| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.145025 |
| VEGFA | vascular endothelial growth factor A | 0.100335 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0882541 |
| STC1 | stanniocalcin 1 | 0.0678048 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0671474 |
| ENO1 | enolase 1, (alpha) | 0.0645377 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.057363 |
| CD44 | CD44 molecule (Indian blood group) | 0.0564348 |
| NDRG1 | N-myc downstream regulated 1 | 0.0533032 |
| TGM2 | transglutaminase 2 | 0.0512678 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0472215 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0465367 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0449171 |
| ZNF292 | zinc finger protein 292 | 0.0424532 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0406293 |
| XPO1 | exportin 1 | 0.040434 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.039908 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0391651 |
| THBS1 | thrombospondin 1 | 0.0390081 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0369437 |
| NRP1 | neuropilin 1 | 0.0356184 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0351085 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0348265 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0345697 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0329759 |
| MSN | moesin | 0.0326812 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.032354 |
| CCNL1 | cyclin L1 | 0.0321612 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0321068 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0318553 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0317319 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0315901 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0311431 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0305632 |
| TMEM178B | transmembrane protein 178B | 0.0301899 |
| ARRDC3 | arrestin domain containing 3 | 0.0300451 |
| SMAD3 | SMAD family member 3 | 0.0296824 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.029536 |
| CLIC4 | chloride intracellular channel 4 | 0.0286015 |
| CDCP1 | CUB domain containing protein 1 | 0.0282745 |
| MYO1B | myosin IB | 0.0280651 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0276268 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0271291 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0263839 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.0260015 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0257106 |
| BRD4 | bromodomain containing 4 | 0.0253558 |
| SSH1 | slingshot protein phosphatase 1 | 0.0252594 |
| MEF2A | myocyte enhancer factor 2A | 0.0248565 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0248532 |
| AHR | aryl hydrocarbon receptor | 0.0246888 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0238017 |
| BRD2 | bromodomain containing 2 | 0.022856 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.02263 |
| DST | dystonin | 0.0226186 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0223758 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.02232 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0219653 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.0218357 |
| PCDHGA2 | protocadherin gamma subfamily A, 2 | 0.0217896 |
| TPM1 | tropomyosin 1 (alpha) | 0.0217574 |
| TPM3 | tropomyosin 3 | 0.0216715 |
| FOSL1 | FOS-like antigen 1 | 0.0216344 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0215931 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.021362 |
| CALR | calreticulin | 0.021037 |
| FAM13A | family with sequence similarity 13, member A | 0.0207363 |
| CALU | calumenin | 0.0206831 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0205071 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0204906 |
| RPN1 | ribophorin I | 0.020442 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0203928 |
| MED13L | mediator complex subunit 13-like | 0.0203474 |
| AHNAK | AHNAK nucleoprotein | 0.0201577 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0201046 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0200165 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0199655 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0197561 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0196772 |
| CANX | calnexin | 0.0196671 |
| FBXO42 | F-box protein 42 | 0.0196552 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0195019 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0193246 |
| MKI67 | marker of proliferation Ki-67 | 0.0192806 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0192363 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.019141 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0190994 |
| RNF213 | ring finger protein 213 | 0.0190855 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0189795 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.018972 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0189089 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0187768 |
| UBC | ubiquitin C | 0.018579 |
| RUNX1 | runt-related transcription factor 1 | 0.0182676 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0181832 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0181313 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0180035 |
| TXNRD1 | thioredoxin reductase 1 | 0.0176732 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.017575 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0175637 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.391233 |
