| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.110552 |
| FAM13A | family with sequence similarity 13, member A | 0.0823353 |
| NDRG1 | N-myc downstream regulated 1 | 0.0714257 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0678698 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0625206 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0542551 |
| ARRDC3 | arrestin domain containing 3 | 0.0430908 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0407099 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0364636 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.035108 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0349706 |
| LAMB3 | laminin, beta 3 | 0.0344272 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0332774 |
| RPS3 | ribosomal protein S3 | 0.0329021 |
| TPD52 | tumor protein D52 | 0.0328492 |
| ANXA2 | annexin A2 | 0.0313119 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.029916 |
| UBC | ubiquitin C | 0.0292455 |
| ENO1 | enolase 1, (alpha) | 0.028647 |
| H1-0 | H1.0 linker histone | 0.0285922 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.027809 |
| TMEM165 | transmembrane protein 165 | 0.026438 |
| SEC61G | Sec61 gamma subunit | 0.0263238 |
| SPAG9 | sperm associated antigen 9 | 0.0259443 |
| AHNAK | AHNAK nucleoprotein | 0.0254524 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0254206 |
| SMAD3 | SMAD family member 3 | 0.0254043 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0253251 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0250233 |
| KCMF1 | potassium channel modulatory factor 1 | 0.024736 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0246034 |
| PTMA | prothymosin, alpha | 0.0245459 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0244178 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0238416 |
| RUNX1 | runt-related transcription factor 1 | 0.023716 |
| ASPH | aspartate beta-hydroxylase | 0.0233652 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0233028 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0232952 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0231744 |
| HELZ | helicase with zinc finger | 0.0228022 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0225115 |
| UVRAG | UV radiation resistance associated | 0.0220493 |
| MXI1 | MAX interactor 1, dimerization protein | 0.02163 |
| NGLY1 | N-glycanase 1 | 0.0215658 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0212467 |
| PDE8A | phosphodiesterase 8A | 0.0210164 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0210094 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0209262 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0206649 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.020461 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0202334 |
| RPS8 | ribosomal protein S8 | 0.0200849 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0200333 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0197042 |
| OGA | O-GlcNAcase | 0.019571 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0190207 |
| NPTN | neuroplastin | 0.0189591 |
| MED13L | mediator complex subunit 13-like | 0.018317 |
| SLMAP | sarcolemma associated protein | 0.0182865 |
| ZNF292 | zinc finger protein 292 | 0.0181183 |
| RPL37A | ribosomal protein L37a | 0.0180779 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0178637 |
| PGK1 | phosphoglycerate kinase 1 | 0.0176996 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.017293 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0170916 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0169798 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0167301 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0166057 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0163519 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0162069 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0161123 |
| CES1 | carboxylesterase 1 | 0.0160691 |
| CANX | calnexin | 0.0159841 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0159274 |
| RPS27A | ribosomal protein S27a | 0.0159142 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0158294 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.015802 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0157762 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0157285 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0156769 |
| PKM | pyruvate kinase, muscle | 0.015675 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0156408 |
| SBF2 | SET binding factor 2 | 0.0154825 |
| WDR45B | WD repeat domain 45B | 0.0153498 |
| ACTG1 | actin gamma 1 | 0.0151358 |
| NCKAP1 | NCK-associated protein 1 | 0.01513 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0150472 |
| USP3 | ubiquitin specific peptidase 3 | 0.0148844 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0148081 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0147234 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0146964 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0146317 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0144488 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0144171 |
| RLF | rearranged L-myc fusion | 0.0143772 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0143012 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0143002 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.014267 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0141688 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0141642 |
| Symbol | Name | Standardized Value |
|---|---|---|
