Benztropine (mesylate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benztropine (mesylate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.217396
AHNAK AHNAK nucleoprotein 0.0625891
ACTG1 actin gamma 1 0.053227
SAMD4A sterile alpha motif domain containing 4A 0.0468731
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0468275
RPS8 ribosomal protein S8 0.0345241
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0344986
HSPA8 heat shock 70kDa protein 8 0.0329651
RPS12 ribosomal protein S12 0.0321412
MT2A metallothionein 2A 0.0319884
ELL2 elongation factor, RNA polymerase II, 2 0.0309299
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0307814
RPL12 ribosomal protein L12 0.0304055
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0303619
FLNA filamin A, alpha 0.0290451
VCL vinculin 0.0289142
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0281858
LOC112694756 uncharaterized LOC112694756 0.027036
RPS2 ribosomal protein S2 0.0269682
EEF2 eukaryotic translation elongation factor 2 0.0266804
RPL26 ribosomal protein L26 0.0259303
MCTP1 multiple C2 domains, transmembrane 1 0.0257009
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0251329
RPL23 ribosomal protein L23 0.0250329
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0247176
ZNF292 zinc finger protein 292 0.0242325
RPL11 ribosomal protein L11 0.0234653
FTL ferritin, light polypeptide 0.02331
NAP1L1 nucleosome assembly protein 1-like 1 0.0232516
SMAD3 SMAD family member 3 0.0231678
RPS27A ribosomal protein S27a 0.0230949
MYH9 myosin, heavy chain 9, non-muscle 0.0217587
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0216538
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.021547
ASPH aspartate beta-hydroxylase 0.0209536
RPL36 ribosomal protein L36 0.0209219
EXT1 exostosin glycosyltransferase 1 0.0206475
FTH1 ferritin, heavy polypeptide 1 0.0189827
RPL28 ribosomal protein L28 0.0189763
SPRED1 sprouty-related, EVH1 domain containing 1 0.0186443
NUP58 nucleoporin 58 0.0184356
EIF4A2 eukaryotic translation initiation factor 4A2 0.0184286
RPL13A ribosomal protein L13a 0.0184128
SRRM2 serine/arginine repetitive matrix 2 0.0179672
RPL6 ribosomal protein L6 0.0179625
BCAR3 breast cancer anti-estrogen resistance 3 0.0179192
KDM3A lysine (K)-specific demethylase 3A 0.0177285
RPL38 ribosomal protein L38 0.0174594
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0174564
RPL35A ribosomal protein L35a 0.0174368
RPL19 ribosomal protein L19 0.0174017
RPS3 ribosomal protein S3 0.0173625
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0173288
CCN2 cellular communication network factor 2 0.0171928
RTN4 reticulon 4 0.0171902
MARCHF6 membrane associated ring-CH-type finger 6 0.017083
RIGI RNA sensor RIG-I 0.0168874
NCKAP1 NCK-associated protein 1 0.0168366
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0167599
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.016367
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0160881
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0159009
RACK1 receptor for activated C kinase 1 0.0158741
ANKRD12 ankyrin repeat domain 12 0.0157429
ATP13A3 ATPase type 13A3 0.0157342
TPT1 tumor protein, translationally-controlled 1 0.0156111
TEX10 testis expressed 10 0.0155261
TRIO trio Rho guanine nucleotide exchange factor 0.015438
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0152936
TSC22D2 TSC22 domain family, member 2 0.0152044
ADAM19 ADAM metallopeptidase domain 19 0.0151566
GLS2 glutaminase 2 (liver, mitochondrial) 0.0148264
WDR43 WD repeat domain 43 0.0148189
NAV1 neuron navigator 1 0.0147511
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0146587
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0144681
YBX1 Y box binding protein 1 0.0144331
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0143814
USP15 ubiquitin specific peptidase 15 0.0140608
RAD21 RAD21 homolog (S. pombe) 0.0139837
CLIC1 chloride intracellular channel 1 0.0139765
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0139503
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0135683
RPLP0 ribosomal protein, large, P0 0.0135393
TPM3 tropomyosin 3 0.0134764
H1-0 H1.0 linker histone 0.0134345
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0132014
PRKCE protein kinase C, epsilon 0.0130619
OSBPL8 oxysterol binding protein-like 8 0.0130224
RPL35 ribosomal protein L35 0.0129457
CALD1 caldesmon 1 0.0128016
CYRIB CYFIP related Rac1 interactor B 0.0128006
ANKRD11 ankyrin repeat domain 11 0.0125593
SPAG9 sperm associated antigen 9 0.0125181
TFRC transferrin receptor 0.0124287
RPLP2 ribosomal protein, large, P2 0.0123796
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0121997
ANXA2 annexin A2 0.0121678
PHF3 PHD finger protein 3 0.0121525
STK17A serine/threonine kinase 17a 0.0121289

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.203233
TMSB10 thymosin beta 10 -0.0876185
MMP12 matrix metallopeptidase 12 -0.0826534
