| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Benztropine (mesylate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.13028 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0808095 |
| TMSB4X | thymosin beta 4, X-linked | 0.0758681 |
| TXNRD1 | thioredoxin reductase 1 | 0.0756951 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0756418 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0744949 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0696928 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0658667 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0633632 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0608346 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0590883 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0582084 |
| MT1X | metallothionein 1X | 0.055738 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0534837 |
| MT2A | metallothionein 2A | 0.05332 |
| AHNAK | AHNAK nucleoprotein | 0.0515868 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0444511 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0442421 |
| CAPRIN2 | caprin family member 2 | 0.0437533 |
| ANGPTL4 | angiopoietin-like 4 | 0.0430238 |
| TMEM41B | transmembrane protein 41B | 0.040401 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.039887 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0387104 |
| XPO1 | exportin 1 | 0.0373582 |
| PODXL | podocalyxin-like | 0.0368776 |
| RTN4 | reticulon 4 | 0.0361434 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0354975 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0347282 |
| YBX3 | Y box binding protein 3 | 0.0344249 |
| ARRDC3 | arrestin domain containing 3 | 0.0343799 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0342356 |
| APP | amyloid beta (A4) precursor protein | 0.0336548 |
| EREG | epiregulin | 0.0325624 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0324185 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0319301 |
| TPM3 | tropomyosin 3 | 0.0317787 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0317252 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0315128 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0301051 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0300646 |
| ENO1 | enolase 1, (alpha) | 0.0293712 |
| ANTXR2 | anthrax toxin receptor 2 | 0.029299 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.029031 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0288546 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0286664 |
| RAI1 | retinoic acid induced 1 | 0.028334 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0282663 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0280811 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0277553 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0277226 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0273571 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.027347 |
| NUP58 | nucleoporin 58 | 0.0265001 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0263631 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0263198 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.026193 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | 0.0259287 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0255433 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0251135 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0250619 |
| BMERB1 | bMERB domain containing 1 | 0.0248594 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0247617 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0247489 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0245519 |
| FOSL1 | FOS-like antigen 1 | 0.0242254 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0242056 |
| SRGN | serglycin | 0.0240015 |
| CDCP1 | CUB domain containing protein 1 | 0.0237517 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0237227 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0234601 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0233813 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0232932 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0232141 |
| F2R | coagulation factor II (thrombin) receptor | 0.0230682 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0229471 |
| ERBIN | erbb2 interacting protein | 0.0226808 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0224316 |
| NCKAP1 | NCK-associated protein 1 | 0.0222027 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0221853 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0221654 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.022053 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0220415 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0219698 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0218986 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0218042 |
| EMP1 | epithelial membrane protein 1 | 0.0217126 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0215758 |
| UPP1 | uridine phosphorylase 1 | 0.0215229 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0213302 |
| CDK19 | cyclin-dependent kinase 19 | 0.0211345 |
| PYGL | phosphorylase, glycogen, liver | 0.0209507 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.020809 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0207551 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0203713 |
| POM121 | POM121 transmembrane nucleoporin | 0.0202347 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0201341 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0200196 |
