Berbamine (dihydrochloride)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Berbamine (dihydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Berbamine (dihydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.301445
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.211983
MEIS2 Meis homeobox 2 0.138888
NRG1 neuregulin 1 0.104711
LIMCH1 LIM and calponin homology domains 1 0.0659403
PRRC2C proline-rich coiled-coil 2C 0.0610785
SLITRK6 SLIT and NTRK-like family, member 6 0.0602191
CENPF centromere protein F, 350/400kDa 0.0599486
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0583259
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0508113
SRRM2 serine/arginine repetitive matrix 2 0.048878
MAP1B microtubule-associated protein 1B 0.0468624
DPH6 diphthamine biosynthesis 6 0.0461283
ZBTB20 zinc finger and BTB domain containing 20 0.0459791
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0448432
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0448399
CADM2 cell adhesion molecule 2 0.0448084
MEF2A myocyte enhancer factor 2A 0.0447241
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.042986
DLC1 DLC1 Rho GTPase activating protein 0.0421869
PRRC2B proline-rich coiled-coil 2B 0.0409301
SOS1 son of sevenless homolog 1 (Drosophila) 0.0405209
PTEN phosphatase and tensin homolog 0.0390801
NAMPT nicotinamide phosphoribosyltransferase 0.0364568
PTPRE protein tyrosine phosphatase, receptor type, E 0.0356562
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0354123
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0350283
COL4A5 collagen, type IV, alpha 5 0.0345924
PTK2 protein tyrosine kinase 2 0.0345511
DNM3 dynamin 3 0.0341357
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0335764
RFX7 regulatory factor X, 7 0.0325599
ANGPT1 angiopoietin 1 0.0320649
PALM2AKAP2 PALM2 and AKAP2 fusion 0.031746
SEPTIN9 septin 9 0.0312638
TLK2 tousled-like kinase 2 0.0311741
BIRC6 baculoviral IAP repeat containing 6 0.0310156
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0305614
WAC WW domain containing adaptor with coiled-coil 0.0305558
TIMP3 TIMP metallopeptidase inhibitor 3 0.0300043
CARD16 caspase recruitment domain family, member 16 0.0290502
TPM3 tropomyosin 3 0.0286329
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0282547
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0281779
NALF1 NALCN channel auxiliary factor 1 0.028141
VEGFA vascular endothelial growth factor A 0.0281143
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0278699
UBA6 ubiquitin-like modifier activating enzyme 6 0.0271904
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0270095
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0268451
TENT5A terminal nucleotidyltransferase 5A 0.0267217
ARHGAP9 Rho GTPase activating protein 9 0.0264777
TCF12 transcription factor 12 0.0264243
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0262952
BCAS3 breast carcinoma amplified sequence 3 0.026244
FMN1 formin 1 0.0259534
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0258759
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0257952
AUTS2 autism susceptibility candidate 2 0.0256804
KDM6A lysine (K)-specific demethylase 6A 0.0256252
EEF2 eukaryotic translation elongation factor 2 0.0255346
SRPK2 SRSF protein kinase 2 0.0251731
DST dystonin 0.0250721
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.0249343
FHIT fragile histidine triad 0.0247694
RNF213 ring finger protein 213 0.0247682
AHR aryl hydrocarbon receptor 0.0247192
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0247155
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0246332
KCTD3 potassium channel tetramerization domain containing 3 0.0244983
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0244459
THSD4 thrombospondin, type I, domain containing 4 0.0242439
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0239542
LPP LIM domain containing preferred translocation partner in lipoma 0.0239349
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0237194
NUP58 nucleoporin 58 0.0236081
EWSR1 EWS RNA-binding protein 1 0.0235549
EVL Enah/Vasp-like 0.0234934
CPNE8 copine VIII 0.0234425
ENAH enabled homolog (Drosophila) 0.0233469
GPC5 glypican 5 0.0232889
NUP160 nucleoporin 160kDa 0.0231763
PIAS1 protein inhibitor of activated STAT, 1 0.0231299
RTN4 reticulon 4 0.0230276
MSI2 musashi RNA-binding protein 2 0.0227484
PSD3 pleckstrin and Sec7 domain containing 3 0.0225042
ANKRD17 ankyrin repeat domain 17 0.0224971
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0223863
CDK19 cyclin-dependent kinase 19 0.0223768
BCLAF1 BCL2-associated transcription factor 1 0.0222844
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0222716
ITPRID2 ITPR interacting domain containing 2 0.0222426
MBNL2 muscleblind-like splicing regulator 2 0.0221674
ZNF609 zinc finger protein 609 0.0220538
