Berbamine (dihydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPC6 glypican 6 0.114622
RPL35A ribosomal protein L35a 0.0810439
P3H2 prolyl 3-hydroxylase 2 0.0714139
VCL vinculin 0.0679944
EXT1 exostosin glycosyltransferase 1 0.0636632
NDRG1 N-myc downstream regulated 1 0.0633262
RTN4 reticulon 4 0.0616508
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0576658
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0555997
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0526844
EIF4H eukaryotic translation initiation factor 4H 0.0515397
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0504182
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0488352
CLTC clathrin, heavy chain (Hc) 0.0442007
CMIP c-Maf inducing protein 0.0438079
NRIP1 nuclear receptor interacting protein 1 0.0430297
PBX1 pre-B-cell leukemia homeobox 1 0.0409281
ANKRD33B ankyrin repeat domain 33B 0.0407194
PAX8 paired box 8 0.0391988
CSF1 colony stimulating factor 1 (macrophage) 0.0382872
PALM2AKAP2 PALM2 and AKAP2 fusion 0.037701
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0351319
UGCG UDP-glucose ceramide glucosyltransferase 0.0347304
TRIO trio Rho guanine nucleotide exchange factor 0.0345606
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0333825
RAB2A RAB2A, member RAS oncogene family 0.0332546
RNF216 ring finger protein 216 0.0327459
KPNB1 karyopherin (importin) beta 1 0.0326772
ZFP36L1 ZFP36 ring finger protein-like 1 0.032538
ARHGAP26 Rho GTPase activating protein 26 0.0324462
DENND2B DENN domain containing 2B 0.032322
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0321549
EFHD2 EF-hand domain family, member D2 0.0312628
RRBP1 ribosome binding protein 1 0.0311639
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0309571
TLE4 transducin-like enhancer of split 4 0.03043
UBAP1 ubiquitin associated protein 1 0.0300951
MYO1E myosin IE 0.0298956
LMNA lamin A/C 0.0298165
PLEC plectin 0.0297262
TNS3 tensin 3 0.0296005
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0291798
FRMD5 FERM domain containing 5 0.0290331
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0286148
TGFB2 transforming growth factor, beta 2 0.0286029
BLZF1 basic leucine zipper nuclear factor 1 0.0279964
BIRC6 baculoviral IAP repeat containing 6 0.0278625
SLC35F3 solute carrier family 35, member F3 0.0275151
ANXA2 annexin A2 0.027483
RBM39 RNA binding motif protein 39 0.0273114
PRRC2C proline-rich coiled-coil 2C 0.0272353
WWC1 WW and C2 domain containing 1 0.0271718
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0262526
RPLP1 ribosomal protein, large, P1 0.0261658
RNF213 ring finger protein 213 0.0256128
HM13 histocompatibility (minor) 13 0.0254081
NOCT nocturnin 0.0253324
CAVIN1 caveolae associated protein 1 0.0252637
HPCAL1 hippocalcin-like 1 0.0252384
ZNF207 zinc finger protein 207 0.0249724
ACTN4 actinin, alpha 4 0.0246402
USP36 ubiquitin specific peptidase 36 0.0244419
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0244321
FOXO3 forkhead box O3 0.0244164
LOC112694756 uncharaterized LOC112694756 0.0243981
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0243275
DLG1 discs, large homolog 1 (Drosophila) 0.0243021
TUFT1 tuftelin 1 0.0242903
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.024197
FKBP10 FK506 binding protein 10, 65 kDa 0.0240108
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0239672
ADM adrenomedullin 0.0239641
SMAD3 SMAD family member 3 0.0238766
SURF4 surfeit 4 0.0236471
ACTG1 actin gamma 1 0.0235498
RAB18 RAB18, member RAS oncogene family 0.0234077
EIF1 eukaryotic translation initiation factor 1 0.023353
CLIP2 CAP-GLY domain containing linker protein 2 0.0230128
TRA2B transformer 2 beta homolog (Drosophila) 0.0229948
ARRDC3 arrestin domain containing 3 0.0226732
ADAM17 ADAM metallopeptidase domain 17 0.0226513
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0225495
MSR1 macrophage scavenger receptor 1 0.0221402
SRRM2 serine/arginine repetitive matrix 2 0.0220073
SHB Src homology 2 domain containing adaptor protein B 0.021799
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0217073
LOXL2 lysyl oxidase-like 2 0.0216167
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0215792
MBD5 methyl-CpG binding domain protein 5 0.021209
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0210796
EML4 echinoderm microtubule associated protein like 4 0.0210464
PGM3 phosphoglucomutase 3 0.0210279
NAP1L4 nucleosome assembly protein 1-like 4 0.0208851
RNF220 ring finger protein 220 0.0208325
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0207636
TJP1 tight junction protein 1 0.0206866
JAK1 Janus kinase 1 0.0206463
VDAC1 voltage-dependent anion channel 1 0.0206187
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0206034
ARHGAP17 Rho GTPase activating protein 17 0.0205571

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.332875
VIM vimentin -0.160124
TMSB10 thymosin beta 10 -0.159293
