| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.12719 |
| B2M | beta-2-microglobulin | 0.110558 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0997429 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0698662 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0679027 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.064461 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0613407 |
| HLA-A | major histocompatibility complex, class I, A | 0.0609084 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0552701 |
| VEGFA | vascular endothelial growth factor A | 0.0550053 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0531756 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0515516 |
| HLA-B | major histocompatibility complex, class I, B | 0.0511607 |
| AHNAK | AHNAK nucleoprotein | 0.0502012 |
| STC1 | stanniocalcin 1 | 0.0491394 |
| MT2A | metallothionein 2A | 0.0470301 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.044878 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0434255 |
| NDRG1 | N-myc downstream regulated 1 | 0.0410698 |
| DSCAM | Down syndrome cell adhesion molecule | 0.040043 |
| ARRDC3 | arrestin domain containing 3 | 0.0366858 |
| HLA-C | major histocompatibility complex, class I, C | 0.0362359 |
| TXNIP | thioredoxin interacting protein | 0.0359158 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0357633 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0356447 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0354518 |
| CTSB | cathepsin B | 0.0354128 |
| GOLGB1 | golgin B1 | 0.0352924 |
| MAP1B | microtubule-associated protein 1B | 0.0343433 |
| RNF24 | ring finger protein 24 | 0.0342816 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0338374 |
| CANX | calnexin | 0.0333061 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0327159 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.032095 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0308115 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0306799 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0298949 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0295032 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0294965 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0291639 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0291615 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0290602 |
| RPS8 | ribosomal protein S8 | 0.0285679 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0282447 |
| SMAD3 | SMAD family member 3 | 0.0279036 |
| THBS1 | thrombospondin 1 | 0.0278773 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0274181 |
| TPX2 | TPX2, microtubule-associated | 0.0261648 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.025948 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0254871 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.0252574 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0248626 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.0247068 |
| SET | SET nuclear proto-oncogene | 0.024665 |
| APP | amyloid beta (A4) precursor protein | 0.0244683 |
| SBF2 | SET binding factor 2 | 0.0243658 |
| TLN1 | talin 1 | 0.0240695 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.024023 |
| OAF | OAF homolog (Drosophila) | 0.0239263 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0237609 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0237436 |
| SPAG9 | sperm associated antigen 9 | 0.0234619 |
| TMEM263 | transmembrane protein 263 | 0.0233869 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0231287 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0231035 |
| RPS3 | ribosomal protein S3 | 0.0231016 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0230412 |
| RIGI | RNA sensor RIG-I | 0.0228828 |
| FKBP10 | FK506 binding protein 10, 65 kDa | 0.0227909 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0226835 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0225137 |
| JAK1 | Janus kinase 1 | 0.0222621 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0221851 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0219525 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0216206 |
| CALR | calreticulin | 0.0215843 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0215715 |
| RPL23 | ribosomal protein L23 | 0.0215517 |
| FLNB | filamin B, beta | 0.021504 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0214955 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0212622 |
| RPL28 | ribosomal protein L28 | 0.0212485 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.0211776 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.021131 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0210968 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.021068 |
| COL5A1 | collagen, type V, alpha 1 | 0.021027 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0209426 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0208896 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0205905 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0203008 |
| CCNB1 | cyclin B1 | 0.0201692 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.020014 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0199753 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0199591 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0197261 |
| ASTN2 | astrotactin 2 | 0.0196324 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0192248 |
| RTN4 | reticulon 4 | 0.0191014 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0190939 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.107733 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0740084 |
| TMSB10 | thymosin beta 10 | -0.0711795 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0519873 |
| LDHA | lactate dehydrogenase A | -0.0437792 |
| GLIS3 | GLIS family zinc finger 3 | -0.0423308 |
| CALD1 | caldesmon 1 | -0.0417237 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0415377 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.039802 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0393888 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0385731 |
| RRBP1 | ribosome binding protein 1 | -0.0367378 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0358711 |
| SEC24D | SEC24 family member D | -0.0357256 |
| EGFR | epidermal growth factor receptor | -0.035688 |
| FRMD4A | FERM domain containing 4A | -0.0335196 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0331822 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0330131 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0329622 |
| SCFD1 | sec1 family domain containing 1 | -0.0327449 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0327442 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0322291 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.032215 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0321541 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0316317 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0307216 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0305111 |
| MYO10 | myosin X | -0.0302208 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0301387 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0295495 |
| RASAL2 | RAS protein activator like 2 | -0.0292163 |
| ATP13A3 | ATPase type 13A3 | -0.0291823 |
| SEC24A | SEC24 family member A | -0.0282364 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0279952 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0278231 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0275533 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0273812 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0271984 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0270239 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0269371 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0267396 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0265283 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0264951 |
| MAP4 | microtubule-associated protein 4 | -0.0262158 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0258914 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0258525 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0256456 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.025554 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0253589 |
| HMGA2 | high mobility group AT-hook 2 | -0.0243337 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0241604 |
| TNS3 | tensin 3 | -0.0240148 |
| SDC4 | syndecan 4 | -0.0239899 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -0.0237325 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0232272 |
| MATR3 | matrin 3 | -0.0230772 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.022935 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0228894 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0225526 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0223611 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0219652 |
| DYM | dymeclin | -0.0219237 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0218073 |
| TXNDC11 | thioredoxin domain containing 11 | -0.0216704 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0214252 |
| PDZD2 | PDZ domain containing 2 | -0.0214083 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0212139 |
| RAI14 | retinoic acid induced 14 | -0.0211846 |
| ATP11B | ATPase, class VI, type 11B | -0.0211107 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0209459 |
| VCAN | versican | -0.0208825 |
| RBM25 | RNA binding motif protein 25 | -0.020189 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0199687 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0198274 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0198129 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0197291 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.0192452 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0192078 |
| FLOT1 | flotillin 1 | -0.0191442 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0190374 |
| RNF216 | ring finger protein 216 | -0.0190146 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0189907 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.018818 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.018808 |
| NRG1 | neuregulin 1 | -0.0187938 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0186661 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0186062 |
| PRELID2 | PRELI domain containing 2 | -0.0185506 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0183084 |
| PHKB | phosphorylase kinase, beta | -0.0183016 |
| RBM6 | RNA binding motif protein 6 | -0.018203 |
| HIP1 | huntingtin interacting protein 1 | -0.0181769 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0181115 |
| LCLAT1 | lysocardiolipin acyltransferase 1 | -0.0181028 |
| TSPAN5 | tetraspanin 5 | -0.018097 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0180128 |
| CLINT1 | clathrin interactor 1 | -0.0179999 |
| MFF | mitochondrial fission factor | -0.0178702 |
| DIDO1 | death inducer-obliterator 1 | -0.0178019 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0177564 |
