| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.120618 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0974189 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0906079 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0872215 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0582499 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0530489 |
| PELO | pelota homolog (Drosophila) | 0.0440975 |
| TMEM156 | transmembrane protein 156 | 0.038812 |
| TXNIP | thioredoxin interacting protein | 0.0373768 |
| SMOX | spermine oxidase | 0.0367979 |
| VEGFA | vascular endothelial growth factor A | 0.0329257 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0322349 |
| CD44 | CD44 molecule (Indian blood group) | 0.0305036 |
| AHR | aryl hydrocarbon receptor | 0.0299477 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0291311 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0277626 |
| FNBP1 | formin binding protein 1 | 0.0277242 |
| OSMR | oncostatin M receptor | 0.0272969 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0272947 |
| SMAD3 | SMAD family member 3 | 0.02664 |
| ITGA1 | integrin, alpha 1 | 0.0264461 |
| EREG | epiregulin | 0.0261522 |
| CAB39 | calcium binding protein 39 | 0.0258431 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0254975 |
| OGA | O-GlcNAcase | 0.0248343 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0245474 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0240582 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0233951 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0231636 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0223487 |
| GLIS3 | GLIS family zinc finger 3 | 0.0213033 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0211067 |
| NEK7 | NIMA-related kinase 7 | 0.0210868 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0210426 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0207187 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0198469 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0196375 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0189227 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0185291 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.018479 |
| TXNRD1 | thioredoxin reductase 1 | 0.0184686 |
| ARRDC3 | arrestin domain containing 3 | 0.0184662 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0184532 |
| NRP1 | neuropilin 1 | 0.0182559 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0180418 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0179593 |
| ZNF292 | zinc finger protein 292 | 0.0178649 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.017721 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 0.0173525 |
| HOMER2 | homer scaffolding protein 2 | 0.0171918 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0171566 |
| FBXO32 | F-box protein 32 | 0.0170185 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0169959 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0169863 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0169014 |
| DENND5B | DENN/MADD domain containing 5B | 0.0164193 |
| ADD3 | adducin 3 (gamma) | 0.016397 |
| ETNK1 | ethanolamine kinase 1 | 0.0162054 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0160056 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0159963 |
| FOXP1 | forkhead box P1 | 0.0159535 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0159198 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0156102 |
| SSH1 | slingshot protein phosphatase 1 | 0.0154443 |
| HELZ | helicase with zinc finger | 0.0154264 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0153067 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0152579 |
| RTN4 | reticulon 4 | 0.0152501 |
| TPR | translocated promoter region, nuclear basket protein | 0.0151073 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0150591 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0150024 |
| CD109 | CD109 molecule | 0.0149972 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0149521 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0149305 |
| MT2A | metallothionein 2A | 0.0148066 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0147314 |
| WDR26 | WD repeat domain 26 | 0.0145088 |
| USP3 | ubiquitin specific peptidase 3 | 0.0141598 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.014062 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0140444 |
| CANX | calnexin | 0.0140008 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0139761 |
| FAM13A | family with sequence similarity 13, member A | 0.0139126 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0139043 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0138865 |
| B2M | beta-2-microglobulin | 0.0137197 |
| DUSP5 | dual specificity phosphatase 5 | 0.0136951 |
| SLTM | SAFB-like, transcription modulator | 0.013526 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0133898 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.01334 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0132814 |
| XPO1 | exportin 1 | 0.013263 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0131827 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0130978 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0129857 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0128722 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0128021 |
| PLPP6 | phospholipid phosphatase 6 | 0.0126942 |
| ZFR | zinc finger RNA binding protein | 0.0125871 |
| SEPTIN9 | septin 9 | 0.0125297 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.100562 |
| NRG1 | neuregulin 1 | -0.0923133 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0733358 |
| FN1 | fibronectin 1 | -0.0549082 |
| PTMA | prothymosin, alpha | -0.0517484 |
| TMSB10 | thymosin beta 10 | -0.050884 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0387964 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0356568 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0351946 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0349306 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0346948 |
| VCL | vinculin | -0.0330649 |
| HMGA2 | high mobility group AT-hook 2 | -0.0326453 |
| PLIN2 | perilipin 2 | -0.0320394 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0316344 |
| S100A6 | S100 calcium binding protein A6 | -0.0291157 |
| VIM | vimentin | -0.0285936 |
| FTL | ferritin, light polypeptide | -0.0268389 |
| ACTG1 | actin gamma 1 | -0.0266031 |
| STC2 | stanniocalcin 2 | -0.0263389 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.025734 |
| PALLD | palladin, cytoskeletal associated protein | -0.0245333 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0243957 |
| RAI14 | retinoic acid induced 14 | -0.0242571 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0232275 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0219867 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0217347 |
| POTEF | POTE ankyrin domain family, member F | -0.0216439 |
| INTS6 | integrator complex subunit 6 | -0.0207053 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0202975 |
| MYOF | myoferlin | -0.0198535 |
| S100A10 | S100 calcium binding protein A10 | -0.0195595 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.019542 |
| LRRC23 | leucine rich repeat containing 23 | -0.0192073 |
| NDRG1 | N-myc downstream regulated 1 | -0.0185962 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.01804 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0179364 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0176169 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0173815 |
| LMNA | lamin A/C | -0.0172991 |
| SFRP1 | secreted frizzled-related protein 1 | -0.016961 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0168902 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0168711 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0164233 |
| HMGA1 | high mobility group AT-hook 1 | -0.0163662 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0162789 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0162149 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0161966 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0161215 |
| EFNA5 | ephrin-A5 | -0.0159952 |
| RPLP1 | ribosomal protein, large, P1 | -0.0157355 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0156948 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0154335 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0153308 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0152358 |
| GNAS | GNAS complex locus | -0.014957 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0148207 |
| CADM1 | cell adhesion molecule 1 | -0.0144859 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0142388 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0142255 |
| CTBP2 | C-terminal binding protein 2 | -0.0142227 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0142089 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0141626 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0140551 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0140184 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0139514 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0135807 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0135378 |
| ASPH | aspartate beta-hydroxylase | -0.0134282 |
| IER3 | immediate early response 3 | -0.0133109 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0133089 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0130549 |
| SFTPA2 | surfactant protein A2 | -0.0129533 |
| PRKCA | protein kinase C, alpha | -0.0127321 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0126633 |
| LMO7 | LIM domain 7 | -0.0125656 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0124738 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0123702 |
| RPS24 | ribosomal protein S24 | -0.0123644 |
| AEBP2 | AE binding protein 2 | -0.0123164 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0122919 |
| GOLGB1 | golgin B1 | -0.0120717 |
| MORF4L2 | mortality factor 4 like 2 | -0.0120067 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.011941 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0118703 |
| MYO1E | myosin IE | -0.011853 |
| RASAL2 | RAS protein activator like 2 | -0.0117675 |
| RPS16 | ribosomal protein S16 | -0.0117208 |
| TENM4 | teneurin transmembrane protein 4 | -0.0117183 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0116923 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0116481 |
| RPL37A | ribosomal protein L37a | -0.0115954 |
| CTSD | cathepsin D | -0.0114855 |
| UBAP2 | ubiquitin associated protein 2 | -0.0113801 |
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | -0.0111365 |
| DSTN | destrin (actin depolymerizing factor) | -0.0111352 |
| RAB10 | RAB10, member RAS oncogene family | -0.010843 |
| TPM4 | tropomyosin 4 | -0.0108297 |
| RND3 | Rho family GTPase 3 | -0.0105062 |
| FLNB | filamin B, beta | -0.0103721 |