| OSMR | oncostatin M receptor | -0.0290321 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0216132 |
| EGR1 | early growth response 1 | -0.0160227 |
| NABP1 | nucleic acid binding protein 1 | -0.0145452 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0141436 |
| EFNA5 | ephrin-A5 | -0.013835 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.013018 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0128039 |
| VCL | vinculin | -0.0122224 |
| GM2A | GM2 ganglioside activator | -0.0113866 |
| LAMA4 | laminin, alpha 4 | -0.0108621 |
| SP100 | SP100 nuclear antigen | -0.0107772 |
| TXNRD1 | thioredoxin reductase 1 | -0.0107251 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0104164 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.00962861 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.00916143 |
| NPC1 | Niemann-Pick disease, type C1 | -0.00886904 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.00817771 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.00752585 |
| RIGI | RNA sensor RIG-I | -0.00713731 |
| PLSCR1 | phospholipid scramblase 1 | -0.00698477 |
| SETX | senataxin | -0.00694562 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00685032 |
| PMP22 | peripheral myelin protein 22 | -0.00645815 |
| RNF213 | ring finger protein 213 | -0.00643374 |
| MX1 | MX dynamin-like GTPase 1 | -0.0062558 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.00623768 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.00607073 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.00599013 |
| SMYD3 | SET and MYND domain containing 3 | -0.00589121 |
| TRIM56 | tripartite motif containing 56 | -0.0058155 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.00578617 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.00575043 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.00572828 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0055441 |
| EGFR | epidermal growth factor receptor | -0.00552248 |
| TMSB10 | thymosin beta 10 | -0.00547262 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.00547253 |
| OXSR1 | oxidative stress responsive 1 | -0.00526474 |
| RPS24 | ribosomal protein S24 | -0.00525648 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | -0.0052135 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00518408 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.00507183 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.00503013 |
| ERI2 | ERI1 exoribonuclease family member 2 | -0.00497759 |
| FOXP1 | forkhead box P1 | -0.00481653 |
| PRKCE | protein kinase C, epsilon | -0.0048138 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00468498 |
| SMIM31 | small integral membrane protein 31 | -0.00466608 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.00463963 |
| RAD51B | RAD51 paralog B | -0.00456934 |
| RAB28 | RAB28, member RAS oncogene family | -0.00453651 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.00451078 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0045081 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0044854 |
| EXT1 | exostosin glycosyltransferase 1 | -0.00441775 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0043742 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.00435385 |
| NCOA7 | nuclear receptor coactivator 7 | -0.00433365 |
| BMP6 | bone morphogenetic protein 6 | -0.00429905 |
| CPNE4 | copine IV | -0.0041842 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.00412282 |
| RBBP6 | retinoblastoma binding protein 6 | -0.004076 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0040324 |
| INTS6 | integrator complex subunit 6 | -0.00399831 |
| NTN4 | netrin 4 | -0.0039946 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.00398923 |
| SYAP1 | synapse associated protein 1 | -0.00397027 |
| HMGA2 | high mobility group AT-hook 2 | -0.00392431 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.00390097 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.00387668 |
| LAP3 | leucine aminopeptidase 3 | -0.00382418 |
| IFI44L | interferon-induced protein 44-like | -0.00382257 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | -0.00381528 |
| CCDC91 | coiled-coil domain containing 91 | -0.00381246 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.00376225 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.00370909 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.00370884 |
| RPLP1 | ribosomal protein, large, P1 | -0.00366661 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.00361477 |
| RSPO3 | R-spondin 3 | -0.00361012 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00360622 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | -0.00358053 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.00351445 |
| CCDC18 | coiled-coil domain containing 18 | -0.00350942 |
| PHF20L1 | PHD finger protein 20-like 1 | -0.00350191 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.00350165 |
| FERMT2 | fermitin family member 2 | -0.00349217 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.00343861 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0034331 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00341055 |
| PLSCR2 | phospholipid scramblase 2 | -0.00338932 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.00336967 |
| SLC38A2 | solute carrier family 38, member 2 | -0.00336491 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.00334491 |
| MGAT4C | MGAT4 family, member C | -0.00334132 |
| CCND1 | cyclin D1 | -0.00333201 |
| CCNH | cyclin H | -0.00333158 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0033197 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.00329805 |
