| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.251629 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.167768 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.1111 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0870659 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0788087 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0715372 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0708869 |
| SLC12A8 | solute carrier family 12, member 8 | 0.0677603 |
| SMAD3 | SMAD family member 3 | 0.0636657 |
| ENO1 | enolase 1, (alpha) | 0.0603379 |
| ZNF841 | zinc finger protein 841 | 0.0595751 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0587845 |
| ATP13A3 | ATPase type 13A3 | 0.0570646 |
| AHNAK | AHNAK nucleoprotein | 0.0543596 |
| B2M | beta-2-microglobulin | 0.0533984 |
| NDRG1 | N-myc downstream regulated 1 | 0.051698 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0509772 |
| FLNA | filamin A, alpha | 0.0500234 |
| TMSB4X | thymosin beta 4, X-linked | 0.0484472 |
| VEGFA | vascular endothelial growth factor A | 0.0470786 |
| FN1 | fibronectin 1 | 0.046928 |
| CALR | calreticulin | 0.0447038 |
| HLA-C | major histocompatibility complex, class I, C | 0.0440064 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0427083 |
| HLA-E | major histocompatibility complex, class I, E | 0.0425834 |
| ACTG1 | actin gamma 1 | 0.0406763 |
| ANXA2 | annexin A2 | 0.0392712 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0386544 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0365278 |
| FLNB | filamin B, beta | 0.0362625 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0350399 |
| PGK1 | phosphoglycerate kinase 1 | 0.0346177 |
| TPM3 | tropomyosin 3 | 0.0344329 |
| COL5A1 | collagen, type V, alpha 1 | 0.0341055 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0338929 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0338797 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0337231 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0334972 |
| RNF213 | ring finger protein 213 | 0.0331373 |
| NAV2 | neuron navigator 2 | 0.0326526 |
| CD44 | CD44 molecule (Indian blood group) | 0.0325673 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0320904 |
| HLA-A | major histocompatibility complex, class I, A | 0.0320773 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0301341 |
| ANXA1 | annexin A1 | 0.0299421 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0299143 |
| POTEF | POTE ankyrin domain family, member F | 0.0292642 |
| TGFB2 | transforming growth factor, beta 2 | 0.0292343 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0286395 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0285586 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0285199 |
| CANX | calnexin | 0.0284918 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0283578 |
| PODXL | podocalyxin-like | 0.028325 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0282348 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0276971 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0271981 |
| ADM | adrenomedullin | 0.0271108 |
| ZNF292 | zinc finger protein 292 | 0.0269565 |
| TSC22D2 | TSC22 domain family, member 2 | 0.026864 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0265848 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0265374 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0258604 |
| RND3 | Rho family GTPase 3 | 0.0256369 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0253572 |
| CCNL1 | cyclin L1 | 0.024908 |
| WAC | WW domain containing adaptor with coiled-coil | 0.024782 |
| ACTN1 | actinin, alpha 1 | 0.0246219 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0244246 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0243539 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0242856 |
| NUP58 | nucleoporin 58 | 0.0242156 |
| TPD52 | tumor protein D52 | 0.0240592 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0235503 |
| RUNX1 | runt-related transcription factor 1 | 0.0234423 |
| SET | SET nuclear proto-oncogene | 0.0233737 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0233014 |
| FOSL1 | FOS-like antigen 1 | 0.0232162 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0226302 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0226002 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.022126 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0215551 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0212481 |
| TXNRD1 | thioredoxin reductase 1 | 0.0212309 |
| ARRDC3 | arrestin domain containing 3 | 0.0210248 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.021006 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.02079 |
| MSN | moesin | 0.0205711 |
| PLK2 | polo-like kinase 2 | 0.0204936 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0203356 |
| USP3 | ubiquitin specific peptidase 3 | 0.0201547 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0201301 |
| MAP1B | microtubule-associated protein 1B | 0.0199185 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0197358 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0194732 |
| SQSTM1 | sequestosome 1 | 0.0194282 |
| DSCAM | Down syndrome cell adhesion molecule | 0.019189 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0191228 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0188195 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.0187211 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.123821 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0636266 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0363003 |
