Benztropine (mesylate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benztropine (mesylate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.128062
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0917505
CLU clusterin 0.0800965
FLNB filamin B, beta 0.079926
TRIO trio Rho guanine nucleotide exchange factor 0.0694519
ENO1 enolase 1, (alpha) 0.0683802
TIMP3 TIMP metallopeptidase inhibitor 3 0.0641549
B2M beta-2-microglobulin 0.0614176
PODXL podocalyxin-like 0.0588769
ANXA1 annexin A1 0.0519278
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0517121
TMSB4X thymosin beta 4, X-linked 0.0511191
FTH1 ferritin, heavy polypeptide 1 0.0454379
PTMA prothymosin, alpha 0.0451603
GOLGA4 golgin A4 0.0441603
NAMPT nicotinamide phosphoribosyltransferase 0.0427796
IGF2 insulin-like growth factor 2 0.0421976
AHNAK AHNAK nucleoprotein 0.0410262
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0406559
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0403941
PGK1 phosphoglycerate kinase 1 0.0400197
RPS8 ribosomal protein S8 0.037432
KRT17 keratin 17, type I 0.0373584
ARRDC3 arrestin domain containing 3 0.0369213
ITCH itchy E3 ubiquitin protein ligase 0.0366926
MEF2A myocyte enhancer factor 2A 0.0360334
CANX calnexin 0.0353374
HLA-A major histocompatibility complex, class I, A 0.0349168
MT2A metallothionein 2A 0.0347034
ANXA2 annexin A2 0.0344238
H1-0 H1.0 linker histone 0.0343337
EMP1 epithelial membrane protein 1 0.0341413
BHLHE40 basic helix-loop-helix family, member e40 0.0331154
MYH9 myosin, heavy chain 9, non-muscle 0.0315329
SQSTM1 sequestosome 1 0.0303924
STC1 stanniocalcin 1 0.030334
SPAG9 sperm associated antigen 9 0.029939
ANLN anillin, actin binding protein 0.0297453
RPS6 ribosomal protein S6 0.0297053
CALR calreticulin 0.0296077
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0293997
MBNL2 muscleblind-like splicing regulator 2 0.0292896
MTSS1 metastasis suppressor 1 0.0292778
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0292344
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0289684
TGM2 transglutaminase 2 0.0283096
SQLE squalene epoxidase 0.0281876
APLP2 amyloid beta (A4) precursor-like protein 2 0.0277662
CUL4B cullin 4B 0.0277208
ESYT2 extended synaptotagmin-like protein 2 0.0268074
HLA-E major histocompatibility complex, class I, E 0.0265696
FLNA filamin A, alpha 0.0265513
LOC112694756 uncharaterized LOC112694756 0.0259641
RPS3 ribosomal protein S3 0.0259272
CALU calumenin 0.0255506
EZR ezrin 0.0253157
OGA O-GlcNAcase 0.0253068
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0250897
EEF2 eukaryotic translation elongation factor 2 0.0243663
DSTN destrin (actin depolymerizing factor) 0.0242946
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0241829
TPM3 tropomyosin 3 0.0238781
HLA-B major histocompatibility complex, class I, B 0.0236074
MYOF myoferlin 0.0235904
P4HB prolyl 4-hydroxylase, beta polypeptide 0.023545
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.02342
TTC3 tetratricopeptide repeat domain 3 0.0234127
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0233788
CD99 CD99 molecule 0.0232146
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0230019
RPL11 ribosomal protein L11 0.0223355
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0220423
CD44 CD44 molecule (Indian blood group) 0.0220169
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0218468
KMT2E lysine (K)-specific methyltransferase 2E 0.0217397
YBX1 Y box binding protein 1 0.0216094
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0215386
EPHA2 EPH receptor A2 0.0212602
KDM3A lysine (K)-specific demethylase 3A 0.0212541
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0212291
RPS21 ribosomal protein S21 0.0211832
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0210784
KDM2A lysine (K)-specific demethylase 2A 0.0208462
UBC ubiquitin C 0.0207982
KRT6A keratin 6A, type II 0.0207747
WASF2 WAS protein family, member 2 0.0207186
SEC31A SEC31 homolog A (S. cerevisiae) 0.0203015
S100A10 S100 calcium binding protein A10 0.0202931
RPS13 ribosomal protein S13 0.0202717
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0202484
RAI14 retinoic acid induced 14 0.0201902
RPL8 ribosomal protein L8 0.0199761
VEGFA vascular endothelial growth factor A 0.0199342
LMNA lamin A/C 0.0196564
MT1X metallothionein 1X 0.0194954
HSPG2 heparan sulfate proteoglycan 2 0.0193579
SRRM2 serine/arginine repetitive matrix 2 0.0192733
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0190386
IFITM3 interferon induced transmembrane protein 3 0.0188288
ZNF292 zinc finger protein 292 0.018545

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0712422
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0371796
OSMR oncostatin M receptor -0.0271814
PDE4D phosphodiesterase 4D, cAMP-specific -0.0230245
