Berbamine (dihydrochloride)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRKG1 protein kinase, cGMP-dependent, type I 0.0866463
PRELID2 PRELI domain containing 2 0.0687562
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0542081
MED13L mediator complex subunit 13-like 0.053607
TRA2A transformer 2 alpha homolog (Drosophila) 0.0534233
FGFR1 fibroblast growth factor receptor 1 0.0505637
ARHGAP21 Rho GTPase activating protein 21 0.0501308
THSD4 thrombospondin, type I, domain containing 4 0.0490889
EIF4H eukaryotic translation initiation factor 4H 0.0481025
OGA O-GlcNAcase 0.0448247
KAZN kazrin, periplakin interacting protein 0.0446581
PRRC2A proline-rich coiled-coil 2A 0.0435652
PDE10A phosphodiesterase 10A 0.0430597
FGFR2 fibroblast growth factor receptor 2 0.0413861
NFIB nuclear factor I/B 0.0385204
SRRM2 serine/arginine repetitive matrix 2 0.0376187
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0371946
SFPQ splicing factor proline/glutamine-rich 0.036822
CLTC clathrin, heavy chain (Hc) 0.0356389
XPO1 exportin 1 0.0334743
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0332339
CDK19 cyclin-dependent kinase 19 0.0323439
TRERF1 transcriptional regulating factor 1 0.0321561
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0319983
MEOX2 mesenchyme homeobox 2 0.031851
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.0300883
FBXL7 F-box and leucine-rich repeat protein 7 0.0292756
ATG5 autophagy related 5 0.0289322
KDM6A lysine (K)-specific demethylase 6A 0.0282956
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0277175
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0275187
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0274905
ITGAV integrin, alpha V 0.0271434
RPL3 ribosomal protein L3 0.0268769
BCLAF1 BCL2-associated transcription factor 1 0.0266728
LOC112694756 uncharaterized LOC112694756 0.0264391
ADNP activity-dependent neuroprotector homeobox 0.0264174
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.026303
YEATS2 YEATS domain containing 2 0.0262502
PANK3 pantothenate kinase 3 0.0261591
ERBIN erbb2 interacting protein 0.0261478
PARD3 par-3 family cell polarity regulator 0.0260114
RBM33 RNA binding motif protein 33 0.0259111
FLNA filamin A, alpha 0.0258596
ZNF207 zinc finger protein 207 0.0256952
VEZT vezatin, adherens junctions transmembrane protein 0.0254557
DIPK2A divergent protein kinase domain 2A 0.0254328
PIAS2 protein inhibitor of activated STAT, 2 0.0253279
CAMTA1 calmodulin binding transcription activator 1 0.0252609
NCKAP1 NCK-associated protein 1 0.0250194
FMNL2 formin-like 2 0.0249331
ADGRA3 adhesion G protein-coupled receptor A3 0.024313
RIMKLB ribosomal modification protein rimK-like family member B 0.0243066
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0240396
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.0240107
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0238734
UBA6 ubiquitin-like modifier activating enzyme 6 0.0236872
FBN1 fibrillin 1 0.0231722
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0230906
KIAA1958 KIAA1958 0.023062
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0230502
PDIA3 protein disulfide isomerase family A, member 3 0.0230439
BCOR BCL6 corepressor 0.0227959
MRTFA myocardin related transcription factor A 0.0223716
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0223478
PRKN parkin RBR E3 ubiquitin protein ligase 0.022208
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0221326
ATG10 autophagy related 10 0.0219554
NAV1 neuron navigator 1 0.02191
MEIS2 Meis homeobox 2 0.0217316
NCOR1 nuclear receptor corepressor 1 0.0214944
TNRC6B trinucleotide repeat containing 6B 0.0214741
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0214652
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.021459
HOXA3 homeobox A3 0.0212991
MAP2K5 mitogen-activated protein kinase kinase 5 0.0211682
CABIN1 calcineurin binding protein 1 0.0211108
TET3 tet methylcytosine dioxygenase 3 0.0210962
NSD1 nuclear receptor binding SET domain protein 1 0.0209928
DNAAF9 dynein axonemal assembly factor 9 0.020953
RNF130 ring finger protein 130 0.0209515
LINGO2 leucine rich repeat and Ig domain containing 2 0.0209126
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0208132
TNRC18 trinucleotide repeat containing 18 0.020607
ARID1A AT rich interactive domain 1A (SWI-like) 0.0205929
FOXO3 forkhead box O3 0.0203594
ITCH itchy E3 ubiquitin protein ligase 0.020323
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0198796
JARID2 jumonji, AT rich interactive domain 2 0.019866
JMJD1C jumonji domain containing 1C 0.0197631
PCM1 pericentriolar material 1 0.0197405
ARHGAP12 Rho GTPase activating protein 12 0.0195527
ZRANB1 zinc finger, RAN-binding domain containing 1 0.0193579
RAB14 RAB14, member RAS oncogene family 0.019246
BRWD1 bromodomain and WD repeat domain containing 1 0.0191401
