Berbamine (dihydrochloride)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.272294
IGFBP3 insulin-like growth factor binding protein 3 0.100109
NDRG1 N-myc downstream regulated 1 0.0897328
EIF4H eukaryotic translation initiation factor 4H 0.0742393
CD109 CD109 molecule 0.068831
LOC112694756 uncharaterized LOC112694756 0.059794
AKAP12 A kinase (PRKA) anchor protein 12 0.0578385
NAV2 neuron navigator 2 0.0543001
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0483852
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.047097
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0461721
ZMIZ1 zinc finger, MIZ-type containing 1 0.045501
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0440387
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0436637
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.042606
GOLGA4 golgin A4 0.042583
CHSY1 chondroitin sulfate synthase 1 0.0421433
CENPF centromere protein F, 350/400kDa 0.0405119
SRRM2 serine/arginine repetitive matrix 2 0.0398963
EEF2 eukaryotic translation elongation factor 2 0.0395842
HLA-C major histocompatibility complex, class I, C 0.0391996
TAC4 tachykinin 4 (hemokinin) 0.0387665
TBC1D22A TBC1 domain family, member 22A 0.0383932
HSPG2 heparan sulfate proteoglycan 2 0.0363801
VEGFA vascular endothelial growth factor A 0.0348828
PRELID2 PRELI domain containing 2 0.0330229
FBXO7 F-box protein 7 0.0329967
BACE2 beta-site APP-cleaving enzyme 2 0.0322523
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0320202
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0318184
IGF2 insulin-like growth factor 2 0.0316201
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.03013
BHLHE40 basic helix-loop-helix family, member e40 0.0300061
FOSL1 FOS-like antigen 1 0.0294538
HLA-B major histocompatibility complex, class I, B 0.0291941
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0290109
TIMP3 TIMP metallopeptidase inhibitor 3 0.0287382
RNF213 ring finger protein 213 0.0286064
MRPS6 mitochondrial ribosomal protein S6 0.0285
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.027896
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0273656
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0269371
SCARB1 scavenger receptor class B, member 1 0.0264614
SET SET nuclear proto-oncogene 0.0263926
STXBP1 syntaxin binding protein 1 0.0258115
RPS12 ribosomal protein S12 0.0246722
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0242835
LMNA lamin A/C 0.0232417
TIMP2 TIMP metallopeptidase inhibitor 2 0.0226639
PLCG1 phospholipase C, gamma 1 0.0216477
PRRC2C proline-rich coiled-coil 2C 0.0214736
NCOA1 nuclear receptor coactivator 1 0.0212056
CEP250 centrosomal protein 250kDa 0.0210399
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0207865
RAB6A RAB6A, member RAS oncogene family 0.0206605
SERGEF secretion regulating guanine nucleotide exchange factor 0.0205339
MFSD12 major facilitator superfamily domain containing 12 0.0204439
CLMN calmin (calponin-like, transmembrane) 0.0202282
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0201322
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0200085
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0198083
FAM162A family with sequence similarity 162, member A 0.0196338
ANO6 anoctamin 6 0.0195826
ZCCHC7 zinc finger, CCHC domain containing 7 0.0194779
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0194353
RPL3 ribosomal protein L3 0.0192047
TMEM255B transmembrane protein 255B 0.0191507
FLNA filamin A, alpha 0.0191084
ESYT2 extended synaptotagmin-like protein 2 0.0189961
CABIN1 calcineurin binding protein 1 0.0188565
PRKCE protein kinase C, epsilon 0.0187162
GRK5 G protein-coupled receptor kinase 5 0.0186784
HLA-A major histocompatibility complex, class I, A 0.0184925
SSH1 slingshot protein phosphatase 1 0.0184565
STRIP2 striatin interacting protein 2 0.0184382
SRRT serrate, RNA effector molecule 0.0182411
SDC3 syndecan 3 0.0182017
ATXN1 ataxin 1 0.0179016
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0177866
PTPRD protein tyrosine phosphatase, receptor type, D 0.0177476
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.01772
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0177057
RPL27 ribosomal protein L27 0.0176554
RACK1 receptor for activated C kinase 1 0.0176027
ZNF148 zinc finger protein 148 0.0175781
FBXO42 F-box protein 42 0.0175639
TPR translocated promoter region, nuclear basket protein 0.0175014
HILPDA hypoxia inducible lipid droplet-associated 0.0173882
SREBF2 sterol regulatory element binding transcription factor 2 0.0173835
HDGF hepatoma-derived growth factor 0.0173471
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.017093
UBE4B ubiquitination factor E4B 0.0170125
TMEM41B transmembrane protein 41B 0.0170012
RILPL1 Rab interacting lysosomal protein-like 1 0.0168837
FOXN3 forkhead box N3 0.0168804
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0168454
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0168438
POM121 POM121 transmembrane nucleoporin 0.0167462
HIP1 huntingtin interacting protein 1 0.016524
KDM2B lysine (K)-specific demethylase 2B 0.0164702

