Benztropine (mesylate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benztropine (mesylate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.108039
GDA guanine deaminase 0.0727975
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0693481
ELL2 elongation factor, RNA polymerase II, 2 0.0644709
IGFBP3 insulin-like growth factor binding protein 3 0.0602336
FN1 fibronectin 1 0.0600296
PYGL phosphorylase, glycogen, liver 0.0573398
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.048096
NPAS2 neuronal PAS domain protein 2 0.0416273
FTH1 ferritin, heavy polypeptide 1 0.0368998
RAB3B RAB3B, member RAS oncogene family 0.0329023
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.032088
CXCL8 chemokine (C-X-C motif) ligand 8 0.0319467
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0312586
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0282565
TGFBI transforming growth factor, beta-induced, 68kDa 0.0279851
SAMD4A sterile alpha motif domain containing 4A 0.0276526
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0273857
FAM13A family with sequence similarity 13, member A 0.0269646
OGA O-GlcNAcase 0.0243355
CTSC cathepsin C 0.0237735
AGFG1 ArfGAP with FG repeats 1 0.0233388
ARRDC3 arrestin domain containing 3 0.0229931
FLNB filamin B, beta 0.0226013
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0223169
PTGR1 prostaglandin reductase 1 0.0221188
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0220848
NEK7 NIMA-related kinase 7 0.0214917
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0214558
CD109 CD109 molecule 0.0214506
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0210983
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0207458
NDRG1 N-myc downstream regulated 1 0.0207177
RTN4 reticulon 4 0.0204976
TMX4 thioredoxin-related transmembrane protein 4 0.0196947
SPAG9 sperm associated antigen 9 0.0195503
ERRFI1 ERBB receptor feedback inhibitor 1 0.0193497
TRIO trio Rho guanine nucleotide exchange factor 0.0192708
DDIT4 DNA-damage-inducible transcript 4 0.0188563
USP3 ubiquitin specific peptidase 3 0.018746
RUNX1 runt-related transcription factor 1 0.018561
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.0179968
STC2 stanniocalcin 2 0.0179802
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0178862
TMSB4X thymosin beta 4, X-linked 0.0178216
ITPRID2 ITPR interacting domain containing 2 0.0175319
UHMK1 U2AF homology motif (UHM) kinase 1 0.0170818
EFNA5 ephrin-A5 0.0169565
KMT2E lysine (K)-specific methyltransferase 2E 0.0169478
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0168796
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0162309
IL1RAP interleukin 1 receptor accessory protein 0.0160987
NCKAP1 NCK-associated protein 1 0.0159908
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0159726
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0155493
CLU clusterin 0.0155282
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0153583
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0153543
ZNF292 zinc finger protein 292 0.0150288
TPD52 tumor protein D52 0.014985
BRWD3 bromodomain and WD repeat domain containing 3 0.0145106
NUP58 nucleoporin 58 0.0143083
BMERB1 bMERB domain containing 1 0.0142539
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0141398
XPO1 exportin 1 0.0134573
RAB1A RAB1A, member RAS oncogene family 0.0134148
TMEM144 transmembrane protein 144 0.0133769
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0131885
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0130795
MFSD12 major facilitator superfamily domain containing 12 0.0129776
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0129596
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0129592
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0129411
ECPAS Ecm29 proteasome adaptor and scaffold 0.0128913
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0128154
UBAP2L ubiquitin associated protein 2-like 0.0126151
SH3KBP1 SH3-domain kinase binding protein 1 0.0123186
CANX calnexin 0.0123156
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0122892
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0122322
WDR43 WD repeat domain 43 0.0122183
USP37 ubiquitin specific peptidase 37 0.0121399
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0121218
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0120566
MAP1B microtubule-associated protein 1B 0.0120456
TFPI2 tissue factor pathway inhibitor 2 0.0120063
UBA6 ubiquitin-like modifier activating enzyme 6 0.0120062
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0119603
PHF21A PHD finger protein 21A 0.0117807
AKR1C2 aldo-keto reductase family 1, member C2 0.0117086
NGLY1 N-glycanase 1 0.011631
WDFY2 WD repeat and FYVE domain containing 2 0.0116243
COL8A1 collagen, type VIII, alpha 1 0.0115795
SKAP2 src kinase associated phosphoprotein 2 0.0115354
ATP13A3 ATPase type 13A3 0.0114509
KDM6A lysine (K)-specific demethylase 6A 0.0114295
