| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.113507 |
| TMSB4X | thymosin beta 4, X-linked | 0.0956435 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0758651 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.074097 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.073037 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0730151 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0620537 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0569958 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0523884 |
| MKI67 | marker of proliferation Ki-67 | 0.0516455 |
| PEG10 | paternally expressed 10 | 0.0501682 |
| CENPF | centromere protein F, 350/400kDa | 0.0438429 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0428028 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0375212 |
| PDGFC | platelet derived growth factor C | 0.0373035 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0372116 |
| PFN1 | profilin 1 | 0.0368559 |
| PTMA | prothymosin, alpha | 0.0368322 |
| AHNAK | AHNAK nucleoprotein | 0.0344386 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0338104 |
| HMGB2 | high mobility group box 2 | 0.0331692 |
| ZNF292 | zinc finger protein 292 | 0.0330191 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.032088 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0312523 |
| RYBP | RING1 and YY1 binding protein | 0.03011 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.030078 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0286945 |
| TPM3 | tropomyosin 3 | 0.0286595 |
| YBX1 | Y box binding protein 1 | 0.0280905 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.026775 |
| NOP58 | NOP58 ribonucleoprotein | 0.0267728 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0264486 |
| RPS3 | ribosomal protein S3 | 0.0261513 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0252923 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0252038 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0251442 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0250364 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0248219 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0243404 |
| DSTN | destrin (actin depolymerizing factor) | 0.0234284 |
| THBS1 | thrombospondin 1 | 0.0234193 |
| EMP1 | epithelial membrane protein 1 | 0.0230448 |
| RPS6 | ribosomal protein S6 | 0.0230128 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0229103 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0228761 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0223326 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.0222844 |
| RBM25 | RNA binding motif protein 25 | 0.0221748 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.022104 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0220672 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.021849 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0217474 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0215995 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0214183 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0211948 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0210976 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0210906 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0210715 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0209277 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0208034 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0207671 |
| CCN2 | cellular communication network factor 2 | 0.0205106 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0204931 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0203861 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0203667 |
| GLO1 | glyoxalase I | 0.0203278 |
| ZFR | zinc finger RNA binding protein | 0.0203031 |
| CDC73 | cell division cycle 73 | 0.0202142 |
| DEK | DEK proto-oncogene | 0.0200836 |
| CLTC | clathrin, heavy chain (Hc) | 0.0200709 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0197824 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0196985 |
| USP3 | ubiquitin specific peptidase 3 | 0.0196489 |
| SIK3 | SIK family kinase 3 | 0.0196423 |
| NCKAP1 | NCK-associated protein 1 | 0.0194433 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0192112 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0192111 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0188087 |
| TPX2 | TPX2, microtubule-associated | 0.0187062 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0187001 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0186309 |
| ANXA1 | annexin A1 | 0.0186259 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0185472 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0183926 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0182002 |
| RDX | radixin | 0.018144 |
| NUP58 | nucleoporin 58 | 0.018018 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0180069 |
| TPR | translocated promoter region, nuclear basket protein | 0.0179792 |
| H2AZ2 | H2A.Z variant histone 2 | 0.0179655 |
| CALR | calreticulin | 0.0179437 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0178097 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0177817 |
| H1-0 | H1.0 linker histone | 0.0177667 |
| ANXA5 | annexin A5 | 0.0176118 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0175962 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0175319 |
| RPLP0 | ribosomal protein, large, P0 | 0.0173664 |
| RPL23 | ribosomal protein L23 | 0.0173515 |
| RPL5 | ribosomal protein L5 | 0.0173133 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0741326 |
| CADM2 | cell adhesion molecule 2 | -0.0624549 |
| LRRC4C | leucine rich repeat containing 4C | -0.0580644 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0550097 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0548509 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0412144 |
| TMSB10 | thymosin beta 10 | -0.0412051 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0411952 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0404386 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0385213 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0378047 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0368613 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.036309 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0350409 |
| RBM20 | RNA binding motif protein 20 | -0.0344725 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0326523 |
| JMJD1C | jumonji domain containing 1C | -0.0320228 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0316854 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0312954 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0309322 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0306939 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0301389 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0275816 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0270344 |
| PLPP1 | phospholipid phosphatase 1 | -0.026584 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0260287 |
| SMYD3 | SET and MYND domain containing 3 | -0.0256402 |
| RIGI | RNA sensor RIG-I | -0.0255238 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0251427 |
| RAD51B | RAD51 paralog B | -0.0251405 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0248585 |
| SNX6 | sorting nexin 6 | -0.0246147 |
| BPTF | bromodomain PHD finger transcription factor | -0.0236107 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0233441 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0231662 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0229608 |
| ANK2 | ankyrin 2, neuronal | -0.0226184 |
| NEBL | nebulette | -0.0224809 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0221856 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0209181 |
| CUX1 | cut-like homeobox 1 | -0.0208508 |
| USP25 | ubiquitin specific peptidase 25 | -0.0208048 |
| TUT4 | terminal uridylyl transferase 4 | -0.0207849 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0206514 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0204631 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0203347 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.020243 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0202331 |
| USP34 | ubiquitin specific peptidase 34 | -0.0201619 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0198131 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0196956 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0195098 |
| CTBP2 | C-terminal binding protein 2 | -0.0194713 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0192893 |
| USP53 | ubiquitin specific peptidase 53 | -0.0192722 |
| PCDH9 | protocadherin 9 | -0.0192216 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0190046 |
| NXN | nucleoredoxin | -0.0189856 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0188236 |
| TOX | thymocyte selection-associated high mobility group box | -0.0187013 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0186492 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0186056 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0185055 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0184492 |
| FLNB | filamin B, beta | -0.0182432 |
| INTS6 | integrator complex subunit 6 | -0.0181061 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0179172 |
| RASAL2 | RAS protein activator like 2 | -0.0179141 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0178833 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0178153 |
| ZFP64 | ZFP64 zinc finger protein | -0.0176636 |
| GSE1 | Gse1 coiled-coil protein | -0.017558 |
| MTCL1 | microtubule crosslinking factor 1 | -0.0175469 |
| SPAG9 | sperm associated antigen 9 | -0.0173201 |
| FRYL | FRY-like | -0.0172921 |
| CCDC138 | coiled-coil domain containing 138 | -0.0172795 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0172608 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.017207 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0171299 |
| DENND5B | DENN/MADD domain containing 5B | -0.0170214 |
| MAP3K7 | mitogen-activated protein kinase kinase kinase 7 | -0.0169217 |
| TBCA | tubulin folding cofactor A | -0.0168596 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0167763 |
| CDK13 | cyclin-dependent kinase 13 | -0.0167204 |
| SVIL | supervillin | -0.0166314 |
| LRRN3 | leucine rich repeat neuronal 3 | -0.0165741 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0165504 |
| NFIA | nuclear factor I/A | -0.0164686 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0164465 |
| THOC2 | THO complex 2 | -0.0164408 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0163816 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0163755 |
| RCOR1 | REST corepressor 1 | -0.0160795 |
| CDH19 | cadherin 19, type 2 | -0.0159317 |
| ITGAV | integrin, alpha V | -0.0159158 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0157717 |
| DMD | dystrophin | -0.0157641 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0157463 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0157221 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0157183 |