| ZNF292 | zinc finger protein 292 | 0.0199174 |
| ETNK1 | ethanolamine kinase 1 | 0.0196682 |
| CEP170 | centrosomal protein 170kDa | 0.0196658 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.13043 |
| TP63 | tumor protein p63 | -0.0814094 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0723386 |
| HLA-B | major histocompatibility complex, class I, B | -0.0688365 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0569372 |
| CADM2 | cell adhesion molecule 2 | -0.0549995 |
| EPHA4 | EPH receptor A4 | -0.0538772 |
| TNS3 | tensin 3 | -0.0517001 |
| PTMA | prothymosin, alpha | -0.0507759 |
| VIM | vimentin | -0.0503354 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0494918 |
| EFNA5 | ephrin-A5 | -0.0478957 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0471928 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0467618 |
| PRELID2 | PRELI domain containing 2 | -0.0461526 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0441487 |
| DST | dystonin | -0.0437081 |
| SP100 | SP100 nuclear antigen | -0.0434259 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0388039 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0358004 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0354217 |
| RPS19 | ribosomal protein S19 | -0.0348843 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0348517 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0332146 |
| VCL | vinculin | -0.0310057 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0298916 |
| CD44 | CD44 molecule (Indian blood group) | -0.0293947 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.029301 |
| RPLP1 | ribosomal protein, large, P1 | -0.0287159 |
| HDLBP | high density lipoprotein binding protein | -0.028056 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0277263 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.027336 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0268221 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0267714 |
| MYOF | myoferlin | -0.0264997 |
| RNF213 | ring finger protein 213 | -0.0261556 |
| LDHA | lactate dehydrogenase A | -0.026085 |
| DENND1A | DENN/MADD domain containing 1A | -0.0257392 |
| RPS24 | ribosomal protein S24 | -0.0255449 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0248829 |
| RPL12 | ribosomal protein L12 | -0.0247822 |
| RPL37 | ribosomal protein L37 | -0.0242527 |
| EGFR | epidermal growth factor receptor | -0.0242202 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0238503 |
| RPS23 | ribosomal protein S23 | -0.023547 |
| DNER | delta/notch-like EGF repeat containing | -0.0228102 |
| PDE10A | phosphodiesterase 10A | -0.0226856 |
| RPL31 | ribosomal protein L31 | -0.0225469 |
| INTS6 | integrator complex subunit 6 | -0.0223874 |
| CMIP | c-Maf inducing protein | -0.0220494 |
| DPH6 | diphthamine biosynthesis 6 | -0.0218469 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0217337 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0215436 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0214393 |
| SMYD3 | SET and MYND domain containing 3 | -0.0211897 |
| RPL38 | ribosomal protein L38 | -0.0208104 |
| FUS | FUS RNA binding protein | -0.0206069 |
| RPL37A | ribosomal protein L37a | -0.0202779 |
| RAD51B | RAD51 paralog B | -0.0199373 |
| FTL | ferritin, light polypeptide | -0.0198773 |
| RPL27A | ribosomal protein L27a | -0.0198091 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0197238 |
| RPS25 | ribosomal protein S25 | -0.0194946 |
| TUBB | tubulin, beta class I | -0.0194115 |
| RPL36A | ribosomal protein L36a | -0.0193537 |
| TMEM123 | transmembrane protein 123 | -0.0190514 |
| EXOC4 | exocyst complex component 4 | -0.0190258 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0189306 |
| RPLP2 | ribosomal protein, large, P2 | -0.018546 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0183022 |
| RPS20 | ribosomal protein S20 | -0.018159 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0179103 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0178412 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0177723 |
| LRRC49 | leucine rich repeat containing 49 | -0.0175897 |
| PLSCR1 | phospholipid scramblase 1 | -0.0175488 |
| PLIN2 | perilipin 2 | -0.0175429 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0174271 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0172884 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0172725 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0172255 |
| NEK10 | NIMA-related kinase 10 | -0.0170258 |
| RPL34 | ribosomal protein L34 | -0.0169777 |
| RPL36 | ribosomal protein L36 | -0.0166175 |
| CAVIN1 | caveolae associated protein 1 | -0.0164174 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0163773 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0163383 |
| CEP350 | centrosomal protein 350kDa | -0.0161749 |
| MORF4L2 | mortality factor 4 like 2 | -0.0160432 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0156389 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0155963 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0155505 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0154544 |
| AFF4 | AF4/FMR2 family, member 4 | -0.015404 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | -0.0152982 |
| RPS8 | ribosomal protein S8 | -0.0152829 |
| GNAS | GNAS complex locus | -0.0151717 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0151508 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.015055 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.015002 |