N4BP2L2 NEDD4 binding protein 2-like 2 0.018959
CALR calreticulin 0.0188601
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0188021
FCHSD2 FCH and double SH3 domains 2 0.0187875
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.0187235

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.218837
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.215777
PTMA prothymosin, alpha -0.108416
TMSB10 thymosin beta 10 -0.100219
RPS8 ribosomal protein S8 -0.0879142
IER3 immediate early response 3 -0.0809417
RPS6 ribosomal protein S6 -0.0791585
MT2A metallothionein 2A -0.0751982
LDHA lactate dehydrogenase A -0.0748362
RPLP1 ribosomal protein, large, P1 -0.0645024
RPS27A ribosomal protein S27a -0.0630259
MAP1B microtubule-associated protein 1B -0.0621572
RPL31 ribosomal protein L31 -0.0607038
MKI67 marker of proliferation Ki-67 -0.059061
RPL34 ribosomal protein L34 -0.0588233
RPS13 ribosomal protein S13 -0.0588216
RPLP2 ribosomal protein, large, P2 -0.0580447
VEGFA vascular endothelial growth factor A -0.0578709
CADM2 cell adhesion molecule 2 -0.0575827
RAD21 RAD21 homolog (S. pombe) -0.0574268
PEG10 paternally expressed 10 -0.0571217
RPS14 ribosomal protein S14 -0.0555851
MGP matrix Gla protein -0.0539691
SOX4 SRY (sex determining region Y)-box 4 -0.0534464
HMGA2 high mobility group AT-hook 2 -0.0527773
ENO1 enolase 1, (alpha) -0.0524481
RPLP0 ribosomal protein, large, P0 -0.0520706
TCF12 transcription factor 12 -0.0508103
FTL ferritin, light polypeptide -0.0503425
ACTG1 actin gamma 1 -0.0487621
RPL35A ribosomal protein L35a -0.0485476
TPT1 tumor protein, translationally-controlled 1 -0.0483757
RPS19 ribosomal protein S19 -0.0472312
CENPF centromere protein F, 350/400kDa -0.0464882
S100A9 S100 calcium binding protein A9 -0.0454712
RPL12 ribosomal protein L12 -0.045195
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0448469
RPS4X ribosomal protein S4, X-linked -0.0441743
FN1 fibronectin 1 -0.0440057
RPL37A ribosomal protein L37a -0.0432589
TMSB4X thymosin beta 4, X-linked -0.0432022
RPS23 ribosomal protein S23 -0.0430559
FNDC3B fibronectin type III domain containing 3B -0.0430156
HDLBP high density lipoprotein binding protein -0.0413085
RPS24 ribosomal protein S24 -0.0411168
RPS11 ribosomal protein S11 -0.0410514
NAP1L1 nucleosome assembly protein 1-like 1 -0.0406582
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0402913
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0400082
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0389364
AHNAK AHNAK nucleoprotein -0.0384336
RPL23 ribosomal protein L23 -0.0382546
DLG1 discs, large homolog 1 (Drosophila) -0.038213
HMGA1 high mobility group AT-hook 1 -0.0376546
HMGB1 high mobility group box 1 -0.0376395
ASPH aspartate beta-hydroxylase -0.0362701
ZNF292 zinc finger protein 292 -0.0361983
PGK1 phosphoglycerate kinase 1 -0.0357603
LOC102724023 ES1 protein homolog, mitochondrial -0.0355486
PAPOLA poly(A) polymerase alpha -0.034528
RAI1 retinoic acid induced 1 -0.0343321
RACK1 receptor for activated C kinase 1 -0.0337691
CENPE centromere protein E, 312kDa -0.0331525
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0330875
RPL37 ribosomal protein L37 -0.0328043
AKAP12 A kinase (PRKA) anchor protein 12 -0.0326857
TPM4 tropomyosin 4 -0.0326624
SFTPA2 surfactant protein A2 -0.0324519
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0323147
RAB7A RAB7A, member RAS oncogene family -0.0322048
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0322013
RPS29 ribosomal protein S29 -0.0321883
RPL28 ribosomal protein L28 -0.0319635
COG5 component of oligomeric golgi complex 5 -0.0318642
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0316435
ZFAND3 zinc finger, AN1-type domain 3 -0.0311695
FOXC1 forkhead box C1 -0.0310846
CUX1 cut-like homeobox 1 -0.0308577
UBE2H ubiquitin-conjugating enzyme E2H -0.0307438
GLG1 golgi glycoprotein 1 -0.0291138
RPL38 ribosomal protein L38 -0.0282735
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0278907
B2M beta-2-microglobulin -0.0278854
POTEF POTE ankyrin domain family, member F -0.0277337
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0273305
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0272477
ZNF106 zinc finger protein 106 -0.0272341
RPS21 ribosomal protein S21 -0.0270077
RPL7A ribosomal protein L7a -0.0269856
UBC ubiquitin C -0.0268414
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0266836
RPL26 ribosomal protein L26 -0.0266331
CALD1 caldesmon 1 -0.0262446
RPS25 ribosomal protein S25 -0.0261737
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) -0.0261312
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0260629
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0260397
FAM162A family with sequence similarity 162, member A -0.0259977
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0257459
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0257457