| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.118278 |
| PTMA | prothymosin, alpha | 0.0873715 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0871031 |
| CENPF | centromere protein F, 350/400kDa | 0.0603292 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0547885 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0504051 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0426486 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0426254 |
| FTL | ferritin, light polypeptide | 0.0421246 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0400315 |
| TENM1 | teneurin transmembrane protein 1 | 0.037312 |
| MKI67 | marker of proliferation Ki-67 | 0.0369531 |
| ZNF292 | zinc finger protein 292 | 0.0337812 |
| JAM3 | junctional adhesion molecule 3 | 0.0330682 |
| NDRG1 | N-myc downstream regulated 1 | 0.0319642 |
| ACTG1 | actin gamma 1 | 0.0315327 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0312945 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0305208 |
| RPS8 | ribosomal protein S8 | 0.0304522 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0303114 |
| WDR45B | WD repeat domain 45B | 0.029878 |
| CA8 | carbonic anhydrase VIII | 0.0298251 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0297623 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0287376 |
| YBX1 | Y box binding protein 1 | 0.028011 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0279699 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0278389 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0271706 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0262641 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0262245 |
| XPO1 | exportin 1 | 0.0261483 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0258118 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0257915 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0252613 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0251673 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0250692 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0249212 |
| NFIA | nuclear factor I/A | 0.0244065 |
| MATR3 | matrin 3 | 0.0243529 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0242398 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0242174 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0240977 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0239439 |
| GSE1 | Gse1 coiled-coil protein | 0.023765 |
| SEPTIN7 | septin 7 | 0.0237575 |
| TPM3 | tropomyosin 3 | 0.0237276 |
| RPS3 | ribosomal protein S3 | 0.0235117 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0232324 |
| RPS2 | ribosomal protein S2 | 0.0230109 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0229663 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0227406 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0227308 |
| NUP58 | nucleoporin 58 | 0.0227058 |
| RPL11 | ribosomal protein L11 | 0.0226096 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0225516 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0225041 |
| RLF | rearranged L-myc fusion | 0.0223692 |
| CCDC88A | coiled-coil domain containing 88A | 0.0222774 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0220163 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0217988 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0208178 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0206583 |
| H1-0 | H1.0 linker histone | 0.0204597 |
| NOP58 | NOP58 ribonucleoprotein | 0.0201412 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0200992 |
| PGK1 | phosphoglycerate kinase 1 | 0.0200826 |
| UBB | ubiquitin B | 0.020054 |
| USP3 | ubiquitin specific peptidase 3 | 0.0198387 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0198015 |
| SET | SET nuclear proto-oncogene | 0.0197749 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0196101 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0194661 |
| HDGF | hepatoma-derived growth factor | 0.0194044 |
| BBX | bobby sox homolog (Drosophila) | 0.0192901 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0192285 |
| OGA | O-GlcNAcase | 0.0191566 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0191353 |
| PRC1 | protein regulator of cytokinesis 1 | 0.0189943 |
| PCM1 | pericentriolar material 1 | 0.018994 |
| RPL6 | ribosomal protein L6 | 0.0189761 |
| KIF1A | kinesin family member 1A | 0.0188247 |
| ECT2 | epithelial cell transforming 2 | 0.0188004 |
| ANLN | anillin, actin binding protein | 0.0187746 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0187523 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0187389 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.018686 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0185594 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0185203 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.018509 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0183428 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.018244 |
| FAT1 | FAT atypical cadherin 1 | 0.0182399 |
| PEG10 | paternally expressed 10 | 0.0181598 |
| CCNY | cyclin Y | 0.0179467 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0179224 |
| RPL8 | ribosomal protein L8 | 0.0178425 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0177629 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0176237 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0175383 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0175358 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.123534 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0936071 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0870254 |
| GPC6 | glypican 6 | -0.0863233 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0839796 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0774788 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0726973 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0698861 |
| PDE10A | phosphodiesterase 10A | -0.0670452 |
| SMYD3 | SET and MYND domain containing 3 | -0.0662368 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0633926 |
| VGF | VGF nerve growth factor inducible | -0.060374 |
| GPC5 | glypican 5 | -0.0589741 |
| SNTG1 | syntrophin, gamma 1 | -0.0566582 |
| NCKAP5 | NCK-associated protein 5 | -0.053742 |
| RIT2 | Ras-like without CAAX 2 | -0.0536754 |
| PTCHD4 | patched domain containing 4 | -0.0515344 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0502307 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0497179 |
| KIF26B | kinesin family member 26B | -0.0495126 |
| EFNA5 | ephrin-A5 | -0.0483536 |
| SCG2 | secretogranin II | -0.0457633 |
| DOCK5 | dedicator of cytokinesis 5 | -0.045318 |
| FGF14 | fibroblast growth factor 14 | -0.045092 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0435798 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.042206 |
| RORA | RAR-related orphan receptor A | -0.0420713 |
| STC1 | stanniocalcin 1 | -0.041309 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.039052 |
| NBEA | neurobeachin | -0.0390066 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.0381379 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0349678 |
| CNKSR3 | CNKSR family member 3 | -0.0344095 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0342937 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0338415 |
| ESRRG | estrogen-related receptor gamma | -0.0338087 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0335287 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.0324326 |
| CPE | carboxypeptidase E | -0.0306202 |
| CNTNAP2 | contactin associated protein-like 2 | -0.0300655 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0292092 |
| LSAMP | limbic system-associated membrane protein | -0.0291571 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0289372 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0285399 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0278014 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0278001 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0271173 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0267862 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0265247 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0265064 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0260032 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0253582 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0248083 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0247789 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0246079 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.024284 |
| NAV2 | neuron navigator 2 | -0.0240705 |
| CHGB | chromogranin B | -0.0234801 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.0230008 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.0224186 |
| MCL1 | myeloid cell leukemia 1 | -0.0223601 |
| RIGI | RNA sensor RIG-I | -0.0221675 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -0.0213747 |
| NELL1 | NEL-like 1 (chicken) | -0.0212592 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0209906 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.0209603 |
| EPHA6 | EPH receptor A6 | -0.020721 |
| MYT1L | myelin transcription factor 1-like | -0.0206904 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | -0.0205737 |
| ANKRD17 | ankyrin repeat domain 17 | -0.020181 |
| SP100 | SP100 nuclear antigen | -0.020146 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0198292 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0194912 |
| TYW1 | tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) | -0.0190357 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.018889 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0188851 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0187939 |
| DACH1 | dachshund family transcription factor 1 | -0.0187088 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0185508 |
| SCFD2 | sec1 family domain containing 2 | -0.018491 |
| NAV1 | neuron navigator 1 | -0.0182687 |
| PAEP | progestagen-associated endometrial protein | -0.0182072 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0181078 |
| RAP2A | RAP2A, member of RAS oncogene family | -0.0180034 |
| PHF14 | PHD finger protein 14 | -0.0179496 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0178157 |
| PLSCR1 | phospholipid scramblase 1 | -0.0177506 |
| DGKB | diacylglycerol kinase, beta 90kDa | -0.0177089 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0176634 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0174573 |
| CADM1 | cell adhesion molecule 1 | -0.0172437 |
| SVIL | supervillin | -0.0165998 |
| CDK13 | cyclin-dependent kinase 13 | -0.0162092 |
| RPL4 | ribosomal protein L4 | -0.016199 |
| FNDC3A | fibronectin type III domain containing 3A | -0.015782 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | -0.0157713 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0155511 |
| THSD7A | thrombospondin, type I, domain containing 7A | -0.0155203 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0154084 |
| FN1 | fibronectin 1 | -0.0153317 |
