Berbamine (dihydrochloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.184349
FTH1 ferritin, heavy polypeptide 1 0.102805
HLA-C major histocompatibility complex, class I, C 0.0994094
TMSB10 thymosin beta 10 0.0867392
LAMB3 laminin, beta 3 0.0826018
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0821317
F3 coagulation factor III (thromboplastin, tissue factor) 0.0694101
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0678279
LOC112694756 uncharaterized LOC112694756 0.065642
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0610422
NDRG1 N-myc downstream regulated 1 0.0605695
AHNAK2 AHNAK nucleoprotein 2 0.0576045
MT1X metallothionein 1X 0.0553738
RPL35A ribosomal protein L35a 0.0486373
ENO1 enolase 1, (alpha) 0.0476126
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0463561
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0427947
ANXA2 annexin A2 0.0424079
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0410176
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0407503
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0405945
ANKRD11 ankyrin repeat domain 11 0.040079
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0390354
CXCL8 chemokine (C-X-C motif) ligand 8 0.0387326
SEC23A Sec23 homolog A (S. cerevisiae) 0.038111
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0378918
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0378652
CCNY cyclin Y 0.0366314
ADAM9 ADAM metallopeptidase domain 9 0.036486
RIOK3 RIO kinase 3 0.0359104
OGA O-GlcNAcase 0.0351858
RNF149 ring finger protein 149 0.0340508
HELZ helicase with zinc finger 0.0339792
VIM vimentin 0.0339545
DAPK1 death-associated protein kinase 1 0.0335434
RTN4 reticulon 4 0.0335356
CALR calreticulin 0.0326753
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0321121
CLMN calmin (calponin-like, transmembrane) 0.0319305
TSC22D2 TSC22 domain family, member 2 0.031602
FAT1 FAT atypical cadherin 1 0.0313589
MUC4 mucin 4, cell surface associated 0.0309074
ZFAND3 zinc finger, AN1-type domain 3 0.0307378
IGF1R insulin-like growth factor 1 receptor 0.0304177
FGFR1 fibroblast growth factor receptor 1 0.0300687
LASP1 LIM and SH3 protein 1 0.0300101
SREBF2 sterol regulatory element binding transcription factor 2 0.029942
HLA-A major histocompatibility complex, class I, A 0.0298994
EIF4H eukaryotic translation initiation factor 4H 0.0297794
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0295579
WIPF2 WAS/WASL interacting protein family, member 2 0.0292563
KMT2C lysine (K)-specific methyltransferase 2C 0.0287145
FDPS farnesyl diphosphate synthase 0.0285628
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0283066
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0275723
GRB10 growth factor receptor-bound protein 10 0.02726
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0271864
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0264836
ZMIZ1 zinc finger, MIZ-type containing 1 0.0264209
PGK1 phosphoglycerate kinase 1 0.026413
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0260663
CD46 CD46 molecule, complement regulatory protein 0.0254398
NCOR2 nuclear receptor corepressor 2 0.0254256
STC2 stanniocalcin 2 0.0253627
NAV2 neuron navigator 2 0.0252465
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0252331
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0251113
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0249214
KDM5B lysine (K)-specific demethylase 5B 0.0246209
LIFR leukemia inhibitory factor receptor alpha 0.0246
FLNB filamin B, beta 0.0242352
MSMO1 methylsterol monooxygenase 1 0.0240689
GCLC glutamate-cysteine ligase, catalytic subunit 0.0240581
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0240547
ELL2 elongation factor, RNA polymerase II, 2 0.0233911
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0230833
WDR45B WD repeat domain 45B 0.0229079
LINGO2 leucine rich repeat and Ig domain containing 2 0.0228972
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0226769
FADS2 fatty acid desaturase 2 0.0223025
PDZD8 PDZ domain containing 8 0.0222743
RAP1B RAP1B, member of RAS oncogene family 0.0222478
NEK6 NIMA-related kinase 6 0.0220695
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0215809
PRRC2A proline-rich coiled-coil 2A 0.0215388
TRA2A transformer 2 alpha homolog (Drosophila) 0.0215284
ZNF185 zinc finger protein 185 (LIM domain) 0.0215082
LMNA lamin A/C 0.0214853
CD47 CD47 molecule 0.0213148
FBXO42 F-box protein 42 0.0212446
EHBP1 EH domain binding protein 1 0.0211364
RUNX1 runt-related transcription factor 1 0.0209827
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 0.0209215
SEC24C SEC24 family member C 0.02091
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0209089
RNF213 ring finger protein 213 0.0208883
CEP250 centrosomal protein 250kDa 0.0206524
RAB6A RAB6A, member RAS oncogene family 0.0204765
LPP LIM domain containing preferred translocation partner in lipoma 0.0202717
ARHGAP23 Rho GTPase activating protein 23 0.0200944

