| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Benztropine (mesylate) perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Benztropine (mesylate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.081982 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0600405 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0557325 |
| XPO1 | exportin 1 | 0.0555471 |
| H1-0 | H1.0 linker histone | 0.0546484 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0510137 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0482945 |
| AHNAK | AHNAK nucleoprotein | 0.0470105 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0439357 |
| CCNL1 | cyclin L1 | 0.0435347 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0411188 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0406002 |
| NCKAP1 | NCK-associated protein 1 | 0.0383529 |
| USP3 | ubiquitin specific peptidase 3 | 0.0382606 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0377297 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0368086 |
| ZNF292 | zinc finger protein 292 | 0.0360487 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0354248 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0352193 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0350372 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0350038 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0346418 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0340938 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0332388 |
| OGA | O-GlcNAcase | 0.0327413 |
| ANXA11 | annexin A11 | 0.0323347 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.031948 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0318845 |
| SNX9 | sorting nexin 9 | 0.0318684 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0297147 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0295076 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.029483 |
| EZR | ezrin | 0.0285622 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0283901 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0280965 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0271675 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0264444 |
| FAM3C | family with sequence similarity 3, member C | 0.0262809 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0262666 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0261628 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0257064 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.025684 |
| PRELID2 | PRELI domain containing 2 | 0.0245789 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0242156 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0238785 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0238592 |
| RYBP | RING1 and YY1 binding protein | 0.0234667 |
| TMEM41B | transmembrane protein 41B | 0.0234303 |
| ARRDC3 | arrestin domain containing 3 | 0.0233489 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0232696 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0231431 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0231125 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0230407 |
| RTN4 | reticulon 4 | 0.0230367 |
| PDS5B | PDS5 cohesin associated factor B | 0.0230313 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0228183 |
| PLEC | plectin | 0.0226795 |
| SERINC5 | serine incorporator 5 | 0.0224758 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0223699 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0220542 |
| FLNA | filamin A, alpha | 0.0220533 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.0219504 |
| HOXA3 | homeobox A3 | 0.0218719 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.021832 |
| RNF213 | ring finger protein 213 | 0.0217983 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0215785 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0214055 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.021212 |
| TPM3 | tropomyosin 3 | 0.0210362 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0209141 |
| TBC1D5 | TBC1 domain family, member 5 | 0.020899 |
| FAT1 | FAT atypical cadherin 1 | 0.0204748 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0204444 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0204198 |
| AFDN | afadin, adherens junction formation factor | 0.0201718 |
| JUN | jun proto-oncogene | 0.0201133 |
| BRD2 | bromodomain containing 2 | 0.019971 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0198086 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0197356 |
| PHIP | pleckstrin homology domain interacting protein | 0.0196202 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0195984 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0195251 |
| STAG2 | stromal antigen 2 | 0.0194719 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.0194263 |
| YAP1 | Yes-associated protein 1 | 0.0193605 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.0191475 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0191185 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0188117 |
| H2AC6 | H2A clustered histone 6 | 0.0187382 |
| APP | amyloid beta (A4) precursor protein | 0.0186796 |
| NPTN | neuroplastin | 0.0183908 |
| TXNIP | thioredoxin interacting protein | 0.0183717 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0183448 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | 0.0183353 |