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0220327
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0219475
ITGAV integrin, alpha V 0.0219087
UBE2H ubiquitin-conjugating enzyme E2H 0.021834
SCRN1 secernin 1 0.021755
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0215823

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.288361
RPS6 ribosomal protein S6 -0.11772
PTMA prothymosin, alpha -0.0859529
RPL23 ribosomal protein L23 -0.0839632
RPL19 ribosomal protein L19 -0.083178
VIM vimentin -0.073943
TMSB10 thymosin beta 10 -0.0703683
ACTG1 actin gamma 1 -0.0610477
TPT1 tumor protein, translationally-controlled 1 -0.0575265
RPLP1 ribosomal protein, large, P1 -0.0571155
RPS19 ribosomal protein S19 -0.0539632
FTL ferritin, light polypeptide -0.0515445
RPL26 ribosomal protein L26 -0.0515277
COL1A1 collagen, type I, alpha 1 -0.0508554
TRIB2 tribbles pseudokinase 2 -0.0479916
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0472101
RPL38 ribosomal protein L38 -0.046665
RPS12 ribosomal protein S12 -0.0463734
RPLP0 ribosomal protein, large, P0 -0.0452339
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0440731
NAP1L1 nucleosome assembly protein 1-like 1 -0.0437964
EIF1 eukaryotic translation initiation factor 1 -0.0429796
RPL35A ribosomal protein L35a -0.0429501
RPL32 ribosomal protein L32 -0.0415464
RPL37A ribosomal protein L37a -0.0410869
RPL28 ribosomal protein L28 -0.0404058
RPS27A ribosomal protein S27a -0.0391915
RPS24 ribosomal protein S24 -0.0385648
B2M beta-2-microglobulin -0.0372629
RNF150 ring finger protein 150 -0.036869
LSAMP limbic system-associated membrane protein -0.0358876
RPL31 ribosomal protein L31 -0.0358393
NPEPPS aminopeptidase puromycin sensitive -0.0357952
WSB1 WD repeat and SOCS box containing 1 -0.035629
RPS25 ribosomal protein S25 -0.0354083
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.035338
IER3 immediate early response 3 -0.0352763
RACK1 receptor for activated C kinase 1 -0.0344569
RPL34 ribosomal protein L34 -0.0331775
FNDC3B fibronectin type III domain containing 3B -0.0327299
HILPDA hypoxia inducible lipid droplet-associated -0.0322822
RPL12 ribosomal protein L12 -0.0313064
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0304338
RPS17 ribosomal protein S17 -0.0302653
RPL36 ribosomal protein L36 -0.030038
RPL30 ribosomal protein L30 -0.0298482
RPS3 ribosomal protein S3 -0.0295729
HMGB2 high mobility group box 2 -0.0294471
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0285593
H1-0 H1.0 linker histone -0.0282995
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0282157
WTAP Wilms tumor 1 associated protein -0.0281465
RPS11 ribosomal protein S11 -0.0278458
CCDC47 coiled-coil domain containing 47 -0.0278048
DNAH14 dynein, axonemal, heavy chain 14 -0.0278001
RBM39 RNA binding motif protein 39 -0.0276509
ARF1 ADP-ribosylation factor 1 -0.0273913
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0269509
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0265823
RPS21 ribosomal protein S21 -0.0263977
RPLP2 ribosomal protein, large, P2 -0.0263266
RPL18 ribosomal protein L18 -0.0261864
RPS29 ribosomal protein S29 -0.0260602
RPS5 ribosomal protein S5 -0.0259155
RPL35 ribosomal protein L35 -0.0257538
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.025629
RPS16 ribosomal protein S16 -0.0256229
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0253607
TBCA tubulin folding cofactor A -0.0253491
FNBP1 formin binding protein 1 -0.0249883
RPS13 ribosomal protein S13 -0.0246501
RPS8 ribosomal protein S8 -0.0245811
INTS6 integrator complex subunit 6 -0.0243812
RPL5 ribosomal protein L5 -0.024048
S100A6 S100 calcium binding protein A6 -0.0239983
RPS14 ribosomal protein S14 -0.0239941
RBM25 RNA binding motif protein 25 -0.0239387
TTC3 tetratricopeptide repeat domain 3 -0.0234934
LMAN1 lectin, mannose-binding, 1 -0.0231884
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0230888
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0228893
MARCHF6 membrane associated ring-CH-type finger 6 -0.0228889
RPS15 ribosomal protein S15 -0.022814
PIBF1 progesterone immunomodulatory binding factor 1 -0.0227038
RPL7 ribosomal protein L7 -0.0226033
AHNAK AHNAK nucleoprotein -0.0225552
SCG2 secretogranin II -0.0222734
DCAF7 DDB1 and CUL4 associated factor 7 -0.0221523
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0220494
TIMP2 TIMP metallopeptidase inhibitor 2 -0.021933
FAM107B family with sequence similarity 107, member B -0.0217628
RPL9 ribosomal protein L9 -0.0211811
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0211159
ANK2 ankyrin 2, neuronal -0.0210596
MYO1E myosin IE -0.0209899
LDHB lactate dehydrogenase B -0.0206981
FREM1 FRAS1 related extracellular matrix 1 -0.0206654
UBE2B ubiquitin-conjugating enzyme E2B -0.0206343
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0205742
SMYD3 SET and MYND domain containing 3 -0.0205674