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.420435
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.183355
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.121505
IFI16 interferon, gamma-inducible protein 16 -0.110524
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.100538
FMN1 formin 1 -0.0992379
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0868265
PDIA4 protein disulfide isomerase family A, member 4 -0.0825808
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0823098
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0719625
GPC6 glypican 6 -0.070266
UBE2H ubiquitin-conjugating enzyme E2H -0.0702204
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0651291
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0601763
MTPN myotrophin -0.0554545
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0548378
PTMA prothymosin, alpha -0.0540148
MACROD2 MACRO domain containing 2 -0.0486456
ZBTB20 zinc finger and BTB domain containing 20 -0.048103
COL19A1 collagen, type XIX, alpha 1 -0.0480406
NAMPT nicotinamide phosphoribosyltransferase -0.047788
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0468987
RHEB Ras homolog enriched in brain -0.0468065
MT2A metallothionein 2A -0.0432478
IFRD1 interferon-related developmental regulator 1 -0.0425239
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.039621
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0387855
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.037866
UBC ubiquitin C -0.0376111
IER3 immediate early response 3 -0.0374408
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0366846
NAV3 neuron navigator 3 -0.0362405
LRMDA leucine rich melanocyte differentiation associated -0.0361352
HMCN1 hemicentin 1 -0.0361344
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0361009
AHNAK AHNAK nucleoprotein -0.0354828
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0353486
NAP1L1 nucleosome assembly protein 1-like 1 -0.0344364
SOX5 SRY (sex determining region Y)-box 5 -0.034411
ARHGAP5 Rho GTPase activating protein 5 -0.0342867
CALU calumenin -0.0338977
COG5 component of oligomeric golgi complex 5 -0.0337727
S100A6 S100 calcium binding protein A6 -0.0336025
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0335975
PTCHD4 patched domain containing 4 -0.0335576
FUS FUS RNA binding protein -0.0327271
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0321972
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0316866
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0313641
TFG TRK-fused gene -0.031255
FMNL2 formin-like 2 -0.0311264
RLF rearranged L-myc fusion -0.0310058
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0309943
EXOC4 exocyst complex component 4 -0.0304765
TPM4 tropomyosin 4 -0.0303283
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0303005
PDE4D phosphodiesterase 4D, cAMP-specific -0.0300239
COPA coatomer protein complex, subunit alpha -0.0297646
VIM vimentin -0.029342
TNPO3 transportin 3 -0.0292277
S100A10 S100 calcium binding protein A10 -0.029016
NCOA7 nuclear receptor coactivator 7 -0.0289708
ZC3H11A zinc finger CCCH-type containing 11A -0.0288684
STAU1 staufen double-stranded RNA binding protein 1 -0.0282311
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0281665
PDIA3 protein disulfide isomerase family A, member 3 -0.0281596
RHOJ ras homolog family member J -0.0281232
FHIT fragile histidine triad -0.0278982
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0274385
TRA2A transformer 2 alpha homolog (Drosophila) -0.0271183
INPP5F inositol polyphosphate-5-phosphatase F -0.0270212
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0261717
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0259403
EGR1 early growth response 1 -0.0258888
TSC22D1 TSC22 domain family, member 1 -0.0258265
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0258199
BICD1 bicaudal D homolog 1 (Drosophila) -0.0256329
SUCO SUN domain containing ossification factor -0.0254197
SDCBP syndecan binding protein (syntenin) -0.0248254
TAGLN2 transgelin 2 -0.0247523
HELZ helicase with zinc finger -0.024613
IFI6 interferon, alpha-inducible protein 6 -0.0244534
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0243608
IFITM1 interferon induced transmembrane protein 1 -0.0243504
NPAS2 neuronal PAS domain protein 2 -0.0243156
PARD3B par-3 family cell polarity regulator beta -0.024156
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.024112
FRMD5 FERM domain containing 5 -0.0239647
LEF1 lymphoid enhancer-binding factor 1 -0.0238118
TM4SF1 transmembrane 4 L six family member 1 -0.0235222
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0234869
PXMP2 peroxisomal membrane protein 2, 22kDa -0.0234857
CDK14 cyclin-dependent kinase 14 -0.0234393
RYBP RING1 and YY1 binding protein -0.0231848
DIAPH3 diaphanous-related formin 3 -0.0231485
EHBP1 EH domain binding protein 1 -0.0230012
MITF microphthalmia-associated transcription factor -0.0229425
CSNK1A1 casein kinase 1, alpha 1 -0.0227283
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0227065
TM9SF3 transmembrane 9 superfamily member 3 -0.0226819