Berbamine (dihydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.123372
ADGRG6 adhesion G protein-coupled receptor G6 0.122128
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.110245
COL5A2 collagen, type V, alpha 2 0.0938716
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0844061
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0804039
EFNA5 ephrin-A5 0.0791489
TENM3 teneurin transmembrane protein 3 0.0780435
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0772718
RAD51B RAD51 paralog B 0.064875
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0647785
SHROOM3 shroom family member 3 0.0629275
JMJD1C jumonji domain containing 1C 0.0619723
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0600614
TOX thymocyte selection-associated high mobility group box 0.0581083
KMT2C lysine (K)-specific methyltransferase 2C 0.057642
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0572584
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.056008
EEF2 eukaryotic translation elongation factor 2 0.0540811
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0535725
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0532638
NUP58 nucleoporin 58 0.0526596
FMNL2 formin-like 2 0.0495785
PCBP2 poly(rC) binding protein 2 0.048779
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0486873
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0486753
GRID2 glutamate receptor, ionotropic, delta 2 0.0485156
MIMS1 mitochondrial inner membrane scaffold 1 0.0454021
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0447659
RAP1B RAP1B, member of RAS oncogene family 0.0443834
RPL3 ribosomal protein L3 0.044219
SLF1 SMC5-SMC6 complex localization factor 1 0.0441549
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.044023
ARB2A ARB2 cotranscriptional regulator A 0.0435399
PIAS2 protein inhibitor of activated STAT, 2 0.042897
CELF2 CUGBP, Elav-like family member 2 0.0428863
USP9X ubiquitin specific peptidase 9, X-linked 0.0428318
SREBF2 sterol regulatory element binding transcription factor 2 0.0425655
SOX5 SRY (sex determining region Y)-box 5 0.0415402
NPAS3 neuronal PAS domain protein 3 0.0413862
LOC112694756 uncharaterized LOC112694756 0.0407227
FASN fatty acid synthase 0.0406011
SLIT2 slit homolog 2 (Drosophila) 0.0401753
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0401035
ATRN attractin 0.0399553
SRRM2 serine/arginine repetitive matrix 2 0.0398943
ZFAND3 zinc finger, AN1-type domain 3 0.0391879
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0389855
CHSY1 chondroitin sulfate synthase 1 0.0388326
PDIA3 protein disulfide isomerase family A, member 3 0.03809
MED13L mediator complex subunit 13-like 0.0379453
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0376557
KTN1 kinectin 1 (kinesin receptor) 0.0361821
LATS2 large tumor suppressor kinase 2 0.0359431
PARD3 par-3 family cell polarity regulator 0.0355352
CHD7 chromodomain helicase DNA binding protein 7 0.0349709
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0348444
CAMTA1 calmodulin binding transcription activator 1 0.0345106
FAT1 FAT atypical cadherin 1 0.0342678
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0340094
UBA6 ubiquitin-like modifier activating enzyme 6 0.0337287
DST dystonin 0.03354
KDM6A lysine (K)-specific demethylase 6A 0.03318
TTC3 tetratricopeptide repeat domain 3 0.032603
CABIN1 calcineurin binding protein 1 0.0324339
YEATS2 YEATS domain containing 2 0.0324189
ATP11A ATPase, class VI, type 11A 0.0314884
MED13 mediator complex subunit 13 0.0314549
CCNY cyclin Y 0.0314363
VMP1 vacuole membrane protein 1 0.0310388
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0306842
RTN4 reticulon 4 0.030225
CEP95 centrosomal protein 95kDa 0.0301397
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0300743
UBC ubiquitin C 0.0300034
HHIP hedgehog interacting protein 0.0299738
ATP9A ATPase, class II, type 9A 0.029904
CALU calumenin 0.0296812
GAB2 GRB2-associated binding protein 2 0.0296389
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0295022
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0294193
FDPS farnesyl diphosphate synthase 0.0292615
SSBP2 single-stranded DNA binding protein 2 0.0289919
ADNP activity-dependent neuroprotector homeobox 0.0288135
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0287735
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0287711
CHD1 chromodomain helicase DNA binding protein 1 0.0286996
TENT4A terminal nucleotidyltransferase 4A 0.0285685
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0283777
KMT2E lysine (K)-specific methyltransferase 2E 0.028358
AHCTF1 AT hook containing transcription factor 1 0.0280198
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0277878
FOXO3 forkhead box O3 0.0276653
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0276506
DPYSL2 dihydropyrimidinase-like 2 0.0276212
BRD4 bromodomain containing 4 0.0274857