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.176343
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.159995
APOL1 apolipoprotein L, 1 -0.142713
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.131772
LAMC2 laminin, gamma 2 -0.127941
ASPH aspartate beta-hydroxylase -0.121002
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.114324
ERRFI1 ERBB receptor feedback inhibitor 1 -0.10121
RPS2 ribosomal protein S2 -0.0909755
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0869341
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0769472
MT2A metallothionein 2A -0.0728276
B2M beta-2-microglobulin -0.0711859
AKAP12 A kinase (PRKA) anchor protein 12 -0.0711545
RPL19 ribosomal protein L19 -0.0710292
POTEF POTE ankyrin domain family, member F -0.0702185
CDCP1 CUB domain containing protein 1 -0.069805
EIF1 eukaryotic translation initiation factor 1 -0.0673801
CP ceruloplasmin (ferroxidase) -0.0672843
PLAUR plasminogen activator, urokinase receptor -0.0670289
UBC ubiquitin C -0.0668603
DSG2 desmoglein 2 -0.0666142
MMP7 matrix metallopeptidase 7 -0.0665018
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.066365
NAMPT nicotinamide phosphoribosyltransferase -0.0657387
RPS8 ribosomal protein S8 -0.0622069
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0602419
TPT1 tumor protein, translationally-controlled 1 -0.0531101
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0521676
RPS6 ribosomal protein S6 -0.0515819
RPL37A ribosomal protein L37a -0.0507465
TPM1 tropomyosin 1 (alpha) -0.0504247
ARHGAP5 Rho GTPase activating protein 5 -0.0491479
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0483645
PLAT plasminogen activator, tissue -0.0477067
RPS29 ribosomal protein S29 -0.0474062
IFI27 interferon, alpha-inducible protein 27 -0.0472696
BRD2 bromodomain containing 2 -0.0469469
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0464394
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0464037
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0461164
TPM4 tropomyosin 4 -0.0459718
VMP1 vacuole membrane protein 1 -0.0459478
ARHGAP26 Rho GTPase activating protein 26 -0.0456774
IFI6 interferon, alpha-inducible protein 6 -0.0446938
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0438525
TMSB4X thymosin beta 4, X-linked -0.0429919
MX2 MX dynamin-like GTPase 2 -0.0428143
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0426601
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0424435
CTNND1 catenin (cadherin-associated protein), delta 1 -0.041885
LAMA4 laminin, alpha 4 -0.0412918
STAT1 signal transducer and activator of transcription 1, 91kDa -0.041237
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0410964
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0404326
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0403131
KRT19 keratin 19, type I -0.0402858
RAB10 RAB10, member RAS oncogene family -0.0396478
LAMB1 laminin, beta 1 -0.0387711
NUMB numb homolog (Drosophila) -0.0382286
TMEM165 transmembrane protein 165 -0.0374058
DSTN destrin (actin depolymerizing factor) -0.0364655
LDHA lactate dehydrogenase A -0.0363772
MYOF myoferlin -0.0363349
S100A6 S100 calcium binding protein A6 -0.0359696
SAMD9 sterile alpha motif domain containing 9 -0.0357197
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0353296
PPARD peroxisome proliferator-activated receptor delta -0.0352823
ITGA6 integrin, alpha 6 -0.0351318
CSTB cystatin B (stefin B) -0.0347188
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0346373
PAPOLA poly(A) polymerase alpha -0.0344967
RPS24 ribosomal protein S24 -0.0344806
RPL36A ribosomal protein L36a -0.0343232
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.033761
NABP1 nucleic acid binding protein 1 -0.0329993
SYNRG synergin, gamma -0.0323698
EPCAM epithelial cell adhesion molecule -0.0318793
FAM107B family with sequence similarity 107, member B -0.0314608
EREG epiregulin -0.0313999
ALCAM activated leukocyte cell adhesion molecule -0.0313883
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.031153
MYO1E myosin IE -0.0310062
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0307004
F11R F11 receptor -0.030646
MACF1 microtubule-actin crosslinking factor 1 -0.0305006
CFLAR CASP8 and FADD-like apoptosis regulator -0.0302188
C15ORF48 chromosome 15 open reading frame 48 -0.0301542
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.030041
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0298565
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0298191
S100A10 S100 calcium binding protein A10 -0.029812
LIPH lipase, member H -0.0293918
RPS27A ribosomal protein S27a -0.0293476
LMO7 LIM domain 7 -0.0293301
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0292776
KTN1 kinectin 1 (kinesin receptor) -0.0290566
RPL9 ribosomal protein L9 -0.0290209
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.02874
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0286469