Benztropine (mesylate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benztropine (mesylate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0633856
EEF2 eukaryotic translation elongation factor 2 0.0427819
AHNAK AHNAK nucleoprotein 0.0402303
KDM2A lysine (K)-specific demethylase 2A 0.0361971
RAD51B RAD51 paralog B 0.0356608
AKAP12 A kinase (PRKA) anchor protein 12 0.0346278
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0343793
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.033744
TPM3 tropomyosin 3 0.0335901
ERRFI1 ERBB receptor feedback inhibitor 1 0.0328316
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0325444
TXNRD1 thioredoxin reductase 1 0.0320494
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0299111
XPO1 exportin 1 0.0288
TRIO trio Rho guanine nucleotide exchange factor 0.0264419
OGA O-GlcNAcase 0.0263492
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0263314
ADAR adenosine deaminase, RNA-specific 0.0263284
GRAMD1B GRAM domain containing 1B 0.0258548
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0257764
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.025413
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0246758
ZCCHC7 zinc finger, CCHC domain containing 7 0.0245244
UBAP2L ubiquitin associated protein 2-like 0.0242361
KDM3A lysine (K)-specific demethylase 3A 0.0237732
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0236727
CANX calnexin 0.0231445
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0223624
SMAD3 SMAD family member 3 0.0223047
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0219874
COPA coatomer protein complex, subunit alpha 0.0216492
BIRC6 baculoviral IAP repeat containing 6 0.021334
PREPL prolyl endopeptidase-like 0.0202654
NABP1 nucleic acid binding protein 1 0.0202051
PDIA4 protein disulfide isomerase family A, member 4 0.0200263
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0199478
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0198075
ANO6 anoctamin 6 0.0192813
UBE2H ubiquitin-conjugating enzyme E2H 0.0189128
CAMKMT calmodulin-lysine N-methyltransferase 0.0184336
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0179237
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0177573
HELZ helicase with zinc finger 0.0175971
SPAG9 sperm associated antigen 9 0.0175427
EXOC6B exocyst complex component 6B 0.0173847
HSPA8 heat shock 70kDa protein 8 0.0173191
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0171309
BRWD3 bromodomain and WD repeat domain containing 3 0.0168812
IGF1R insulin-like growth factor 1 receptor 0.0165539
ZFR zinc finger RNA binding protein 0.0165004
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0164525
PCNX1 pecanex 1 0.0164462
ANKRD36 ankyrin repeat domain 36 0.016208
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0159967
CSNK1A1 casein kinase 1, alpha 1 0.0159782
MYH9 myosin, heavy chain 9, non-muscle 0.0159156
CSDE1 cold shock domain containing E1, RNA-binding 0.0158642
TLN1 talin 1 0.0158372
USP34 ubiquitin specific peptidase 34 0.0154794
PHIP pleckstrin homology domain interacting protein 0.0151798
ZNF638 zinc finger protein 638 0.0150888
GPHN gephyrin 0.0149839
PCLO piccolo presynaptic cytomatrix protein 0.0148863
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0147656
FBXO11 F-box protein 11 0.0146238
ENO1 enolase 1, (alpha) 0.0146071
H1-0 H1.0 linker histone 0.0143558
ZNF292 zinc finger protein 292 0.0141017
KMT2E lysine (K)-specific methyltransferase 2E 0.0140403
MARCHF4 membrane associated ring-CH-type finger 4 0.0137032
ZFAND3 zinc finger, AN1-type domain 3 0.0136999
BBX bobby sox homolog (Drosophila) 0.013548
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0135444
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0135086
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0134276
NCKAP1 NCK-associated protein 1 0.0134131
PYGL phosphorylase, glycogen, liver 0.0134024
ANKRD36B ankyrin repeat domain 36B 0.0132355
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0131434
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0130979
SRP72 signal recognition particle 72kDa 0.0130911
RAB1A RAB1A, member RAS oncogene family 0.0130844
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0130202
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0129958
NAMPT nicotinamide phosphoribosyltransferase 0.0129513
CCND2 cyclin D2 0.0127177
THSD4 thrombospondin, type I, domain containing 4 0.0127138
EPN2 epsin 2 0.0126392
STK4 serine/threonine kinase 4 0.0125713
SAMD4A sterile alpha motif domain containing 4A 0.0124011
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0123421
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0122897
PLEC plectin 0.0121976
FAM168A family with sequence similarity 168, member A 0.0121764
