| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.171215 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.118681 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.110702 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.106041 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0989925 |
| VEGFA | vascular endothelial growth factor A | 0.0891625 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0817695 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0725015 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0674527 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0658603 |
| ZNF292 | zinc finger protein 292 | 0.0644817 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0640258 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0619415 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0598518 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0583911 |
| ARRDC3 | arrestin domain containing 3 | 0.0578602 |
| THBS1 | thrombospondin 1 | 0.0575951 |
| OGA | O-GlcNAcase | 0.056813 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0557843 |
| SMAD3 | SMAD family member 3 | 0.0536648 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0513863 |
| ANXA2 | annexin A2 | 0.0475538 |
| FLNA | filamin A, alpha | 0.0435621 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0385668 |
| ANLN | anillin, actin binding protein | 0.0382978 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.036911 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0354914 |
| SPAG9 | sperm associated antigen 9 | 0.0349395 |
| AHNAK | AHNAK nucleoprotein | 0.0332125 |
| BICC1 | BicC family RNA binding protein 1 | 0.0329961 |
| TMSB4X | thymosin beta 4, X-linked | 0.0324553 |
| HELZ | helicase with zinc finger | 0.0322787 |
| TXNIP | thioredoxin interacting protein | 0.0320296 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0317488 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0308267 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0305216 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0299119 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0296486 |
| ATP13A3 | ATPase type 13A3 | 0.0295999 |
| KLF6 | Kruppel-like factor 6 | 0.029227 |
| RTN4 | reticulon 4 | 0.0290424 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0288642 |
| YBX1 | Y box binding protein 1 | 0.0282252 |
| MSN | moesin | 0.028225 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0277545 |
| PLPP6 | phospholipid phosphatase 6 | 0.0272468 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0271442 |
| SDC4 | syndecan 4 | 0.0271363 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0268068 |
| CCNL1 | cyclin L1 | 0.0267903 |
| AHR | aryl hydrocarbon receptor | 0.0262175 |
| POTEF | POTE ankyrin domain family, member F | 0.0258954 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0251078 |
| XPO1 | exportin 1 | 0.0249011 |
| MKI67 | marker of proliferation Ki-67 | 0.0248737 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0246824 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0233369 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0232039 |
| RUNX2 | runt-related transcription factor 2 | 0.0231524 |
| APP | amyloid beta (A4) precursor protein | 0.0231199 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0231024 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0230868 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0229628 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0228709 |
| TMEM123 | transmembrane protein 123 | 0.0228692 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0228425 |
| DUSP5 | dual specificity phosphatase 5 | 0.0226186 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0225665 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0225269 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0224594 |
| PHIP | pleckstrin homology domain interacting protein | 0.0217303 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0216075 |
| QKI | QKI, KH domain containing, RNA binding | 0.0215017 |
| DIAPH3 | diaphanous-related formin 3 | 0.0214929 |
| SBF2 | SET binding factor 2 | 0.0211837 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0207385 |
| FOSL1 | FOS-like antigen 1 | 0.0206917 |
| HLA-C | major histocompatibility complex, class I, C | 0.0206889 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0206436 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0206421 |
| CDK19 | cyclin-dependent kinase 19 | 0.0203732 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0203078 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0201508 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0199324 |
| SRGN | serglycin | 0.0197074 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.019692 |
| RLF | rearranged L-myc fusion | 0.0195709 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0194929 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0194477 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0194151 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0189113 |
| TXNRD1 | thioredoxin reductase 1 | 0.018891 |
| PGK1 | phosphoglycerate kinase 1 | 0.0188827 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.018759 |
| WTAP | Wilms tumor 1 associated protein | 0.0186051 |
| SYAP1 | synapse associated protein 1 | 0.0185243 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0184078 |
| TPM3 | tropomyosin 3 | 0.0183295 |
| RPS2 | ribosomal protein S2 | 0.0181689 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0178849 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.275536 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.104835 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0990482 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0918914 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0791674 |
| IER3 | immediate early response 3 | -0.0762464 |
| TMSB10 | thymosin beta 10 | -0.0743256 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0739336 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0711175 |
| HMGA2 | high mobility group AT-hook 2 | -0.0684805 |
| PLIN2 | perilipin 2 | -0.0676155 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0603009 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0595328 |
| FTL | ferritin, light polypeptide | -0.0572433 |
| CDH13 | cadherin 13 | -0.0562168 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0528053 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0515806 |
| HLA-B | major histocompatibility complex, class I, B | -0.0512217 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0469329 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0434039 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0406143 |
| LDHA | lactate dehydrogenase A | -0.0402863 |
| TMEM132D | transmembrane protein 132D | -0.0393044 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0381271 |
| RPS24 | ribosomal protein S24 | -0.0357057 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0354326 |
| CTSD | cathepsin D | -0.0353284 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0352045 |
| GLIS3 | GLIS family zinc finger 3 | -0.0351871 |
| EGFR | epidermal growth factor receptor | -0.0342269 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0339499 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0338197 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0337133 |
| INTS6 | integrator complex subunit 6 | -0.0330144 |
| DIAPH2 | diaphanous-related formin 2 | -0.0294857 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0289954 |
| PTMA | prothymosin, alpha | -0.0286037 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0277149 |
| RPL31 | ribosomal protein L31 | -0.0276541 |
| GOLGB1 | golgin B1 | -0.0267215 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0266343 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0261787 |
| RPLP1 | ribosomal protein, large, P1 | -0.0248752 |
| ASPH | aspartate beta-hydroxylase | -0.0246979 |
| NAV1 | neuron navigator 1 | -0.0240913 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0238074 |
| RPL37A | ribosomal protein L37a | -0.0237047 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0236413 |
| EFNA5 | ephrin-A5 | -0.023434 |
| MT2A | metallothionein 2A | -0.0228807 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0228519 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0224518 |
| SP100 | SP100 nuclear antigen | -0.0220724 |
| PHF3 | PHD finger protein 3 | -0.022063 |
| RPS23 | ribosomal protein S23 | -0.0220147 |
| LOX | lysyl oxidase | -0.0220123 |
| MORF4L2 | mortality factor 4 like 2 | -0.0219578 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0219373 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0216273 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0213226 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0213091 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0212051 |
| CLMP | CXADR-like membrane protein | -0.0208002 |
| RPL9 | ribosomal protein L9 | -0.020609 |
| BNC2 | basonuclin 2 | -0.0204854 |
| NRN1 | neuritin 1 | -0.0203278 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0199226 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0199145 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0198516 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0194373 |
| TBCA | tubulin folding cofactor A | -0.0192643 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0192422 |
| RPL35A | ribosomal protein L35a | -0.0191321 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0189568 |
| SLC38A2 | solute carrier family 38, member 2 | -0.018826 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -0.0187178 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.018673 |
| RAI14 | retinoic acid induced 14 | -0.01857 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0185216 |
| RPL36A | ribosomal protein L36a | -0.018485 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0183667 |
| MMP12 | matrix metallopeptidase 12 | -0.0181875 |
| RPLP2 | ribosomal protein, large, P2 | -0.0181859 |
| INHBA | inhibin, beta A | -0.0181727 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0180192 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0178381 |
| FBXO11 | F-box protein 11 | -0.0175533 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0173208 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0172581 |
| MYO9A | myosin IXA | -0.0169035 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0168992 |
| TCEAL9 | transcription elongation factor A like 9 | -0.0168859 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.016478 |
| DST | dystonin | -0.016395 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.016263 |
| RND3 | Rho family GTPase 3 | -0.0160496 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0159436 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0159222 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0157169 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0155497 |
