Benztropine (mesylate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Benztropine (mesylate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Benztropine (mesylate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.116848
INHBA inhibin, beta A 0.11126
STC1 stanniocalcin 1 0.104992
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0892733
CD44 CD44 molecule (Indian blood group) 0.0838221
HMGA2 high mobility group AT-hook 2 0.0767778
FN1 fibronectin 1 0.0659592
AKAP12 A kinase (PRKA) anchor protein 12 0.0617991
VEGFA vascular endothelial growth factor A 0.0608001
ATP13A3 ATPase type 13A3 0.0555259
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0534257
NAV1 neuron navigator 1 0.0514161
NALF1 NALCN channel auxiliary factor 1 0.050819
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0502663
MYH9 myosin, heavy chain 9, non-muscle 0.047923
FTH1 ferritin, heavy polypeptide 1 0.0473767
PRKG1 protein kinase, cGMP-dependent, type I 0.0408313
ADGRB3 adhesion G protein-coupled receptor B3 0.040524
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0393572
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0375934
NDRG1 N-myc downstream regulated 1 0.0346799
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.033913
LIMS1 LIM and senescent cell antigen-like domains 1 0.0329174
ELL2 elongation factor, RNA polymerase II, 2 0.032804
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0323166
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0312045
LOXL2 lysyl oxidase-like 2 0.0302354
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0285006
WNT5A wingless-type MMTV integration site family, member 5A 0.0280951
PDE4D phosphodiesterase 4D, cAMP-specific 0.0280617
GLIS3 GLIS family zinc finger 3 0.0246615
RAI14 retinoic acid induced 14 0.0242787
FAM13A family with sequence similarity 13, member A 0.0241317
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0239117
COL6A1 collagen, type VI, alpha 1 0.0232704
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0224445
RUNX1 runt-related transcription factor 1 0.0224286
EGFR epidermal growth factor receptor 0.0210558
COL6A2 collagen, type VI, alpha 2 0.0205136
MYO10 myosin X 0.0204815
OSMR oncostatin M receptor 0.0202545
COL5A3 collagen, type V, alpha 3 0.0195066
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0194862
MEIS1 Meis homeobox 1 0.0192787
SMAD3 SMAD family member 3 0.0191011
AHNAK AHNAK nucleoprotein 0.01891
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0185455
GREM1 gremlin 1, DAN family BMP antagonist 0.0183523
SASH1 SAM and SH3 domain containing 1 0.0183268
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.018274
OXR1 oxidation resistance 1 0.0180565
DST dystonin 0.0169491
PDE8A phosphodiesterase 8A 0.0164155
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0162359
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.0160565
TGFBI transforming growth factor, beta-induced, 68kDa 0.0158819
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0156224
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0156134
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.015568
PLPP3 phospholipid phosphatase 3 0.0154041
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0152211
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.015209
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0151391
NOTCH2 notch 2 0.0151087
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0149237
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0148552
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0148342
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0147259
VEGFC vascular endothelial growth factor C 0.0144334
TPM3 tropomyosin 3 0.0142744
SEPTIN9 septin 9 0.0141869
FLNA filamin A, alpha 0.0141111
ITGA11 integrin, alpha 11 0.0138455
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0137891
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0136595
LOX lysyl oxidase 0.0136212
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0136066
SMOX spermine oxidase 0.0135379
ASPH aspartate beta-hydroxylase 0.0135202
EXT1 exostosin glycosyltransferase 1 0.0134713
NT5E 5'-nucleotidase, ecto (CD73) 0.0129146
EPAS1 endothelial PAS domain protein 1 0.0128446
RAD51B RAD51 paralog B 0.0125331
JARID2 jumonji, AT rich interactive domain 2 0.0122807
ERRFI1 ERBB receptor feedback inhibitor 1 0.0122198
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0122171
SRRM2 serine/arginine repetitive matrix 2 0.0121444
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0121416
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0121051
KIAA1549L KIAA1549-like 0.0120376
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0120025
MMP12 matrix metallopeptidase 12 0.0117015
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0116663
MACF1 microtubule-actin crosslinking factor 1 0.0116162
ARHGAP21 Rho GTPase activating protein 21 0.0115148
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0115042
