| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Benztropine (mesylate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.0972367 |
| DSCAM | Down syndrome cell adhesion molecule | 0.095449 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0800587 |
| FN1 | fibronectin 1 | 0.0759432 |
| LAMB3 | laminin, beta 3 | 0.0719937 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0669365 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0601197 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0577731 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.056945 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0565838 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0526473 |
| LAMC2 | laminin, gamma 2 | 0.0524064 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0520686 |
| KRT17 | keratin 17, type I | 0.0493109 |
| SPAG9 | sperm associated antigen 9 | 0.0490041 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0489444 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0487697 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.04812 |
| CCNL1 | cyclin L1 | 0.0468852 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0455986 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0454046 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0450397 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0443479 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0439477 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0423682 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0415378 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0404229 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0402705 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0383835 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0380134 |
| USP34 | ubiquitin specific peptidase 34 | 0.0374448 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0372615 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0365898 |
| IRS2 | insulin receptor substrate 2 | 0.0359386 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0359049 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0358717 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0355523 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0353125 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0352501 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.035159 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0343352 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0341299 |
| ATOSA | atos homolog A | 0.0333476 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0329501 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0329029 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0327687 |
| ZNF207 | zinc finger protein 207 | 0.0321729 |
| HELZ | helicase with zinc finger | 0.0315901 |
| USP3 | ubiquitin specific peptidase 3 | 0.0315633 |
| FOXO3 | forkhead box O3 | 0.031024 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0309992 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0308834 |
| MATR3 | matrin 3 | 0.0308671 |
| FRMD5 | FERM domain containing 5 | 0.030827 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0305995 |
| FNIP1 | folliculin interacting protein 1 | 0.0301907 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0301211 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0300909 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0300427 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0299719 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0298966 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0298528 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0292098 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0291671 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0290112 |
| NPTN | neuroplastin | 0.0290011 |
| RBM39 | RNA binding motif protein 39 | 0.0287461 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0287368 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0286291 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0282484 |
| RUNX1 | runt-related transcription factor 1 | 0.0280953 |
| RHEB | Ras homolog enriched in brain | 0.028075 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0278549 |
| RTN4 | reticulon 4 | 0.0278515 |
| RNF149 | ring finger protein 149 | 0.0278463 |
| EVI5 | ecotropic viral integration site 5 | 0.0278329 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0275953 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0275828 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0275136 |
| DIAPH1 | diaphanous-related formin 1 | 0.027384 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.027372 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0272013 |
| KLF6 | Kruppel-like factor 6 | 0.0271782 |
| JMJD1C | jumonji domain containing 1C | 0.0271301 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0269873 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0269109 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0268046 |
| RREB1 | ras responsive element binding protein 1 | 0.0267744 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0261465 |
| NCKAP1 | NCK-associated protein 1 | 0.0261215 |
| RAD51B | RAD51 paralog B | 0.0260819 |
| MEMO1 | mediator of cell motility 1 | 0.0260135 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0259337 |
| PARD3 | par-3 family cell polarity regulator | 0.0257268 |
| RNF216 | ring finger protein 216 | 0.0256366 |
| WDR43 | WD repeat domain 43 | 0.0255234 |
| HDLBP | high density lipoprotein binding protein | 0.0253838 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.025347 |