RPS27A ribosomal protein S27a -0.116294
UBC ubiquitin C -0.112067
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0930183
B2M beta-2-microglobulin -0.0929105
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0897942
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0894842
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0777553
APP amyloid beta (A4) precursor protein -0.0737056
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0715012
NAMPT nicotinamide phosphoribosyltransferase -0.0709999
JUN jun proto-oncogene -0.0707477
CANX calnexin -0.0698542
CD44 CD44 molecule (Indian blood group) -0.06452
AHNAK AHNAK nucleoprotein -0.0640725
CCL2 chemokine (C-C motif) ligand 2 -0.063275
CP ceruloplasmin (ferroxidase) -0.0564838
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0554619
SOD2 superoxide dismutase 2, mitochondrial -0.0531875
PDIA4 protein disulfide isomerase family A, member 4 -0.0527836
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.052093
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0508716
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0506101
SPDYA speedy/RINGO cell cycle regulator family member A -0.0497297
PDIA6 protein disulfide isomerase family A, member 6 -0.0466776
TPM3 tropomyosin 3 -0.0455878
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0455783
RPL23 ribosomal protein L23 -0.0449288
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0448726
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0426385
MT2A metallothionein 2A -0.0412189
EHBP1 EH domain binding protein 1 -0.0379742
NAP1L1 nucleosome assembly protein 1-like 1 -0.0372407
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0370743
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0370307
LDHA lactate dehydrogenase A -0.0369958
CALR calreticulin -0.0369309
ENO1 enolase 1, (alpha) -0.0366811
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0364313
PTMA prothymosin, alpha -0.036034
RAD21 RAD21 homolog (S. pombe) -0.0357956
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0347337
CA12 carbonic anhydrase XII -0.0344465
MAP1B microtubule-associated protein 1B -0.0339594
SET SET nuclear proto-oncogene -0.0331145
POTEF POTE ankyrin domain family, member F -0.0328643
TLN1 talin 1 -0.032821
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0325116
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0322985
PKM pyruvate kinase, muscle -0.031022
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0305201
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0303136
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0300293
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0299685
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0298719
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0287862
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0287414
EEF2 eukaryotic translation elongation factor 2 -0.0284999
FUS FUS RNA binding protein -0.0283787
TPM1 tropomyosin 1 (alpha) -0.0283557
CALU calumenin -0.0280246
SOD1 superoxide dismutase 1, soluble -0.0277554
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0277287
S100A6 S100 calcium binding protein A6 -0.0276813
SQLE squalene epoxidase -0.0270768
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0269935
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0257744
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0257671
VCAN versican -0.0254551
EIF4A2 eukaryotic translation initiation factor 4A2 -0.025204
CERS2 ceramide synthase 2 -0.0251029
VEGFA vascular endothelial growth factor A -0.0249909
NFE2L1 nuclear factor, erythroid 2-like 1 -0.0245829
FTH1 ferritin, heavy polypeptide 1 -0.0244862
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0242508
GPX3 glutathione peroxidase 3 -0.0241569
FAM107B family with sequence similarity 107, member B -0.0238398
TUSC3 tumor suppressor candidate 3 -0.0234279
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0234211
TFPI2 tissue factor pathway inhibitor 2 -0.0232143
GARS1 glycyl-tRNA synthetase 1 -0.0229615
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0228552
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0219486
AARS1 alanyl-tRNA synthetase 1 -0.0218501
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0216817
RIGI RNA sensor RIG-I -0.0215079
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0213895
HLA-E major histocompatibility complex, class I, E -0.0213043
DPYSL3 dihydropyrimidinase-like 3 -0.0211453
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0208198
MRFAP1 Morf4 family associated protein 1 -0.0207571
RPL4 ribosomal protein L4 -0.0204197
SAMD9 sterile alpha motif domain containing 9 -0.0203262
UGDH UDP-glucose 6-dehydrogenase -0.0202538
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.020178
G0S2 G0/G1 switch 2 -0.0201691
RPL26 ribosomal protein L26 -0.0199354
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0198611