosomal protein, large, P0 -0.0313832
RPS23 ribosomal protein S23 -0.0306389
RPL31 ribosomal protein L31 -0.0296454
LDHA lactate dehydrogenase A -0.0278512
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0278187
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.027165
RBM39 RNA binding motif protein 39 -0.027026
NPR2 natriuretic peptide receptor 2 -0.026439
RPS5 ribosomal protein S5 -0.0255629
RPS12 ribosomal protein S12 -0.0249918
WDR45B WD repeat domain 45B -0.0249666
AHSG alpha-2-HS-glycoprotein -0.0245435
PLIN2 perilipin 2 -0.0244494
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0242135
RPL5 ribosomal protein L5 -0.0236268
ISG15 ISG15 ubiquitin-like modifier -0.0231491
RPL26 ribosomal protein L26 -0.0224643
APOE apolipoprotein E -0.0222665
RPL9 ribosomal protein L9 -0.0219945
RPL37A ribosomal protein L37a -0.0219107
LOC112694756 uncharaterized LOC112694756 -0.0219031
RPLP2 ribosomal protein, large, P2 -0.021524
RPL32 ribosomal protein L32 -0.0214243
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0213235
RPL8 ribosomal protein L8 -0.0212135
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.020732
RPS25 ribosomal protein S25 -0.0203403
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.020164
VDAC1 voltage-dependent anion channel 1 -0.0198429
RPS21 ribosomal protein S21 -0.0195284
RACK1 receptor for activated C kinase 1 -0.0194678
RPS20 ribosomal protein S20 -0.0193389
RPL19 ribosomal protein L19 -0.0192776
RPS14 ribosomal protein S14 -0.019104
ACTG1 actin gamma 1 -0.018599
RPS16 ribosomal protein S16 -0.0184519
RPL37 ribosomal protein L37 -0.0182286
AMBP alpha-1-microglobulin/bikunin precursor -0.0177712
RPL10A ribosomal protein L10a -0.0177363
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0176484
RPL27A ribosomal protein L27a -0.017542
KIF21A kinesin family member 21A -0.0174072
PDLIM5 PDZ and LIM domain 5 -0.0171209
ZBTB20 zinc finger and BTB domain containing 20 -0.0167091
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0165779
FMNL2 formin-like 2 -0.0165517
SESTD1 SEC14 and spectrin domains 1 -0.0165363
FRMD5 FERM domain containing 5 -0.0163474
EEF1G eukaryotic translation elongation factor 1 gamma -0.0162766
RPL7 ribosomal protein L7 -0.0162525
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.016155
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0161198
APOA1 apolipoprotein A-I -0.016002
SEC62 SEC62 homolog (S. cerevisiae) -0.0158988
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0158824
RPS11 ribosomal protein S11 -0.0157734
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0157685
RPL39 ribosomal protein L39 -0.0157081
TXNRD1 thioredoxin reductase 1 -0.0155078
LYZ lysozyme -0.0154146
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0153833
RPL15 ribosomal protein L15 -0.0152907
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0150643
RPS17 ribosomal protein S17 -0.0150343
IER3 immediate early response 3 -0.0149852
LMCD1 LIM and cysteine-rich domains 1 -0.0149728
ARHGAP18 Rho GTPase activating protein 18 -0.0149161
RPL4 ribosomal protein L4 -0.0149045
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0148428
SLC38A1 solute carrier family 38, member 1 -0.0148337
IFITM1 interferon induced transmembrane protein 1 -0.0147444
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0146658
PKM pyruvate kinase, muscle -0.0146226
NDRG1 N-myc downstream regulated 1 -0.0144881
ASPH aspartate beta-hydroxylase -0.0143375
INSIG2 insulin induced gene 2 -0.0142524
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0142075
SEC31A SEC31 homolog A (S. cerevisiae) -0.0141908
FAM107B family with sequence similarity 107, member B -0.0141907