| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.184049 |
| NDRG1 | N-myc downstream regulated 1 | 0.177656 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.162811 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.139107 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.138993 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.109776 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.10076 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0932443 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0923589 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0900363 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0857781 |
| ASPH | aspartate beta-hydroxylase | 0.0831603 |
| ARRDC3 | arrestin domain containing 3 | 0.0762739 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0738383 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0681968 |
| CTSB | cathepsin B | 0.0669952 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0642417 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0642245 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0609145 |
| TXNIP | thioredoxin interacting protein | 0.0604839 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0593052 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0579295 |
| ENO1 | enolase 1, (alpha) | 0.0574326 |
| LAMB3 | laminin, beta 3 | 0.0555045 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0529635 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0528551 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0522009 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0517418 |
| AHNAK | AHNAK nucleoprotein | 0.0517372 |
| LAMC2 | laminin, gamma 2 | 0.0485228 |
| PTMA | prothymosin, alpha | 0.0482863 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0481986 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.046436 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.046242 |
| SDC4 | syndecan 4 | 0.0461115 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0456751 |
| FAM13A | family with sequence similarity 13, member A | 0.0443596 |
| TMSB4X | thymosin beta 4, X-linked | 0.0437342 |
| CCNL1 | cyclin L1 | 0.0431977 |
| ZNF292 | zinc finger protein 292 | 0.0425623 |
| G0S2 | G0/G1 switch 2 | 0.0421479 |
| RYBP | RING1 and YY1 binding protein | 0.0408137 |
| F11R | F11 receptor | 0.0405119 |
| TPM3 | tropomyosin 3 | 0.040495 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0403292 |
| VEGFA | vascular endothelial growth factor A | 0.0399434 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0391841 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0377684 |
| UBC | ubiquitin C | 0.0376028 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0365615 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0365101 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0364003 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0363736 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0362887 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0358286 |
| DEK | DEK proto-oncogene | 0.0348889 |
| MSN | moesin | 0.0348809 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0348725 |
| UPP1 | uridine phosphorylase 1 | 0.0347319 |
| NPTN | neuroplastin | 0.0347202 |
| PTK2 | protein tyrosine kinase 2 | 0.0345147 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.034068 |
| KIAA1217 | KIAA1217 | 0.0337634 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0337499 |
| DSTN | destrin (actin depolymerizing factor) | 0.0335462 |
| CD47 | CD47 molecule | 0.0333953 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0328957 |
| HMGB2 | high mobility group box 2 | 0.0326627 |
| TFG | TRK-fused gene | 0.0324961 |
| RTN4 | reticulon 4 | 0.0323539 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0322144 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0318218 |
| STEAP4 | STEAP family member 4 | 0.0312725 |
| HOMER2 | homer scaffolding protein 2 | 0.0311979 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.031001 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0309932 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0307908 |
| RHEB | Ras homolog enriched in brain | 0.0304678 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0303519 |
| DSG2 | desmoglein 2 | 0.0298555 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0295733 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0292618 |
| ANXA1 | annexin A1 | 0.0290277 |
| STK24 | serine/threonine kinase 24 | 0.0289697 |
| NCKAP1 | NCK-associated protein 1 | 0.0285964 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0285608 |
| TXNRD1 | thioredoxin reductase 1 | 0.028027 |
| KLF6 | Kruppel-like factor 6 | 0.0278993 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0278816 |
| ZFR | zinc finger RNA binding protein | 0.0278031 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0277299 |
| MATR3 | matrin 3 | 0.0274283 |
| PLAU | plasminogen activator, urokinase | 0.0273779 |
| DSPP | dentin sialophosphoprotein | 0.027234 |
| SMAD3 | SMAD family member 3 | 0.027149 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0270839 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0270139 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0267397 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0265711 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0265283 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0710536 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0662367 |