LSAMP limbic system-associated membrane protein -0.0674289
EGR1 early growth response 1 -0.0634084
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0498652
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0494849
PHACTR1 phosphatase and actin regulator 1 -0.0426746
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0370326
LDHA lactate dehydrogenase A -0.0340559
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0324148
PRKG1 protein kinase, cGMP-dependent, type I -0.0315029
TPM4 tropomyosin 4 -0.0297092
CDH13 cadherin 13 -0.027603
HMGA1 high mobility group AT-hook 1 -0.0267447
JMJD1C jumonji domain containing 1C -0.0247724
C2CD2 C2 calcium-dependent domain containing 2 -0.0242327
JUN jun proto-oncogene -0.0233506
FN1 fibronectin 1 -0.0230417
HAS2 hyaluronan synthase 2 -0.0225502
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0223797
SAMD3 sterile alpha motif domain containing 3 -0.0218451
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0215207
VDAC1 voltage-dependent anion channel 1 -0.0214898
USP34 ubiquitin specific peptidase 34 -0.0208064
BTG1 B-cell translocation gene 1, anti-proliferative -0.0207045
LIMCH1 LIM and calponin homology domains 1 -0.0204078
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.0197663
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0197422
MCL1 myeloid cell leukemia 1 -0.0195697
ENO2 enolase 2 (gamma, neuronal) -0.0195177
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0194859
TAOK1 TAO kinase 1 -0.0193456
PKM pyruvate kinase, muscle -0.0188811
PTPRG protein tyrosine phosphatase, receptor type, G -0.0187086
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.018414
ESM1 endothelial cell-specific molecule 1 -0.0172984
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0168052
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0167445
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0166691
BPTF bromodomain PHD finger transcription factor -0.0166406
MSN moesin -0.0164536
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0164153
SLC38A2 solute carrier family 38, member 2 -0.0162757
PTK2 protein tyrosine kinase 2 -0.0160027
MAP4 microtubule-associated protein 4 -0.0149658
MAP3K7CL MAP3K7 C-terminal like -0.0148485
TXNRD1 thioredoxin reductase 1 -0.0146342
FOXP1 forkhead box P1 -0.0145632
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0144064
DIAPH2 diaphanous-related formin 2 -0.0138532
LOC102724023 ES1 protein homolog, mitochondrial -0.0138111
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0136654
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0136588
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0136488
CDK6 cyclin-dependent kinase 6 -0.0134714
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.013419
ATXN2 ataxin 2 -0.0132963
JARID2 jumonji, AT rich interactive domain 2 -0.0132166
MYADM myeloid-associated differentiation marker -0.0132125
ITGA6 integrin, alpha 6 -0.0132034
PCBP2 poly(rC) binding protein 2 -0.0130346
AKAP12 A kinase (PRKA) anchor protein 12 -0.0130054
VMP1 vacuole membrane protein 1 -0.0129976
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0129439
WWC1 WW and C2 domain containing 1 -0.0127783
BIRC6 baculoviral IAP repeat containing 6 -0.0126563
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0123085
PTPRK protein tyrosine phosphatase, receptor type, K -0.0121312
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0120549
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0120178
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0119724
ESYT2 extended synaptotagmin-like protein 2 -0.0119323
ZNF609 zinc finger protein 609 -0.0119145
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.011701
POTEF POTE ankyrin domain family, member F -0.0115764
NAV3 neuron navigator 3 -0.0115724
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0115527
MACF1 microtubule-actin crosslinking factor 1 -0.0114233
TENM2 teneurin transmembrane protein 2 -0.0113838
RND3 Rho family GTPase 3 -0.0110196
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0110158
SEPTIN10 septin 10 -0.0110044
ARHGAP18 Rho GTPase activating protein 18 -0.0109035
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0107649
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0107507
WASF2 WAS protein family, member 2 -0.0107055
DOCK4 dedicator of cytokinesis 4 -0.0106803
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0105407
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0104824
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -0.0104668
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0103985
SERINC3 serine incorporator 3 -0.0101933
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0101687
ATM ATM serine/threonine kinase -0.0101128
DNER delta/notch-like EGF repeat containing -0.00968508
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.00968248
NBEAL1 neurobeachin-like 1 -0.00958856
TM4SF1 transmembrane 4 L six family member 1 -0.00957395
MYO10 myosin X -0.00955232