Benztropine (mesylate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

189 genes differentially expressed following the Benztropine (mesylate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 0.11124
COL6A3 collagen, type VI, alpha 3 0.109683
HMGA2 high mobility group AT-hook 2 0.10316
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0937243
INHBA inhibin, beta A 0.0920538
FNIP1 folliculin interacting protein 1 0.0888613
NALF1 NALCN channel auxiliary factor 1 0.0872981
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0870393
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0801728
NCKAP1 NCK-associated protein 1 0.0730059
RBM33 RNA binding motif protein 33 0.0703408
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0691791
MSI2 musashi RNA-binding protein 2 0.0666612
RORA RAR-related orphan receptor A 0.0664749
GPHN gephyrin 0.0641599
SCAF11 SR-related CTD-associated factor 11 0.0639874
FN1 fibronectin 1 0.0632577
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.063133
PDE10A phosphodiesterase 10A 0.062866
PUM2 pumilio RNA-binding family member 2 0.0620037
ABI1 abl-interactor 1 0.0611927
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0601265
RAB7A RAB7A, member RAS oncogene family 0.0599155
NIPBL Nipped-B homolog (Drosophila) 0.0544018
N4BP2L2 NEDD4 binding protein 2-like 2 0.0532221
FRMD5 FERM domain containing 5 0.0519954
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0508917
RUNX1 runt-related transcription factor 1 0.0497262
ZNF292 zinc finger protein 292 0.0494438
ANKRD11 ankyrin repeat domain 11 0.046918
OSBPL8 oxysterol binding protein-like 8 0.0459692
WAC WW domain containing adaptor with coiled-coil 0.0446146
NAV1 neuron navigator 1 0.0432665
STC1 stanniocalcin 1 0.0402883
ARHGAP32 Rho GTPase activating protein 32 0.0399336
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0395181
FMNL2 formin-like 2 0.0395157
NRCAM neuronal cell adhesion molecule 0.0392779
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0378423
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0372329
DSCAM Down syndrome cell adhesion molecule 0.0364324
PNISR PNN-interacting serine/arginine-rich protein 0.0363942
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0352311
KDM4C lysine (K)-specific demethylase 4C 0.0339793
ERBIN erbb2 interacting protein 0.0334186
PABPC1 poly(A) binding protein, cytoplasmic 1 0.033374
EEF2 eukaryotic translation elongation factor 2 0.0323066
ESYT2 extended synaptotagmin-like protein 2 0.0301809
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0276717
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0261322
ZNF609 zinc finger protein 609 0.025743
ATP13A3 ATPase type 13A3 0.0253923
SMYD3 SET and MYND domain containing 3 0.0252386
NAMPT nicotinamide phosphoribosyltransferase 0.0232855
MACF1 microtubule-actin crosslinking factor 1 0.02232
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0214368
CAVIN1 caveolae associated protein 1 0.020517
TGFBI transforming growth factor, beta-induced, 68kDa 0.020176
CD2AP CD2-associated protein 0.0197207
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0191532
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0190284
AOPEP aminopeptidase O (putative) 0.0179982
LPP LIM domain containing preferred translocation partner in lipoma 0.0168202
RBM39 RNA binding motif protein 39 0.0152744
PICALM phosphatidylinositol binding clathrin assembly protein 0.0151194
PDE4D phosphodiesterase 4D, cAMP-specific 0.0143752
TRIO trio Rho guanine nucleotide exchange factor 0.013827
NF1 neurofibromin 1 0.0138062
ATXN1 ataxin 1 0.013663
DOCK4 dedicator of cytokinesis 4 0.012641
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0118527
EFNA5 ephrin-A5 0.00924383
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0090772
ELL2 elongation factor, RNA polymerase II, 2 0.00869149
FLNB filamin B, beta 0.0086302
OXR1 oxidation resistance 1 0.0085343
MYO10 myosin X 0.00816831
GLG1 golgi glycoprotein 1 0.00808533
MAML3 mastermind-like 3 (Drosophila) 0.00780412
KMT2E lysine (K)-specific methyltransferase 2E 0.00736905
P4HB prolyl 4-hydroxylase, beta polypeptide 0.00503193
BPTF bromodomain PHD finger transcription factor 0.00484935
KANSL1 KAT8 regulatory NSL complex subunit 1 0.00426007
CCNI cyclin I 0.00335602
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.00289544
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00138427
SLC38A1 solute carrier family 38, member 1 9.15783E-4
BIRC6 baculoviral IAP repeat containing 6 8.64404E-4
MYOF myoferlin 1.42827E-4

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.155589
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.154454
TMSB10 thymosin beta 10 -0.144737
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139619
IGFBP3 insulin-like growth factor binding protein 3 -0.124791