| FTL | ferritin, light polypeptide | -0.0594908 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0541798 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0533437 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0531981 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0478964 |
| RPLP1 | ribosomal protein, large, P1 | -0.0371448 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0365454 |
| MCU | mitochondrial calcium uniporter | -0.0356385 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0355447 |
| ACTG1 | actin gamma 1 | -0.0349503 |
| GOLGB1 | golgin B1 | -0.0332458 |
| FNIP1 | folliculin interacting protein 1 | -0.0329677 |
| RPL9 | ribosomal protein L9 | -0.0328667 |
| RPS23 | ribosomal protein S23 | -0.0326086 |
| RPL34 | ribosomal protein L34 | -0.0303115 |
| RPL35A | ribosomal protein L35a | -0.0293831 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0275606 |
| S100A10 | S100 calcium binding protein A10 | -0.0271985 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.026737 |
| RPLP2 | ribosomal protein, large, P2 | -0.0267006 |
| HLA-B | major histocompatibility complex, class I, B | -0.0262492 |
| RPS8 | ribosomal protein S8 | -0.026225 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.025097 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0249573 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0247841 |
| POTEF | POTE ankyrin domain family, member F | -0.0247477 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0247303 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0243543 |
| MSI2 | musashi RNA-binding protein 2 | -0.0240562 |
| SCFD1 | sec1 family domain containing 1 | -0.023775 |
| DTNA | dystrobrevin, alpha | -0.0237392 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0237192 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0236889 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0232757 |
| VCL | vinculin | -0.0232217 |
| RPL23 | ribosomal protein L23 | -0.0231996 |
| CEP350 | centrosomal protein 350kDa | -0.0231985 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.0230292 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0228838 |
| COPA | coatomer protein complex, subunit alpha | -0.02214 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0220356 |
| CUX1 | cut-like homeobox 1 | -0.0220316 |
| RPL30 | ribosomal protein L30 | -0.0219916 |
| DUSP10 | dual specificity phosphatase 10 | -0.0217849 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0216506 |
| CCND1 | cyclin D1 | -0.0216214 |
| RPS6 | ribosomal protein S6 | -0.0216158 |
| CTBP2 | C-terminal binding protein 2 | -0.0215945 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0213978 |
| KRT7 | keratin 7, type II | -0.021231 |
| CSTB | cystatin B (stefin B) | -0.0211126 |
| SP100 | SP100 nuclear antigen | -0.0210806 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0209056 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.020905 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.020715 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.0205728 |
| FBXO34 | F-box protein 34 | -0.0203666 |
| SEC24D | SEC24 family member D | -0.0199958 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0199169 |
| HMGA1 | high mobility group AT-hook 1 | -0.0197943 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0196094 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0195163 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0194991 |
| CERT1 | ceramide transporter 1 | -0.0192246 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0191173 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0191087 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0190461 |
| COG6 | component of oligomeric golgi complex 6 | -0.0190361 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0189181 |
| ZNF644 | zinc finger protein 644 | -0.0188608 |
| PLSCR1 | phospholipid scramblase 1 | -0.0188316 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0186679 |
| SEC24A | SEC24 family member A | -0.0184316 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0183821 |
| RIGI | RNA sensor RIG-I | -0.0183702 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0183211 |
| RAI14 | retinoic acid induced 14 | -0.0183053 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0180526 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0179602 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.017931 |
| RPS25 | ribosomal protein S25 | -0.0179148 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0178804 |
| RPL12 | ribosomal protein L12 | -0.017816 |
| RPS16 | ribosomal protein S16 | -0.0176603 |
| ARF1 | ADP-ribosylation factor 1 | -0.0173847 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0173805 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0173591 |
| RPS19 | ribosomal protein S19 | -0.0173209 |
| CLTC | clathrin, heavy chain (Hc) | -0.0171773 |
| ARF4 | ADP-ribosylation factor 4 | -0.0171766 |
| MORF4L2 | mortality factor 4 like 2 | -0.0171733 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0170876 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0167831 |
| RPS14 | ribosomal protein S14 | -0.0167685 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0167539 |
| RNF213 | ring finger protein 213 | -0.0162828 |
| ASTN2 | astrotactin 2 | -0.0161501 |
| FAM107B | family with sequence similarity 107, member B | -0.015933 |
