Berbamine (dihydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.177857
FLNB filamin B, beta 0.16506
ERRFI1 ERBB receptor feedback inhibitor 1 0.136674
BAIAP2L1 BAI1-associated protein 2-like 1 0.122231
AKAP12 A kinase (PRKA) anchor protein 12 0.106867
ITGA6 integrin, alpha 6 0.0816758
PSD3 pleckstrin and Sec7 domain containing 3 0.0786872
AHNAK AHNAK nucleoprotein 0.0741511
BZW1 basic leucine zipper and W2 domains 1 0.070292
EFNA5 ephrin-A5 0.057921
LOC112694756 uncharaterized LOC112694756 0.0548874
SMAD3 SMAD family member 3 0.0546897
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0543901
GRB10 growth factor receptor-bound protein 10 0.0531209
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0513881
EGFR epidermal growth factor receptor 0.0489956
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0471942
NDRG1 N-myc downstream regulated 1 0.0469509
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0451375
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0430425
MPRIP myosin phosphatase Rho interacting protein 0.0413799
KDM3A lysine (K)-specific demethylase 3A 0.0403006
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0388175
ESYT2 extended synaptotagmin-like protein 2 0.0382922
SLMAP sarcolemma associated protein 0.0365682
FAM107B family with sequence similarity 107, member B 0.0360316
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0352127
XPO1 exportin 1 0.0348621
OSBPL3 oxysterol binding protein-like 3 0.0341985
AHNAK2 AHNAK nucleoprotein 2 0.0336593
HPCAL1 hippocalcin-like 1 0.0334947
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0332331
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0329299
ANLN anillin, actin binding protein 0.0324591
OGA O-GlcNAcase 0.0324075
ARRDC3 arrestin domain containing 3 0.0321044
FAM13A family with sequence similarity 13, member A 0.0319257
STK39 serine threonine kinase 39 0.0315645
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 0.0314055
TRIO trio Rho guanine nucleotide exchange factor 0.0308901
DSPP dentin sialophosphoprotein 0.030436
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.029268
MYH9 myosin, heavy chain 9, non-muscle 0.0292557
EZR ezrin 0.0291804
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0288263
STAG2 stromal antigen 2 0.0268619
ZMYM2 zinc finger, MYM-type 2 0.0267937
FGD4 FYVE, RhoGEF and PH domain containing 4 0.02672
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0265888
TRA2A transformer 2 alpha homolog (Drosophila) 0.0262466
CCNY cyclin Y 0.0258113
NCOR2 nuclear receptor corepressor 2 0.0255186
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0255098
MED13L mediator complex subunit 13-like 0.0254134
RAD21 RAD21 homolog (S. pombe) 0.0252959
TSC22D2 TSC22 domain family, member 2 0.024455
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0243845
PPARG peroxisome proliferator-activated receptor gamma 0.0242267
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.024122
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0240616
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0239025
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0237945
CTBP2 C-terminal binding protein 2 0.0231195
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0230691
MYOF myoferlin 0.0229513
ITPRID2 ITPR interacting domain containing 2 0.0228545
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0226006
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0223603
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0222446
SUN1 Sad1 and UNC84 domain containing 1 0.021399
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0212422
AFDN afadin, adherens junction formation factor 0.0211947
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0210767
COL17A1 collagen, type XVII, alpha 1 0.0210172
TOP1 topoisomerase (DNA) I 0.020829
LHFPL2 lipoma HMGIC fusion partner-like 2 0.020819
ANXA2 annexin A2 0.0206561
UBE2I ubiquitin-conjugating enzyme E2I 0.0206059
PICALM phosphatidylinositol binding clathrin assembly protein 0.020535
CAPRIN2 caprin family member 2 0.0205056
BIRC6 baculoviral IAP repeat containing 6 0.0203428
EMP1 epithelial membrane protein 1 0.0202956
USP3 ubiquitin specific peptidase 3 0.0202621
KCMF1 potassium channel modulatory factor 1 0.0202519
NEK7 NIMA-related kinase 7 0.0201338
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0199554
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0199245
NAP1L1 nucleosome assembly protein 1-like 1 0.0195799
SLTM SAFB-like, transcription modulator 0.0195366
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0195282
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0194709
SLK STE20-like kinase 0.0192483
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0192184
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0191949
KANSL1 KAT8 regulatory NSL complex subunit 1 0.019157
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0187923
HMGB2 high mobility group box 2 0.0187373
HP1BP3 heterochromatin protein 1, binding protein 3 0.0187216