| ZNF292 | zinc finger protein 292 | 0.0248664 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0246144 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.129786 |
| TMSB10 | thymosin beta 10 | -0.0894899 |
| EGFR | epidermal growth factor receptor | -0.0879403 |
| VIM | vimentin | -0.0834784 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.08079 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0781225 |
| HLA-B | major histocompatibility complex, class I, B | -0.0749734 |
| LMO7 | LIM domain 7 | -0.0731358 |
| PGK1 | phosphoglycerate kinase 1 | -0.070995 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0678315 |
| FTL | ferritin, light polypeptide | -0.0665885 |
| IGF2 | insulin-like growth factor 2 | -0.0634552 |
| RPL19 | ribosomal protein L19 | -0.0623458 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0612012 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0602271 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0601869 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0592653 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0590094 |
| RPS8 | ribosomal protein S8 | -0.0573868 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0571063 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0561858 |
| MSI2 | musashi RNA-binding protein 2 | -0.0556582 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0521428 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0512 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0496533 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.049276 |
| NUP98 | nucleoporin 98kDa | -0.0487684 |
| RPL7A | ribosomal protein L7a | -0.0482411 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0481111 |
| RPS3 | ribosomal protein S3 | -0.0478522 |
| MUC13 | mucin 13, cell surface associated | -0.0477701 |
| RPS21 | ribosomal protein S21 | -0.0471824 |
| RBM25 | RNA binding motif protein 25 | -0.0468699 |
| RPL35A | ribosomal protein L35a | -0.0465768 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0448857 |
| RPS25 | ribosomal protein S25 | -0.0448446 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0447926 |
| TPX2 | TPX2, microtubule-associated | -0.0445974 |
| EFNA5 | ephrin-A5 | -0.0444849 |
| MED13L | mediator complex subunit 13-like | -0.0432771 |
| RPLP1 | ribosomal protein, large, P1 | -0.0432214 |
| RPS11 | ribosomal protein S11 | -0.0419547 |
| PRELID2 | PRELI domain containing 2 | -0.0417703 |
| METTL15 | methyltransferase like 15 | -0.0417073 |
| LDHA | lactate dehydrogenase A | -0.0409433 |
| SMYD3 | SET and MYND domain containing 3 | -0.0406109 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0402758 |
| CSTB | cystatin B (stefin B) | -0.0399901 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0399675 |
| AUTS2 | autism susceptibility candidate 2 | -0.0392697 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.0392639 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.0387892 |
| MAP7 | microtubule-associated protein 7 | -0.0384276 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0383015 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0381318 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0381229 |
| RBM15 | RNA binding motif protein 15 | -0.0379084 |
| RPL26 | ribosomal protein L26 | -0.0376678 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.037392 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0372414 |
| PKP4 | plakophilin 4 | -0.0367985 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0367763 |
| TMEM263 | transmembrane protein 263 | -0.0367563 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0365109 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0360427 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0354954 |
| WWOX | WW domain containing oxidoreductase | -0.0352891 |
| FAT1 | FAT atypical cadherin 1 | -0.0352056 |
| SLC25A51 | solute carrier family 25, member 51 | -0.0349834 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0343748 |
| S100A10 | S100 calcium binding protein A10 | -0.034348 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.034218 |
| HMGB1 | high mobility group box 1 | -0.03418 |
| RPL38 | ribosomal protein L38 | -0.0340083 |
| RIGI | RNA sensor RIG-I | -0.0340058 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0339776 |
| AK1 | adenylate kinase 1 | -0.0337402 |
| ASTN2 | astrotactin 2 | -0.0336114 |
| IER3 | immediate early response 3 | -0.0332408 |
| RPL11 | ribosomal protein L11 | -0.0332374 |
| FHIT | fragile histidine triad | -0.0327627 |
| RPS13 | ribosomal protein S13 | -0.032596 |
| LASP1 | LIM and SH3 protein 1 | -0.0324937 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0323177 |
| DNM2 | dynamin 2 | -0.0319088 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0312082 |
| DENND1A | DENN/MADD domain containing 1A | -0.0311944 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0310253 |
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 | -0.0308413 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0307641 |
| WDR70 | WD repeat domain 70 | -0.0306972 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0300109 |
| RPS17 | ribosomal protein S17 | -0.0298765 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0298661 |
| RPLP2 | ribosomal protein, large, P2 | -0.0298341 |
| BPTF | bromodomain PHD finger transcription factor | -0.0297352 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0294405 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0290294 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0289954 |
| RPL15 | ribosomal protein L15 | -0.0289797 |