PRRC2C proline-rich coiled-coil 2C 0.0273175
TMEM41B transmembrane protein 41B 0.0273152
FXR1 fragile X mental retardation, autosomal homolog 1 0.0271846
STRN3 striatin, calmodulin binding protein 3 0.0271324

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.106074
RPS6 ribosomal protein S6 -0.0577575
RPLP1 ribosomal protein, large, P1 -0.0564197
RPL26 ribosomal protein L26 -0.0563559
TMSB10 thymosin beta 10 -0.0521886
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0491344
RPS8 ribosomal protein S8 -0.0465188
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0417804
RPL12 ribosomal protein L12 -0.0409585
RPL18 ribosomal protein L18 -0.0393184
RPL34 ribosomal protein L34 -0.0384027
RPS12 ribosomal protein S12 -0.0382198
RPS3 ribosomal protein S3 -0.0370165
RCC1 regulator of chromosome condensation 1 -0.0365556
RPS19 ribosomal protein S19 -0.0363401
CENPF centromere protein F, 350/400kDa -0.0339983
ASPH aspartate beta-hydroxylase -0.0326407
RPL37A ribosomal protein L37a -0.0322613
BPTF bromodomain PHD finger transcription factor -0.0316872
NAP1L1 nucleosome assembly protein 1-like 1 -0.0313178
RPL23 ribosomal protein L23 -0.029786
SOX4 SRY (sex determining region Y)-box 4 -0.0295352
RPS27A ribosomal protein S27a -0.0295167
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0290143
RPL36 ribosomal protein L36 -0.0286377
RPS17 ribosomal protein S17 -0.0270903
ZC3H12B zinc finger CCCH-type containing 12B -0.0270767
PTMA prothymosin, alpha -0.0267535
RPS29 ribosomal protein S29 -0.0262872
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -0.0257134
RPS2 ribosomal protein S2 -0.0256617
HMGB1 high mobility group box 1 -0.0255338
PNISR PNN-interacting serine/arginine-rich protein -0.0247844
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0247164
SNX14 sorting nexin 14 -0.0244843
LARS1 leucyl-tRNA synthetase 1 -0.024217
GNAS GNAS complex locus -0.0241766
RPL28 ribosomal protein L28 -0.0234251
PABPN1 poly(A) binding protein, nuclear 1 -0.0232176
RPL32 ribosomal protein L32 -0.0229273
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0223061
RPLP0 ribosomal protein, large, P0 -0.022072
RPL35 ribosomal protein L35 -0.0217765
SPDYA speedy/RINGO cell cycle regulator family member A -0.0216186
ISG15 ISG15 ubiquitin-like modifier -0.0215706
RPL19 ribosomal protein L19 -0.0215202
RPL13A ribosomal protein L13a -0.0213274
RPS21 ribosomal protein S21 -0.0211816
RPS28 ribosomal protein S28 -0.0211783
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.0211417
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.020904
BRCA1 breast cancer 1, early onset -0.0208761
RPL31 ribosomal protein L31 -0.0208747
H1-0 H1.0 linker histone -0.0207727
EIF3A eukaryotic translation initiation factor 3, subunit A -0.020662
MKI67 marker of proliferation Ki-67 -0.0206455
RPS27 ribosomal protein S27 -0.0205351
RPS24 ribosomal protein S24 -0.0199802
PAPOLA poly(A) polymerase alpha -0.0198994
B2M beta-2-microglobulin -0.0198177
RPL11 ribosomal protein L11 -0.0198098
RPL38 ribosomal protein L38 -0.0197974
E2F3 E2F transcription factor 3 -0.0195171
RPL7 ribosomal protein L7 -0.0191068
CCDC47 coiled-coil domain containing 47 -0.0188778
ZNF609 zinc finger protein 609 -0.0188539
HMGB2 high mobility group box 2 -0.0188241
IFI6 interferon, alpha-inducible protein 6 -0.0186347
NALF1 NALCN channel auxiliary factor 1 -0.0186203
RPLP2 ribosomal protein, large, P2 -0.0185787
UBAP2 ubiquitin associated protein 2 -0.0185684
HMGA1 high mobility group AT-hook 1 -0.0185337
MSH4 mutS homolog 4 -0.0183497
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0181808
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0180273
MMS22L MMS22-like, DNA repair protein -0.0179882
RFC3 replication factor C (activator 1) 3, 38kDa -0.0179036
MTAP methylthioadenosine phosphorylase -0.0178699
CCDC88A coiled-coil domain containing 88A -0.0178184
DUSP16 dual specificity phosphatase 16 -0.0177461
DENND1A DENN/MADD domain containing 1A -0.0177451
APTX aprataxin -0.0177316
RPL36A ribosomal protein L36a -0.0177265
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.017623
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0175074
RIGI RNA sensor RIG-I -0.0171766
AHI1 Abelson helper integration site 1 -0.0168818
ATP5F1E ATP synthase F1 subunit epsilon -0.0168522
PBRM1 polybromo 1 -0.0167306
ZNF608 zinc finger protein 608 -0.0165174
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0165125
TPR translocated promoter region, nuclear basket protein -0.016487
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.016404
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0161963
RPL7A ribosomal protein L7a -0.0159896
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0158546
RANBP17 RAN binding protein 17 -0.0155919
SYF2 SYF2 pre-mRNA-splicing factor -0.0152716
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0151571
PCNX2 pecanex 2 -0.0149357