| TMSB10 | thymosin beta 10 | -0.0813537 |
| FTL | ferritin, light polypeptide | -0.0693701 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0683041 |
| RPLP1 | ribosomal protein, large, P1 | -0.0604491 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0588413 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.058464 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0542148 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0516318 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0505915 |
| CDH13 | cadherin 13 | -0.0410194 |
| S100A10 | S100 calcium binding protein A10 | -0.0371814 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0362251 |
| RPL35A | ribosomal protein L35a | -0.0351288 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0304349 |
| RPS6 | ribosomal protein S6 | -0.0297891 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0297815 |
| SP100 | SP100 nuclear antigen | -0.0296326 |
| COL1A1 | collagen, type I, alpha 1 | -0.0295724 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0284383 |
| NAV1 | neuron navigator 1 | -0.0272638 |
| COL1A2 | collagen, type I, alpha 2 | -0.0272524 |
| S100A6 | S100 calcium binding protein A6 | -0.0271097 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0263932 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0256972 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0256599 |
| RBM39 | RNA binding motif protein 39 | -0.025463 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0251555 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0247746 |
| RPL31 | ribosomal protein L31 | -0.0242075 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0238598 |
| HMGA2 | high mobility group AT-hook 2 | -0.0238026 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0236546 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.02355 |
| LDHA | lactate dehydrogenase A | -0.023538 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0229961 |
| GNAS | GNAS complex locus | -0.0229712 |
| RPL34 | ribosomal protein L34 | -0.0225346 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0222247 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0222202 |
| FMNL2 | formin-like 2 | -0.0221558 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0218718 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0217257 |
| RPS19 | ribosomal protein S19 | -0.0216425 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0215985 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0215774 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0213718 |
| EGFR | epidermal growth factor receptor | -0.0212135 |
| SCFD2 | sec1 family domain containing 2 | -0.0208566 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0207905 |
| GPATCH2L | G patch domain containing 2-like | -0.0207657 |
| FRMD4A | FERM domain containing 4A | -0.020555 |
| GPR173 | G protein-coupled receptor 173 | -0.0204444 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.0204419 |
| MT2A | metallothionein 2A | -0.0204105 |
| EML5 | echinoderm microtubule associated protein like 5 | -0.0203682 |
| PCBP3 | poly(rC) binding protein 3 | -0.0198544 |
| SERF2 | small EDRK-rich factor 2 | -0.0196952 |
| EXT1 | exostosin glycosyltransferase 1 | -0.019653 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0196235 |
| COL5A1 | collagen, type V, alpha 1 | -0.0196226 |
| CCDC138 | coiled-coil domain containing 138 | -0.0196095 |
| IER3 | immediate early response 3 | -0.0194654 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0194552 |
| HDLBP | high density lipoprotein binding protein | -0.019309 |
| ANXA2 | annexin A2 | -0.0191791 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0191612 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0189275 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0188774 |
| RPS24 | ribosomal protein S24 | -0.0186666 |
| FAM20C | family with sequence similarity 20, member C | -0.01866 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.018618 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0182593 |
| COL6A2 | collagen, type VI, alpha 2 | -0.018259 |
| RPS23 | ribosomal protein S23 | -0.0181994 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.018028 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.017944 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.017859 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0177019 |
| SEPTIN2 | septin 2 | -0.0176374 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0176358 |
| VMP1 | vacuole membrane protein 1 | -0.0175183 |
| RPL11 | ribosomal protein L11 | -0.0172462 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0171142 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0170995 |
| HLA-B | major histocompatibility complex, class I, B | -0.0170542 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0168697 |
| TSHZ3 | teashirt zinc finger homeobox 3 | -0.0166683 |
| NUMB | numb homolog (Drosophila) | -0.016619 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0165266 |
| RPS27 | ribosomal protein S27 | -0.0164997 |
| LMNA | lamin A/C | -0.0164767 |
| FAM162A | family with sequence similarity 162, member A | -0.016224 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0161783 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0161773 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0159082 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0157168 |
| DNER | delta/notch-like EGF repeat containing | -0.0155859 |
| RAI14 | retinoic acid induced 14 | -0.0155845 |
| MORF4L2 | mortality factor 4 like 2 | -0.0155768 |
