| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Benztropine (mesylate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.130832 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0895818 |
| ACTG1 | actin gamma 1 | 0.0641469 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0637415 |
| AHNAK | AHNAK nucleoprotein | 0.0617054 |
| UPP1 | uridine phosphorylase 1 | 0.056469 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0557771 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.048751 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0451204 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0437659 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0422287 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0418528 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0381629 |
| MCL1 | myeloid cell leukemia 1 | 0.0334432 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0327845 |
| CD68 | CD68 molecule | 0.0306234 |
| STC1 | stanniocalcin 1 | 0.0298288 |
| SHANK1 | SH3 and multiple ankyrin repeat domains 1 | 0.029145 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.028958 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0288489 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0285977 |
| NUP58 | nucleoporin 58 | 0.0281281 |
| CALU | calumenin | 0.0280097 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0275168 |
| CDCP1 | CUB domain containing protein 1 | 0.0271549 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0268381 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.026832 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0266486 |
| TMEM156 | transmembrane protein 156 | 0.0266095 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0265718 |
| TPM3 | tropomyosin 3 | 0.0246599 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0240764 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0239556 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0237212 |
| CAPRIN2 | caprin family member 2 | 0.0232063 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0228948 |
| CDK17 | cyclin-dependent kinase 17 | 0.0225084 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0223696 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0223687 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0219118 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0215217 |
| HLA-A | major histocompatibility complex, class I, A | 0.0214639 |
| SGMS2 | sphingomyelin synthase 2 | 0.0211907 |
| ANGPTL4 | angiopoietin-like 4 | 0.0208318 |
| FLNA | filamin A, alpha | 0.0206329 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0204602 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0204131 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0202635 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0201281 |
| CORO1C | coronin, actin binding protein, 1C | 0.020075 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0200129 |
| TUT7 | terminal uridylyl transferase 7 | 0.0198549 |
| TMF1 | TATA element modulatory factor 1 | 0.01941 |
| CALR | calreticulin | 0.0191169 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.018979 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0189347 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0189035 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.018811 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0186759 |
| DUSP6 | dual specificity phosphatase 6 | 0.0185903 |
| RYBP | RING1 and YY1 binding protein | 0.0182386 |
| AAK1 | AP2 associated kinase 1 | 0.0182358 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0182342 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0179836 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0179043 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0178732 |
| UBC | ubiquitin C | 0.0178495 |
| G0S2 | G0/G1 switch 2 | 0.0178385 |
| RPS2 | ribosomal protein S2 | 0.0177629 |
| RECQL | RecQ helicase-like | 0.0174826 |
| RLF | rearranged L-myc fusion | 0.0174668 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0174659 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0173554 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0173455 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0173414 |
| EXOC6B | exocyst complex component 6B | 0.0173283 |
| ENO1 | enolase 1, (alpha) | 0.0173142 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0172615 |
| LRRC8C | leucine rich repeat containing 8 family, member C | 0.0171944 |
| IL6ST | interleukin 6 signal transducer | 0.0170455 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0169473 |
| ATP13A3 | ATPase type 13A3 | 0.0166922 |
| OGA | O-GlcNAcase | 0.0166715 |
| EZR | ezrin | 0.0165423 |
| STXBP1 | syntaxin binding protein 1 | 0.0164986 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0164623 |
| ANXA5 | annexin A5 | 0.0163238 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0161827 |
| KIF1B | kinesin family member 1B | 0.0161424 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0159388 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0158701 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0158611 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0158481 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0158115 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0157578 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0155955 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0155265 |
