Benztropine (mesylate)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benztropine (mesylate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming 0.165124
CEMIP cell migration inducing protein, hyaluronan binding 0.136973
TNS4 tensin 4 0.124894
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0899735
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0877995
FAT1 FAT atypical cadherin 1 0.0746086
VEGFA vascular endothelial growth factor A 0.0736615
NALF1 NALCN channel auxiliary factor 1 0.0720808
KRT8 keratin 8, type II 0.0541098
AHNAK AHNAK nucleoprotein 0.0531361
ITGA6 integrin, alpha 6 0.0489165
EEF2 eukaryotic translation elongation factor 2 0.0478206
TPM3 tropomyosin 3 0.0455454
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0445359
GMDS GDP-mannose 4,6-dehydratase 0.0433509
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0429487
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0426721
ACTN4 actinin, alpha 4 0.0423781
PDIA4 protein disulfide isomerase family A, member 4 0.0406629
TRIM2 tripartite motif containing 2 0.0402347
RAD51B RAD51 paralog B 0.0398784
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0394832
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0388619
PPARG peroxisome proliferator-activated receptor gamma 0.0385573
ABHD2 abhydrolase domain containing 2 0.038142
ENO1 enolase 1, (alpha) 0.0376604
FHIT fragile histidine triad 0.0374688
SRRM2 serine/arginine repetitive matrix 2 0.0373188
MYH9 myosin, heavy chain 9, non-muscle 0.0368335
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0367371
DSPP dentin sialophosphoprotein 0.036356
CCSER1 coiled-coil serine-rich protein 1 0.0354025
ANXA2 annexin A2 0.0353868
FOSL1 FOS-like antigen 1 0.0335302
AREG amphiregulin 0.0332558
FLNB filamin B, beta 0.033158
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0324535
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0322744
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0309483
KRT18 keratin 18, type I 0.0305412
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0301353
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0298902
LPP LIM domain containing preferred translocation partner in lipoma 0.0298601
ANXA11 annexin A11 0.0296326
TMSB4X thymosin beta 4, X-linked 0.029609
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0295309
EZR ezrin 0.0291474
VCL vinculin 0.0279345
KLF3 Kruppel-like factor 3 (basic) 0.0278485
EPHA2 EPH receptor A2 0.0277263
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0276262
CALB1 calbindin 1, 28kDa 0.0274262
POTEF POTE ankyrin domain family, member F 0.0272907
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0271465
ZNF292 zinc finger protein 292 0.0271355
FAM13A family with sequence similarity 13, member A 0.0265599
PRELID2 PRELI domain containing 2 0.0264731
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0259888
SAMD12 sterile alpha motif domain containing 12 0.0259716
CALR calreticulin 0.0254765
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0253945
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.025077
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0248119
TPM4 tropomyosin 4 0.0247326
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.0240196
ARHGAP26 Rho GTPase activating protein 26 0.0239702
PTPRG protein tyrosine phosphatase, receptor type, G 0.0239551
SFPQ splicing factor proline/glutamine-rich 0.0239174
PDIA3 protein disulfide isomerase family A, member 3 0.0237905
ATXN1 ataxin 1 0.0236211
DIAPH2 diaphanous-related formin 2 0.0235522
CD46 CD46 molecule, complement regulatory protein 0.0234892
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0234424
TMEM45B transmembrane protein 45B 0.0234384
CAMKMT calmodulin-lysine N-methyltransferase 0.0232309
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0230702
FTH1 ferritin, heavy polypeptide 1 0.0230393
PDE4D phosphodiesterase 4D, cAMP-specific 0.0230186
EREG epiregulin 0.0227968
NPSR1 neuropeptide S receptor 1 0.0227351
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0227043
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.022664
PIGR polymeric immunoglobulin receptor 0.0225414
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0224246
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0218241
ALCAM activated leukocyte cell adhesion molecule 0.0218219
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0216959
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0216192
SHB Src homology 2 domain containing adaptor protein B 0.0215475
NRXN3 neurexin 3 0.0208118
GPA33 glycoprotein A33 (transmembrane) 0.0206597
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0205581
RPL3 ribosomal protein L3 0.0204736
APLP2 amyloid beta (A4) precursor-like protein 2 0.0201707
FERMT1 fermitin family member 1 0.0200412
TPM1 tropomyosin 1 (alpha) 0.0199768
