| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.154169 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0841691 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0738317 |
| RTN4 | reticulon 4 | 0.060994 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0594684 |
| FGB | fibrinogen beta chain | 0.0587818 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.058567 |
| GRAMD1B | GRAM domain containing 1B | 0.0555512 |
| WDR43 | WD repeat domain 43 | 0.0530163 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0511883 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0499965 |
| USP3 | ubiquitin specific peptidase 3 | 0.049507 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0431109 |
| TPM3 | tropomyosin 3 | 0.0422143 |
| PTMA | prothymosin, alpha | 0.0391424 |
| FAM168A | family with sequence similarity 168, member A | 0.0350838 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0343718 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.033877 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0337915 |
| YBX3 | Y box binding protein 3 | 0.0319723 |
| ZNF292 | zinc finger protein 292 | 0.0296909 |
| CCNL1 | cyclin L1 | 0.0296109 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0290473 |
| RAD21 | RAD21 homolog (S. pombe) | 0.028857 |
| FTL | ferritin, light polypeptide | 0.0287463 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0285501 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0285423 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0280898 |
| YBX1 | Y box binding protein 1 | 0.0279718 |
| TPD52 | tumor protein D52 | 0.0277834 |
| NTN4 | netrin 4 | 0.0277405 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0272112 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0265543 |
| RHEB | Ras homolog enriched in brain | 0.0260617 |
| KLF6 | Kruppel-like factor 6 | 0.0254842 |
| ENAH | enabled homolog (Drosophila) | 0.0244527 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0240279 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0238607 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0235771 |
| OLA1 | Obg-like ATPase 1 | 0.0235687 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0235326 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0234732 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0234156 |
| SRGN | serglycin | 0.0233579 |
| NUP58 | nucleoporin 58 | 0.0229028 |
| WWOX | WW domain containing oxidoreductase | 0.0226925 |
| HBS1L | HBS1-like translational GTPase | 0.0222109 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0221362 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0220811 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0220131 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0218791 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0218657 |
| TNPO1 | transportin 1 | 0.0214419 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0213994 |
| TPX2 | TPX2, microtubule-associated | 0.0213797 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0212045 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.021043 |
| WBP11 | WW domain binding protein 11 | 0.0208517 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0207823 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0206561 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0205441 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0203215 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0201797 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0201335 |
| RBM33 | RNA binding motif protein 33 | 0.0198429 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0195346 |
| PSMA3 | proteasome (prosome, macropain) subunit, alpha type, 3 | 0.0192717 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0191223 |
| RYBP | RING1 and YY1 binding protein | 0.0190004 |
| TFG | TRK-fused gene | 0.018945 |
| RBM8A | RNA binding motif protein 8A | 0.0187868 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0186015 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0184924 |
| WTAP | Wilms tumor 1 associated protein | 0.0184851 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.018256 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0182358 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0181697 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0179904 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0178477 |
| CENPF | centromere protein F, 350/400kDa | 0.0177563 |
| NCKAP1 | NCK-associated protein 1 | 0.0173502 |
| RPS27A | ribosomal protein S27a | 0.017327 |
| ANLN | anillin, actin binding protein | 0.0173126 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0171722 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0171282 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | 0.0168263 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.0166641 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0165958 |
| FGG | fibrinogen gamma chain | 0.0165925 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0165376 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.0164099 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0163989 |
| RPL19 | ribosomal protein L19 | 0.0163856 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0163552 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0163304 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.016136 |
| CSPP1 | centrosome and spindle pole associated protein 1 | 0.0161345 |
| SPAG9 | sperm associated antigen 9 | 0.0158729 |
| AREG | amphiregulin | 0.0158717 |
| RNF145 | ring finger protein 145 | 0.0158639 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.161535 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.13798 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.136563 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.136232 |
| MT2A | metallothionein 2A | -0.120236 |
| DOCK4 | dedicator of cytokinesis 4 | -0.108587 |
| CMIP | c-Maf inducing protein | -0.101094 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.100016 |
| VIM | vimentin | -0.0978823 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0963916 |
| TMSB10 | thymosin beta 10 | -0.0956971 |
| FMNL2 | formin-like 2 | -0.0941841 |
| PYGL | phosphorylase, glycogen, liver | -0.0817835 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0797706 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.074499 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0693618 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0680611 |
| ACTG1 | actin gamma 1 | -0.0647994 |
| FLNB | filamin B, beta | -0.0618513 |
| EGFR | epidermal growth factor receptor | -0.0615835 |
| LDHA | lactate dehydrogenase A | -0.0607193 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0600925 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0597595 |
| SVIL | supervillin | -0.0587153 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0581334 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0539194 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0487684 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0469811 |
| S100A6 | S100 calcium binding protein A6 | -0.0466252 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0458155 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.044143 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0425919 |
| IER3 | immediate early response 3 | -0.039983 |
| ACTN1 | actinin, alpha 1 | -0.0398762 |
| POTEF | POTE ankyrin domain family, member F | -0.0392148 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0388975 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0385541 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0385443 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0381314 |
| VCL | vinculin | -0.0381019 |
| HLA-B | major histocompatibility complex, class I, B | -0.0377867 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0377404 |
| CUX1 | cut-like homeobox 1 | -0.0376659 |
| MYO1E | myosin IE | -0.0371947 |
| S100A10 | S100 calcium binding protein A10 | -0.0367428 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0367117 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0364006 |
| CFDP1 | craniofacial development protein 1 | -0.0358864 |
| MCL1 | myeloid cell leukemia 1 | -0.0356553 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.035644 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0350055 |
| TPM1 | tropomyosin 1 (alpha) | -0.0349021 |
| DST | dystonin | -0.0348826 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0348804 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0345862 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0343809 |
| EHBP1 | EH domain binding protein 1 | -0.0341469 |
| NDRG1 | N-myc downstream regulated 1 | -0.0340279 |
| SNX14 | sorting nexin 14 | -0.0337774 |
| NEBL | nebulette | -0.033771 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0337345 |
| NF1 | neurofibromin 1 | -0.033684 |
| FAM107B | family with sequence similarity 107, member B | -0.0325367 |
| MORF4L2 | mortality factor 4 like 2 | -0.0324902 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0319231 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0315764 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0315519 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0313256 |
| UTRN | utrophin | -0.0312316 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0310972 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0305609 |
| BICC1 | BicC family RNA binding protein 1 | -0.0305393 |
| USP34 | ubiquitin specific peptidase 34 | -0.030283 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.029642 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0288174 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.02868 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0283579 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0283435 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0281082 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0277293 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0277094 |
| NUMB | numb homolog (Drosophila) | -0.0276869 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0273386 |
| GLG1 | golgi glycoprotein 1 | -0.0265463 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0261837 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0261375 |
| ATG7 | autophagy related 7 | -0.0260281 |
| CAVIN1 | caveolae associated protein 1 | -0.0260247 |
| COPA | coatomer protein complex, subunit alpha | -0.0259144 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0258658 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0257898 |
| CTBP2 | C-terminal binding protein 2 | -0.0256253 |
| ANGPTL4 | angiopoietin-like 4 | -0.0253901 |
| CYTH1 | cytohesin 1 | -0.0253348 |
| GOLGA4 | golgin A4 | -0.025159 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0251486 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0249425 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0249161 |
| ATXN1 | ataxin 1 | -0.024833 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.0245898 |