CANX calnexin -0.0994804
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0918263
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0774867
FAM13A family with sequence similarity 13, member A -0.0770364
WSB1 WD repeat and SOCS box containing 1 -0.0764756
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0758227
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0743261
RPL35A ribosomal protein L35a -0.0727978
TPT1 tumor protein, translationally-controlled 1 -0.072702
EIF1 eukaryotic translation initiation factor 1 -0.0721463
RPS6 ribosomal protein S6 -0.0720261
ACTG1 actin gamma 1 -0.071561
CUX1 cut-like homeobox 1 -0.0708362
FTL ferritin, light polypeptide -0.0671842
MED13L mediator complex subunit 13-like -0.0664381
EXT1 exostosin glycosyltransferase 1 -0.0651883
CDH13 cadherin 13 -0.0645984
GOLGA4 golgin A4 -0.0644937
RPS8 ribosomal protein S8 -0.0639354
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0622763
ASPH aspartate beta-hydroxylase -0.0618499
NDRG1 N-myc downstream regulated 1 -0.061162
FNDC3A fibronectin type III domain containing 3A -0.0611426
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0592015
MT2A metallothionein 2A -0.0573343
RPL23 ribosomal protein L23 -0.0552448
CD44 CD44 molecule (Indian blood group) -0.0545309
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.054076
OGA O-GlcNAcase -0.0527739
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0518823
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0516891
KTN1 kinectin 1 (kinesin receptor) -0.0483323
GPC6 glypican 6 -0.0472908
NAP1L1 nucleosome assembly protein 1-like 1 -0.0465735
FTH1 ferritin, heavy polypeptide 1 -0.0442987
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.041927
EGFR epidermal growth factor receptor -0.041513
DLG1 discs, large homolog 1 (Drosophila) -0.0411985
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0407409
MED13 mediator complex subunit 13 -0.0403266
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0398083
OSMR oncostatin M receptor -0.0378844
B2M beta-2-microglobulin -0.0350573
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0335074
VIM vimentin -0.0324029
GLIS3 GLIS family zinc finger 3 -0.0318452
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.031492
MRPS6 mitochondrial ribosomal protein S6 -0.0298439
GNAS GNAS complex locus -0.0284354
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0282364
ZBTB20 zinc finger and BTB domain containing 20 -0.027518
PTMA prothymosin, alpha -0.0260721
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0259677
ZFAND3 zinc finger, AN1-type domain 3 -0.0235161
VMP1 vacuole membrane protein 1 -0.0216511
AHNAK AHNAK nucleoprotein -0.0214952
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0208879
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0207229
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0191704
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0185292
PSD3 pleckstrin and Sec7 domain containing 3 -0.0184795
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0179201
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0179175
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0176039
NKD1 naked cuticle homolog 1 (Drosophila) -0.0171983
CEP170 centrosomal protein 170kDa -0.0166818
USP34 ubiquitin specific peptidase 34 -0.0164412
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0160028
AKAP12 A kinase (PRKA) anchor protein 12 -0.0156271
SPAG9 sperm associated antigen 9 -0.0155131
FNDC3B fibronectin type III domain containing 3B -0.0151824
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0151486
COL6A1 collagen, type VI, alpha 1 -0.0150859
DST dystonin -0.0149096
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0148571
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0125078
HELZ helicase with zinc finger -0.0119964
TMSB4X thymosin beta 4, X-linked -0.0119307
ANXA2 annexin A2 -0.0117475
TMEM165 transmembrane protein 165 -0.0102934
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.00919429
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.00919121
WDFY3 WD repeat and FYVE domain containing 3 -0.00896863
SPIDR scaffolding protein involved in DNA repair -0.00787327
KMT2C lysine (K)-specific methyltransferase 2C -0.00757673
BACE2 beta-site APP-cleaving enzyme 2 -0.00739308
TXNRD1 thioredoxin reductase 1 -0.00689426
SAMD4A sterile alpha motif domain containing 4A -0.0066167
ENO1 enolase 1, (alpha) -0.00583465
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.00533703
JMJD1C jumonji domain containing 1C -0.00499162
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00487816
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.00347708
DOCK5 dedicator of cytokinesis 5 -0.00346592
LDHA lactate dehydrogenase A -0.00300149