Benztropine (mesylate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benztropine (mesylate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.219612
EZR ezrin 0.0963251
EEF2 eukaryotic translation elongation factor 2 0.0956046
DSPP dentin sialophosphoprotein 0.0848771
MYO1E myosin IE 0.0845365
ANXA2 annexin A2 0.0789635
THSD4 thrombospondin, type I, domain containing 4 0.0660101
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0642305
FAT1 FAT atypical cadherin 1 0.0628261
ITPRID2 ITPR interacting domain containing 2 0.0619173
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0591901
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0562247
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0552897
NDRG1 N-myc downstream regulated 1 0.0508194
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0494903
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0484779
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0482799
CCSER1 coiled-coil serine-rich protein 1 0.0474259
SERINC5 serine incorporator 5 0.0459131
RPS3 ribosomal protein S3 0.0458467
MUC13 mucin 13, cell surface associated 0.0454675
EIF4A2 eukaryotic translation initiation factor 4A2 0.0444107
VEGFA vascular endothelial growth factor A 0.0435586
PRELID2 PRELI domain containing 2 0.0428887
ENO1 enolase 1, (alpha) 0.0427256
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0417064
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0413549
PTPRG protein tyrosine phosphatase, receptor type, G 0.0411568
PTPRR protein tyrosine phosphatase, receptor type, R 0.0410387
VCL vinculin 0.0406835
FLNB filamin B, beta 0.0399003
ATXN1 ataxin 1 0.0398865
SRRM2 serine/arginine repetitive matrix 2 0.0396832
RPS12 ribosomal protein S12 0.0392141
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0388674
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0386255
EPHA2 EPH receptor A2 0.0383207
AFDN afadin, adherens junction formation factor 0.0381474
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0378905
AHNAK AHNAK nucleoprotein 0.0375288
DSG2 desmoglein 2 0.0364787
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0360216
CEMIP cell migration inducing protein, hyaluronan binding 0.0359368
BACE2 beta-site APP-cleaving enzyme 2 0.0358719
LAMB3 laminin, beta 3 0.0356688
SQSTM1 sequestosome 1 0.035637
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.035032
KLF5 Kruppel-like factor 5 (intestinal) 0.0333255
ACTN4 actinin, alpha 4 0.0331543
S100P S100 calcium binding protein P 0.0329235
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.032427
KRT8 keratin 8, type II 0.0321395
PDE4D phosphodiesterase 4D, cAMP-specific 0.0319378
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0318349
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0312722
DSG3 desmoglein 3 0.0312591
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0310669
EFNB2 ephrin-B2 0.0309537
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0301688
TMEM45B transmembrane protein 45B 0.0299637
MYH9 myosin, heavy chain 9, non-muscle 0.0295889
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0290127
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0288967
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0284593
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0277236
DUSP5 dual specificity phosphatase 5 0.0275854
DSCAM Down syndrome cell adhesion molecule 0.0275018
FHL2 four and a half LIM domains 2 0.0274651
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0273296
RPL3 ribosomal protein L3 0.0271136
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 0.0270756
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0270421
KRT18 keratin 18, type I 0.0269267
TPM3 tropomyosin 3 0.026748
DSC3 desmocollin 3 0.0266723
KDM7A lysine (K)-specific demethylase 7A 0.0265746
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0264151
SLTM SAFB-like, transcription modulator 0.0263797
UBE3C ubiquitin protein ligase E3C 0.0260894
RABGAP1L RAB GTPase activating protein 1-like 0.0260585
CUX1 cut-like homeobox 1 0.025937
HSPA8 heat shock 70kDa protein 8 0.02576
DGLUCY D-glutamate cyclase 0.0257
OSBPL10 oxysterol binding protein-like 10 0.0256107
JMY junction mediating and regulatory protein, p53 cofactor 0.0254775
PICALM phosphatidylinositol binding clathrin assembly protein 0.025422
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0252291
AFF1 AF4/FMR2 family, member 1 0.0250104
EGFR epidermal growth factor receptor 0.0249174
MPRIP myosin phosphatase Rho interacting protein 0.0248444
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0247572
FRMD5 FERM domain containing 5 0.0245412
RPS2 ribosomal protein S2 0.0243291
ANXA3 annexin A3 0.02401
FAF1 Fas (TNFRSF6) associated factor 1 0.0239924
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.023866
ARRDC3 arrestin domain containing 3 0.0238178
