| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.126998 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0822324 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0779841 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0770836 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0736057 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0638684 |
| CANX | calnexin | 0.0620947 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0618248 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0522165 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0514704 |
| ENO1 | enolase 1, (alpha) | 0.0460147 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0459807 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0459579 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.045284 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0420087 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0417421 |
| CD44 | CD44 molecule (Indian blood group) | 0.0413418 |
| MSN | moesin | 0.0408489 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0386559 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0386552 |
| SQSTM1 | sequestosome 1 | 0.0384454 |
| MT2A | metallothionein 2A | 0.038203 |
| NDRG1 | N-myc downstream regulated 1 | 0.0371835 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.03629 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0359227 |
| TPM3 | tropomyosin 3 | 0.0358144 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0353633 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0353487 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0338936 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0325612 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0301136 |
| NOTCH2 | notch 2 | 0.0300962 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0294219 |
| USP3 | ubiquitin specific peptidase 3 | 0.0290162 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0289154 |
| TXNRD1 | thioredoxin reductase 1 | 0.0281175 |
| MT1X | metallothionein 1X | 0.0279418 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0271711 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0270824 |
| ARRDC3 | arrestin domain containing 3 | 0.0264004 |
| UBC | ubiquitin C | 0.0260195 |
| FLNA | filamin A, alpha | 0.0258589 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0258456 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.025809 |
| KLF6 | Kruppel-like factor 6 | 0.0256959 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0255773 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0250895 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0249915 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0249061 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0246694 |
| CTSB | cathepsin B | 0.0245932 |
| RTN4 | reticulon 4 | 0.0242749 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0237217 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0236831 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0236369 |
| RACK1 | receptor for activated C kinase 1 | 0.0235557 |
| SPAG9 | sperm associated antigen 9 | 0.0234097 |
| ANGPTL4 | angiopoietin-like 4 | 0.0232096 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0229813 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | 0.0226835 |
| AHNAK | AHNAK nucleoprotein | 0.0225503 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0220875 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.021956 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0213124 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0211916 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0210521 |
| HELZ | helicase with zinc finger | 0.020939 |
| VEGFA | vascular endothelial growth factor A | 0.0208669 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0208303 |
| AFDN | afadin, adherens junction formation factor | 0.020579 |
| CALR | calreticulin | 0.0205776 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0204737 |
| FOXO3 | forkhead box O3 | 0.0204226 |
| TPD52 | tumor protein D52 | 0.0202088 |
| COG5 | component of oligomeric golgi complex 5 | 0.0201001 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0198965 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0197713 |
| TRIM33 | tripartite motif containing 33 | 0.0196232 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0196161 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0195876 |
| ZNF292 | zinc finger protein 292 | 0.0195375 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0194838 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0191168 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0189884 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0189601 |
| SSH1 | slingshot protein phosphatase 1 | 0.0189013 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0185883 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0183608 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0183308 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.018327 |
| IDS | iduronate 2-sulfatase | 0.0182758 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0181628 |
| PKM | pyruvate kinase, muscle | 0.0180723 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0178437 |
| PGK1 | phosphoglycerate kinase 1 | 0.0178075 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0177554 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0176072 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0175566 |
| OGA | O-GlcNAcase | 0.0175128 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.017352 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.228194 |
| LSAMP | limbic system-associated membrane protein | -0.17027 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.122683 |
| NRG3 | neuregulin 3 | -0.116228 |
| RAD51B | RAD51 paralog B | -0.0694844 |
| FMN1 | formin 1 | -0.0652936 |
| FRMD4A | FERM domain containing 4A | -0.0645122 |
| FHIT | fragile histidine triad | -0.0484609 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0479355 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0478045 |
| CENPF | centromere protein F, 350/400kDa | -0.0461796 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0454379 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0436092 |
| VIM | vimentin | -0.0427863 |
| MSI2 | musashi RNA-binding protein 2 | -0.0417259 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0414033 |
| DST | dystonin | -0.0403477 |
| CCND1 | cyclin D1 | -0.0398941 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0398256 |
| COMMD10 | COMM domain containing 10 | -0.0362191 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0339216 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0327313 |
| TMSB10 | thymosin beta 10 | -0.0323759 |
| EXOC4 | exocyst complex component 4 | -0.0320816 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0306723 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.030565 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0296476 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.02934 |
| DIAPH2 | diaphanous-related formin 2 | -0.029333 |
| EHBP1 | EH domain binding protein 1 | -0.0289299 |
| IFI44L | interferon-induced protein 44-like | -0.0280894 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0274291 |
| SP100 | SP100 nuclear antigen | -0.0261016 |
| CDK6 | cyclin-dependent kinase 6 | -0.0253621 |
| TNNC1 | troponin C type 1 (slow) | -0.0252874 |
| PTMA | prothymosin, alpha | -0.0250374 |
| POU2F1 | POU class 2 homeobox 1 | -0.0248434 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0240706 |
| RPLP1 | ribosomal protein, large, P1 | -0.0240649 |
| FGGY | FGGY carbohydrate kinase domain containing | -0.023785 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0230923 |
| PRKCE | protein kinase C, epsilon | -0.0229187 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0228086 |
| TULP4 | tubby like protein 4 | -0.0223553 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.021848 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0217307 |
| HDAC4 | histone deacetylase 4 | -0.0215592 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0213766 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.021284 |
| RNF213 | ring finger protein 213 | -0.0212299 |
| GPHN | gephyrin | -0.0210402 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0209255 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0208136 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0203756 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0202305 |
| CHD6 | chromodomain helicase DNA binding protein 6 | -0.0200411 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0199625 |
| SBF2 | SET binding factor 2 | -0.0199366 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0198279 |
| MKI67 | marker of proliferation Ki-67 | -0.019752 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0196409 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0196321 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0194719 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.01939 |
| EFNA5 | ephrin-A5 | -0.0193187 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0192777 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0190623 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0190459 |
| PRELID2 | PRELI domain containing 2 | -0.018868 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0187897 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0185696 |
| CTTN | cortactin | -0.0185074 |
| AUTS2 | autism susceptibility candidate 2 | -0.0183849 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0182251 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0181856 |
| CFAP20DC | CFAP20 domain containing | -0.0181604 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0179766 |
| DIAPH3 | diaphanous-related formin 3 | -0.0178835 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0178816 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0178588 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0177496 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.0176434 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | -0.0174295 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0172546 |
| DPP6 | dipeptidyl-peptidase 6 | -0.0171593 |
| PTK2 | protein tyrosine kinase 2 | -0.0170973 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0170694 |
| NHSL1 | NHS-like 1 | -0.0168957 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0168667 |
| RPL9 | ribosomal protein L9 | -0.0167987 |
| TCERG1 | transcription elongation regulator 1 | -0.0167683 |
| RPL23 | ribosomal protein L23 | -0.0166407 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0164751 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0164579 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0164483 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.0164033 |
| ZNF704 | zinc finger protein 704 | -0.0162952 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0162788 |
| PHF14 | PHD finger protein 14 | -0.0162314 |
| SHTN1 | shootin 1 | -0.0162117 |