SPRED1 sprouty-related, EVH1 domain containing 1 0.0115015
FRMD4A FERM domain containing 4A 0.0113185
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0110572
HAS2 hyaluronan synthase 2 0.0107987

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.235525
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.175615
TMSB10 thymosin beta 10 -0.101156
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0744517
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0691589
FTL ferritin, light polypeptide -0.0674362
TPT1 tumor protein, translationally-controlled 1 -0.0529467
RPLP1 ribosomal protein, large, P1 -0.052719
CAVIN1 caveolae associated protein 1 -0.0397883
LDHA lactate dehydrogenase A -0.0373554
EIF1 eukaryotic translation initiation factor 1 -0.0350676
IER3 immediate early response 3 -0.0346148
MT2A metallothionein 2A -0.03326
ADM adrenomedullin -0.0310497
PTMA prothymosin, alpha -0.0303874
RPS6 ribosomal protein S6 -0.0303447
TM4SF1 transmembrane 4 L six family member 1 -0.029656
GOLGA4 golgin A4 -0.0270235
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0267761
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0247148
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0240938
RPL34 ribosomal protein L34 -0.0232537
RPL35A ribosomal protein L35a -0.0229858
TPM4 tropomyosin 4 -0.0221822
RPS24 ribosomal protein S24 -0.0220212
MORF4L2 mortality factor 4 like 2 -0.0215726
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0212058
LMNA lamin A/C -0.0210913
KDM3A lysine (K)-specific demethylase 3A -0.0202237
RPS19 ribosomal protein S19 -0.0202082
GNAS GNAS complex locus -0.0201742
RPL31 ribosomal protein L31 -0.0201087
HDLBP high density lipoprotein binding protein -0.0201006
ACTG1 actin gamma 1 -0.019447
WSB1 WD repeat and SOCS box containing 1 -0.0192694
POTEF POTE ankyrin domain family, member F -0.0189573
S100A6 S100 calcium binding protein A6 -0.0189041
RPL32 ribosomal protein L32 -0.018579
CLINT1 clathrin interactor 1 -0.0183443
VDAC1 voltage-dependent anion channel 1 -0.0181585
FUS FUS RNA binding protein -0.0180375
RRBP1 ribosome binding protein 1 -0.0178655
RPL37A ribosomal protein L37a -0.0175531
S100A10 S100 calcium binding protein A10 -0.0175472
BTG1 B-cell translocation gene 1, anti-proliferative -0.0174779
HILPDA hypoxia inducible lipid droplet-associated -0.0174553
CALR calreticulin -0.0167731
RPLP0 ribosomal protein, large, P0 -0.0166858
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0165106
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0161921
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0158948
RAB2A RAB2A, member RAS oncogene family -0.0156986
RBM39 RNA binding motif protein 39 -0.0156696
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0156046
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0155849
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0155802
CD63 CD63 molecule -0.015485
HLA-B major histocompatibility complex, class I, B -0.0151475
RPL9 ribosomal protein L9 -0.0149454
NOP58 NOP58 ribonucleoprotein -0.0146627
HMGB2 high mobility group box 2 -0.0146348
RPL23 ribosomal protein L23 -0.0146143
RPL8 ribosomal protein L8 -0.0142571
RPL11 ribosomal protein L11 -0.0141855
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0141252
RPS5 ribosomal protein S5 -0.0138727
LMAN1 lectin, mannose-binding, 1 -0.0138023
RPL12 ribosomal protein L12 -0.0135283
RPLP2 ribosomal protein, large, P2 -0.0135054
PKM pyruvate kinase, muscle -0.0134741
RPL4 ribosomal protein L4 -0.0133431
RPL27A ribosomal protein L27a -0.0131312
HMGA1 high mobility group AT-hook 1 -0.0130355
RPL26 ribosomal protein L26 -0.0129869
WDR45B WD repeat domain 45B -0.0128781
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0124769
ARF1 ADP-ribosylation factor 1 -0.0124137
LOC112694756 uncharaterized LOC112694756 -0.0123138
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0120703
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0119794
RAB7A RAB7A, member RAS oncogene family -0.0119345
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0118385
FAM162A family with sequence similarity 162, member A -0.0118247
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0117173
RPL30 ribosomal protein L30 -0.0116937
RPS20 ribosomal protein S20 -0.0116925
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0116805
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0116747
RNF145 ring finger protein 145 -0.0115896
SOD2 superoxide dismutase 2, mitochondrial -0.0113736
RPS16 ribosomal protein S16 -0.0113639
HBP1 HMG-box transcription factor 1 -0.0112142
SEC24D SEC24 family member D -0.0111386
SEPTIN2 septin 2 -0.0110573
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0109851
RLF rearranged L-myc fusion -0.0108822
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0108808
TCEAL9 transcription elongation factor A like 9 -0.0108436
RPL7A ribosomal protein L7a -0.0108091
SPDYA speedy/RINGO cell cycle regulator family member A -0.0108078