| RTN4 | reticulon 4 | 0.0154951 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.015354 |
| ANLN | anillin, actin binding protein | 0.0153503 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DLC1 | DLC1 Rho GTPase activating protein | -0.196983 |
| MT2A | metallothionein 2A | -0.139431 |
| ZNF438 | zinc finger protein 438 | -0.10576 |
| NAV3 | neuron navigator 3 | -0.0963938 |
| FRMD6 | FERM domain containing 6 | -0.0868749 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.078725 |
| HDAC9 | histone deacetylase 9 | -0.0781226 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0771327 |
| TTR | transthyretin | -0.0755195 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0727854 |
| CALD1 | caldesmon 1 | -0.0725254 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0712866 |
| FRMD4A | FERM domain containing 4A | -0.0698479 |
| FLNB | filamin B, beta | -0.0667518 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0634036 |
| HMGA2 | high mobility group AT-hook 2 | -0.0632825 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0583653 |
| ANKRD17 | ankyrin repeat domain 17 | -0.055441 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0543427 |
| RPL35A | ribosomal protein L35a | -0.0540166 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0534688 |
| NF1 | neurofibromin 1 | -0.0528502 |
| NABP1 | nucleic acid binding protein 1 | -0.0526141 |
| BNC2 | basonuclin 2 | -0.0515557 |
| RAB3IP | RAB3A interacting protein | -0.0501811 |
| PCNX4 | pecanex 4 | -0.0493175 |
| RPL12 | ribosomal protein L12 | -0.0474222 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0468687 |
| TMSB10 | thymosin beta 10 | -0.0462799 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0446477 |
| RPLP1 | ribosomal protein, large, P1 | -0.0438506 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0437741 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0425384 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0402034 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0400754 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0398288 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0396508 |
| RPL9 | ribosomal protein L9 | -0.0390975 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0389867 |
| FTL | ferritin, light polypeptide | -0.0386606 |
| RPS6 | ribosomal protein S6 | -0.0382511 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0382058 |
| RPLP2 | ribosomal protein, large, P2 | -0.0381464 |
| DENND1A | DENN/MADD domain containing 1A | -0.0368424 |
| TCF12 | transcription factor 12 | -0.0366301 |
| RAD51B | RAD51 paralog B | -0.0365249 |
| RPL34 | ribosomal protein L34 | -0.0362808 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0359937 |
| PARD3 | par-3 family cell polarity regulator | -0.0359217 |
| RPS8 | ribosomal protein S8 | -0.0358454 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0348549 |
| RPL37A | ribosomal protein L37a | -0.0347775 |
| RPL35 | ribosomal protein L35 | -0.0344886 |
| RPL31 | ribosomal protein L31 | -0.0338154 |
| RPS24 | ribosomal protein S24 | -0.0337824 |
| RPS21 | ribosomal protein S21 | -0.0336736 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0333983 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0332859 |
| RPL30 | ribosomal protein L30 | -0.0327857 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0325648 |
| ASPH | aspartate beta-hydroxylase | -0.0324339 |
| RPS19 | ribosomal protein S19 | -0.0322049 |
| PGK1 | phosphoglycerate kinase 1 | -0.0320209 |
| PTK2 | protein tyrosine kinase 2 | -0.0316235 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0315897 |
| RBM25 | RNA binding motif protein 25 | -0.0315618 |
| DIAPH3 | diaphanous-related formin 3 | -0.0315011 |
| RPL11 | ribosomal protein L11 | -0.0310295 |
| LDHA | lactate dehydrogenase A | -0.0306751 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0303412 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0300243 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0299017 |
| HMGA1 | high mobility group AT-hook 1 | -0.0297608 |
| MT1X | metallothionein 1X | -0.0289999 |
| SRPK1 | SRSF protein kinase 1 | -0.0289506 |
| FHIT | fragile histidine triad | -0.028856 |
| RPL23 | ribosomal protein L23 | -0.0288247 |
| CUX1 | cut-like homeobox 1 | -0.0284128 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.027828 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.0277929 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0273633 |
| RPL4 | ribosomal protein L4 | -0.027135 |
| UBE3C | ubiquitin protein ligase E3C | -0.0268166 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0267689 |
| RPL8 | ribosomal protein L8 | -0.0265436 |
| MAP4 | microtubule-associated protein 4 | -0.0264552 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0263894 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0260043 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0259836 |
| RPL32 | ribosomal protein L32 | -0.0258773 |
| CD274 | CD274 molecule | -0.025541 |
| GOLGA4 | golgin A4 | -0.0253788 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0253353 |
| RIGI | RNA sensor RIG-I | -0.0252413 |
| SP100 | SP100 nuclear antigen | -0.0251531 |
| RPS23 | ribosomal protein S23 | -0.0246125 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0245745 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0243425 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0242067 |
| JMJD1C | jumonji domain containing 1C | -0.0241365 |