SPRED1 sprouty-related, EVH1 domain containing 1 0.0199207
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0198989
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.019805
DENND1A DENN/MADD domain containing 1A 0.0197755

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.184792
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.174633
TMSB10 thymosin beta 10 -0.115653
PTMA prothymosin, alpha -0.106003
RPLP1 ribosomal protein, large, P1 -0.0711473
TPT1 tumor protein, translationally-controlled 1 -0.0709359
RPS6 ribosomal protein S6 -0.0614891
RPL34 ribosomal protein L34 -0.0584469
FTL ferritin, light polypeptide -0.0556202
LMO7 LIM domain 7 -0.0554158
RPL12 ribosomal protein L12 -0.054538
GDF15 growth differentiation factor 15 -0.0527832
RPL35A ribosomal protein L35a -0.051131
EIF1 eukaryotic translation initiation factor 1 -0.0418142
RPS19 ribosomal protein S19 -0.0396814
RPS24 ribosomal protein S24 -0.0374078
RPLP0 ribosomal protein, large, P0 -0.0370265
RPL11 ribosomal protein L11 -0.0361657
RPL32 ribosomal protein L32 -0.0356984
LOC112694756 uncharaterized LOC112694756 -0.0336499
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0334648
S100A10 S100 calcium binding protein A10 -0.030392
RPS8 ribosomal protein S8 -0.0285352
RPS16 ribosomal protein S16 -0.0283195
RPL23 ribosomal protein L23 -0.0270199
RPL31 ribosomal protein L31 -0.0269089
SLC38A2 solute carrier family 38, member 2 -0.0262676
RPL19 ribosomal protein L19 -0.0255821
ARF1 ADP-ribosylation factor 1 -0.024603
RPL27A ribosomal protein L27a -0.0243293
SEC31A SEC31 homolog A (S. cerevisiae) -0.0240993
HDLBP high density lipoprotein binding protein -0.0240635
RPS25 ribosomal protein S25 -0.0239832
S100P S100 calcium binding protein P -0.0234428
RPS23 ribosomal protein S23 -0.0231913
EXT1 exostosin glycosyltransferase 1 -0.0229208
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0228946
RRBP1 ribosome binding protein 1 -0.0220852
WDR45B WD repeat domain 45B -0.0218582
LDHA lactate dehydrogenase A -0.0218188
GOLGA4 golgin A4 -0.0215886
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0214135
RPL26 ribosomal protein L26 -0.0212999
MED13 mediator complex subunit 13 -0.0204214
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0203241
RPS20 ribosomal protein S20 -0.0200638
RPL7 ribosomal protein L7 -0.0199403
RPL35 ribosomal protein L35 -0.0198647
RPLP2 ribosomal protein, large, P2 -0.0198615
AGR2 anterior gradient 2 -0.0197528
NRN1 neuritin 1 -0.0196972
IARS1 isoleucyl-tRNA synthetase 1 -0.0196774
RPS27 ribosomal protein S27 -0.0195476
ESYT2 extended synaptotagmin-like protein 2 -0.0195002
RPL9 ribosomal protein L9 -0.0194245
ANXA1 annexin A1 -0.0193557
RPL36 ribosomal protein L36 -0.0193461
MORF4L2 mortality factor 4 like 2 -0.0185761
BTG1 B-cell translocation gene 1, anti-proliferative -0.018502
RPS21 ribosomal protein S21 -0.018376
RPL8 ribosomal protein L8 -0.0182813
LOC102724023 ES1 protein homolog, mitochondrial -0.0180728
KDM3A lysine (K)-specific demethylase 3A -0.0180699
COPB1 coatomer protein complex, subunit beta 1 -0.0180295
RPS5 ribosomal protein S5 -0.0176431
STK17A serine/threonine kinase 17a -0.017598
RPL37 ribosomal protein L37 -0.0175642
GCC2 GRIP and coiled-coil domain containing 2 -0.0174407
RNF145 ring finger protein 145 -0.0173713
MON2 MON2 homolog (S. cerevisiae) -0.0173678
BTN3A3 butyrophilin, subfamily 3, member A3 -0.0168422
HMGA1 high mobility group AT-hook 1 -0.0167274
RPL13A ribosomal protein L13a -0.0166567
RTN3 reticulon 3 -0.0163244
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0162953
RPS4X ribosomal protein S4, X-linked -0.0162741
RPL38 ribosomal protein L38 -0.0158118
POF1B premature ovarian failure, 1B -0.0157889
RPL30 ribosomal protein L30 -0.0157011
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0156403
ISG15 ISG15 ubiquitin-like modifier -0.0155282
DERA deoxyribose-phosphate aldolase (putative) -0.0154221
RPL27 ribosomal protein L27 -0.0154192
RPL14 ribosomal protein L14 -0.0154038
MYL12B myosin, light chain 12B, regulatory -0.0153859
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0153751
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0152686
RPL10A ribosomal protein L10a -0.0150061
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0149628
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.014954
CHD1 chromodomain helicase DNA binding protein 1 -0.0149227
LMAN1 lectin, mannose-binding, 1 -0.0148691
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0147315
UBE2I ubiquitin-conjugating enzyme E2I -0.0145766
KLF5 Kruppel-like factor 5 (intestinal) -0.0144988
RBM39 RNA binding motif protein 39 -0.0144904
GSTP1 glutathione S-transferase pi 1 -0.0144661
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0139659
TXNIP thioredoxin interacting protein -0.0139581
RPL4 ribosomal protein L4 -0.0139294