Benztropine (mesylate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benztropine (mesylate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.117482
NAMPT nicotinamide phosphoribosyltransferase 0.103653
CXCL8 chemokine (C-X-C motif) ligand 8 0.102397
AKAP12 A kinase (PRKA) anchor protein 12 0.101114
VEGFA vascular endothelial growth factor A 0.0881239
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0761799
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0660792
TFPI2 tissue factor pathway inhibitor 2 0.0619344
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0611524
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0593674
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0564912
FAM13A family with sequence similarity 13, member A 0.0554912
FTH1 ferritin, heavy polypeptide 1 0.048879
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0486793
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0479989
B2M beta-2-microglobulin 0.0454751
ZNF292 zinc finger protein 292 0.0449136
GPC6 glypican 6 0.0447999
MAML3 mastermind-like 3 (Drosophila) 0.042229
SDK1 sidekick cell adhesion molecule 1 0.0419285
ENO1 enolase 1, (alpha) 0.0410696
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0410499
ELL2 elongation factor, RNA polymerase II, 2 0.0401176
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0398666
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.035327
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.03476
PHF21A PHD finger protein 21A 0.0324263
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0311106
MTSS1 metastasis suppressor 1 0.0307762
TGM2 transglutaminase 2 0.0302032
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0299753
TMSB4X thymosin beta 4, X-linked 0.02951
TXNRD1 thioredoxin reductase 1 0.0285844
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0270796
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0266718
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0266264
KTN1 kinectin 1 (kinesin receptor) 0.02659
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.026276
NAP1L1 nucleosome assembly protein 1-like 1 0.0262122
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0261765
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0260726
EEF2 eukaryotic translation elongation factor 2 0.0258931
CA12 carbonic anhydrase XII 0.0258636
APLP2 amyloid beta (A4) precursor-like protein 2 0.0256096
PTMA prothymosin, alpha 0.0255226
XPO1 exportin 1 0.0254147
IGF1R insulin-like growth factor 1 receptor 0.0253315
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0251945
AHNAK AHNAK nucleoprotein 0.024866
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0248394
MAP2K1 mitogen-activated protein kinase kinase 1 0.0243763
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0243549
IGFBP3 insulin-like growth factor binding protein 3 0.0240687
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0240514
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0238104
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0237933
JARID2 jumonji, AT rich interactive domain 2 0.0237815
SOD2 superoxide dismutase 2, mitochondrial 0.0235849
AMPD3 adenosine monophosphate deaminase 3 0.0235759
PDIA3 protein disulfide isomerase family A, member 3 0.0234761
ARRDC3 arrestin domain containing 3 0.0231414
LRRC8C leucine rich repeat containing 8 family, member C 0.0229751
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0228498
CDH13 cadherin 13 0.0227567
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0227502
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0227294
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0227114
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0226853
ANGPTL4 angiopoietin-like 4 0.0225743
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0223617
IL1B interleukin 1, beta 0.022354
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0221317
MEF2A myocyte enhancer factor 2A 0.0219589
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0218302
BHLHE40 basic helix-loop-helix family, member e40 0.0218174
FMNL2 formin-like 2 0.0217388
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0215699
CRYBG3 beta-gamma crystallin domain containing 3 0.0211512
SNX9 sorting nexin 9 0.0211233
SAMD9 sterile alpha motif domain containing 9 0.0210433
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0208739
NPAS2 neuronal PAS domain protein 2 0.0207592
MSI2 musashi RNA-binding protein 2 0.020744
BIRC3 baculoviral IAP repeat containing 3 0.0205188
LIFR leukemia inhibitory factor receptor alpha 0.0203045
EYA4 EYA transcriptional coactivator and phosphatase 4 0.0199124
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.019907
CALR calreticulin 0.019874
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0198705
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0196969
CLMP CXADR-like membrane protein 0.0195208
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0194241
PCDHB16 protocadherin beta 16 0.0193346
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.019331
CTNNBL1 catenin, beta like 1 0.0192106
VEGFC vascular endothelial growth factor C 0.0191375
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0189588