RAD51B RAD51 paralog B 0.023535
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0230476
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0230095

decreased expression

Symbol Name Standardized Value
RPLP1 ribosomal protein, large, P1 -0.13203
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125512
TMSB10 thymosin beta 10 -0.116132
RPS6 ribosomal protein S6 -0.101152
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0832091
PTMA prothymosin, alpha -0.0800904
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0781431
RPLP0 ribosomal protein, large, P0 -0.0694251
RPL12 ribosomal protein L12 -0.0514865
TPT1 tumor protein, translationally-controlled 1 -0.0481309
RPS23 ribosomal protein S23 -0.0441556
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0436745
RPL23 ribosomal protein L23 -0.0413238
RPS27 ribosomal protein S27 -0.0398039
RPL9 ribosomal protein L9 -0.0397682
RPL27A ribosomal protein L27a -0.0380653
RPS19 ribosomal protein S19 -0.0368505
RPL32 ribosomal protein L32 -0.0366389
EIF1 eukaryotic translation initiation factor 1 -0.036519
RPS20 ribosomal protein S20 -0.0336045
LDHA lactate dehydrogenase A -0.0332825
RPL34 ribosomal protein L34 -0.0319459
PRSS3 protease, serine, 3 -0.0315534
RPS5 ribosomal protein S5 -0.0310809
MON2 MON2 homolog (S. cerevisiae) -0.0285789
RPS24 ribosomal protein S24 -0.027812
S100A10 S100 calcium binding protein A10 -0.0277559
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0273129
RPL35A ribosomal protein L35a -0.0272636
HDLBP high density lipoprotein binding protein -0.0272394
RPL4 ribosomal protein L4 -0.0268287
RPL31 ribosomal protein L31 -0.0268286
RPS16 ribosomal protein S16 -0.0267038
TMEM263 transmembrane protein 263 -0.0255093
USP15 ubiquitin specific peptidase 15 -0.0253761
RPLP2 ribosomal protein, large, P2 -0.0239401
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0238375
PDE8A phosphodiesterase 8A -0.0231455
SEC24A SEC24 family member A -0.0230988
TMEM87A transmembrane protein 87A -0.0226148
PTEN phosphatase and tensin homolog -0.0220414
SEC31A SEC31 homolog A (S. cerevisiae) -0.0219126
SERF2 small EDRK-rich factor 2 -0.0218672
RPL11 ribosomal protein L11 -0.0218249
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0218245
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0217345
KIF13B kinesin family member 13B -0.0215067
TSC22D2 TSC22 domain family, member 2 -0.0214364
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0213968
RRBP1 ribosome binding protein 1 -0.021298
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0210979
YBX3 Y box binding protein 3 -0.0209078
RPL10A ribosomal protein L10a -0.020615
CCNG1 cyclin G1 -0.0205509
RBM25 RNA binding motif protein 25 -0.0202046
RPL14 ribosomal protein L14 -0.0201209
PTPRK protein tyrosine phosphatase, receptor type, K -0.0199286
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0195861
NACA nascent polypeptide-associated complex alpha subunit -0.0194378
RPL18 ribosomal protein L18 -0.0189496
GCC2 GRIP and coiled-coil domain containing 2 -0.018809
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0187701
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.018598
VDAC1 voltage-dependent anion channel 1 -0.0181479
LMO7 LIM domain 7 -0.0180772
ETNK1 ethanolamine kinase 1 -0.0179901
EPSTI1 epithelial stromal interaction 1 (breast) -0.0177777
RIGI RNA sensor RIG-I -0.017766
ZC3H11A zinc finger CCCH-type containing 11A -0.0177009
RPS14 ribosomal protein S14 -0.0176319
ARF4 ADP-ribosylation factor 4 -0.0173809
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0173499
BTN3A3 butyrophilin, subfamily 3, member A3 -0.0173463
CALM3 calmodulin 3 (phosphorylase kinase, delta) -0.0170717
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0170015
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0169959
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0169352
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0168718
CCNK cyclin K -0.0168073
SEC61G Sec61 gamma subunit -0.0167399
SAR1A secretion associated, Ras related GTPase 1A -0.0166948
NRN1 neuritin 1 -0.0166536
HMGB2 high mobility group box 2 -0.016512
FTL ferritin, light polypeptide -0.0163963
NMD3 NMD3 ribosome export adaptor -0.0161242
COG5 component of oligomeric golgi complex 5 -0.0159874
DIAPH3 diaphanous-related formin 3 -0.0158187
ARHGAP29 Rho GTPase activating protein 29 -0.0157915
COPS2 COP9 signalosome subunit 2 -0.0157485
BTBD10 BTB (POZ) domain containing 10 -0.0157274
MORF4L2 mortality factor 4 like 2 -0.0157104
ITGB5 integrin, beta 5 -0.0156314
NT5C2 5'-nucleotidase, cytosolic II -0.0154959
RPL8 ribosomal protein L8 -0.0154474
HMGB1 high mobility group box 1 -0.01531
HMGA1 high mobility group AT-hook 1 -0.0150381
GOLGB1 golgin B1 -0.014991
OXSR1 oxidative stress responsive 1 -0.0149473
TBCA tubulin folding cofactor A -0.0148054
SEC24D SEC24 family member D -0.0147539