CLCC1 chloride channel CLIC-like 1 0.012164
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0121394
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0120734
KDM7A lysine (K)-specific demethylase 7A 0.0120667
CTTN cortactin 0.0120577
NOTCH2 notch 2 0.0119727

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157525
TMSB10 thymosin beta 10 -0.120895
VIM vimentin -0.0681993
PTMA prothymosin, alpha -0.058838
EGR1 early growth response 1 -0.0408185
MT2A metallothionein 2A -0.039876
RPLP1 ribosomal protein, large, P1 -0.0395785
TPI1 triosephosphate isomerase 1 -0.0394024
RPL35A ribosomal protein L35a -0.0390192
RPS21 ribosomal protein S21 -0.0342488
RPL23 ribosomal protein L23 -0.0286281
RPL37 ribosomal protein L37 -0.0284255
HLA-B major histocompatibility complex, class I, B -0.0280333
RPS19 ribosomal protein S19 -0.0276108
RPL31 ribosomal protein L31 -0.0274575
POTEF POTE ankyrin domain family, member F -0.026968
RPL12 ribosomal protein L12 -0.0268686
RPL9 ribosomal protein L9 -0.025739
RPLP2 ribosomal protein, large, P2 -0.0251314
TPT1 tumor protein, translationally-controlled 1 -0.0249166
RPS15 ribosomal protein S15 -0.0247463
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.024004
RPS29 ribosomal protein S29 -0.0239835
RPS24 ribosomal protein S24 -0.0236426
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0235008
RPLP0 ribosomal protein, large, P0 -0.0230282
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0225125
RPL26 ribosomal protein L26 -0.0222895
RPS6 ribosomal protein S6 -0.0222391
RPL37A ribosomal protein L37a -0.0220372
RPS27 ribosomal protein S27 -0.0213075
RPL32 ribosomal protein L32 -0.0212081
FTL ferritin, light polypeptide -0.0208854
RPL11 ribosomal protein L11 -0.0207192
MYL12B myosin, light chain 12B, regulatory -0.0200171
TM4SF1 transmembrane 4 L six family member 1 -0.0197375
RPS23 ribosomal protein S23 -0.0197172
RPS10 ribosomal protein S10 -0.0196336
RPL36A ribosomal protein L36a -0.0191224
IFI6 interferon, alpha-inducible protein 6 -0.0190634
RPL36 ribosomal protein L36 -0.0190379
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0190144
EIF5B eukaryotic translation initiation factor 5B -0.0189185
ATP5F1E ATP synthase F1 subunit epsilon -0.0187373
PFN1 profilin 1 -0.0183252
RPS17 ribosomal protein S17 -0.018148
ACTG1 actin gamma 1 -0.0180749
OSMR oncostatin M receptor -0.0178608
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0177985
YBX3 Y box binding protein 3 -0.0176942
RPS12 ribosomal protein S12 -0.0176813
RPL34 ribosomal protein L34 -0.0176052
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0175213
TPM4 tropomyosin 4 -0.0171646
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0170924
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0166978
RPS3 ribosomal protein S3 -0.0165739
RPS8 ribosomal protein S8 -0.0160494
RPS14 ribosomal protein S14 -0.0157081
RPL5 ribosomal protein L5 -0.0154936
RPL19 ribosomal protein L19 -0.0153951
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0153527
S100A10 S100 calcium binding protein A10 -0.0151411
RPL8 ribosomal protein L8 -0.015094
S100A11 S100 calcium binding protein A11 -0.0150448
VDAC1 voltage-dependent anion channel 1 -0.0149307
TPM2 tropomyosin 2 (beta) -0.014865
RPL38 ribosomal protein L38 -0.0144609
TUBA1B tubulin, alpha 1b -0.014425
CBX3 chromobox homolog 3 -0.0143492
LOC102724023 ES1 protein homolog, mitochondrial -0.0143361
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0141775
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0141476
RPS20 ribosomal protein S20 -0.0139201
RPS13 ribosomal protein S13 -0.0136135
RPL27 ribosomal protein L27 -0.0134713
HMGA1 high mobility group AT-hook 1 -0.0133145
IER3 immediate early response 3 -0.0131072
LDHA lactate dehydrogenase A -0.013009
PRH1 proline-rich protein HaeIII subfamily 1 -0.0128448
TAPBP TAP binding protein (tapasin) -0.012816
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0127838
RPS4X ribosomal protein S4, X-linked -0.0127671
RAN RAN, member RAS oncogene family -0.0127599
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0127583
VCL vinculin -0.0126326
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.012589
TFPI2 tissue factor pathway inhibitor 2 -0.0124631
RPL30 ribosomal protein L30 -0.0122018
RBM25 RNA binding motif protein 25 -0.0121507
PKM pyruvate kinase, muscle -0.0120706
RPS11 ribosomal protein S11 -0.0118973
GSTP1 glutathione S-transferase pi 1 -0.0118846
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0117655
HMGA2 high mobility group AT-hook 2 -0.0109712
RPL35 ribosomal protein L35 -0.0107482
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0106723
RAB7A RAB7A, member RAS oncogene family -0.0105582
ATP5F1B ATP synthase F1 subunit beta -0.0103997
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0103656