| ATP13A3 | ATPase type 13A3 | 0.0181721 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0181204 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.018025 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0179849 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0179689 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0179605 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.205806 |
| PTMA | prothymosin, alpha | -0.119493 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.103741 |
| TMSB10 | thymosin beta 10 | -0.102405 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0705607 |
| RPS6 | ribosomal protein S6 | -0.0670624 |
| RPLP1 | ribosomal protein, large, P1 | -0.0625911 |
| RPL35A | ribosomal protein L35a | -0.0544688 |
| RPL12 | ribosomal protein L12 | -0.0532714 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0531031 |
| RPL31 | ribosomal protein L31 | -0.0523732 |
| KRT18 | keratin 18, type I | -0.0521932 |
| LDHA | lactate dehydrogenase A | -0.0519304 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0474575 |
| PERP | PERP, TP53 apoptosis effector | -0.0433744 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0431788 |
| RPS19 | ribosomal protein S19 | -0.0429096 |
| HM13 | histocompatibility (minor) 13 | -0.0424666 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.041937 |
| EGR1 | early growth response 1 | -0.0412187 |
| RPL23 | ribosomal protein L23 | -0.0410411 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0402059 |
| RPS21 | ribosomal protein S21 | -0.0400128 |
| RPS24 | ribosomal protein S24 | -0.0384572 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0374954 |
| RPL37A | ribosomal protein L37a | -0.0373429 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0373017 |
| GNAS | GNAS complex locus | -0.037273 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0351215 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0338517 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0337522 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0335853 |
| S100A6 | S100 calcium binding protein A6 | -0.0333257 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0332503 |
| GOLGB1 | golgin B1 | -0.0332343 |
| RPLP0 | ribosomal protein, large, P0 | -0.0331602 |
| RPLP2 | ribosomal protein, large, P2 | -0.0326574 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0322923 |
| S100A10 | S100 calcium binding protein A10 | -0.0316374 |
| RPS8 | ribosomal protein S8 | -0.0309774 |
| RPS25 | ribosomal protein S25 | -0.0308746 |
| RPS5 | ribosomal protein S5 | -0.0307401 |
| RPS11 | ribosomal protein S11 | -0.0302604 |
| TMEM123 | transmembrane protein 123 | -0.0300547 |
| RPS14 | ribosomal protein S14 | -0.0290064 |
| RPL32 | ribosomal protein L32 | -0.0289121 |
| IER3 | immediate early response 3 | -0.027899 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0276671 |
| MYO1E | myosin IE | -0.0275623 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0275411 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0270585 |
| HMGA1 | high mobility group AT-hook 1 | -0.0269697 |
| BCL2L1 | BCL2-like 1 | -0.0267616 |
| RPS17 | ribosomal protein S17 | -0.0266947 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0264079 |
| WWC1 | WW and C2 domain containing 1 | -0.0262786 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0260909 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0259053 |
| RPL27A | ribosomal protein L27a | -0.0257856 |
| RPS27A | ribosomal protein S27a | -0.0254078 |
| MORF4L2 | mortality factor 4 like 2 | -0.0251167 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0250971 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0247069 |
| CST3 | cystatin C | -0.0246861 |
| RPL36A | ribosomal protein L36a | -0.0245756 |
| RPL7A | ribosomal protein L7a | -0.0240169 |
| RPS27 | ribosomal protein S27 | -0.0239056 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0238534 |
| RCOR1 | REST corepressor 1 | -0.0235887 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0235531 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0234406 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0232669 |
| TJP1 | tight junction protein 1 | -0.0226652 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.022665 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.021937 |
| CTSD | cathepsin D | -0.0219316 |
| FRMD5 | FERM domain containing 5 | -0.0218562 |
| RPS16 | ribosomal protein S16 | -0.0216893 |
| INTS6 | integrator complex subunit 6 | -0.0216771 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0215759 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0215058 |
| RPS29 | ribosomal protein S29 | -0.0214365 |
| RPL9 | ribosomal protein L9 | -0.0212234 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.0212118 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0211543 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0210837 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0208656 |
| RPL34 | ribosomal protein L34 | -0.0208091 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0206932 |
| HDLBP | high density lipoprotein binding protein | -0.0206427 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.020548 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0201151 |
| RPL39 | ribosomal protein L39 | -0.0200578 |
| SETX | senataxin | -0.0199614 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0199363 |
| RPL37 | ribosomal protein L37 | -0.0198473 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0197331 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0196935 |
| RPL35 | ribosomal protein L35 | -0.0196642 |
| RPL28 | ribosomal protein L28 | -0.0195501 |