FOXO3 forkhead box O3 0.0186912
EEF2 eukaryotic translation elongation factor 2 0.0186178

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.237804
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.141551
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.141383
FTH1 ferritin, heavy polypeptide 1 -0.130347
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.116921
TPT1 tumor protein, translationally-controlled 1 -0.107486
KLK10 kallikrein-related peptidase 10 -0.101058
FTL ferritin, light polypeptide -0.0915692
EGR1 early growth response 1 -0.0841373
B2M beta-2-microglobulin -0.0818393
TXNIP thioredoxin interacting protein -0.0765246
HMGA1 high mobility group AT-hook 1 -0.0725544
RAB7A RAB7A, member RAS oncogene family -0.0718491
SACK1A scaffolding CK1 anchoring protein A -0.070656
AKAP9 A kinase (PRKA) anchor protein 9 -0.0701762
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0590674
FBXO11 F-box protein 11 -0.0583935
POTEF POTE ankyrin domain family, member F -0.0579967
CCNL1 cyclin L1 -0.0577785
RPS21 ribosomal protein S21 -0.057694
PARD3 par-3 family cell polarity regulator -0.056452
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0555691
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0536538
RPL37A ribosomal protein L37a -0.0513122
LAMC2 laminin, gamma 2 -0.0504754
S100A11 S100 calcium binding protein A11 -0.050349
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0491501
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.048209
SMC3 structural maintenance of chromosomes 3 -0.0475914
F3 coagulation factor III (thromboplastin, tissue factor) -0.0464398
PDLIM5 PDZ and LIM domain 5 -0.0461101
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0434198
RPL31 ribosomal protein L31 -0.0433315
MXD1 MAX dimerization protein 1 -0.0423322
APLP2 amyloid beta (A4) precursor-like protein 2 -0.041684
RPLP2 ribosomal protein, large, P2 -0.0416715
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0413788
RPS13 ribosomal protein S13 -0.0412958
HDAC9 histone deacetylase 9 -0.0393035
LY6E lymphocyte antigen 6 complex, locus E -0.0390599
RTN4 reticulon 4 -0.0386363
TJP1 tight junction protein 1 -0.0379085
MT2A metallothionein 2A -0.0372983
VMP1 vacuole membrane protein 1 -0.0367468
BLZF1 basic leucine zipper nuclear factor 1 -0.0367022
SNX9 sorting nexin 9 -0.0366814
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0365728
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0361031
RPS3 ribosomal protein S3 -0.0356375
LAMA4 laminin, alpha 4 -0.0354012
AK1 adenylate kinase 1 -0.035387
RPS23 ribosomal protein S23 -0.034591
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0344736
FOSL1 FOS-like antigen 1 -0.0342407
COG5 component of oligomeric golgi complex 5 -0.0334394
ARF4 ADP-ribosylation factor 4 -0.0333812
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0332728
RBM25 RNA binding motif protein 25 -0.0331633
MIDN midnolin -0.03302
IFI6 interferon, alpha-inducible protein 6 -0.0329693
RPL23 ribosomal protein L23 -0.0329505
RPL35A ribosomal protein L35a -0.0328311
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0319838
GOLGB1 golgin B1 -0.0317583
EXT1 exostosin glycosyltransferase 1 -0.0312697
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0306127
UBE2H ubiquitin-conjugating enzyme E2H -0.0301386
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0300633
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0299808
RPL8 ribosomal protein L8 -0.0297125
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0296562
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0295497
SDC4 syndecan 4 -0.0293458
DENND2C DENN/MADD domain containing 2C -0.0292867
VEGFA vascular endothelial growth factor A -0.0292674
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0291172
PFN1 profilin 1 -0.0291092
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0290809
DIAPH1 diaphanous-related formin 1 -0.0290147
PDE4D phosphodiesterase 4D, cAMP-specific -0.0289888
SAMD4A sterile alpha motif domain containing 4A -0.0286028
SP100 SP100 nuclear antigen -0.0285728
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0283187
PLAUR plasminogen activator, urokinase receptor -0.0281693
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.028041
UBE2B ubiquitin-conjugating enzyme E2B -0.0279107
AKAP13 A kinase (PRKA) anchor protein 13 -0.0278685
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0276354
RPL28 ribosomal protein L28 -0.0275949
OSMR oncostatin M receptor -0.0272482
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0270472
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0269722
RPL36 ribosomal protein L36 -0.0268694
RPS27A ribosomal protein S27a -0.0268249
MRPS6 mitochondrial ribosomal protein S6 -0.0268093
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0268066
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0267549
GCC2 GRIP and coiled-coil domain containing 2 -0.02671
SEM1 SEM1 26S proteasome subunit -0.0263732
RPL9 ribosomal protein L9 -0.0258836