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.022171
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0215718
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0198482
FOXO1 forkhead box O1 -0.0163929
RIGI RNA sensor RIG-I -0.0146591
BMAL2 basic helix-loop-helix ARNT like 2 -0.0139021
PRELID2 PRELI domain containing 2 -0.0132599
FOXP1 forkhead box P1 -0.0128818
PDLIM5 PDZ and LIM domain 5 -0.0128631
CNTNAP3 contactin associated protein-like 3 -0.012143
EFNA5 ephrin-A5 -0.0113232
PALLD palladin, cytoskeletal associated protein -0.0112613
RIN2 Ras and Rab interactor 2 -0.0109138
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0108087
CTNND1 catenin (cadherin-associated protein), delta 1 -0.010695
C4BPB complement component 4 binding protein, beta -0.0104748
SOX13 SRY (sex determining region Y)-box 13 -0.010346
VCL vinculin -0.0096382
NEK7 NIMA-related kinase 7 -0.00947958
DOCK9 dedicator of cytokinesis 9 -0.00938789
SMYD3 SET and MYND domain containing 3 -0.00918141
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.00914775
NRG1 neuregulin 1 -0.00853211
KIAA0040 KIAA0040 -0.00843539
DOK5 docking protein 5 -0.00837774
DPYD dihydropyrimidine dehydrogenase -0.00837309
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.00830428
CEMIP cell migration inducing protein, hyaluronan binding -0.0082091
NRCAM neuronal cell adhesion molecule -0.00809609
SLC35F3 solute carrier family 35, member F3 -0.00802963
EFCAB13 EF-hand calcium binding domain 13 -0.00789541
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.00789122
RPS24 ribosomal protein S24 -0.00768412
RAD51B RAD51 paralog B -0.00762645
ZC3H12C zinc finger CCCH-type containing 12C -0.00761601
FRMD4A FERM domain containing 4A -0.00729197
AOPEP aminopeptidase O (putative) -0.00726859
HMGA2 high mobility group AT-hook 2 -0.00716675
RASAL2 RAS protein activator like 2 -0.00690528
MECOM MDS1 and EVI1 complex locus -0.00684082
IFI44 interferon-induced protein 44 -0.00677541
MBD5 methyl-CpG binding domain protein 5 -0.00676841
GM2A GM2 ganglioside activator -0.00675476
LUZP1 leucine zipper protein 1 -0.00649189
MAML2 mastermind-like 2 (Drosophila) -0.00641732
RRBP1 ribosome binding protein 1 -0.00639592
PLXNA2 plexin A2 -0.00631095
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 -0.00612505
PLSCR1 phospholipid scramblase 1 -0.0060818
PARK7 parkinson protein 7 -0.00598324
CFLAR CASP8 and FADD-like apoptosis regulator -0.00596055
FRMD4B FERM domain containing 4B -0.00587737
NTSR1 neurotensin receptor 1 (high affinity) -0.0057208
SAMD9 sterile alpha motif domain containing 9 -0.00565851
SLC35H1 solute carrier family 35 member H1 -0.00561198
ATM ATM serine/threonine kinase -0.00557912
NRIP1 nuclear receptor interacting protein 1 -0.00544207
RHOJ ras homolog family member J -0.00544095
MAPK10 mitogen-activated protein kinase 10 -0.00542991
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.00529026
TTC28 tetratricopeptide repeat domain 28 -0.00526653
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.00525958
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.0052513
GOLGA3 golgin A3 -0.00522568
NPC1 Niemann-Pick disease, type C1 -0.00521305
PRKCH protein kinase C, eta -0.00520566
NCKAP5 NCK-associated protein 5 -0.00517774
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.00516276
IFI16 interferon, gamma-inducible protein 16 -0.00513957
STK10 serine/threonine kinase 10 -0.00513768
MTAP methylthioadenosine phosphorylase -0.00513338
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.00509434
CORO2A coronin, actin binding protein, 2A -0.00503471
WNT2B wingless-type MMTV integration site family, member 2B -0.00502412
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.00492208
BLCAP bladder cancer associated protein -0.00488532
IVNS1ABP influenza virus NS1A binding protein -0.00486051
MAML3 mastermind-like 3 (Drosophila) -0.00483721
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.00483641
THSD4 thrombospondin, type I, domain containing 4 -0.00479493
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00479209
SLC38A6 solute carrier family 38, member 6 -0.00477592
SETX senataxin -0.00472078
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0046824
EGFR epidermal growth factor receptor -0.00467409
EXOC4 exocyst complex component 4 -0.00465468
TEK TEK tyrosine kinase, endothelial -0.00462654
ITGB8 integrin, beta 8 -0.00456131
WDR1 WD repeat domain 1 -0.00453385
CDK6 cyclin-dependent kinase 6 -0.00441524
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.00436949
ANKRD12 ankyrin repeat domain 12 -0.00436334
MX2 MX dynamin-like GTPase 2 -0.00428478
PMP22 peripheral myelin protein 22 -0.00428149
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.00426977
PROCR protein C receptor, endothelial -0.00419833