Berbamine (dihydrochloride)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.309686
FBN1 fibrillin 1 0.211378
ANXA2 annexin A2 0.0983595
FNDC3B fibronectin type III domain containing 3B 0.0963779
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0942282
CD44 CD44 molecule (Indian blood group) 0.0832725
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.080668
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0774702
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0769853
LOXL2 lysyl oxidase-like 2 0.0749505
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0724989
COL8A1 collagen, type VIII, alpha 1 0.0702726
VIM vimentin 0.065234
IQGAP1 IQ motif containing GTPase activating protein 1 0.0639613
PSD3 pleckstrin and Sec7 domain containing 3 0.0636684
ATP13A3 ATPase type 13A3 0.0631448
ELL2 elongation factor, RNA polymerase II, 2 0.0585283
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0583046
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.05576
COL1A2 collagen, type I, alpha 2 0.055619
COL3A1 collagen, type III, alpha 1 0.0547405
GLS2 glutaminase 2 (liver, mitochondrial) 0.0542474
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0526121
RTN4 reticulon 4 0.0502839
PDIA3 protein disulfide isomerase family A, member 3 0.0494681
PLAT plasminogen activator, tissue 0.0489402
STC1 stanniocalcin 1 0.0487884
SOD2 superoxide dismutase 2, mitochondrial 0.0472003
PALM2AKAP2 PALM2 and AKAP2 fusion 0.046417
OGA O-GlcNAcase 0.0460674
CD99 CD99 molecule 0.0458081
UBC ubiquitin C 0.0450437
SBF2 SET binding factor 2 0.0434542
LOX lysyl oxidase 0.0431014
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.041492
DPYSL2 dihydropyrimidinase-like 2 0.0407155
ARL15 ADP-ribosylation factor-like 15 0.039786
OPTN optineurin 0.0397334
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0396351
DPYSL3 dihydropyrimidinase-like 3 0.0383176
AKAP12 A kinase (PRKA) anchor protein 12 0.038282
KIFAP3 kinesin-associated protein 3 0.0380563
ADAM17 ADAM metallopeptidase domain 17 0.0380369
GPC6 glypican 6 0.0378933
WWTR1 WW domain containing transcription regulator 1 0.0371695
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0369016
ARRDC3 arrestin domain containing 3 0.0366097
TNIP1 TNFAIP3 interacting protein 1 0.0365777
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0365351
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0352121
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0351619
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0347737
YEATS2 YEATS domain containing 2 0.0346596
RHOBTB3 Rho-related BTB domain containing 3 0.0346002
SEPTIN9 septin 9 0.0339905
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0338659
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0338339
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0337657
GOLGA4 golgin A4 0.0337469
ANXA5 annexin A5 0.0334822
SQSTM1 sequestosome 1 0.0332396
LOC112694756 uncharaterized LOC112694756 0.0330406
NAV2 neuron navigator 2 0.0327707
TDRD7 tudor domain containing 7 0.0321844
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0321269
WDFY1 WD repeat and FYVE domain containing 1 0.0319752
ITPRID2 ITPR interacting domain containing 2 0.0319335
MYH9 myosin, heavy chain 9, non-muscle 0.0318875
FRMD5 FERM domain containing 5 0.0315663
CTSB cathepsin B 0.031534
FADS2 fatty acid desaturase 2 0.0310602
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0309684
EIF4H eukaryotic translation initiation factor 4H 0.0306349
DST dystonin 0.0305589
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0299973
CLIP2 CAP-GLY domain containing linker protein 2 0.0291805
AHNAK2 AHNAK nucleoprotein 2 0.0289944
ZBTB7C zinc finger and BTB domain containing 7C 0.0289559
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0286022
FTH1 ferritin, heavy polypeptide 1 0.0283768
ZNF148 zinc finger protein 148 0.0283329
RAB6A RAB6A, member RAS oncogene family 0.0281969
FNIP1 folliculin interacting protein 1 0.0280902
EIF1 eukaryotic translation initiation factor 1 0.028068
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0275952
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0274294
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0271202
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0269684
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0267077
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0266295
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.0264469
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0263715
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0259775
JMJD1C jumonji domain containing 1C 0.0259542
VCL vinculin 0.0256536
TMOD1 tropomodulin 1 0.0254691
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0252901
SRRM2 serine/arginine repetitive matrix 2 0.0250413
UBAP1 ubiquitin associated protein 1 0.0248717
MXI1 MAX interactor 1, dimerization protein 0.0247739

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.191157