PHIP pleckstrin homology domain interacting protein 0.0189079
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0187225
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.018716

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.105013
RBM39 RNA binding motif protein 39 -0.0986905
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0771654
CD44 CD44 molecule (Indian blood group) -0.0713379
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0666608
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0612026
GOLGA4 golgin A4 -0.0610627
SEC31A SEC31 homolog A (S. cerevisiae) -0.0543099
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0533161
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0531372
VCL vinculin -0.0526166
GLCCI1 glucocorticoid induced 1 -0.0520028
TMSB10 thymosin beta 10 -0.0480265
MORF4L2 mortality factor 4 like 2 -0.0455519
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.041019
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.039981
HMGA2 high mobility group AT-hook 2 -0.0399141
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0398894
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0397915
MON2 MON2 homolog (S. cerevisiae) -0.0397739
FNDC3B fibronectin type III domain containing 3B -0.0396928
NTN4 netrin 4 -0.0390064
BLZF1 basic leucine zipper nuclear factor 1 -0.0383121
FAM20C family with sequence similarity 20, member C -0.0372481
OSMR oncostatin M receptor -0.0368734
VMP1 vacuole membrane protein 1 -0.0365764
IL1R1 interleukin 1 receptor, type I -0.0339634
NCOA7 nuclear receptor coactivator 7 -0.0338931
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0334893
C15ORF48 chromosome 15 open reading frame 48 -0.033218
OXSR1 oxidative stress responsive 1 -0.0322478
HDLBP high density lipoprotein binding protein -0.0320257
GRB10 growth factor receptor-bound protein 10 -0.0310483
GOLGA3 golgin A3 -0.0305267
EXT1 exostosin glycosyltransferase 1 -0.0303722
ANKRD17 ankyrin repeat domain 17 -0.0297809
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0296318
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0295151
USP15 ubiquitin specific peptidase 15 -0.0294595
PDLIM5 PDZ and LIM domain 5 -0.0293086
ANKRD28 ankyrin repeat domain 28 -0.0292784
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0290132
FAM107B family with sequence similarity 107, member B -0.0285235
TRIO trio Rho guanine nucleotide exchange factor -0.0284179
YME1L1 YME1-like 1 ATPase -0.0272478
SEPTIN2 septin 2 -0.0270567
RAB1A RAB1A, member RAS oncogene family -0.0266193
HM13 histocompatibility (minor) 13 -0.0265602
RAB5A RAB5A, member RAS oncogene family -0.0265587
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.026476
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0263527
LOX lysyl oxidase -0.025833
RPLP1 ribosomal protein, large, P1 -0.0255539
AKAP9 A kinase (PRKA) anchor protein 9 -0.0254117
NF1 neurofibromin 1 -0.0252074
TNNC1 troponin C type 1 (slow) -0.0249909
DSCAM Down syndrome cell adhesion molecule -0.0248576
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0248302
GLIPR1 GLI pathogenesis-related 1 -0.024786
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0247386
SBF2 SET binding factor 2 -0.0241478
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0240516
NLK nemo-like kinase -0.0238656
SEC24D SEC24 family member D -0.0238103
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0237724
TXLNG taxilin gamma -0.023744
DAAM1 dishevelled associated activator of morphogenesis 1 -0.023669
RNF24 ring finger protein 24 -0.0232891
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.0230418
COPA coatomer protein complex, subunit alpha -0.0229867
BIRC6 baculoviral IAP repeat containing 6 -0.0226409
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0225666
ZBTB38 zinc finger and BTB domain containing 38 -0.0221618
RSU1 Ras suppressor protein 1 -0.0221521
CTNND1 catenin (cadherin-associated protein), delta 1 -0.022151
SYAP1 synapse associated protein 1 -0.0221441
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0219456
ARF4 ADP-ribosylation factor 4 -0.0219015
COG5 component of oligomeric golgi complex 5 -0.0217448
ZC3H11A zinc finger CCCH-type containing 11A -0.0217408
ACBD3 acyl-CoA binding domain containing 3 -0.020995
PALLD palladin, cytoskeletal associated protein -0.0207837
SEC24A SEC24 family member A -0.0204842
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0204459
RAB2A RAB2A, member RAS oncogene family -0.0203212
LCORL ligand dependent nuclear receptor corepressor-like -0.0202655
SRP54 signal recognition particle 54kDa -0.0202628
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0202318
RPL4 ribosomal protein L4 -0.0202241
SEC23A Sec23 homolog A (S. cerevisiae) -0.020204
SEC13 SEC13 homolog (S. cerevisiae) -0.020066
FNIP1 folliculin interacting protein 1 -0.0199046
BASP1 brain abundant, membrane attached signal protein 1 -0.0194972
ESYT2 extended synaptotagmin-like protein 2 -0.0194691
ANXA2 annexin A2 -0.0194655
SIK3 SIK family kinase 3 -0.0194612
ACTN4 actinin, alpha 4 -0.0193849
GPATCH2L G patch domain containing 2-like -0.0193547
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -0.0193337
FN1 fibronectin 1 -0.0191833