| TMSB10 | thymosin beta 10 | -0.0334614 |
| RPL35A | ribosomal protein L35a | -0.0309567 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0288881 |
| VDAC1 | voltage-dependent anion channel 1 | -0.024293 |
| RPS6 | ribosomal protein S6 | -0.0236204 |
| VIM | vimentin | -0.0231498 |
| PLIN2 | perilipin 2 | -0.0227899 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0226025 |
| TUBB | tubulin, beta class I | -0.0225607 |
| RPLP1 | ribosomal protein, large, P1 | -0.020347 |
| RPS24 | ribosomal protein S24 | -0.020062 |
| S100A10 | S100 calcium binding protein A10 | -0.0199676 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0195331 |
| MT2A | metallothionein 2A | -0.0185957 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0179904 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0163726 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0159415 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0149164 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0148091 |
| RPL34 | ribosomal protein L34 | -0.0141113 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0140543 |
| CBX3 | chromobox homolog 3 | -0.0139434 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0139189 |
| RPL9 | ribosomal protein L9 | -0.0138576 |
| HMGB1 | high mobility group box 1 | -0.0138169 |
| SCFD2 | sec1 family domain containing 2 | -0.013803 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0133767 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0133753 |
| RPLP2 | ribosomal protein, large, P2 | -0.0132954 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0132745 |
| MORF4L2 | mortality factor 4 like 2 | -0.0130419 |
| RPL36A | ribosomal protein L36a | -0.0130054 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0129609 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0120476 |
| SEPTIN2 | septin 2 | -0.0119248 |
| E2F7 | E2F transcription factor 7 | -0.0117975 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0117864 |
| RPS23 | ribosomal protein S23 | -0.01163 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0115904 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0114757 |
| RASAL2 | RAS protein activator like 2 | -0.0114075 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0113324 |
| RPS19 | ribosomal protein S19 | -0.0113202 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0109821 |
| GLRX | glutaredoxin (thioltransferase) | -0.0109361 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0108044 |
| RPL11 | ribosomal protein L11 | -0.0107301 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0106114 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.010601 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0103863 |
| RPL4 | ribosomal protein L4 | -0.010301 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0102803 |
| RPL12 | ribosomal protein L12 | -0.0100401 |
| NOL7 | nucleolar protein 7, 27kDa | -0.00989319 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.00986702 |
| NF1 | neurofibromin 1 | -0.00973327 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.00969427 |
| PDCD5 | programmed cell death 5 | -0.00957112 |
| USP34 | ubiquitin specific peptidase 34 | -0.00956287 |
| RPL37 | ribosomal protein L37 | -0.00955448 |
| RB1 | retinoblastoma 1 | -0.00954082 |
| FNDC3A | fibronectin type III domain containing 3A | -0.00949609 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.00946762 |
| HDLBP | high density lipoprotein binding protein | -0.00942032 |
| TUT7 | terminal uridylyl transferase 7 | -0.0094037 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0093629 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.00926598 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | -0.00917484 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.00916642 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.00914277 |
| ANKRD17 | ankyrin repeat domain 17 | -0.00897468 |
| PFDN1 | prefoldin subunit 1 | -0.00892994 |
| ZNF33A | zinc finger protein 33A | -0.00891311 |
| CPNE1 | copine I | -0.00885566 |
| OSMR | oncostatin M receptor | -0.00881788 |
| RAB1B | RAB1B, member RAS oncogene family | -0.00874521 |
| S100A6 | S100 calcium binding protein A6 | -0.00860785 |
| RPL19 | ribosomal protein L19 | -0.00857376 |
| NUP155 | nucleoporin 155kDa | -0.00855708 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0084661 |
| LAMTOR5 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 | -0.00845869 |
| FBXO34 | F-box protein 34 | -0.00844535 |
| RPL23 | ribosomal protein L23 | -0.00838118 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00831804 |
| JMJD1C | jumonji domain containing 1C | -0.00829513 |
| BRCA2 | breast cancer 2, early onset | -0.00828353 |
| SCFD1 | sec1 family domain containing 1 | -0.00827795 |
| RPLP0 | ribosomal protein, large, P0 | -0.0082765 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0082557 |
| SERF2 | small EDRK-rich factor 2 | -0.00824918 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.00823635 |
| GOLGA2 | golgin A2 | -0.00820333 |
| GOLT1B | golgi transport 1B | -0.00819601 |
| TMEM87A | transmembrane protein 87A | -0.00818837 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.00815176 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.00808102 |
| BTG3 | BTG family, member 3 | -0.00805824 |