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0112383
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0112355
TSC22D2 TSC22 domain family, member 2 0.0112194
MT2A metallothionein 2A 0.0111981

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.177966
PDE4D phosphodiesterase 4D, cAMP-specific -0.161253
VIM vimentin -0.126139
TMSB10 thymosin beta 10 -0.115175
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.10546
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0759931
PSD3 pleckstrin and Sec7 domain containing 3 -0.0710811
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0695686
COL5A2 collagen, type V, alpha 2 -0.06722
RPS24 ribosomal protein S24 -0.0609519
CDH13 cadherin 13 -0.0604532
RPLP1 ribosomal protein, large, P1 -0.0571535
PTMA prothymosin, alpha -0.053493
RPS6 ribosomal protein S6 -0.0524454
ASPH aspartate beta-hydroxylase -0.0503305
UBC ubiquitin C -0.0487568
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0481414
LDHA lactate dehydrogenase A -0.0467683
RPL23 ribosomal protein L23 -0.0440437
PRKN parkin RBR E3 ubiquitin protein ligase -0.0419251
TPT1 tumor protein, translationally-controlled 1 -0.039888
RPS27A ribosomal protein S27a -0.0396535
RPL31 ribosomal protein L31 -0.0390574
TM4SF1 transmembrane 4 L six family member 1 -0.038316
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0381502
RPL12 ribosomal protein L12 -0.0376343
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0363448
RPS8 ribosomal protein S8 -0.0358807
RPL9 ribosomal protein L9 -0.0350182
RPS12 ribosomal protein S12 -0.0344114
RPL26 ribosomal protein L26 -0.0342557
RPS4X ribosomal protein S4, X-linked -0.0338678
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0337488
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0329288
S100A10 S100 calcium binding protein A10 -0.032427
RPS23 ribosomal protein S23 -0.03229
S100A6 S100 calcium binding protein A6 -0.0318769
NALF1 NALCN channel auxiliary factor 1 -0.0310123
RPL37A ribosomal protein L37a -0.0302456
RPL4 ribosomal protein L4 -0.0294782
FTL ferritin, light polypeptide -0.0293845
KIAA0825 KIAA0825 -0.0293353
PKM pyruvate kinase, muscle -0.0288369
PCBP2 poly(rC) binding protein 2 -0.0286052
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0282654
DOCK4 dedicator of cytokinesis 4 -0.0279738
WARS1 tryptophanyl-tRNA synthetase 1 -0.02742
VCL vinculin -0.0272144
RPL34 ribosomal protein L34 -0.0263678
RPS19 ribosomal protein S19 -0.0263073
RPL36A ribosomal protein L36a -0.0261117
DNER delta/notch-like EGF repeat containing -0.0258104
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0257171
SLC38A2 solute carrier family 38, member 2 -0.0253286
RPLP0 ribosomal protein, large, P0 -0.0248724
RPS16 ribosomal protein S16 -0.0233573
RPLP2 ribosomal protein, large, P2 -0.0226444
RPS17 ribosomal protein S17 -0.021926
NRCAM neuronal cell adhesion molecule -0.0217421
P3H2 prolyl 3-hydroxylase 2 -0.0214878
RPS27 ribosomal protein S27 -0.0214699
SAR1A secretion associated, Ras related GTPase 1A -0.0213477
PALLD palladin, cytoskeletal associated protein -0.021161
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0210681
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0210177
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0208753
ZSWIM6 zinc finger, SWIM-type containing 6 -0.020778
RPS5 ribosomal protein S5 -0.0207329
LMNA lamin A/C -0.0203895
SMYD3 SET and MYND domain containing 3 -0.0203798
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0203138
RPL35A ribosomal protein L35a -0.0199333
HDLBP high density lipoprotein binding protein -0.0198068
LSAMP limbic system-associated membrane protein -0.0195389
PTPRM protein tyrosine phosphatase, receptor type, M -0.0195385
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0194104
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0191551
ENO1 enolase 1, (alpha) -0.0191405
RPL19 ribosomal protein L19 -0.0191355
RPL11 ribosomal protein L11 -0.019094
EPHA4 EPH receptor A4 -0.01906
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0189828
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0189314
POTEF POTE ankyrin domain family, member F -0.0188641
RPL37 ribosomal protein L37 -0.0187658
RPS25 ribosomal protein S25 -0.0187029
CUL4A cullin 4A -0.0186911
RPL32 ribosomal protein L32 -0.0186377
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0185929
BASP1 brain abundant, membrane attached signal protein 1 -0.0183724
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0183163
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0182946
RPS14 ribosomal protein S14 -0.018264
RPS21 ribosomal protein S21 -0.0181451
ANTXR1 anthrax toxin receptor 1 -0.0178356
FAM107B family with sequence similarity 107, member B -0.017546
SOD2 superoxide dismutase 2, mitochondrial -0.0173555
CDK6 cyclin-dependent kinase 6 -0.0171663
SET SET nuclear proto-oncogene -0.0170849
VDAC1 voltage-dependent anion channel 1 -0.0170334