COL5A1 collagen, type V, alpha 1 -0.160125
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.158735
CDH13 cadherin 13 -0.14026
TMSB10 thymosin beta 10 -0.130779
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0975518
ABI3BP ABI family, member 3 (NESH) binding protein -0.0968858
FN1 fibronectin 1 -0.0931506
RIGI RNA sensor RIG-I -0.09109
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0881678
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.083993
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0744964
SAMD9 sterile alpha motif domain containing 9 -0.0712712
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0647079
MT1X metallothionein 1X -0.0633281
RSAD2 radical S-adenosyl methionine domain containing 2 -0.058437
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0579854
EFNA5 ephrin-A5 -0.0524822
RNF213 ring finger protein 213 -0.0501706
TRIO trio Rho guanine nucleotide exchange factor -0.0461457
SLC39A11 solute carrier family 39, member 11 -0.0441443
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0435192
ASPH aspartate beta-hydroxylase -0.0415914
MAP1B microtubule-associated protein 1B -0.041403
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0397122
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0363757
AHNAK AHNAK nucleoprotein -0.0357789
MACF1 microtubule-actin crosslinking factor 1 -0.0356961
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0356175
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0354891
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0350549
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0333338
CAVIN1 caveolae associated protein 1 -0.0332095
SORBS2 sorbin and SH3 domain containing 2 -0.0330017
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0325541
PCDH7 protocadherin 7 -0.0321473
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0318318
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0304631
LMNA lamin A/C -0.0302193
DGKG diacylglycerol kinase, gamma 90kDa -0.0301174
OASL 2'-5'-oligoadenylate synthetase-like -0.0299142
INTS6 integrator complex subunit 6 -0.0292863
PLXNA2 plexin A2 -0.0289819
SLC38A1 solute carrier family 38, member 1 -0.0288613
MX2 MX dynamin-like GTPase 2 -0.0281132
PRSS23 protease, serine, 23 -0.0280344
IL7R interleukin 7 receptor -0.0273898
TNS3 tensin 3 -0.0269621
IARS1 isoleucyl-tRNA synthetase 1 -0.0259972
FLT1 fms-related tyrosine kinase 1 -0.0257755
MBNL1 muscleblind-like splicing regulator 1 -0.0251558
SH3RF3 SH3 domain containing ring finger 3 -0.0249498
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0246974
CENPF centromere protein F, 350/400kDa -0.0244551
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0240321
SP100 SP100 nuclear antigen -0.0239314
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0235542
EGFR epidermal growth factor receptor -0.0229434
AEBP2 AE binding protein 2 -0.0228335
DIAPH3 diaphanous-related formin 3 -0.022809
ANKRD11 ankyrin repeat domain 11 -0.0223432
CUX1 cut-like homeobox 1 -0.0222354
MED13L mediator complex subunit 13-like -0.0222311
ALCAM activated leukocyte cell adhesion molecule -0.0221165
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0220275
FSTL1 follistatin-like 1 -0.0220162
KIAA1549L KIAA1549-like -0.0219362
RPTOR regulatory associated protein of MTOR, complex 1 -0.0219035
SDCCAG8 serologically defined colon cancer antigen 8 -0.0218835
TMSB4X thymosin beta 4, X-linked -0.0217602
SYT1 synaptotagmin I -0.0217435
VEGFA vascular endothelial growth factor A -0.0216313
NALF1 NALCN channel auxiliary factor 1 -0.0216249
PEA15 phosphoprotein enriched in astrocytes 15 -0.0215191
TPM1 tropomyosin 1 (alpha) -0.0214482
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0213758
OR51B5 olfactory receptor, family 51, subfamily B, member 5 -0.0213472
COL6A1 collagen, type VI, alpha 1 -0.0211832
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0211556
TBCA tubulin folding cofactor A -0.0208315
TAGLN2 transgelin 2 -0.0205109
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0203986
HLA-B major histocompatibility complex, class I, B -0.020373
PODXL podocalyxin-like -0.0203359
IFITM3 interferon induced transmembrane protein 3 -0.0201596
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0201445
MCL1 myeloid cell leukemia 1 -0.0201055
SMC4 structural maintenance of chromosomes 4 -0.0201015
PBX3 pre-B-cell leukemia homeobox 3 -0.0199799
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0198668
PDE4D phosphodiesterase 4D, cAMP-specific -0.0196718
NAP1L1 nucleosome assembly protein 1-like 1 -0.0196407
RAD51B RAD51 paralog B -0.0195203
PLCB4 phospholipase C, beta 4 -0.0194203
ATF4 activating transcription factor 4 -0.0192939
NAV1 neuron navigator 1 -0.0192876
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0190737
FNDC3A fibronectin type III domain containing 3A -0.0190367
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0187747
SEC61G Sec61 gamma subunit -0.0187151